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J Korean Cancer Assoc > Volume 19(2); 1987 > Article
Journal of the Korean Cancer Association 1987;19(2): 114-119.
암 환자에서 Ibuprofen ( Motrin ) 의 부가적 진통 효과
이민상, 전영수, 문한림, 홍영선, 김훈교, 김호연, 이경식, 김동집
The Additive Analgesic Effect of Ibuprofen ( Motrin ) in the Pain Control of the Cancer Patients
Min Sang Yi, Young Soo Jun, Han Lim Moon, Young Seon Hong, Hoon Kyo Kim, Ho Yun Kim, Kyung Shik Lee, Dong Jip Kim
We have studied the additive analgesic effect of Ibuprofen (Motrin) to other analgesics, such as Acetaminophen, Codeine, and Morphine Tincture, in 29 cancer patients with pain. Ibuprofen was administered 600 mg every 6 hour orally in addition to the other 3 drugs. Ibuprofen had additive analgesic effect only in mild or moderate pain (effectivity 77.8%) but not in severe pain. The drug was more effective in localized pain than in systemic pain (p<0.002), but the reported superiority of the drug in bone pain could not be confirmed. The adverse effects of Ibuprofen was minimal in frequency and severity. In twenty six of the 29 studied patients (89.7%), the pain could be controlled with these 4 drugs, alone or in combination.
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