| 인형 암세포주에 대한 Doxorubicin 의 In Vitro Chemosencitivity 에 관한 연구 |
| 박정규, 임동균, 국윤호, 차창룡, 백철기 |
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| In Vitro Chemosencitivity of Doxorubicin on Human Cancer Cell Lines |
| Chung Gyu Park, Dong Kyun Lim, Yoon Hoh Kook, Chang Yong Cha, Chul Gi Paik |
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| ABSTRACT |
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The anticancer effect of doxorubicin was evaluated on human cancer cell lines (K562, KATOIII, PC-14, HeLa, SNU-C5, NCI-H417 and Nalm-6) after exposure to doxorubicin at 5, 50, 500 ng/ml for 1 hour at 37`C using in vitro agar-methylcellulose clonogenic assay. The drug concentration which produced 50g inhibition of colony formation (ID) of each cell line were as follows: K562, 258.2 (ng/ml); KATO IIL, 473 (ng/ml); PC-14, 268.5 (ng/ml); HeLa, 355.7 (ng/ ml), SNU-C5, 241.5 (ng/ml); NCI-H417, 13 (ng/ml); Nalm-6, 20 (ng/ml). From this assay NCI-H417 and Nalm-6 were considered to be sensitive to doxorubicin on the basis of the fact that the ID,. for these cell lines was within a clinically achievable range. |
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