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J Korean Cancer Assoc > Volume 26(1); 1994 > Article
Journal of the Korean Cancer Association 1994;26(1): 144-151.
고형암의 항암제 치료후 발생하는 호중구감소증에 대한 Granulocyte Colony Stimulation Factor ( G - CSF ) 의 효과
신상원, 남용진, 최철원, 송관규, 김준석, 김순덕, 김열홍
The Effects of Granulocyte Colony Stimulating Factor on Neutropenia Induced by the Chemotherapy in the Solid Tumor Patient
Sang Won Shin, Young Jin Nam, Chul Won Choi, Gwan Gyu Song, Jun Suk Kim, Soon Duck Kim, Yeul Hong Kim
We evaluated the effect of aranulocyte colony stimulating factor (G-CSF) to prevent chemo- therapy induced neutropenia and fever development during neutropenic period. The twenty patients with solid tumor were treated with various cytotoxic chemotherapeutic agents at least two cycles. The patients were given G-CSF 75pg/day after 2nd cycle chemotherapy for least 14 consecutive days and clinical, laboratory results were compared to the first cycle's results. Treatment with G-CSF resulted in increase of mean neutrophil count(320+-230/mm(3) vs 1030 +-1020/mm(2)), reduced the duration of neutropenic days(4.25 dyas vs 1.30 days, absolute neutrophil count less than 500/mm) snd reduced the incidence of neutropenic fever(75% vs 25% ). The side effect af G-CSF was not so significant. These results demonsrated that the use of G-CSF as an adjunct to chemotherapy with various solid cancer patients was well tolerated and led to reduction in the incidence of neutropenic fever; in the terms of incidence, duratian, and severity of neutropenia.
Key words: Granulocyte colony stimulating factor, Neutropenia, Chemotherapy
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