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J Korean Cancer Assoc > Volume 27(3); 1995 > Article
Journal of the Korean Cancer Association 1995;27(3): 353-360.
위암 (胃癌) 환자의 위 점막내 Carotenoids 와 α-Tocopherol 농도에 관한 연구
이윤경, 염경진, 이경식, 박인서, 송시영, 이양자
A Study on Concentration of Carotenoids and α-Tocopherol in Mucosa of the Gastric Cancer Patients
Yoon Kyoung Lee, Kyung Jin Yeum, Kyung Shik Lee, In Suh Park, Si Young Song, Yang Cha Lee
ABSTRACT
To explore the relationships between carotenoids, a-tocopherol and gastric cancer we determined the concentration of B-carotene, lycopene, and a-tocopherol in mucosa from gastric cancer patients and control subjects with mild gastritis. The concentrations of B-carotene in both cancerous and non-cancerous gastric mucosa from cancer patients(242.5 ng/g, 197.6 ng/g) were significantly lower than those of control subiects(355.0 nR/ R). Lycopene concentrations in both cancerous and non-cancerous gastric mucosa from cancer patients(92.8 ng/g, 64.3 ng/g) were also significantly lower than those of control(162.6 ng/g). The a-to- copherol concentrations of cancerous(12.4ug/g) and non-cancerous mucosa(16.9ug/g) were lower than those of control(18.5 ug/g) but, the difference was not significant. Carotenoids and a-tocopherol were almost mually distributed in gastric mucosa. The concentrations of otene, 1ycopene, and a-tacopherol in gastric mucosa of females were higher than those of males for both cancer and control groups. The concentration of B-carotene decreased gradually with advancing age. Thus, B-carotene and lycopene might be protective against gastric cancer.
Key words: B-bcarotene, Lycopene, a-tocopherol, Gastric cancer
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