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J Korean Cancer Assoc > Volume 14(1); 1982 > Article
Journal of the Korean Cancer Association 1982;14(1): 31-39.
급성골수성백혈병의 급성전화
허대석, 김로경, 허인목, 이문호
Clinical Observation of Acute Transformation in Chronic Myelocytic Leukemia
Dae Seog Heo, Noe Kyeong Kim, In Mok Heu, Mun Ho Lee
44 patients with chronic myelogenous leukemia in terminal pha e(accelerated phase & blast crisis) were evaluated in their clinical characteristics and response to treatment. Their median survival time was 31 months from diagnosis and 2 months from blast crisis. Median duration from diagnosis to accelerated phase was 23 months, 3 months from accelerated phase to blast crisis. Of 23 expired patient, seven patients (30%) progressed to blast crisis without acce- .lerated phase and another seven patients (30%) died in accelerated phase without progrescion to blast crisis. Their clinical characteristics are as follows: fever (64%), inexplicable malaise (83%), .anemia (94%,), leukocytosis (55%) and thrombocytopenia (69%). But no significant difference was obser.ved between accelerated phase and blast crisis. Eight patient in accelerated phase were treated with hydroxyurea. Of the 8 patients, one patient showed complete remission and partial remission obtained in 5 patients. hledian duration of accelerated phase in hydroxyurea-treated group(7 months) was longer than tbat of untreated group (2 months) (p<0.05). Fourteen patients in blast crisis were treated with Vincristine and Prednisone, of which four patients showed complete remission and partial remission obtained in 5 patients. Median survival of non-responders was 1 month which showed no difference from that of the untreated group. Of the four patients who showed response, two died in B months, one in 8 months and another one is still alive for 7 months.
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