| 대장암에 대한 5-Fluorouracil 지속주입 및 Mitomycin-C ( FM ) 복합화학요법의 치료효과 |
| 강윤구, 윤성수, 이재훈, 김승택, 방영주, 김노경, 박재갑, 이건욱, 홍성국, 최국진, 김수태, 하성환, 박찬일 |
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| 5-Fluorouracil Continuous Infusion and Mitomycin-C ( FM ) Combination Chemotherapy for Metastatic or Recurrent Colorectal Cancer |
| Keun Chil Park, Sung Soo Yoon, Jae Hoon Lee, Seung Taek Kim, Yung Jue Bang, Noe Kyeong Kim, Jae Gahb Park, Kuhn Uk Lee, Sung Kuk Hong, Kuk Jin Choe, Soo Tae Kim, Sung Whan Ha, Charn Il Park |
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| ABSTRACT |
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Between March, 1983 and June, 1986, 64 patients with metastatic or recurrent colorectal cancer were treated with a combination chemotherapy consisting of 5-fluorouracil (5-FV), 1,000 mg/m iv continuous infusion over .12 hours on day 1-5; mitomycin-C, 10 mg/m iv on day 1; cycled every 4 weeks. Among 46 patients with measurable lesions, none achieved complete remission and 5 (11%) achieved partial remissions. The median duration of remission was 31 weeks. Overall median survival was 49 weeks for all patients; 65 weeks for patients with remission; 51 weeks for those with stable disease; and 31 weeks for those with progressive disease, Greater response rates were observed in patient groups with age over 50, performance status 0-1, no previous history of chemotherapy, initial CEA level less than 10 ng/ml, or metastatic sites of lymph node, than in respective comparative patient groups. But, these differences did not achieved statistical significance. Toxicity was common, but generally mild to moderate and rapidly reversible. |
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