1Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2Departments of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
3Departments of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Copyright © 2014 by the Korean Cancer Association.
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/)which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Age(yr)/Gender | Race | Ca(mg/dL) | PTHrP(normal range) | LDH (IU/L) | Involved sites | Initial symptoms | Treatment | Outcome |
---|---|---|---|---|---|---|---|---|
76/M | Guatemalana)[9] | 15.3 | UK | UK | Lung, BM, spleen, brain, liver, spinal cord, adrenal gland | Dyspnea, confusion, fever | Steroid | Early death |
64/F | Asian [8] | 13.1 | 151 pg/mL (13.8-55.3 pg/mL) | 1,750 | Brain, BM | Seizure, mental deterioration | CHOP | Early death |
52/M | Caucasian [7] | 18.6 | 8 pmol/L (< 0.8 pmol/L) | No data | Liver, BM | Not described | MACOP-B | Not described |
71/M | Asian [10] | 14.9 | 113 pmol/L (< 11 pmol/L) | 2,140 | Lung, kidney, BM | Lethargy, drowsy mentality, hypoxemia | R-CHOP with MTX | Relapse |
68/Mb) | Asian | 20.6 | 2.7 pmol/L (< 1.1 pmol/L) | 2,668 | BM | Stuporous mentality, lethargy, fever | R-CHOP | Alive in complete response |
IVLBCL, intravascular large B-cell lymphoma; PTHrP, parathyroid hormone-related protein; LDH, lactate dehydrogenase; M, male; BM, bone marrow; F, female; CHOP, cyclophosphamide, doxorubicin, vincristine, and prednisone; MACOP-B, methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin; R-CHOP, rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone; MTX, methotrexate.
a) His race was not described in more details in the report,
b) Present case.
Age(yr)/Gender | Race | Ca(mg/dL) | PTHrP(normal range) | LDH (IU/L) | Involved sites | Initial symptoms | Treatment | Outcome |
---|---|---|---|---|---|---|---|---|
76/M | Guatemalan |
15.3 | UK | UK | Lung, BM, spleen, brain, liver, spinal cord, adrenal gland | Dyspnea, confusion, fever | Steroid | Early death |
64/F | Asian [8] | 13.1 | 151 pg/mL (13.8-55.3 pg/mL) | 1,750 | Brain, BM | Seizure, mental deterioration | CHOP | Early death |
52/M | Caucasian [7] | 18.6 | 8 pmol/L (< 0.8 pmol/L) | No data | Liver, BM | Not described | MACOP-B | Not described |
71/M | Asian [10] | 14.9 | 113 pmol/L (< 11 pmol/L) | 2,140 | Lung, kidney, BM | Lethargy, drowsy mentality, hypoxemia | R-CHOP with MTX | Relapse |
68/M |
Asian | 20.6 | 2.7 pmol/L (< 1.1 pmol/L) | 2,668 | BM | Stuporous mentality, lethargy, fever | R-CHOP | Alive in complete response |
IVLBCL, intravascular large B-cell lymphoma; PTHrP, parathyroid hormone-related protein; LDH, lactate dehydrogenase; M, male; BM, bone marrow; F, female; CHOP, cyclophosphamide, doxorubicin, vincristine, and prednisone; MACOP-B, methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin; R-CHOP, rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone; MTX, methotrexate. His race was not described in more details in the report, Present case.