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Original Article
- bcl-2 and p53 Gene Expression in Colonic Adenoma and Carcinoma
- Chang Young Lim, Jeong Won Kim, Il Han Song, Young Joo Jin, Im Whan Rho, Dong Kook Park, Jeong Hee Cho, Sung Bae Choi
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Journal of the Korean Cancer Association 1998;30(1): 89-99.
1Department of Internal Medicine, College of Medicine, Dankook Universirty, Cheonan, Korea.
2Department of General Surgery, College of Medicine, Dankook Universirty, Cheonan, Korea.
3Department of Pathology, College of Medicine, Dankook Universirty, Cheonan, Korea.
4Department of Microbiology, College of Medicine, Seoul National University, Seoul, Korea.
2Department of General Surgery, College of Medicine, Dankook Universirty, Cheonan, Korea.
3Department of Pathology, College of Medicine, Dankook Universirty, Cheonan, Korea.
4Department of Microbiology, College of Medicine, Seoul National University, Seoul, Korea.
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Abstract
PURPOSE
Recently, it is suggested that the inhibitian of apoptosis is associated with tumorigenesis of colon. Bcl-2 gene is an important inhibitory regulator of apoptosis, and bcl-2 acts antagonistly with the wild type p53 gene, one of the tumor suppressor genes, in apoptosis. To detnmine the role of bcl-2 and p53 gene in colonic tumorigenesis, we performed the study.
MATERIALS AND METHODS
We tested the tissue obtained by polypectomy and surgical resection by immunohistochemical staining for Bcl-2 and p53.
RESULTS
We found that in normal colonic tissue, the Bcl-2 was sparcely expressed, and the p53 was expressed sporadically. The rate of positivity of staining was below 5%. However, in colonic adenoma and colon cancer tissue, Bcl-2 and p53 were expressed more than in nonnal colonic tissue(p<0.05). (Scoring in Colonic adenoma: Bcl-2 6.2+/-1.1, p53 5.7+/-1.0; Scoring in Colonic carcinoma: Bcl-2 4.7+/-1.0, p53 8.3+/-0.9) CONCLUSION: Our results suggested that the bcl-2 and p53 play an important role in colonic tumorigenesis.
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