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J Korean Cancer Assoc > Volume 27(6); 1995 > Article
Journal of the Korean Cancer Association 1995;27(6): 961-968.
융모상피암 세포주에서 Transforming Growth Fasctor-β1 의 세포 성장 및 c-myc 암유전자 발현 억제효과
김사진, 김진우, 나종구, 이귀세라, 송승규, 남궁성은
Inhibitory Effect of Transforming Growth Fasctor-β1 on Cellular Proliferation and c-myc Expression in Choriocarcinoma Cell Line
Sa Jin Kim, Jin Woo Kim, Jong Gu Rha, Guisera Lee, Seung Kyu Song, Sung Eun Namkoong
ABSTRACT
Modulation of cellular proliferation and c-myc oncogene expression after treatment of human choriocarcinoma cell line(BeWo) with trsnsorming growth factor-¥a1(TGF-¥a1) have been investigated by MTT [3-(4,5-dimethylthiaxol-2-yl)-2, 5-diphenyltetrazolium bromide] assay and Northern blotting analysis, respectively. TGF-¥a1 inhibited BeWo cell growth in a dose dependent manner at concentrations of 0.00110 ng/mL. When BeWo cells were exposed to 10 ng/ml of TGF-¥a1,c-myc was repressed after 4hr and completely aboiished at 24hr of stimulation. These results show that TGF-¥a1 may play an antiproliferative effect on BeWo cell growth via c-myc gene product. In vitro analysis of cellular and molecular alterations in BeWo cells in this study may aid in elucidating the mechanism of action of TGF-¥a1 on human choriocarcinoma tissues in vivo.
Key words: Transforming growth factor-¥a1, c-myc oncogene, Choriocarcinoma
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