Primary CNS lym poma is a multifocal, infiltrative, malignant lymphoma that has a predilection for paraventricular areas. This tumor occurs with increased frequency in patients who are immunologically suppressed, particulary those with organ transplants or AIDS. Radiotherapy has traditionally been administered to patients with CNS lymphomas. But the failure in the brain at sites of other than those originally involved was common in spite of the use of whole brain irradiation. We experienced a case of a patient with primary CNS malignant lymphoma who had multicentric recurrence in spinal axis following whole brain radiotherapy. So we have reported the case with the review of previous literatures.
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