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J Korean Cancer Assoc > Volume 21(2); 1989 > Article
Journal of the Korean Cancer Association 1989;21(2): 290-304.
3'-Methyl-4-dimethylaminoazobenzene 으로 유발된 담관세포암에서의 세포성 암유전자의 발현양상에 관한 연구
방영주, 김노경, 김용일, 서정선
Expression of Celluar Oncogenes in the 3'-Methyl-4-dimethylaminoazobenzene Induced Cholangiocarcinoma in Rat
Yung Jue Bang, Noe Kyeong Kim, Yong Il Kim, Jeong Sun Seo
To find out the roll of cellular oncogenes in 3'-methyl-4-dimethyl-aminoazobenzene (MeDAB)- induced carcinogenesis in rat, an experimental study was made using Sprague-Dawley rat. In additirm, to explore whether selenium could prevent the development of cancer in this model, selenium was also given. The resuits were as follow.. 1) Histnpathologic changes were proliferation of ovalocytes, proliferation of bile ducts, cholan- giodysplasia, and cholangiocarcinoma in sequence. 2) Induced carcinomas were all cholangiocarcinoma, but one case also showed the foci of hepatoceiluiar carcinoma and another one the foci of mixed tumor. 3) Selenium did not show the preventive effect on the development of cholangiocarcinoma induced by MeDAB. 4) One case with normal histology showed the elevated expression of 5 cellular oncogenes, namely H-ras. IC-ras, myc, fps, and myb. 5) Casec with cholangiodysplasia also showed the enhanced expression of cellular rmcogenes. 6) Four weeks after the cessation of the administration of MeDAB, 2 cases with the cholangiodys plasia did not show the elevated expression of any cellular oncogene, but 4 cases with cholangiocarcinoma showed the enhanced expression offps and/or myc, suggesting the important role of these two oncogenes in the final development of cholangiocarcinoma.
Key words: 3'-methyl-4-dimethylaminoazobenzene, Cellular oncogene, Carcinogenesis, Selenium
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