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J Korean Cancer Assoc > Volume 30(5); 1998 > Article
Journal of the Korean Cancer Association 1998;30(5): 1005-1013.
TGFbeta1 Effect on Survival of Anticancer Drug - resistant L1210 Sublines
Sung Yong Kim, Kyung Sub Lee, Jae Ryong Kim, Jeong Hee Kim
1Department of Biochemistry, College of Medicine, Yeungnam University, Daegu, Korea.
2Department of Urology, College of Medicine, Dongguk University, Kyongju, Korea.
The inhibitory effect of TGFbeta1 on survivals of L1210 and anticancer drug- resistant L1210 sublines was investigated and the gene expression of TGFbeta1 in these cells was examined.
The survivals of L1210, adriamycin-resistant(L1210AdR), vincristine-resistant(L1210VcR) or cisplatin-resistant(L1210Cis) cells were measured by MTT assay after treatment of TGFbeta1. Northern analysis was performed for TGFbeta1 gene expression in L1210, L1210AdR, L1210VcR or L1210Cis.
There was no different survival ratio between two groups, control and TGFbeta1(10 ng/ml) treated groups in L1210 cells. However, the survival ratio of L1210AdR was 59% in TGFbeta1 treated group for 96 hours. The survival ratio of L1210VcR was 61% for 96 hours in TGFbeta1 treated group. The survival ratio of L1210Cis was 40% for 96 hours in TGFbeta1 treated group. Expressions of TGFbeta1 gene in drug-resistant sublines were significantly decreased than that of L1210 cells.
Growth of anticancer drug-resistant L1210 sublines were inhibited by TGFbeta1 but not in L1210 cells. So, it is suggested that TGFbeta1 gene expression may have a part in anticancer drug-resistance.
Key words: TGFbeta1;Anticancer drug resistance;Growth inhibition
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