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J Korean Cancer Assoc > Volume 26(5); 1994 > Article
Journal of the Korean Cancer Association 1994;26(5): 815-822.
정상인과 암환자에서 혈중 Tumor Necrosis Factor - α 치의 비교 및 항암제 투여에 따른 변화
이용구, 김경년
The Comparison of Blood TNF - α Level between Normal Person and Cancer Patients , and the Change of Blood TNF - α Level in Cancer Patients Receivint the Ablation Chemotherapy Regimens
Yong Koo Lee, Kyoung Nyeon Kim
Tumor Necrosis Factor(TNF) is a polypeptide hormone produced in vivo by activated macrophages and lymphocytes, and they called TNF-a and TNF4 respectively. TNF has diverse biological effects which may provide either benefical or detrimental to the host depending on the amount of TNF produced. Blood concentration of tumor necrosis factor- a(TNF-a)were measured by enzyme-linked immunosorbent assay(ELISA) methods in 28 patients receiving the ablative chemotherapy regimens. And serum TNF-a level of patients with solid tumors were examined(esophegeal 10, gastric 10, and lung 8)along with 27 healthy controis. The most striking finding was spontaneous production of TNF-a in a significant proportion of cancer patients(28.72+-23.74 pg/ml: p<0.005) against control person. We also found that chemotherapy increased TNF-a production with 48.4+-23.69 pg/mL This increase was significant(p<0.005) compared to the prechemotherapy. Activated macrophage have been shown to exhibit selective cytotoxicity for neoplastic cells and are thought to play a significant role in tumor regression. There is experimental evidence for its interaction with other biological agents and cytotoxic drugs. Several chemotherapy agents might increase macrophage-generated TNF-a through some mechanisms. For TNF-a the biological agents and importance is certain and methods designed to antagonize the release or effects of TNF may have clinical application.
Key words: Tumor necrosis factor-a (TNF-a), Cancer
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