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Original Article
- Relation Between Hormone Receptor (Enzyme-Immunoassay and Immunohistochemistry), Histologic Grade and Mammographic Findings in Patients with Primary Breast Cancer
- Byung Chul Kang, Ki Keun Oh, Jae Keun Kim, Woo Hee Jung, Hy De Lee, Kyung Soon Song
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Journal of the Korean Cancer Association 1997;29(1): 53-61.
1Department of Radiology, College of Medicine, Yonsei University, Seoul, Korea.
2Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea.
3Department of Surgery, College of Medicine, Yonsei University, Seoul, Korea.
4Department of Clinical Pathology, College of Medicine, Yonsei University, Seoul, Korea.
2Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea.
3Department of Surgery, College of Medicine, Yonsei University, Seoul, Korea.
4Department of Clinical Pathology, College of Medicine, Yonsei University, Seoul, Korea.
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Abstract
PURPOSE
To evaluate the relationship between the hormone receptor status, histologic grade and, the film-mammographic findings in primary breast cancer.
MATERIALS AND METHODS
198 breast cancer patients with hormonal receptor assay were included in this study.
Estrogen receptor (ER) and progesterone receptor (PR) were determined by immunohistochemical method and enzyme-immunoassay. And film-mammographic findings were evaluated to disclose the relationship among the three variables (film-mmamographic findings, histologic grade and hormonal receptor status). Film- mammographic findings of the breast cancer are classified as spiculation, increased parenchymal density, calcification and mass.
RESULTS
There is no correlation between estrogen receptor and histologic grade in 154 patients. Some correlation between estrogen receptor by enzyme-immunoassay and by immunohistochemistrical methods with 28 available data were observed (R=0.428). Among high estrogen receptor (ER) patients, there is a high possibility of spiculation or mass in mammography with 79 available data (Modified t-test, P<0.01).
CONCLUSION
Spiculation or/and mass of the mammography can be related to the high possibile factor of the positive estrogen receptor or high level of estrogen receptor in primary breast cancer.
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