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J Korean Cancer Assoc > Volume 17(1); 1985 > Article
Journal of the Korean Cancer Association 1985;17(1): 55-59.
인체 대장 선암유래 세포주 ( SC-1 ) 의 누드 마우스 이식
양한광, 김용일, 박재갑, 김진복, 김우호, 장우현, 이문호
Heterotransplantation of Cell Line ( SC-I ) derived from Human Colon Adenocarcinoma in Athymic Nude mice
Han Kwang Yang, Yong Il Kim, Jae Gahb Park, Jin Pok Kim, Woo Ho Kim, Woo Hyun Chang, Mun Ho Lee
The result of subcutaneous inoculation of SC- I (Seoul National University, Adenocarcin- oma of the Colon) cell line into nude mice is descibed. Twenty-three million and four hundred thousand SC- I cells were injected subcutaneously into the subscapular area of a 28-day-old male nude mouse. After 10 days, tumor was palpable and measured 15.0x7.4x4.0 mm. After 22 days it measured 14.7X12.3x3.7 mm. After 24 days the nude mouse died from unknown cause. Twenty-six million and six hundred thousand SC- I cells were injected subcutaneously into the subscapular area af a 33-day-old male nude mouse. After 3 dys tumor was palpa- ble, but it did not grow any more. On the 26 th day from the first iny. tion, 23. 5x10' SC- I cells were reinjected into the same site of .the same mouse. After 6 days from the second injection, tumor began to grow. After 63 days it measured 22.4x24.0XI2.0 mm and was subpassed to two 33-day-old male nude mice. Histopathologically the tumor produced in the nude mouse showed gland forming tendency with scanty stroma and tumor cells infiltrated into the skeletal muscle of the nude mouse.
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