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J Korean Cancer Assoc > Volume 19(2); 1987 > Article
Journal of the Korean Cancer Association 1987;19(2): 63-68.
화학요법제와 Polysaccharide-K 의 병합치료가 위암환자의 Natural Killer Cell 활성도에 미치는 영향
정영환, 김창민, 이진오, 조성기, 윤택구
Effects of Chemotherapeutic Agents and Polysaccharide-K Combination Therapy on Natural Killer Cell Activitiy in Stomach Cancer Patients
Young Hwan Chung, Chang Min Kim, Jhin Oh Lee, Sung Kee Jo, Taik Ku Yun
This study was performed to evaluate effects of chemotherapeutic agents and polysaccharide-K combination therapy on natural killer cell activity in 29 patients with inoperable stomach cancer. Of total 29 patienta 9 patients received chemotherapy and krestin and 12 patients received chemotherapy and copolang. In 8 control patiente, only chemotherapy was given. All groups showed the decreasing tendency in NK cell activity after 4 weeks' treatment, but in contrast to control group, krestin and copolang group revealed the inclination to restore NK cell activity after H weeks' treatment. There was significant decrease in peripheral lymphocytes count after 8 weeks treatment. No difference in clinical outcome was found during follow up periods among the groups. We expect that the long-term administration of polysaccharide-K would give beneficial effects on inoperable patients with stomach cancer through the mechanism involving augmentation of NK cell activity.
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