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J Korean Cancer Assoc > Volume 26(3); 1994 > Article
Journal of the Korean Cancer Association 1994;26(3): 484-495.
마우스에 이식된 Sarcoma 180 에 대한 Mycoplasma hominis 의 항암 효과
박무인, 김광혁, 장명웅
Anti - tumor Effect of Mycoplasma hominis on Transplanted Sarcoma 180 in Mice
Mu In Park, Kwang Hyuk Kim, Myung Woong Chang
Sarcoma 180(S.180) tumor cells were transplanted to the peritoneal cavity and subcutaneous tissue of the inguinal region of mice, and then, Mycoplusma kominis were inculated into the peritoneal cavity of the mice 7 times. Inhibitory effect of tumor growth, effect of life prolongation, and changes of T cell subsets in the spleen, and changes of phagocytic rate of the macro- phages were examined. The growth of S. 180 in the peritoneal cavity was suppressed and the survival rate of those mice was increased in the group of mice inoculated with M, hominis after transplantation with S. 180. The growth of tumor was suppressed and the suppression rate of the tumor growth was 43.6% in the group inoculated with M. hominis after transplanta- tion with S. 180. In the spleen, the number of total T cells and T helper cells of each study groups was not different from that of the control group. In the group, however, inoculated with M. #homi#nis alone and the group preinoculated with M. hoinis 7 times before transplantaton with S, 180, T suppresor cells were decreased in number. In the spleen, in both group transplanted with S. 180, and inaculated with M. hominis after 7 days, and the group transplanted with S. 1SO after M. hominis was inoculated 7 times, the number of NK cells was increased. In other groups, however, the number of NK cells was decreased. The rate of phagocytosis of peritoneal macrophage from the mice inoculated with M. kominss was increased. The titers of serum antibody against M. hominis in the group of mice inoculated with M. hominis at different times after transplantation with S. 180 were increased from 320 to 1280 folds. All above results suggest that the tumor growth was inhibited by inoculation with M. hominis in the mice transplanted with S. 180., and propose that the tumor growth inhibition is not caused by the changes of number of T cell subsets but by number of NK cells and activity of macrophages.
Key words: Sarcoma 180, M. hominis, Anti-tumor effect
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