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J Korean Cancer Assoc > Volume 26(6); 1994 > Article
Journal of the Korean Cancer Association 1994;26(6): 878-885.
직장대장암에서 p53 단백질의 발현이 예후에 미치는 영향
이강춘, 최동욱, 문난모, 김용규, 백남선, 이종인, 황대용, 장자준
Prognostic Significance of p53 Protein Expression in Colorectal Cancer
Kang Choon Lee, Dong Wook Choi, Nan Mo Moon, Yong Kyu Kim, Nam Sun Paik, Jong Inn Lee, Dae Yong Hwang, Ja June Jang
Molecular carcinogenesis model in colorectal cancer was proposed by Vogelstein in 19B9, that is, the accumulation of a series of genetic alterations results in malignant transformation from normal epithelium. Among them, p 53 gene mutation is known to take place in late stage, and is detected in more than 70% of colorectal cancers. Also, it was suggested that genetic alteration of p53 gene was related to worse prognosis in colorectal cancer patients. On the other hand, it is controversial still now whether p53 oncoprotein expression have relation with poor prognosis in colorectal cancers or not. So, we studied the p53 protein expression in l39 case of colorectal cancer patients who underwent curative surgical resection in Korean Cancer Center Hospital from Jan. 1984 to Dec. 1988 with immunohistochemical technique using Pab 1801, which is monoclonal antibody to p53 protein. We also analyzed the relevance between p53 protein expression and the conventional prognostic parameters. The positive rate of p53 protein expression was 43.9%. We didn't find any relevance between positive p53 protein expression and the conventional prognostic parameters except significantly lower expression rate in mucinous carcinoma(p=0.02). And, we could not detect any prognostic significance of p53 protein expression in resectable colorectal cancer patients. In conclusion, nuclear p53 protein expression by immunohistochemistry is considered to have no prognostic impact in resectable colorectal cancer patients. and we suggest that further study shou1d be going on including multiple genetic alteraions, and cytoplasmic p53 protein expression to detect the factors influencing on prognosis.
Key words: Colorectal cancer, Tumor suppressor gene, p53 gene, Prognostic parameter
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