Journal of the Korean Cancer Association 1982;14(1): 21-30.
위암 , 대장 및 직장암과 유암 환자에서 암의 임상기와 항체 의존성 세포 파괴능에 관한 연구
김영석, 김상준, 김진복
The Study on the Relation Between the Clinical Stage and Antibody Dependent Cellular Cytotoxicty in Patients with Stomach , Colo - rectal , and Breast Cancer
51 Cr release assay was performed to evaluate the antibody-dependent cellular cytotoxi- city(ADCC) activity of lympho-mononuclear cells from the peripheral blood of patients with stoniach, colo-rectal, and breast cancer by clinical stage. Chicken red blaod cells were used as target cell and anti-chicken red blood cell sera were made frem rabbit. We used the effector cell; target cell ratio as 10:1. 49 healthy narmal persons were chosen by age and sex match as controls. ADCC activity in 49 normal per ons was 44.0+-15. 9%. There was no difference of ADCC activity by age and sex in normal controls. ADCC activity was decreased in patients with stomach, colo-rectal, and breast cancer, comparing to that of normal controls (p<0. 001). A delcline of ADCC activity was well observed with increasing clinical stage in stomach cancer patients, partially observed in colo-rectal cancer patients, and not observed in breast cancer patients.