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J Korean Cancer Assoc > Volume 28(1); 1996 > Article
Journal of the Korean Cancer Association 1996;28(1): 145-151.
할미꽃 뿌리의 세포 독성 물질 Sterol 유도체 분리
현진원, 양용만, 성민숙, 정하숙, 백우현, 강삼식, 박재갑
The Cytotoxic Activity of Sterol Derivatives from Pulsatilla Chinensis Regal
Jin Won Hyun, Yong Man Yang, Min Sook Sung, Ha Sook Chang, Woo Hun Paik, Sam Sik Kang, Jae Gahb Park
In order to search for antineoplastic components from plants, cytotoxic activity against human carcinoma cell lines was measured in 266 extracts from 236 plants using the MTT (3-[4,5-dimethyl thiazol-2-yl]-2,5-diphenyl tetrazolium bromide) method. As a result, the root of Pulsatilla chinensis (Ranunculaceae), which has been used as an insecticide in oriental medicine, showed a cytotoxic effect. Its structure was determined to be a mixture of ¥a-sitosterol-3-O-glucoside and stigmasterol-3-O-glucoside (3:1). Its IC value was 26¥ig/ml against SNU-I stomach cancer cell line.
Key words: Pulsatilla chinensis, Ranunculaceae, Stomach cancer cell line, Cytotoxic activity, ¥a-Sitosterol-3-O-glucoside, Stigmasterol-3-O-glucoside
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