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J Korean Cancer Assoc > Volume 27(4); 1995 > Article
Journal of the Korean Cancer Association 1995;27(4): 535-544.
위암 환자에서의 Neopterin 의 의의
하우송, 조현언, 정태섭, 김세엽, 최진상, 박순태, 김영채
Clinical Significance of Neopterin in Gastric Cancer Pancer Patients
Woo Song Ha, Hyun Un Cho, Tae Sub Jung, Se Yeop Kim, Jin Sang Choi, Soon Tae Park, Young Chae Kim
Neopterin can be used as an objective index of disease activity and response of therapy. In malignant diseases, the degree of neopterin elevation is a measure of clinical activity, and serves as a measure of extent of disease in some tumors. Since the analysis of urinary neopterin in gastrointestinal cancer patients is important in diagnosing malignancy, a method has been developed for its rapid and sensitive separation and quantitation using high perform- ance liquid chromatography(HPLC) on reverse phase. The aim of this study was to evaluate the correlation of the clinical and pathologic stage in gastric cancer and the neopterin leveL Using HPLC method, urinary levels of neopterin related to creatinine were determined for 40 gastric cancer patients(December, 1993--5eptember, 1994). The samples were the patients first morning urine(1 ml) and added 25 mg of disodium ethylenediamine tetraecetate and stored at 20'C in the dark state. Then samples were preparated with 1%, 12% KI and ascorbic acid, after then centrifuged at 3,000 rpm for 15 minutes. The supernatant was injected into HPLC. The other method was the use of commercially available Sep-Pak Cl8 cartridges(Waters Asso.). With this method, urinary neopterin level was measured in gastric cancer patients with stage IV and recurrence. The data was analysed with students t-test and it was statistically significant when p value was lower than 0.05. The results were as follows; in TNM classification, the neopterin/Cr. level was positively correlated with advanced stage(p<0.05). In WHO classification, the neopterin/ Cr. level of poorly differentiated group was higher than well differentiated group(p<0.05). In Mings classification urinary neopterin level of infiltrative type group was higher than that of expanding type group(p<0.05). In Laurens classification the neopterin/Cr. level of diffuse type group was higher than that of intestinal type group(p<0.05). In conclusion, there was a positive correlation between neopterin/creatinine ratio and the stage af gastric cancer and the severity of gastric cancer(Severity means advanced state in Pathologic classification. For example, stage II than stage I, stage III than II, stage IV than stage III in TNM classification, poorly differentiated than well differentiated in WHO classification, infiltrative type than expanding type in Mings classification, diffuse type than intestinal type in Laurens classification). So urinary neopterin levels were closely related to the extent of the lesion and severity of the disease.
Key words: Gastric cancer, Neopterin
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