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J Korean Cancer Assoc > Volume 22(1); 1990 > Article
Journal of the Korean Cancer Association 1990;22(1): 125-131.
췌장 및 담낭암에 대한 5-FU , ACNU , Mitomycin-C ( FUM ) 복합 화학요법
차중직, 김석균, 현인영, 홍원선, 이진오
Combination Chemotherapy with 5-fluorouacil , ACNU and Mitomycin-C ( FUM ) for Carcinoma of the Pancreas and Gallbladder
Joong Jik Cha, Seok Kyun Kim, In Young Hyun, Weon Seon Hong, Jhin Oh Lee
Ten patients with pancreatic cancer and four with gailbladder cancer were treated with FUM: 5-fluorouracil (5-FU), ACNU and mitomycin-C (MMC): 5-FV 1,000 mg/m' i.v. on day 1 5, ACNU 60 mg/m(2) i.v. on day 1 and MMC 10 mg/m i.v. on day 5, everv four weeks. All patients had previously untreated and unresectable cancer due to direct invasion and/or distant metastasis. No complete response was observed. Three of 14 patients (21.4%) obtained partial response. Four patients (28.6%) showed no change and seven (50.0%) evidenced progressive disease. The median survival was 7.1 months for all patients, i.5 months for patients without metastasis and 3.8 months for patients with metastasis. Nine vf 14 patients (64.3%) have survived more than six months and four (28.6%) are still alive. Response rate were analyzed with regard to the age, sex, distant metastasis, serum carcinoem- bryonic antigen (CEA) level and jaundice. Patients with more than 50 years old, no metastasis, high CEA (>10 ng/ml) and low bilirubin (<2.0 mg/ml) showed higher response rate compared with those with less than 50 years old, metastasis, low CEA (<10 ng/ml) and high bilirubin (>=2.0 mg/ml), however, there was no statistical significance between these factors and response rate. The toxicity was mild to moderate. Patients were generally well tolerated, although all patients experienced nausea, vomiting and alopecia. Three patients had moderate degree of stomatitis and four showed severe myelosuppression for more than four weeks, however, myelosuppression was recovered by five or six weeks after treatment in all casea We think that these results provide a rationale for the conduction of the initiation of a large prospective randomized controlled trials with FVM therapy for the carcinorna of pancreas and gallbladder.
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