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J Korean Cancer Assoc > Volume 27(5); 1995 > Article
Journal of the Korean Cancer Association 1995;27(5): 857-869.
암빈발 가족과 그 유전적 성향에 관한 연구
김민영, 김수태, 김진복, 박귀원, 안효섭, 오승근, 최국진, 박규주, 오재환, 박재갑
A Study on Cancer Frequent Families and Their Hereditary Tendency
Minyoung Kim, Soo Tae Kim, Jin Pok Kim, Kwi Won Park, Hyo Seop Ahn, Seung Keun Oh, Kyk Jin Choe, Kyu Joo Park, Jae Hwan Oh, Jae Gagb Park
ABSTRACT
Authors have defined "Cancer Frequent Family (CFF)" as a family that yresents with clustering of different types of cancers among its members, but does not satisfy the arite- ria of any known hereditary cancer syndromes. The inclusion criteria for CFF are: three or more cancer patients (1) among siblings or (2) in more tbsn two successive generations or (3) in 3 or more cousins, with at least one of the patients diagnosed before the age of 50. Gastric cancer after age of 45 and primary liver cancer were excluded. By screening family history of cancer patients admitted to Seoul National University Hospital since l992, nine families fulfiling the CFF criteria were identified. Among 294 family members from these 9 families, thirty-six(12%) were affected with cancer. A total of 41 primary cancers affecting 10 different organs were found, with the average age at diaenosis of the first primary cancer being 47. Five members were affected with double primary cancers; four with 2 colorectal cancers and one with a rectal cancer and a malignant thymoma. Colorectal cancer was by far the most common malignancy encountered, accounting for 5l% of all the malignancies found. The average age at diagnosis of colorectal cancers in CFF was significantly younger than that of sporedic cases(43 vs 56, P<0.01). The incidence of metachronous colorectal cancer was aleo high(24%) in this group. On the basis of familial aggregation, younger age of onset, and multiplicity of tumors in affected individuals, hereditary backgrounds can be suspected in colorectal cancer patients of CFF families. Our resuits indicate that clustering of different malignancies in a family may suggest possible hereditary causes and that regular screening may aid in the early detection of other affected individuals in CFF families
Key words: Cancer, Hereditary, Cancer frequent family
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