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J Korean Cancer Assoc > Volume 20(2); 1988 > Article
Journal of the Korean Cancer Association 1988;20(2): 153-160.
침윤성 자궁경부암 환자에서의 SCC Antigen 측정의 의의
김수녕, 최동희, 강성호, 박찬규
Clinical Significance of Squamous Cell Carcinoma Associated Antigen in Patients With Invasive Carcinoma of Uterine Cervix
Soo Nyung Kim, Dong Hee Choi, Sung Ho Kang, Tchan Kyu Park
The squamous cell carcinoma antigen, SCC antigen, is a subfraction of TA-4 tumor antigen which is purified from squamous cell carcinoma tissue of the uterine cervix. Recently, it has been found to be elevated in patients wit.h squamous cell carcinoma. In this study, SCC antigen levels in sera from 43 patients with invasive cervical carcinoma, 10 healthy women, and 10 patients with various behign gynecologic tumors were detennined by radioimmunoassay. The results were summarized as follows: 1) The mean value and positive rate af SCC antigen were higher in invasive cervical cancer (4.6 ng/ ml and 58.1%. respectively) compared with control (1.0 ng/ml and 0%, respectively) and benign gynecologic diseases (1.7 ng/ml and 30.0%, respectively). 2) Mean value of serum SCC antigen before treatment was 2.8 ng/ml in stage I, 4.8 ng/ml in stage lI, and 10.8 in stage lII nr IV, and 2.6 in recurrent cervical carcinoma, respectively. There was an increasing serum SCC antigen value with advancing stage, however, there were no significant differences in the mean values of seum SCC antigen according to stage. 3) Serum Scc antigen values above 2,0 ng/ml were observed in 35.7% of patients with stage I, 73.7 % with stage II, 60.0% with stage III or IV, and 60% with recurrent disease, respectively. According to stage uf ceivical cancer, the posit.ive rate of SCC antigen in stage II or more was higher than stage 1. 4) Mean value of serum SCC antigen level was more elevated in patients with squamous cell carcinoma(53 ng,"ml) than in patients with endocervical adenocarcinoma (1.3 ng/ml). However, this difference was not statistically significant. 5) SCC antigen values were serially determined in eight cases of invasive cervical carcinoma. In patients with cervical cancer who shawed an elevated pretreatment value, the serial determination of SCC antigen correlated well with the clinical course. It would be suggested that serial serum SCC antigen measurements, especially in the cases with high pretreatment antigen levels of the antigen, may be helpful in the early detection of persistent or recurrent cervical cancer and in determining therapeutic response after treatment.
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