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J Korean Cancer Assoc > Volume 22(1); 1990 > Article
Journal of the Korean Cancer Association 1990;22(1): 171-183.
Difluoromethylornithine 이 대장암 및 위암 세포주의 성장에 미치는 영향에 관한 연구
전호경, 박재갑, 황이숙, 홍성국
Effects of α-difluormethylornithine ( DFMO ) on Growth Inhibition of Human Gastric and Colorectal Carcinoma Cell Lines
Ho Kyung Chun, Jae Gahb Park, Ee Sook Hwang, Sung Kuk Hong
DFMO, an irreversible inhibitor of ornithine decarboxylase, blocks polyamine biosynthesis, is reported to have antitumor effects in vitro at the peak achievable plasma concentration (about 0.5 mM). We determined the effects of DFMO on the growth of gastric and colorectal carcinoma cell lines using the semiautomated tetrazollum MTT assay. At a concentration of 0.5 mM and a 4 day incubation periad, DFMO inhibited the growth of 4 gastric cell lines by a median value of 5% and the growth of 7 colorectal cell lines by a median value of 22%. These effects were reversible by the addition of 0.1 mM of putrescine. Conciusians: 1) at the peak achievable plasma concentration, DFMO has very modest inhibitory effects on the growth of gastrointestinal carcinoma cell lines: and 2) DFMO may have a greater growth inhibitory effect on colorectal than on gastric carcinoma cell lines.
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