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J Korean Cancer Assoc > Volume 13(1); 1981 > Article
Journal of the Korean Cancer Association 1981;13(1): 31-48.
N-Methyl-N'- Nitro-N-Nitrosoguanidine 경구투여에 의하여 발생된 흰쥐의 간엽성 종양에 고나한 병리조직학적 연구
이건욱, 김진복, 김용일
A Histopathologic Study on Mesenchymal Neoplasms of Gastrointestinal Tract in Rats Induced by Peroral Administration of N-Methyl-N'- Nitro-N-Nitrosoguanidine
Kuhn Uk Lee, Jin Pok Kim, Yong Il Kim
ABSTRACT
A histopathologic studp on the experimentally induced mesenchymal neoplasms of the stomach and small intestine by peroral administration of N-Methyl-N'-Nitro-N- Nitrosoguanidine(MNNG) was carried out to clarify the morphologic characteristics .and nature of their tumorigenesis. A total of 220 male rats were divided into two groups; control group of 83 Wistar .rats and experimental group(MNNQ group) of 86 Wistar and 51 Fisher rats that were .administered with MNNG at the level of 100 ng/ml in drinkiag distilled water ad lib- itum for a period of 37 weeks. The control group was fed with distilled water. After 87 weeks of exposure experimental animals were sacrificed and autopsied. Followfng the macroseopic examination of entire ga'strointestinal traet, stamach and amall intestine were serially cut, embedded in paraffin and were examined histopatho- logicallv. The results were as follows; 1. In MNNG administered group the mesenchymal lesions including true neoplastic growth developed in 52 cases(37. 9%), of which 37 were found in the stomach and 15 in the small bowel. Among these mesenchymal lesions submucosal fibroplastic lesions was the most common one being 75.2%. And the remainders consisted of truelp neo- plastic of both benign and malignant neoplasms, i.e., 3 leiomyomas, I hemangioma, 1 lymphangioma, I fibroma, 6 angiosarcomas, 4 leiom#yosarcotnas, 1 ntalignant achwann- ama and I sarcoma of unclassified type. 2. Seventeen cases(50.0%) of the submucosal fibroplastlc lesions was found as isolated lesion without aacompanying pathological process, and was confined witbin the submu- cosal tissue of the gastrointestinal trset. And the rerasinder was associated with
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