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J Korean Cancer Assoc > Volume 22(1); 1990 > Article
Journal of the Korean Cancer Association 1990;22(1): 24-32.
신피막하 종양이식 분석법에 의한 부인과악성 종야의 화학감수성 검사에 관한 연구
강순범, 조경훈, 이필량, 김승철, 최영민, 이효표, 정동근, 김로경, 박재갑, 박성회
신피막하 종양이식 분석법에 의한 부인과악성 종야의 화학감수성 검사에 관한 연구
Soon Beom Kang, Kyeong Hoon Cho, Pil Ryang Lee, Seung Cheol Kim, Young Min Choi, Hyo Pyo Lee, Dong Geun Chung, Noe Kyeong Kim, Jae Gahb Park, Seong Hoe Park
ABSTRACT
The chemosensitivity testing is important in the research of cancer biology, development and screening of anticancer drug, and improvement of chemotherapy modalities. Subrenal capsule tumor implant assay (SRCA) is a promising rapid method in the selection of individual chemotherapy for cancer patients clinically. A total of 100 SRCA were performed with several gynecologic malignancies(69 cervical, 10 ovarian, 10 endometrial carcinomas, 6 vulva carcinoma, 4 sarcoma, and 1 choriocarcinoma). 1 mm x 1 mm x 1 mm fragments oi fresh human gynenologic tumors were implanted under the renal capsule of immunocompetent female adult BALB-C mice and tested against several chemotherapeutic agents or their combinations. An average of 75% of tumors showed positive growth. The evaluable assay rate was 91%(91/100). Variable response rate were noted in each gynenologic tumor. An overall predictive accuracy rate of SRCA was 73% in present series. In conclusion, the SRCA is considered as a reliable in vivo clinical chemosensitivity test in the selection of individual cancer chemotherapy.
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