Proliferating cell nuciear antigen (PCNA) is a nuclear protein sssociated with the cell prolif- erative state. The relationship between the presence of human papillomavirus (HPV) and proliferative indices (PI) was studied. Determination of PI was done by immunohistochemical staining via the avidin-biotin-complex immunoperoxidase method and HPV 16 and HPV 18 status by Southern blot hybridization on paraffin-embedded material from 49 patients with carcinoma of the uterine cervix. HPV 16 was present in 15 cases, HPV 18 wes observed in 6 cases, and both HPV 16 and HPV 18 were found in 4 cases. There was significant correlation between PI and HPV types. PI was 59.7+-9.0% in HPV 16 positive lesion, 67.4+-10.6% in HPV 18 positive lesion, 79.4+-4.2% in both HPV 16 and HPV 18 positive lesion, and 57.5+-16.9% in HPV negative lesion. Among cervical adenocarcinomas, PI was 72.5+-5 14.9% in HPV l6 or HPV 18 positive lesion, as compared to 39.8+-15.1% in HPV negative leaion. No correlation was found between HPV-DNA positivity and PI in relation to clinical stages, histologic typea, and lesion size.
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