Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Articles

Page Path
HOME > J Korean Cancer Assoc > Volume 27(4); 1995 > Article
Original Article
Expression of HLA Class 1 and 2 in Gastric Cancer and Adjacent Mucosa
Young Jin Kim, Ji Yun Kook, Hyun Jong Kim, Shin Kon Kim, Sang Woo Juhng
Journal of the Korean Cancer Association 1995;27(4): 544-550.
  • 3,085 Views
  • 19 Download
  • 0 Crossref
  • 0 Scopus
prev next

Expression of HLA-ABC and HLA-DR was observed in 24 fresh surgical specimens of both gastric cancer and adjacent mucosa with flow cytometry after staining with monoclonal antibodies. In gastric cancer tissues, the HLA-ABC positive cells were 79.9+-5.3% and the HLA-DR positive cells were 75.2+-t5.1%. These ratio of HLA-ABC and HLA-DR positive cells in gas- tric cancer tissues was higher than those in normal adjacent mucosa ( HLA-ABC; 68.0+-6.6 %, HLA-DR; 62.0+-6.2%). In metastatic gastric cancer, HLA-ABC was higher than normal mucosa in most cases. However, HAL-ABC expression in all cases with peritoneal seeding was less than normal mucosa. In stage I gastric cancers, HLA-ABC and HAL-DR positive cells were more than advanced gastric cancers. HLA-ABC positive cells were more com- mon in well and moderately differentiated gastric cancers than in poorly differentiated cancers (85.7+-26.4%: 76.7+-27.1%). The HLA-DR positive cells were less in aneuploid cancers than in diploid cancers (70.2+-28.1%: 87.8+-7.9%). We established method to quantitativ . analysis of HLA expression in tissue. Expression of HLA-ABC & DR were higher in gastric cancer tissues than in normal mucosa. Among the tumors, the HLA-ABC expression was higher in stage I, well differentiated and small cancers, and HLA-DR in diploid and nonmetastatic cancers.

  • Cite
    CITE
    export Copy Download
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Expression of HLA Class 1 and 2 in Gastric Cancer and Adjacent Mucosa
    J Korean Cancer Assoc. 1995;27(4):544-550.
    Close

Cancer Res Treat : Journal of the Korean Cancer Association
Close layer
TOP