Liomyoblstoma, which has first proposed by Stout in 1962, is a rare disease that has a benign clinical course. But about 8-13% of cases change to malignancy. In complicated case, hemorrhage, necrosis, fistula formation can occur. A case of exogastric growing giant leiomyoblastoma with fistula manifested as hamate- mesis is presented. A 61-year old male patient suffering from massive hematemesis and epigastric discomfort for 1 month was proved to have large gastric leiomyoblastoma which had com- municating fistula into the gastric lumen by gastrofibroscopy and abdominal CT scanning. At operation, the mass was originated at lesser curvature of the stomach and located under pos- terior wall of the stomach and the transverse mesocolon waa protruded by the mass. The easily bleeding, multi-pedunculated mass was resected and diagnosed as leiomyoblastoma by Masson-trichrome and Vimentin stain. He is good health without evidence of disease, 2 months after operation.
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