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J Korean Cancer Assoc > Volume 27(1); 1995 > Article
Journal of the Korean Cancer Association 1995;27(1): 8-18.
위암 세포주에 대한 항암제 5-FU 와 Alpha-interferon 의 상승적 항암효과
김삼용, 박상준, 김종숙, 최지영, 윤환중, 전의건, 조덕연, 배진선
Synergistic Antitumor Effects of 5-Fluorouracil ( 5-FU ) and Alpha-interferon 2a Gastric Cnancer Cells
Sam Yong Kim, Sang Jun Park, Jong Suk Kim, Jee Young Choi, Hwan Jung Yun, Eui Gun Chun, Deog Yeon Jo, Chin Sun Bae
Many in vitro studies or clinical trials reported synergistic effect of the combination of 5-FU and alpha-interferon 2a(IFNa-2a) in patients with colorectal cancer, urinary bladder cancer, and esophageal cancer. There have been few reports on the effects of the combination of 5-FU and IFN against gastric cancer ce11 lines. This study was conducted to investigate the com- bined cytotoxic effects of 5-FU or cisplatin with IFNa-2a against two gastric cancer cell lines. SNU-1 and SNU-l6 cell lines were treated with a serial concentrations of 5-FU plus IFNa-2a (5000: 1, molar ratio) and cisplatin plus IFNa-2a (400: 1, molar ratio). Cytotoxicity was determined using a tetrazolium-based colorimetric (MTT) assay. The combination effect of two drugs was evaluated by the median effect principle after Chou et aL Calculation of Assay-AUC was done after Park et aL In SNU-1 cell line, combination of 5-FU and IFNa-2a showed a synergistic effect (combination index, CI<1). Assay AUC of 5-FU was markedly reduced com- parable to clinically achievable-AUC in all combinations. In SNU-16 cell line, combination of 5- FU or cisplatin with IFNa-2a showed no synergism (CI> 1). But inhibitory concentration (IC ) value was markedly reduced. So 5-FU or cisplatin activity were markedly enhanced by IFNa- 2a, especially at low doses.
Key words: 5-FU, IFNa-2a, Synergistic antitumor effects, Gastric cancer
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