Abstract

The examinations were conducted with Copolang (protein bound polysaccharides from na- tural Coriolus versicolor) and PSK(protein bound polysaccharides from cultured Coriolas versicolar) referring to anti-tumor effect on several experimental tumor lines, influence on host immune function and its toxicity. Acute toxicity of Copolang could not be observed because the case of death was occured at higher dose administrations. There were significant inhibition of tumor growth in Sarcoma 180 by intraperitoneal administration of Copolang or PSK compared with control(p<0.01), Two cases of complete tumor regression was observed in the Copolang or PSK,treatment group. However, the results indicated that Copolang or PSK did not inhibit the growth of L1210 solid tumor and not prolonged life span of L1210 or P 388 tumor bearing mice. Natural killer ce11 activities of splenic lymphocytes and non-adherent peritoneal exudate cells were augmented by Copolang administration in EL-4 transplanted C57BL/6 mice. Cytoto.xicity of T lymphocyte against EL-4 was enhanced by Copolang in the tumor-bearing mice.