The beta-lipoprotein was isolated from human placenta by means of macromolecular dextran sulfate method, and its tumor inhibitory action on Ehrlich cncer and Sarcoma 180 was studied. The human placental beta-lipoprotein caused marked regression or disappearance of tumor in proortion to the in crement of the injected dose. The possibility that the human placental beta-lipoprotein, like serum beta-lipoprotein, is one of the main components of the tumor inhibitory factor was discussed.