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J Korean Cancer Assoc > Volume 22(3); 1990 > Article
Journal of the Korean Cancer Association 1990;22(3): 355-360.
배추 추출물의 디에칠 니트로사민에 의한 백서 간장 변이소 수식에 관한 효과
이윤실, 장원석, 어미정, 이선주, 장자준
Inhibitory Effect of Chinese Cabbage Extract on Diethylnitrosamine - Induced Hepatic Foci in Sprague - Dawley Rats
Yun Sil Lee, Won Suk Jang, Mi Jung Eui, Sun Ju Lee, Ja June Jang
ABSTRACT
The modifying effect of Chinese cabbage extract on the development of preneoplastic hepatic enzyme altered foci was examined in an in vivo mid-term assay system. Diethylnitrosamine (DEN) of 15 mg/kg body weight was injected to newborn Sprague-Dawley rat subcutaneously within 24 hours, and after 3 weeks, Chinese cabbage (95% ethanol extract) was given at a dose of 2 mg/ml in drinking water. All rats were sacrificed at week 12. The modifying effect was evaluated comparing the number of foci and area/cm of induced glutathione S-transferase placental form positive (GST-P ) foci in the liver with those of the corresponding control group given DEN alone. Chinese cabbage extract showed statistically significant decrease in the number and area of GST-P+ foci. The result suggests that Chinese cabbage could have inhibitory effect on rat hepatocar- cinogenesie.
Key words: Chinese cabbage extract, GST-P+ foci, DEN, Hepatocarcinogenesis
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