Abstract

We attempted to investigate the influence of immunochemosurgery on peripheral natural killer cell activity of longterm survivor patients, and to compare the results of immediate postoperative patients and that of longterm survivor patients. The natural killer cell activity of 95 stomach cancer patients was studied preoperativley and postoperatively, and the following results were obtained: 1) The mean natural killer cell activity of longterm survivors among the patients who had received curative surgery for gastric carcinoma was 34.20+14.56%, which was significantly higher than that of preoperative patients (P < 0.01). And the value of early postoperative group was 43.37+-19.89%, also significantly higher than that of preoperative patients (P<0.01). 2) The mean natural killer cell activity of 22 patients with perigastic lymph node invasion was 30. 57+-12.23%, lower than that of other 32 patients who had no invasion (P<0.05). 3) There was no correlation between the natural killer cell activity and the percent values of the T-cell count, weight loss, age and sex, clinical stage, or depth of serosal invasion.