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J Korean Cancer Assoc > Volume 22(2); 1990 > Article
Journal of the Korean Cancer Association 1990;22(2): 229-239.
NIH3T3 섬유 아세포의 c-myc 유전자 발현에 있어서 Exon 1 과 Upstream Sequence 의 영향
이영환, 황태주
Effect of Exogenous Exon 1 and Upstream Sequences on c-myc Expression in NIH3T3 Cells
Young Hwan Rhee, Tai Ju Hwang
ABSTRACT
Several mechanisms regarding activation of c-myc have been proposed. However, the molecular mechanism by which c-myc deregulation can occur remains obscure and no supparting evidence for a clearly defined regulation of c-myc expression has been provided. This research was designed to investigate the possible effect of exon 1 and its upstream sequences on c-myc expression. The transcriptional activities of exogenous plasmids and endogenous c-myc were studied for their expression after NIH3T3 cells were transiently transfected with plasmids containing exon 1 and upstream sequences of mouse c-myc that are putativelv regulatory sequences. The results of this research rule out a possible role of putatively regulatory sequences for transacting elements, an activator and a repressor, because the expressions of c-myc were not affected by the exogenous elements of exon 1 or upstream sequence in NIH3T3 fibroblast cells.
Key words: c-Myc, Exon 1, Upstream Sequence
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