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J Korean Cancer Assoc > Volume 20(1); 1988 > Article
Journal of the Korean Cancer Association 1988;20(1): 67-73.
원격전이 및 재발된 두경부 악성종양 ( 편평상피암 ) 에 대한 5-FU Infusion 및 Cisplatin ( FP ) 복합 화학요법
이재훈, 윤성수, 강윤구, 김승택, 방영주, 김노경, 김광현, 민양기, 박찬일
5-FU Infusion and Cisplatin in Patients with Disseminated or Recurrent Head and Neck Cancer
Jae Hoon Lee, Sung Soo Yoon, Keun Chil Park, Seung Taek Kim, Yung Jue Bang, Noe Kyeong Kim, Kwang Hyun Kim, Yang Gi Min, Charn Il Park
56 patients with dissminated or recurrent head and neck cancer were treated with 5-FU infusion and cisplatin between July, 1983 and June, 1986. The results were as follows; 1) Among 54 evaluable patients, response rate was 48.1% (complete responses 7.4% partial responses 40.7%).Response rates of disseminated and recurrent group were 88.9% and 40%, respectively (p<0. 05). 2) Median time to disease progression was 4.4 months for overall patients, and 7.5 months and 2. 9 month for responders and nonresponders; there was statistically significant difference (P<0.05). 3) Median survival was 15.3 month for overall patients and 24.5 month and 9.2 month for responders and nonresponders; there was statistically significant difference (P<0.05). 4) Nausea and vomitting were observed in all patients but easily controlled, and stomatitis, alopecia, diarrhea were obrerved infrequently, 1eukopenia and thrombocytopenia were observed in 25, 9% and 1, 9%, In conclusion, combination chemotherapy with 5 FV infusion and cisplatin in patients with disseninated or recurrent head and neck cancer seemed to be relatively effective and well tolerable.
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