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Cancer Research and Treatment > Accepted Articles
doi: https://doi.org/10.4143/crt.2018.476    [Accepted]
Characteristics and Treatment Patterns of Patients with Advanced Soft Tissue Sarcoma in Korea
Hyo Song Kim1, Chung Mo Nam2, Suk-Yong Jang3, Sun Kyu Choi4, Minkyung Han5, Seonmin Kim4, Maria Victoria Moneta6, Sae Young Lee7, Jae Min Cho7, Diego Novick8, Sun Young Rha1
1Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
2Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea
3Department of Preventive Medicine, Eulji University College of Medicine, Daejeon, Korea
4Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Korea
5Department of Public Health, Yonsei University Graduate School, Seoul, Korea
6Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain
7Eli Lilly and Company, Seoul, Korea
8Eli Lilly and Company, Windlesham, UK
Correspondence  Diego Novick ,Tel: 44-1276-483-832, Fax: 44-1276-483-192, Email: novick_diego@lilly.com
Sun Young Rha ,Tel: 82-2-2228-8130, Fax: 82-2-2227-7810, Email: rha7655@yuhs.ac
Received: August 22, 2018;  Accepted: February 15, 2019.  Published online: February 18, 2019.
*Hyo Song Kim and Chung Mo Nam contributed equally to this work.
A soft tissue sarcoma (STS) is a rare type of cancer, accounting for 1% of adult solid cancers. The aim of the present study is to determine the incidence of localized and advanced STS in Korean patients, their treatment patterns, and the survival of patients by disease status.
Materials and Methods
The STS patient cohort was defined using National Health Insurance Service medical data from 2002 to 2015. Incidence, distribution, anatomical location of tumors, survival rates (Kaplan-Meyer survival function) and treatment patterns were analyzed by applying different algorithms to the STS cohort containing localized and advanced STS cases.
A total of 7,813 patients were diagnosed with STS from 2007 to 2014, 4,307 were localized STS and 3,506 advanced STS cases. The total incidence of STS was 2.49 per 100,000 person-years: 1.37 per 100,000 person-years for localized STS and 1.12 per 100,000 person-years for advanced STS. The 5-year survival rate after diagnosis was 56.4% for all STS, 82.4% for localized, and 27.2% for advanced STS. Half (49.98%) of the advanced STS patients received anthracycline-containing chemotherapy as initial treatment after diagnosis.
This study provides insights into localized and advanced STS epidemiology, treatment patterns and outcomes in Korea, which could be used as fundamental data in improving clinical outcomes of STS patients in the future.
Key words: Epidemiology, Korean population, Advanced soft tissue sarcoma, Treatment pattern, Modality
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