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J Korean Cancer Assoc > Volume 26(5); 1994 > Article
Journal of the Korean Cancer Association 1994;26(5): 793-801.
전립선 양성 및 악성종양에서 p53 의 발견
Expression of p53 in the Benign and Malignant Tumor of Prostate
Ki Kwon Kim
Immunohistochemical expression of the p53 was studied in 20 csses of benign proststic hypertrophy(BPH) and 56 prostatic adenocarcinomas using a monoclonal p53-specific DO7 anti- body (Novocastra, U.K.) on formaline-fixed paraffin-embedded tissue sections. Proliferative activity was determined by immunahistochemical detectian of proliferative cell nuclear antigen (PCNA) using a monoclonal PCIO antibody (Novocastra, U.K.). Eleven of 56 prostatic carcinomas(19.6%) showed strong immunostaining for p53 in more than 20% of tumor cells and 15 (28.6%) had focal(<=20%) immunoreactivity. The glandular epithelium adjacent to carcinomas showed features of prostatic intraepithelial neoplasia which was stained positively for p53 in 25%,but all cases of BPH showed no staining. High grade carcinomas(Gleasons combined score >=7) were associated with more intense and extensive p53 staining. High PCNA staining(higher than 50%)showed more p53 immunoreactivity(81.8%) than those cases with lower PCNA staining(40%). These findings indicste that altered expression of p53 protein occurs in a prostate cancer and is associated with increased proliferative activity and appears to play a role in the develpment of highly malignant prostatic carcinomas.
Key words: Prostatic carcinoma, p53, PCNA
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