| Home | E-Submission | Sitemap | Contact Us |  
top_img
J Korean Cancer Assoc > Volume 26(6); 1994 > Article
Journal of the Korean Cancer Association 1994;26(6): 959-964.
각종 암세포주에 대한 SB-31 의 항암효과
김삼용, 김송배
Anti-tumor Effects of extracts of Pulsatilla koreana ( SB-31 ) in vitro
Sam Yong Kim, Song Bae Kim
ABSTRACT
Extracts of P. koreana(SB-3l) has been tried as an antitumor agent by traditional medicine practitioner in Korea for the past 30 years. It is a specially prepared extract af P. koreana whose fractions lose efficacy compared to the original mixture. Lee" observed substantial antitumor effects and minimal toxicity of SB-31 in sarcoma 180 animal tumor model(unpublished data). For the past 5 ears, there has been dramatic though anecdotal therapeutic outcomes with SB-3l in some advanced stage cancer patients. We evaluated the in vitro antitumor effects of SB-31 against 3 kinds of gastric cancer cells, A549, HeLa and Caski, MCF7, HepG2 and Hep3B and normal mononuclear cells. Cytotoxicity ws evaluated with the Tetrazolium-based colori- metric assay(MTT) after incubation of cancer cells with SB-31. Results; in 3 gastric cancer cells, ID of SB-31 were 0.16, 0.34 and 0.53 mg/mL Most effective tumor cell kill was achieved after 96 hrs of incubation with SB-31. The ID values of SB-31 on various cancer cell lines ranged from 0.14 mg/ml to 0.27 mg/mL Keeping SB-31 ampul in room temperature up to 4 days did not affect the efficacy but the activity decreased after more than 4 days in the ambient temperature. It is concluded that SB-31 is an active antitumor agent without significanct toxicity. The mechanism of action of SB-31 and its toxicity and efficacy should be further evaluated.
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Share:      
METRICS
2,396
View
31
Download
Related articles
Anti - tumor Effect of Mycoplasma hominis on Transplanted Sarcoma 180 in Mice  1994 ;26(3)
Anti-tumor Effect of the Complex of Acriflavine and Guanosine (AG60)  1997 February;29(1)
Editorial Office
Korean Cancer Association
Room 1824, Gwanghwamun Officia
92 Saemunan-ro, Jongno-gu, Seoul 03186, Korea
TEL: +82-2-3276-2410   FAX: +82-2-792-1410   E-mail: journal@cancer.or.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © Korean Cancer Association.                 Developed in M2PI