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J Korean Cancer Assoc > Volume 16(2); 1984 > Article
Journal of the Korean Cancer Association 1984;16(2): 229-233.
인체 위 선암유래 세포주 ( SS-I ) 의 누드 마우스 이식
김진복, 박재갑, 양만광, 차창용, 문신용, 김우호, 김용일, 장우현, 이문호
Heterotransplantation of Cell Line ( SS-I ) derived from Human Stomach Adenocarcinoma in Athymic Nude Mice
Jin Pok Kim, Jae Gahb Park, Han Kwang Yang, ng Yong Cha, Shin Yong Moon, Woo Ho Kim, Yong Il Kim, Woo Hyun Chang, Mun Ho Lee
The result of subcutaneous inoculation of SS-1(Seoul National University, Adenocarcinoma of the Stomach) cell line"' into nude mice is described Three million SS-I cells from passage 29 were injected subcutaneously into the subscapular area of a 57-day-old male nude mouse. But tumor was not produced. Twenty million and one hundred thousand SS-I cells from passage 35-37 were injected into a 27-day-old male nude mouse. After eight days seven million and eight hundred SS-I cells from pasaage 39-40 were injected again into the same site of the mouse. Nineteen days after initial injection: a.tumor became visible at the site of inoculation. After 53 days, the nude mouse died due to wasting by the huge tumor. Sixty-six million SS-I cells from passage 42-45 were injected into a 26-day-old male nude mouae. After 18 days a tumor became visible and it grew fast. After 53 days the tumor measured. 20.8 x 20. 1 x 15.0 mm and the tumot was subpassed to a 21-day-old male nude mouse. After 58days from the first subpassage the.' tumor measured 26. 4 x 22. 4 x 12. 5 mm and the tumor was subpassed again to a 44-day-old male nude mouse. Doubling time of the tumor was about 5.5 days. Histopathalogically the tumors produced in nude mice. were similar to the human tumor of arigin.
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