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J Korean Cancer Assoc > Volume 26(6); 1994 > Article
Journal of the Korean Cancer Association 1994;26(6): 860-868.
진행위암 환자에서 5 - Fluorouracil 과 Cisplatin ( FP ) 의 복합화학요법
주흥돈, 조영삼, 박운식, 정윤형, 손영우, 한창완, 이귀래, 이홍복, 김정례, 변종훈
5 - Fluorouracil and Cisplatin ( FP ) Chemotherapy for Advanced Gastric Cancer
Hong Don Joo, Young Sam Cho, Woon Sik Park, Yun Hyoung Joung, Young Woo Son, Chang Wan Han, Chang Wan Han, Hong Bock Lee, Jeong Rye Kim, Jong Hoon Byun
ABSTRACT
Backgro#nnd: Evaluation has been undertaken in recent years to define the rale of 5- fluorouracil and cisplatin(FP) combination chemotherapy in the management of patients with locally advanced, metastatic and recurrent gastric cancer. We performed a retrospective analy- sis to assess the efficacy of FP chemotherapy on advanced gastric cancer. Method: Fifty-one patients with advanced gastric cancer were treated with FP chemothera- py. The regimen consisted of infusion of 1g/m of 5- fluorouracil for 5 consecutive days and in- fusion of 60mg/m of cisplatin on the first day. The treatment was repeated every 3 weeks until the progression of disease or development of unacceptable toxicities. Resnlte: Among 31 evaluble patients, 1 patient achieved complete remission(3.2%) and 16 patients, partial remission(51.6%). The median survival of overall patients was 203 days. The me- dian survival of responders was 413 days and that of nonresponders, 125.5 days(p=0.0091). No prognostic factors for response were identified. Perfomance status (p=0.0022) and the main site of measurable disease(p=0.0392) were statistically significant prognostic factors for survi- vaL Major toxicities were neutropenia(33.0%), anemia(59.2%), nausea and vomiting (69.2%). Coneluslon: FP chemotherapy had a modest antitumor effect in terms of median survival and was well tolerated.
Key words: Gastric cancer, Chemotherapy, 5- fluorouracil, Cisplatin
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