Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

Search
Advanced Search
OPEN ACCESS
mobile search button mobile menu button

Articles

Page Path
HOME > Cancer Res Treat > Volume 46(1); 2014 > Article
Review Article Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice
Sahdeo Prasad, PhD, Amit K. Tyagi, PhD, Bharat B. Aggarwal, PhD
Cancer Research and Treatment : Official Journal of Korean Cancer Association 2014;46(1):2-18.
DOI: https://doi.org/10.4143/crt.2014.46.1.2
Published online: January 15, 2014

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Correspondence: Bharat B. Aggarwal, PhD. Division of Cancer Medicine (Biochemistry), The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Tel: 1-713-794-1817, Fax: 1-713-745-1710, aggarwal@mdanderson.org
• Received: December 25, 2013   • Accepted: December 31, 2013

Copyright © 2014 by the Korean Cancer Association

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • 61,953 Views
  • 1,248 Download
  • 775 Web of Science
  • 675 Crossref
  • 841 Scopus
prev next
Full Article

Download PDF Download PDF

  • Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. In addition, over one hundred clinical studies have been carried out with curcumin. One of the major problems with curcumin is perceived to be the bioavailability. How curcumin should be delivered in vivo, how bioavailable is it, how well curcumin is absorbed and how it is metabolized, is the focus of this review. Various formulations of curcumin that are currently available are also discussed.
  • Key words: Curcumin, Nano-formulation, Biological availability, Metabolism, Anticancer
Curcumin is the major active component of turmeric, a yellow compound originally isolated from the plant Curcuma longa. It is a member of the curcuminoid family and has been used for centuries in traditional medicines. As a spice, it provides curry with its distinctive color and flavor. Furthermore, traditional Indian medicine has considered curcumin a drug effective for various respiratory conditions (asthma, bronchial hyperactivity, and allergy) as well as for other disorders including anorexia, coryza, cough, hepatic diseases, and sinusitis [1,2]. Extensive research over the past 30 years has shown that it plays an important role in the prevention and treatment of various pro-inflammatory chronic diseases including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and malignant diseases.
How curcumin could exhibit these diverse effects has been a clandestine over the years. However, numerous line of evidence indicates that this agent is highly pleiotropic with anti-inflammatory [3], hypoglycemic [4,5], antioxidant [6], wound healing [7], and antimicrobial activities [8]. It has been shown to possess chemosensitization, chemotherapeutic and radiosensitization activities as well [9]. Curcumin has been studied for its chemopreventive potential in a wide variety of cancers, in both preclinical studies and in clinical trials [10]. Many clinical trials using curcumin as a therapeutic agent are underway [11]. Because of its marvelous properties, curcumin is being marketed in several countries including the United States, India, Japan, Korea, Thailand, China, Turkey, South Africa, Nepal, and Pakistan in different form such as capsules, tablets, ointments, energy drinks, soaps, and cosmetics (Fig. 1).
The molecular basis of these pleiotropic effects of curcumin is due to the modulation of various signaling molecules. Various experimental studies have reported that curcumin has ability to inhibit proinflammatory transcription factors nuclear factor-kappaB (NF-κB) in several types of cancer [12]. Beside NF-κB, curcumin also inhibits activation of signal transducer and activator of transcription-3, and Wnt/beta-catenin, and activates peroxisome proliferator-activated receptor-gamma and Nrf2 cell-signaling pathways, thus leading to the down regulation of adipokines, including tumor necrosis factor (TNF), interleukin (IL)-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products [13]. Curcumin also modulate several inflammatory molecules along with cell survival proteins, histone acetylase, histone deacetylase, protein kinases, protein reductases, glyoxalase I, proteasome, human immunodeficiency virus type 1 (HIV1) integrase, HIV1 protease, FtsZ protofilaments, carrier proteins, DNA, RNA, and metal ions [14].
In this context, curcumin seems to offer an ideal agent because significant evidence has indicated its potential against several chronic diseases. Also, curcumin targets several of molecular pathways without any associated toxicity or resistance. In spite of its efficacy and safety, curcumin has not yet been approved as a therapeutic agent in part perhaps because of lack of intellectual rights to it. The poor aqueous solubility, relatively low bioavailability, and intense staining color of curcumin have been highlighted as major problems [15]. However, numerous reports suggest that bioavailability could not be a concern. Various type of formulations that have been designed with curcumin are outlined in Fig. 2. In this article, we analyze the delivery, bioavailability and metabolism of curcumin and its formulation.
1. Oral delivery
In most of studies curcumin has been delivered orally whether subject is human or animals. This orally delivered curcumin showed several biological effects such as antioxidant, anti-inflammatory, anticancer, antidiabetic, etc. Recently, it has been shown that curcumin (3 mg) administered orally in mice attenuate oxidative stress following downhill running-induced muscle damage [16]. Curcumin has also reported to affects exercise-induced oxidative stress in humans. In a study, oral administration of 90 mg of curcumin or the placebo 2 hours before exercise and immediately after exercise. Curcumin supplementation attenuated exercise-induced oxidative stress by increasing blood antioxidant capacity [17]. Orally administered curcumin inhibited inflammatory cytokines such as TNF, cyclooxygenase (COX)-2, inducible nitric oxide synthase in mice indicating its anti-inflammatory activity and further suppressing dextran sodium sulfate-induced colon carcinogenesis [18]. Clinical trials have also shown that orally delivered curcumin inhibited inflammatory molecules [12].
Curcumin showed beneficial effects in several types of cancer in patients. Recently it has been reported that oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients [19]. In animal model oral administration of curcumin inhibited cancer of lung [20], skin [21], head and neck [22], oral [23], hepatocellular carcinoma [24], mammary tumors, lymphomas, leukemias [25], and familial adenomatous polyposis [26]. Oral treatment of curcumin found to effective in diabetic condtion. It attenuated high fat diet-induced glucose intolerance and elevations of oxidative stress in the skeletal muscle [27]. Curcumin also enhanced wound repair in diabetic impaired healing in mice [28]. Curcumin improves the peripheral neuropathy of R98C mice by alleviating endoplasmic reticulum stress, reducing the activation of unfolded protein response and promoting Schwann cell differentiation [29]. It also protects against the pulmonary and cardiovascular effects in mice [30].
2. Subcutaneous delivery
Subcutaneous treatment of curcumin in animals has been used to provide effective and sustained tissue concentrations. Since sustained release of subcutaneously injected unformulated curcumin in animals is likely not possible, curcumin is formulated. A single subcutaneous dose of microparticles sustained curcumin in liver for nearly a month in mice [31]. It has been also shown that the microparticle formulation of curcumin showed marked anticancer efficacy in nude mice bearing MDA-MB-231 xenografts in mice compared with controls [32].
3. Intraperitoneal (IP) delivery
IP injection is the injection of a substance into the peritoneum (body cavity). IP injection is more often applied to animals than to humans. In case of IP the bioavailability of compound is higher than gavage. Curcumin, delivered intraperitoneally, has shown inhibitory effect against lipopolysaccharide induced cardiac hypertrophy in rodents [33]. It also reduced volume of glioma tumor implanted in nude mice, and prolonged the survival of animals [34]. Another study showed that IP injection of curcumin inhibited tumorigenicity and tumor growth, decreased the percentages of myeloid-derived suppressor cells in the spleen, blood, and tumor tissues, reduced IL-6 levels in the serum and tumor tissues in a human gastric cancer xenograft model and a mouse colon cancer allograft model [35]. It has been also shown that curcumin ameliorates intracerebral hemorrhage damage by preventing matrix metalloproteinase-mediated blood-brain barrier damage and brain edema, which might provide therapeutic potential for intracerebral hemorrhage [36]. Beside these, curcumin acts against asthma. In a study it has been shown that curcumin attenuates the development of allergic airway inflammation and hyper-responsiveness, possibly through inhibition of NF-κB activation in the asthmatic lung tissue. Thus, it attenuates development of asthma by inhibition of NF-κB activation [37]. Curcumin administered IP inhibited human oral squamous cell carcinoma xenograft tumor in mice, indicating its therapeutic efficacy in vivo [23]. Interestingly, it has been shown that oral curcumin treatment showed no effect on important measures of bleomycin-induced injury in mice, whereas IP curcumin administration effectively inhibited inflammation and collagen deposition along with a trend toward improved survival of animals. IP curcumin also reduced fibrotic progression even when administered after the acute bleomycin-induced inflammation had subsided [38].
Numerous reports have been shown that intravenous injection of curcumin exhibits anticancer property in animal model. Kim et al. [39] has shown that in curcumin has in antitumor effects in xenograft mouse model of colorectal cancer. They have also shown that curcumin loaded human serum albumin (HSA) nanoparticles has greater therapeutic effect than curcumin without inducing toxicity [39]. Several other studies reported that liposomal curcumin inhibited different type of tumor growth in mouse models. It inhibited the growth of head and neck squamous cell carcinoma in xenograft mouse by the inhibition of NF-κB without affecting the expression of pAKT [40]. Liposomal formulation of curcumin also enhanced the effect of radio and chemotherapy. Shi et al. [41] showed that liposomal curcumin when combined with radiation enhanced the inhibition of tumor growth in a murine lung carcinoma (LL/2) model. It has been also reported that intravenous treatment of liposomal curcumin in combination of cisplatin significantly enhances growth inhibition of xenograft head and neck tumors in mice. The suppressive effect of curcumin was mediated through inhibition of cytoplasmic and nuclear IKKβ, resulting in inhibition of NF-κB activity [42].
Another derivative of curcumin conjugated with luteinizing hormone releasing hormone, [DLys(6)]-LHRH-curcumin, when given intravenously caused a reduction in tumor weights and volumes, and free curcumin given by gavage at an equal dose failed to cause a significant reduction in tumor weights and volumes in the nude mouse pancreatic cancer model. This bioconjugate enhanced apoptosis in tumor tissue [43]. The encapsulated curcumin with monomethoxy poly (ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles also showed stronger anticancer effect than that of free curcumin. When curcumin/MPEG-PCL micelle applied intravenously inhibited the growth of subcutaneous C-26 colon carcinoma in vivo [44]. The intravenous administration of another curcumin derivative, curcumin-loaded HSA nanoparticles also showed greater therapeutic effect than curcumin in tumor xenograft HCT116 models without inducing toxicity [39].
1. Topical delivery
A topical treatment is a medication that is applied to body surfaces such as the skin or mucous membranes to treat ailments. Curcumin has been used topically to study its effect mostly on inflammation on target organ, wound healing, skin cancer and other. In a study it has been reported that topical use of a curcumin gel formulation strongly inhibited imiquimod-induced psoriasis-like inflammation in BALB/c mouse ear. It inhibited mRNA levels of IL-17A, IL-17F, IL-22, IL-1β, IL-6, and TNF-α cytokines in ear skin [45]. Topical curcumin is also found to be effective in CO2 laser-induced skin wound healing. It improved re-epithelialization of wound after 7 days [46]. It has been revealed that topical treatment of curcumin and the photoinactivation of Candida albicans in a murine model of oral candidiasis caused a significant reduction in C. albicans viability. Thus, it acts photosensitizer without harming the host tissue of mice [47].
Topical treatment of curcumin also inhibited ultraviolet B (UVB)-induced tumor formation in mice. Average number of tumors formed per mouse was lesser in curcumin and UVB treated mice compared to UVB exposed animals and it also delayed the onset of tumorigenesis [21]. Beside these when curcumin applied as a noninvasive topical paste to the head and neck squamous cell carcinoma (HNSCC) xenografts tumors in mice, resulted in inhibition of its growth. Thus, it can be used as an adjuvant or chemopreventive agent in several cancer [48].
2. Nasal delivery
To increase the bioavailability and also direct nose-to-brain drug transport, nasal delivery of curcumin has been used. In a study, the pharmacokinetics results showed that the absolute bioavailability of curcumin in the microemulsion-based in situ ion-sensitive gelling system was 55.82% by intranasal administration. And the distribution of curcumin in brain versus blood following intranasal administration was higher than that following intravenous administration [49]. Another study also showed that the drug-targeting efficiencies of the curcumin in the cerebrum, cerebellum, hippocampus and olfactory bulb after intranasal administration of the curcumin hydrogel were 1.82, 2.05, 2.07, and 1.51 times higher than intravenous administration of the curcumin solution injection, respectively, indicating that the hydrogel and intranasal administration significantly increased the distribution of curcumin into the rat brain tissue [50].
In another study intranasal curcumin has been detected in plasma of mice after 15 minutes to 3 hours at pharmacological dose (5 mg/kg), which has shown antiasthmatic potential by inhibiting bronchoconstriction and inflammatory cell recruitment to the lungs. Thus, this study indicates that intranasal treatment of curcumin prevents airway inflammations and bronchoconstrictions in asthma without any side effect [51].
Evidence from numerous literatures revealed that curcumin has poor absorption, biodistribution, metabolism, and bioavailability. Thus, continuous research on curcumin found some possible ways to overcome these problems. To increase the bioavailability, longer circulation, better permeability, and resistance to metabolic processes of curcumin several formulations have been prepared which include nanoparticles, liposomes, micelles, and phospholipid complexes (Table 1) [52-93].
1. Unformulated curcumin
The pharmacological studies revealed that curcumin is safe and effective which makes it a potential compound for treatment and prevention of a wide variety of human diseases. In spite of these, accumulating data revealed that curcumin has relatively low bioavailability and poor solubility in aqueous solution. First time Wahlstrom and Blennow in 1978 [94] reported that after oral administration of 1 g/kg of curcumin in Sprague-Dawley rats, negligible amounts of curcumin in blood plasma of rats was observed which could be its poor absorption from the gut. Later several studies conducted on bioavailability of curcumin and found that certain amount of curcumin are bioavailable in serum of animals. In a study, when curcumin was given orally at a dose of 2 g/kg to rats, a maximum serum concentration of 1.35±0.23 µg/mL was observed at time 0.83 hours, whereas in humans the same dose of curcumin resulted in either undetectable or extremely low (0.006±0.005 µg/mL at 1 hour) serum levels [95].
Another study conducted in freely moving rats showed that administration of curcumin (500 mg/kg, p.o.) resulted in 1% bioavailability of curcumin in rat plasma [96]. It has been also observed that oral administration of curcumin (1,000 mg/kg) in rats showed 15 ng/mL in blood plasma at 50 minutes [97]. In contrast to rodents, oral dosing of 4-8 g of curcumin in humans showed peak plasma levels of 0.41-1.75 µM after 1 hour of dosing [98]. Similarly, in a human clinical trial, 3.6 g of curcumin via oral route was found to produce a plasma curcumin level of 11.1 nmol/L after an hour of dosing [99].
However, it has been found that 10 mg/kg of curcumin given intravenous in rats gave a maximum serum curcumin level of 0.36 µg/mL, whereas a 50-fold higher curcumin dose administered orally gave only 0.06±0.01 µg/mL maximum serum level in rat [96]. A very recent study by Sun et al. [69] showed that intravenous administration of unformulated curcumin to rats showed better availability of curcumin in blood plasma. The concentration was 6.6 µg/mL of blood plasma when administered 2 mg/kg through tail vain [69]. These studies suggest the role of route of administration on achievable serum levels of curcumin and also the comparison of serum level in rodents and humans.
2. Nanocurcumin
To increase the bioavailability of curcumin different formulations have been made. Among them, nanoglobules based nanoemulsion formulation has been prepared to evaluate the potential for the solubility enhancement of curcumin (Fig. 2). During ex vivo study, the release of curcumin from nanoemulsion was found much higher than curcumin suspension. This indicated the enhancement of solubility of curcumin in aqueous solution [70]. Another study showed an encapsulating the curcumin into the hydrogel nanoparticles yielded a homogenous curcumin dispersion in aqueous solution compared to the free form of curcumin. Also, the in vitro release profile showed up to 95% release of curcumin from the developed nano-microparticulate systems [100].
The pharmacokinetics of curcumin and another formulation nanoemulsion curcumin (NEC) containing up to 20% curcumin (w/w) showed a 10 fold increase in the area under the blood concentration-time curve (AUC) 24 hours and more than 40-fold increase in the C(max) in NEC compared to curcumin in mice [54]. Another curcumin-loaded apotransferrin nanoparticles (nano-curcumin), prepared by sol-oil chemistry, releases significant quantities of drug gradually over a fairly long period, ~50% of curcumin still remaining at 6 hours of time. In contrast, intracellular soluble curcumin (sol-curcumin) reaches a maximum at 2 hours followed by its complete elimination by 4 hours [101]. The colloidal nanoparticles, named as 'theracurmin' showed AUC after the oral administration more than 40-fold higher than that of curcumin powder in rats. In healthy human volunteers, theracurmin (30 mg) when administered orally resulted 27-fold higher AUC than that of curcumin powder [102]. The nanoparticle of curcumin prepared by Cheng et al. [103] produced significantly higher curcumin concentration in plasma and six times higher AUC and mean residence time in mice brain than regular curcumin. Thus, nanocurcumin enhances bioavailability of curcumin in animals as well as in humans.
3. Polylactic-co-glycolic acid (PLGA)
To improve the pharmacokinetics of curcumin with enhancing its bioavailability other effective formulation PLGA encapsulated curcumin was prepared. In vitro study showed that PLGA-curcumin has very rapid and more efficient cellular uptake than curcumin. Intravenous administration of either curcumin or PLGA-curcumin (2.5 mg/kg), exhibited almost twice as high serum concentration of PLGA-curcumin than curcumin [104]. Another formulation PLGA and PLGA-polyethylene glycol (PEG) (PLGA-PEG) blend nanoparticles containing curcumin were prepared. The PLGA and PLGA-PEG nanoparticles increased the curcumin mean half-life in approximately 4 and 6 hours, respectively, and the C(max) of curcumin increased 2.9- and 7.4-fold, respectively. Compared to the curcumin aqueous suspension, the PLGA and PLGA-PEG nanoparticles increased the curcumin bioavailability by 15.6- and 55.4-fold, respectively. Thus these formulations are potential carriers for the oral delivery of curcumin [105]. Other study showed that curcumin encapsulated in low and high molecular weight PLGA have relatively different oral bioavailability of curcumin. It has been found that the relative bioavailability of high molecular weight PLGA conjugated curcumin has 1.67- and 40-fold higher than that of low molecular weight PLGA conjugated curcumin and conventional curcumin, respectively [106].
In support of previous study, it has been found that after oral administration of curcumin-PLGA-nanoparticles, the relative bioavailability was increased 5.6-fold and has a longer half-life compared with that of native curcumin. This improved oral bioavailability of curcumin found to be associated with improved water solubility, higher release rate in the intestinal juice, enhanced absorption by improved permeability, inhibition of P-glycoprotein-mediated efflux, and increased residence time in the intestinal cavity [107]. It has been also observed that PLGA-curcumin enhances two and six fold increases in the cellular uptake performed in cisplatin resistant A2780CP ovarian and metastatic MDA-MB-231 breast cancer cells, respectively, compared to free curcumin [108].
4. Liposomal encapsulation
Another formulation designed for improvement of bioavailability of curcumin is liposomal curcumin. Liposomes are considered as effective drug carriers because of their ability to solubilize hydrophobic compounds and to alter their pharmacokinetic properties. In rat oral administration of liposome-encapsulated curcumin (LEC) showed high bioavailability of curcumin. In addition, a faster rate and better absorption of curcumin were observed as compared to the other forms. Oral LEC gave higher C(max) and shorter T(max) values, as well as a higher value for the AUC, at all time points [109].
The formulation silica-coated flexible liposomes loaded with curcumin (CUR-SLs) and curcumin-loaded flexible liposomes (CUR-FLs) without silica-coatings have been designed and found that the bioavailability of CUR-SLs and CUR-FLs was 7.76- and 2.35-fold higher, respectively, than that of curcumin suspensions. Silica coating markedly improved the stability of flexible liposomes, and CUR-SLs exhibited a 3.31-fold increase in bioavailability compared with CUR-FLs [59]. Another study showed that curcumin incorporated into N-trimethyl chitosan chloride (TMC)-coated liposomes exhibited different pharmacokinetic parameters and enhanced bioavailability, compared with curcumin encapsulated by uncoated liposomes and curcumin suspension. Uncoated curcumin liposomes and TMC-coated curcumin liposomes showed a similar in vitro release profile [62]. In order to facilitate the intracellular delivery of curcumin, a new type of liposomes-propylene glycol liposomes (PGL) were prepared. It has been observed from cell experiment in vitro, PGL exhibited the highest uptake of curcumin compared with that of conventional liposomes and free curcumin solution [63]. These studies indicate that liposome conjugated curcumin increases the bioavailabllity of curcumin.
5. Cyclodextrin (CD)
CD, cyclic oligosaccharides, has been also used in order to improve curcumin's delivery and bioavailability via its encapsulation with CD. It has been found that CD encapsulated curcumin (CDC) had a greater cellular uptake and longer half-life in the cancer cells compared with free curcumin indicating CDC has superior attributes compared with free curcumin for cellular uptake [86]. In addition, the improvement of CUR permeability acrossed animal skin tissue was observed in CD encapsulated curcumin and was about 1.8-fold when compared with the free curcumin [110]. Thus, these studies suggest that CDC has improved in vitro and in vivo bioavailability and chemotherapeutic efficacy compared to curcumin alone.
6. Piperine
Besides these natural compounds have been also used to increase the bioavailability of curcumin. One of them is piperine, a major component of black pepper, known as inhibitor of hepatic and intestinal glucuronidation and is also shown to increase the bioavailability of curcumin. This effect of piperine on the pharmacokinetics of curcumin has been shown to be much greater in humans than in rats. In humans, curcumin bioavailability was increased by 2,000% at 45 minutes after co-administering curcumin orally with piperine, whereas in rats, it has been found that concomitant administration of piperine 20 mg/kg with curcumin 2 g/kg increased the serum concentration of curcumin by 154% for a short period of 1-2 hours post drug. The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects [95].
Another study also showed that piperine (20 mg/kg orally) when administered with curcumin (2 g/kg orally) enhances the bioavailability of the latter up to 20-fold more in epileptic rats [111]. Enhanced bioavailability of curcumin was also evidenced by other researcher when curcumin was administered orally concomitant with piperine. Intestinal absorption of curcumin was also found relatively higher when administered concomitantly with piperine, and it stayed significantly longer in the body tissues [112]. In view of these findings, curcumin-piperine (Cu-Pi) nanoparticles has been prepared by various methods [113]. The bioavailability, cellular uptake and biological effects of this nanoparticles are being tested.

Biological Activities of Formulated Curcumin

Accumulating data evident that most, if not all, formulated curcumin have better bioavailability and biological activities than unformulated curcumin. Nanosuspension of curcumin also induces more cytotoxicity in Hela and MCF-7 cells than curcumin [44]. Curcumin-decorated nanoliposomes has shown high affinity for amyloid-β1-42 peptide and exhibit protective effects against Alzhiemer's disease [66]. LEC also suppresses HNSCC growth in vitro and xenograft tumor in mice [40]. Curcumin liposomes of dimyristoyl phosphatidyl choline and cholesterol inhibit proliferation of prostate cancer cell 10 times more than curcumin [67].
Beside these, PLGA encapsulated curcumin has shown more potent than curcumin in inducing apoptosis of leukemic cells and in suppressing proliferation of various tumor cell lines. It was also more active than curcumin in inhibiting TNF-induced NF-κB activation and in suppression of NF-κB-regulated proteins involved in cell proliferation, invasion, and angiogenesis [104]. PLGA nanocapsulated curcumin found to eliminate diethylnitrosamine-induced hepatocellular carcinoma in rat [72]. Doxorubicin and curcumin in a single PLGA nanoparticle formulation, curcumin facilitates the retention of doxorubicin in nucleus for a longer period of time. It also inhibits the development of drug resistance for the enhancement of antiproliferative activity of doxorubicin in K562 cells [114].
CDC is another formulation of curcumin having anti-inflammatory and antiproliferative effects. CDC was found more active than free curcumin in inhibiting TNF-induced activation of the NF-κB and in suppressing gene products regulated by NF-κB, including those involved in cell proliferation, invasion, and angiogenesis. CDC was also more active than free curcumin in inducing the death receptors DR4 and DR5 and apoptosis [86]. CD entrapped curcuminoid also induces autophagic cell death in lung cancer cells and inhibits tumor growth in nude rats [115]. Besides these, other formulations such as dipeptide nanoparticles, phosphatidylcholine encapsulated curcumin, etc. have better efficacy in their biological activities compared to free curcumin. Dipeptide nanoparticle of curcumin inhibits tumor growth in mice [87]. Phosphatidylcholine encapsulated curcumin exhibits antimalarial activity [88], inhibits vaginal inflammation [116] and induce cytotoxicity of cancer cells [81]. There are several other cucrumin formulation are synthesized having more biological activities than curcumin.
Uptake and distribution of curcumin in body tissues is obviously important for its biological activity. Most of curcumin get metabolized in liver and intestine however, a small quantity is still remains detectable in the organs (Fig. 3A). Ryu et al. [117] has also shown bioavailability of curcumin in different organ of mice. Intravenous injection of [18F]-curcumin in mice found to persistently accumulated in the liver and spleen while lung uptake was found to decrease with time. Brain uptake of [18F]-curcumin was at 2 minutes postinjection, and its radioactivity was rapidly washed out from the brain at 30 minutes [117]. Study by using radioactive [18F]-curcumin and [18F]-piperine in mice, it has been observed that initial brain uptake of [18F]-curcumin was increased by 48% relative to that without piperine, although other organ uptakes were almost similar to those without piperine (Fig. 3B) [117]. These studies indicate that curcumin is bioavailable in several organs and its availability decreases with time depend on the organs.
Ravindranath and Chandrasekhara [118] showed oral administration of 400 mg curcumin to rats, about 60% of the dose was absorbed. However, very small quantities in liver and kidney (<20 µg/tissue) were observed from 15 minutes up to 24 hours after administration of curcumin [118]. Another study showed distribution of curcumin in the intestines, spleen, liver, and kidneys, which was 177.04, 26.06, 26.90, and 7.51 µg/g, respectively after one hour i.p. administration of curcumin (0.1 g/kg) to mice. Only traces (0.41 µg/g) were observed in the brain at 1 hour [119]. Dietary curcumin (2%) has shown to yield low curcumin levels in the plasma, between 0 and 12 nM when given to the animals, whereas tissue concentrations of curcumin in liver and colon mucosa were 0.1-0.9 nmol/g and 0.2-1.8 µmol/g, respectively. In comparison with dietary administration, when curcumin given intragastric resulted more curcumin in the plasma but much less in the colon mucosa, indicating mode of administration play a role in distribution of curcumin [120]. In contrast, curcumin was poorly detected in patients of colorectal cancer. In a study of 12 patients with hepatic metastases from colorectal cancer, treatment of 450-3,600 mg of curcumin daily, for 1 week prior to surgery, poor availability of curcumin was observed in the peripheral or portal circulation following oral administration. While curcumin was not found in liver tissue, trace levels of products of its metabolic reduction were detected [121].
Using ultra performance liquid chromatography by Marczylo et al. [122] showed higher quantity of curcumin distribution in animals. In their experiment, rats were given oral curcumin (340 mg/kg) and after 2 hours tissue distribution was measured. Curcumin was found in plasma (16.1 ng/mL), urine (2.0 ng/mL), intestinal mucosa (1.4 mg/g), liver (3,671.8 ng/g), kidney (206.8 ng/g), and heart (807.6 ng/g) [122]. Another study evaluated the tissue distribution of curcumin using tritium-labeled drug. They found that radioactivity was detectable in blood, liver, and kidney following doses of 400, 80, or 10 mg of [3H] curcumin. With 400 mg, considerable amount of radio labeled products were present in tissues 12 days after dosing. The percentage of curcumin absorbed (60-66% of the given dose) remained constant regardless of the dose indicating that administration of more curcumin does not result in higher absorption [123].
Numerous studies evaluated that curcumin undergoes metabolism in different components after oral administration in animals. Because of its metabolism, curcumin has demonstrated poorly bioavailable after p.o. dosing in animals [124], which may be related to its inadequate absorption. Curcumin bioavailability may also be poor in humans, as indicated by a pilot study of a standardized curcuma extract in colorectal cancer patients [120]. After p.o. dosing, curcumin undergoes metabolic O-conjugation to curcumin glucuronide and curcumin sulfate and bioreduction to tetrahydrocurcumin, hexahydrocurcumin, octahydrocurcumin, and hexahydrocurcuminol (Fig. 4) in rats and mice in vivo [119,124,125] and in suspensions of human and rat hepatocytes [124]. Reduced curcumin also subjected to glucuronidation into curcumin glucuronide, dihydro-curcumin-glucuronide, tetrahydrocurcumin-glucuronide, and curcumin sulfate [119]. Holder et al. [126] reported that the major billiary metabolites of curcumin are glucuronides of tetrahydrocurcumin and hexahydrocurcumin in rats. A minor biliary metabolite was dihydroferulic acid together with traces of ferulic acid.
Numerous studies have revealed that curcumin metabolites have antioxidative, anti-inflammatory and anticancer activities. Tetrahydrocurcumin (THC) inhibits radiation-induced lipid peroxidation [127] and induced antioxidant enzymes in vitro [128]. In rats, dietary administration of THC reduces aberrant crypt foci and polyps formation in azoxymethane-induced colon carcinogenesis [129]. Hexahydrocurcumin, another metabolite, has reduced ability to inhibit COX-2 expression compared to curcumin [124]. Hexahydrocurcumin also induce cell cycle arrest in human colorectal cancer SW480 cells [130]. Pan et al. [131] has shown that another metabolite, octahydrocurcumin, has very less NF-κB suppressive activity compared to curcumin. However, the free radical scavenging activity of octahydrocurcumin is higher than curcumin [132]. Beside these, we have recently showed that none of curcumin mono- or di-glucurnoid showed biological activity such as anti-inflammatory or antiproliferative activity compared to curcumin [133]. The curcumin metabolite, curcumin sulfate has shown to have less biological activities compared to curcumin. Curcumin sulfate inhibits prostaglandin E2 activity very poor than curcumin [124]. Thus these studies indicate that after metabolism of curcumin in different components, shows biological activities differ from parent curcumin.
Since ancient times, curcumin has been used in Asian countries against human ailments. Modern science has delineated the molecular basis for the pharmaceutical uses of curcumin. Multiple studies over the past decade have indicated the safety and efficacy of this polyphenol and have provided a solid basis for evaluating its efficacy in human clinical trials. Despite its efficacy and safety, limited curcumin bioavailability continues to be highlighted as a major concern. However in attempts to improve the bioavailability of curcumin, several strategies have been explored such as modulation of route and medium of curcumin administration, blocking of metabolic pathways by concomitant administration with other agents, and conjugation and structural modifications of curcumin. Evidence from literatures indicated its increased bioavailability and efficacy in different experimental models with these strategies. In spite of these, improvements in curcumin bioavailability enhancement and efficacy have not gained significant attention in human. Therefore, further exploration in attempts to enhance the bioavailability, medicinal value, and application of this interesting molecule from Mother Nature are needed for human use.
Acknowledgements
Dr. Aggarwal is the Ransom Horne, Jr., Professor of Cancer Research. This work was supported by a grant from Center for Targeted Therapy of MD Anderson Cancer Center.

Conflict of interest relevant to this article was not reported.

  • 1. Rahman I, Biswas SK, Kirkham PA. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol. 2006;72:1439–1452. PMID: 16920072ArticlePubMed
  • 2. Tirkey N, Kaur G, Vij G, Chopra K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC Pharmacol. 2005;5:15PMID: 16225695ArticlePubMedPMC
  • 3. Gupta SC, Kim JH, Prasad S, Aggarwal BB. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 2010;29:405–434. PMID: 20737283ArticlePubMedPMC
  • 4. Sharma S, Kulkarni SK, Chopra K. Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 2006;33:940–945. PMID: 17002671ArticlePubMed
  • 5. Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M, et al. Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem. 2005;53:959–963. PMID: 15713005ArticlePubMed
  • 6. Sharma OP. Antioxidant activity of curcumin and related compounds. Biochem Pharmacol. 1976;25:1811–1812. PMID: 942483ArticlePubMed
  • 7. Sidhu GS, Singh AK, Thaloor D, Banaudha KK, Patnaik GK, Srimal RC, et al. Enhancement of wound healing by curcumin in animals. Wound Repair Regen. 1998;6:167–177. PMID: 9776860ArticlePubMed
  • 8. Negi PS, Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK. Antibacterial activity of turmeric oil: a byproduct from curcumin manufacture. J Agric Food Chem. 1999;47:4297–4300. PMID: 10552805ArticlePubMed
  • 9. Goel A, Aggarwal BB. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer. 2010;62:919–930. PMID: 20924967ArticlePubMed
  • 10. Gupta SC, Kismali G, Aggarwal BB. Curcumin, a component of turmeric: from farm to pharmacy. Biofactors. 2013;39:2–13. PMID: 23339055ArticlePubMed
  • 11. Reuter S, Gupta SC, Park B, Goel A, Aggarwal BB. Epigenetic changes induced by curcumin and other natural compounds. Genes Nutr. 2011;6:93–108. PMID: 21516481ArticlePubMedPMC
  • 12. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15:195–218. PMID: 23143785ArticlePubMedPMC
  • 13. Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr. 2010;30:173–199. PMID: 20420526ArticlePubMedPMC
  • 14. Gupta SC, Prasad S, Kim JH, Patchva S, Webb LJ, Priyadarsini IK, et al. Multitargeting by curcumin as revealed by molecular interaction studies. Nat Prod Rep. 2011;28:1937–1955. PMID: 21979811ArticlePubMedPMC
  • 15. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4:807–818. PMID: 17999464ArticlePubMed
  • 16. Kawanishi N, Kato K, Takahashi M, Mizokami T, Otsuka Y, Imaizumi A, et al. Curcumin attenuates oxidative stress following downhill running-induced muscle damage. Biochem Biophys Res Commun. 2013;441:573–578. PMID: 24184481ArticlePubMed
  • 17. Takahashi M, Suzuki K, Kim HK, Otsuka Y, Imaizumi A, Miyashita M, et al. Effects of curcumin supplementation on exercise-induced oxidative stress in humans. Int J Sports Med. 2013;10. 28[Epub]. http://dx.doi.org/10.1055/s-0033-1357185 Article
  • 18. Murakami A, Furukawa I, Miyamoto S, Tanaka T, Ohigashi H. Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis. Biofactors. 2013;39:221–232. PMID: 23233214ArticlePubMed
  • 19. Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, et al. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res. 2013;180:34–43. PMID: 23745991ArticlePubMedPMC
  • 20. Cheng KW, Wong CC, Mattheolabakis G, Xie G, Huang L, Rigas B. Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics. Int J Oncol. 2013;43:895–902. PMID: 23807084ArticlePubMedPMC
  • 21. Phillips J, Moore-Medlin T, Sonavane K, Ekshyyan O, McLarty J, Nathan CA. Curcumin inhibits UV radiation-induced skin cancer in SKH-1 mice. Otolaryngol Head Neck Surg. 2013;148:797–803. PMID: 23386626ArticlePubMed
  • 22. Clark CA, McEachern MD, Shah SH, Rong Y, Rong X, Smelley CL, et al. Curcumin inhibits carcinogen and nicotine-induced mammalian target of rapamycin pathway activation in head and neck squamous cell carcinoma. Cancer Prev Res (Phila). 2010;3:1586–1595. PMID: 20851953ArticlePubMed
  • 23. Lin YC, Chen HW, Kuo YC, Chang YF, Lee YJ, Hwang JJ. Therapeutic efficacy evaluation of curcumin on human oral squamous cell carcinoma xenograft using multimodalities of molecular imaging. Am J Chin Med. 2010;38:343–358. PMID: 20387230ArticlePubMed
  • 24. Yoysungnoen P, Wirachwong P, Bhattarakosol P, Niimi H, Patumraj S. Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice. Clin Hemorheol Microcirc. 2006;34:109–115. PMID: 16543625PubMed
  • 25. Huang MT, Lou YR, Xie JG, Ma W, Lu YP, Yen P, et al. Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice. Carcinogenesis. 1998;19:1697–1700. PMID: 9771944ArticlePubMed
  • 26. Perkins S, Verschoyle RD, Hill K, Parveen I, Threadgill MD, Sharma RA, et al. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev. 2002;11:535–540. PMID: 12050094PubMed
  • 27. He HJ, Wang GY, Gao Y, Ling WH, Yu ZW, Jin TR. Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice. World J Diabetes. 2012;3:94–104. PMID: 22645638ArticlePubMedPMC
  • 28. Sidhu GS, Mani H, Gaddipati JP, Singh AK, Seth P, Banaudha KK, et al. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen. 1999;7:362–374. PMID: 10564565ArticlePubMed
  • 29. Patzko A, Bai Y, Saporta MA, Katona I, Wu X, Vizzuso D, et al. Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice. Brain. 2012;135(Pt 12):3551–3566. PMID: 23250879ArticlePubMedPMC
  • 30. Nemmar A, Subramaniyan D, Ali BH. Protective effect of curcumin on pulmonary and cardiovascular effects induced by repeated exposure to diesel exhaust particles in mice. PLoS One. 2012;7:e39554PMID: 22745783ArticlePubMedPMC
  • 31. Shahani K, Swaminathan SK, Freeman D, Blum A, Ma L, Panyam J. Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention. Cancer Res. 2010;70:4443–4452. PMID: 20460537ArticlePubMedPMC
  • 32. Shahani K, Panyam J. Highly loaded, sustained-release microparticles of curcumin for chemoprevention. J Pharm Sci. 2011;100:2599–2609. PMID: 21547911ArticlePubMedPMC
  • 33. Chowdhury R, Nimmanapalli R, Graham T, Reddy G. Curcumin attenuation of lipopolysaccharide induced cardiac hypertrophy in rodents. ISRN Inflamm. 2013;2013:539305PMID: 24236240ArticlePubMedPMCPDF
  • 34. Du WZ, Feng Y, Wang XF, Piao XY, Cui YQ, Chen LC, et al. Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo. CNS Neurosci Ther. 2013;19:926–936. PMID: 24165291ArticlePubMedPMC
  • 35. Tu SP, Jin H, Shi JD, Zhu LM, Suo Y, Lu G, et al. Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. Cancer Prev Res (Phila). 2012;5:205–215. PMID: 22030090ArticlePubMedPMC
  • 36. Sun Y, Dai M, Wang Y, Wang W, Sun Q, Yang GY, et al. Neuroprotection and sensorimotor functional improvement by curcumin after intracerebral hemorrhage in mice. J Neurotrauma. 2011;28:2513–2521. PMID: 21770745ArticlePubMedPMC
  • 37. Oh SW, Cha JY, Jung JE, Chang BC, Kwon HJ, Lee BR, et al. Curcumin attenuates allergic airway inflammation and hyperresponsiveness in mice through NF-kappaB inhibition. J Ethnopharmacol. 2011;136:414–421. PMID: 20643202ArticlePubMed
  • 38. Smith MR, Gangireddy SR, Narala VR, Hogaboam CM, Standiford TJ, Christensen PJ, et al. Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2010;298:L616–L625. PMID: 20061443ArticlePubMedPMC
  • 39. Kim TH, Jiang HH, Youn YS, Park CW, Tak KK, Lee S, et al. Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity. Int J Pharm. 2011;403:285–291. PMID: 21035530ArticlePubMed
  • 40. Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, et al. Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res. 2008;14:6228–6236. PMID: 18829502ArticlePubMed
  • 41. Shi HS, Gao X, Li D, Zhang QW, Wang YS, Zheng Y, et al. A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation. Int J Nanomedicine. 2012;7:2601–2611. PMID: 22679371ArticlePubMedPMC
  • 42. Duarte VM, Han E, Veena MS, Salvado A, Suh JD, Liang LJ, et al. Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of IKKbeta protein of the NFkappaB pathway. Mol Cancer Ther. 2010;9:2665–2675. PMID: 20937593ArticlePubMedPMC
  • 43. Aggarwal S, Ndinguri MW, Solipuram R, Wakamatsu N, Hammer RP, Ingram D, et al. [DLys(6)]-luteinizing hormone releasing hormone-curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo. Int J Cancer. 2011;129:1611–1623. PMID: 21484797ArticlePubMedPMC
  • 44. Gou M, Men K, Shi H, Xiang M, Zhang J, Song J, et al. Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Nanoscale. 2011;3:1558–1567. PMID: 21283869ArticlePubMed
  • 45. Sun J, Zhao Y, Hu J. Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice. PLoS One. 2013;8:e67078PMID: 23825622ArticlePubMedPMC
  • 46. Lopez-Jornet P, Camacho-Alonso F, Jimenez-Torres MJ, Orduna-Domingo A, Gomez-Garcia F. Topical curcumin for the healing of carbon dioxide laser skin wounds in mice. Photomed Laser Surg. 2011;29:809–814. PMID: 21819258ArticlePubMed
  • 47. Dovigo LN, Carmello JC, de Souza Costa CA, Vergani CE, Brunetti IL, Bagnato VS, et al. Curcumin-mediated photodynamic inactivation of Candida albicans in a murine model of oral candidiasis. Med Mycol. 2013;51:243–251. PMID: 22934533ArticlePubMed
  • 48. LoTempio MM, Veena MS, Steele HL, Ramamurthy B, Ramalingam TS, Cohen AN, et al. Curcumin suppresses growth of head and neck squamous cell carcinoma. Clin Cancer Res. 2005;11(19 Pt 1):6994–7002. PMID: 16203793ArticlePubMed
  • 49. Wang S, Chen P, Zhang L, Yang C, Zhai G. Formulation and evaluation of microemulsion-based in situ ion-sensitive gelling systems for intranasal administration of curcumin. J Drug Target. 2012;20:831–840. PMID: 22934854ArticlePubMed
  • 50. Chen X, Zhi F, Jia X, Zhang X, Ambardekar R, Meng Z, et al. Enhanced brain targeting of curcumin by intranasal administration of a thermosensitive poloxamer hydrogel. J Pharm Pharmacol. 2013;65:807–816. PMID: 23647674ArticlePubMed
  • 51. Subhashini , Chauhan PS, Kumari S, Kumar JP, Chawla R, Dash D, et al. Intranasal curcumin and its evaluation in murine model of asthma. Int Immunopharmacol. 2013;17:733–743. PMID: 24021755ArticlePubMed
  • 52. Gao Y, Li Z, Sun M, Guo C, Yu A, Xi Y, et al. Preparation and characterization of intravenously injectable curcumin nanosuspension. Drug Deliv. 2011;18:131–142. PMID: 20939679ArticlePubMed
  • 53. Gao Y, Li Z, Sun M, Li H, Guo C, Cui J, et al. Preparation, characterization, pharmacokinetics, and tissue distribution of curcumin nanosuspension with TPGS as stabilizer. Drug Dev Ind Pharm. 2010;36:1225–1234. PMID: 20545506ArticlePubMed
  • 54. Zhongfa L, Chiu M, Wang J, Chen W, Yen W, Fan-Havard P, et al. Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice. Cancer Chemother Pharmacol. 2012;69:679–689. PMID: 21968952ArticlePubMedPMC
  • 55. Dandekar P, Dhumal R, Jain R, Tiwari D, Vanage G, Patravale V. Toxicological evaluation of pH-sensitive nanoparticles of curcumin: acute, sub-acute and genotoxicity studies. Food Chem Toxicol. 2010;48:2073–2089. PMID: 20470854ArticlePubMed
  • 56. Peng SF, Lee CY, Hour MJ, Tsai SC, Kuo DH, Chen FA, et al. Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway. Int J Oncol. 2014;44:238–246. PMID: 24247158ArticlePubMed
  • 57. Li H, Zhang N, Hao Y, Wang Y, Jia S, Zhang H, et al. Formulation of curcumin delivery with functionalized single-walled carbon nanotubes: characteristics and anticancer effects in vitro. Drug Deliv. 2013;10. 25[Epub]. http://dx.doi.org/10.3109/10717544.2013.848246 Article
  • 58. John MK, Xie H, Bell EC, Liang D. Development and pharmacokinetic evaluation of a curcumin co-solvent formulation. Anticancer Res. 2013;33:4285–4291. PMID: 24122994PubMed
  • 59. Li C, Zhang Y, Su T, Feng L, Long Y, Chen Z. Silica-coated flexible liposomes as a nanohybrid delivery system for enhanced oral bioavailability of curcumin. Int J Nanomedicine. 2012;7:5995–6002. PMID: 23233804ArticlePubMedPMC
  • 60. Isacchi B, Bergonzi MC, Grazioso M, Righeschi C, Pietretti A, Severini C, et al. Artemisinin and artemisinin plus curcumin liposomal formulations: enhanced antimalarial efficacy against Plasmodium berghei-infected mice. Eur J Pharm Biopharm. 2012;80:528–534. PMID: 22142592ArticlePubMed
  • 61. Agarwal NB, Jain S, Nagpal D, Agarwal NK, Mediratta PK, Sharma KK. Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice. Fundam Clin Pharmacol. 2013;27:169–172. PMID: 22044441ArticlePubMed
  • 62. Chen H, Wu J, Sun M, Guo C, Yu A, Cao F, et al. N-trimethyl chitosan chloride-coated liposomes for the oral delivery of curcumin. J Liposome Res. 2012;22:100–109. PMID: 22007962ArticlePubMed
  • 63. Zhang L, Lu CT, Li WF, Cheng JG, Tian XQ, Zhao YZ, et al. Physical characterization and cellular uptake of propylene glycol liposomes in vitro. Drug Dev Ind Pharm. 2012;38:365–371. PMID: 21854252ArticlePubMed
  • 64. Dhule SS, Penfornis P, Frazier T, Walker R, Feldman J, Tan G, et al. Curcumin-loaded gamma-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma. Nanomedicine. 2012;8:440–451. PMID: 21839055ArticlePubMedPMC
  • 65. Lin YL, Liu YK, Tsai NM, Hsieh JH, Chen CH, Lin CM, et al. A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on curcumin-sensitive and curcumin-resistance cells. Nanomedicine. 2012;8:318–327. PMID: 21704596ArticlePubMed
  • 66. Mourtas S, Canovi M, Zona C, Aurilia D, Niarakis A, La Ferla B, et al. Curcumin-decorated nanoliposomes with very high affinity for amyloid-beta1-42 peptide. Biomaterials. 2011;32:1635–1645. PMID: 21131044ArticlePubMed
  • 67. Thangapazham RL, Puri A, Tele S, Blumenthal R, Maheshwari RK. Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells. Int J Oncol. 2008;32:1119–1123. PMID: 18425340ArticlePubMedPMC
  • 68. Pawar YB, Purohit H, Valicherla GR, Munjal B, Lale SV, Patel SB, et al. Novel lipid based oral formulation of curcumin: development and optimization by design of experiments approach. Int J Pharm. 2012;436:617–623. PMID: 22842624ArticlePubMed
  • 69. Sun J, Bi C, Chan HM, Sun S, Zhang Q, Zheng Y. Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability. Colloids Surf B Biointerfaces. 2013;111C:367–375. PMID: 23856543ArticlePubMed
  • 70. Kumar A, Ahuja A, Ali J, Baboota S. Curcumin loaded nano globules for solubility enhancement: preparation, characterization and ex vivo release study. J Nanosci Nanotechnol. 2012;12:8293–8302. PMID: 23421209ArticlePubMed
  • 71. Saengkrit N, Saesoo S, Srinuanchai W, Phunpee S, Ruktanonchai UR. Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy. Colloids Surf B Biointerfaces. 2014;114:349–356. PMID: 24246195ArticlePubMed
  • 72. Ghosh D, Choudhury ST, Ghosh S, Mandal AK, Sarkar S, Ghosh A, et al. Nanocapsulated curcumin: oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat. Chem Biol Interact. 2012;195:206–214. PMID: 22197969ArticlePubMed
  • 73. Rejinold NS, Sreerekha PR, Chennazhi KP, Nair SV, Jayakumar R. Biocompatible, biodegradable and thermo-sensitive chitosan-g-poly (N-isopropylacrylamide) nanocarrier for curcumin drug delivery. Int J Biol Macromol. 2011;49:161–172. PMID: 21536066ArticlePubMed
  • 74. Pandey MK, Kumar S, Thimmulappa RK, Parmar VS, Biswal S, Watterson AC. Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells. Eur J Pharm Sci. 2011;43:16–24. PMID: 21426935ArticlePubMed
  • 75. Nair KL, Thulasidasan AK, Deepa G, Anto RJ, Kumar GS. Purely aqueous PLGA nanoparticulate formulations of curcumin exhibit enhanced anticancer activity with dependence on the combination of the carrier. Int J Pharm. 2012;425:44–52. PMID: 22266528ArticlePubMed
  • 76. Yallapu MM, Dobberpuhl MR, Maher DM, Jaggi M, Chauhan SC. Design of curcumin loaded cellulose nanoparticles for prostate cancer. Curr Drug Metab. 2012;13:120–128. PMID: 21892919ArticlePubMedPMC
  • 77. Mukerjee A, Vishwanatha JK. Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res. 2009;29:3867–3875. PMID: 19846921PubMed
  • 78. Gong C, Deng S, Wu Q, Xiang M, Wei X, Li L, et al. Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles. Biomaterials. 2013;34:1413–1432. PMID: 23164423ArticlePubMed
  • 79. Marrache S, Dhar S. Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. Proc Natl Acad Sci U S A. 2012;109:16288–16293. PMID: 22991470ArticlePubMedPMC
  • 80. Feng R, Song Z, Zhai G. Preparation and in vivo pharmacokinetics of curcumin-loaded PCL-PEG-PCL triblock copolymeric nanoparticles. Int J Nanomedicine. 2012;7:4089–4098. PMID: 22888245ArticlePubMedPMC
  • 81. Pandelidou M, Dimas K, Georgopoulos A, Hatziantoniou S, Demetzos C. Preparation and characterization of lyophilised egg PC liposomes incorporating curcumin and evaluation of its activity against colorectal cancer cell lines. J Nanosci Nanotechnol. 2011;11:1259–1266. PMID: 21456169ArticlePubMed
  • 82. Hegge AB, Andersen T, Melvik JE, Bruzell E, Kristensen S, Tonnesen HH. Formulation and bacterial phototoxicity of curcumin loaded alginate foams for wound treatment applications: studies on curcumin and curcuminoides XLII. J Pharm Sci. 2011;100:174–185. PMID: 20575064ArticlePubMed
  • 83. Liu L, Sun L, Wu Q, Guo W, Li L, Chen Y, et al. Curcumin loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis. Int J Pharm. 2013;443:175–182. PMID: 23287774ArticlePubMed
  • 84. Wang C, Nie H, Li K, Zhang YX, Yang F, Li CB, et al. Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice. Eur J Pharmacol. 2012;697:152–157. PMID: 23063543ArticlePubMed
  • 85. Park JH, Kim HA, Lee M. Amphiphilic peptide carrier for the combined delivery of curcumin and plasmid DNA into the lungs. Biomaterials. 2012;33:6542–6550. PMID: 22687757ArticlePubMed
  • 86. Yadav VR, Prasad S, Kannappan R, Ravindran J, Chaturvedi MM, Vaahtera L, et al. Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake. Biochem Pharmacol. 2010;80:1021–1032. PMID: 20599780ArticlePubMedPMC
  • 87. Alam S, Panda JJ, Chauhan VS. Novel dipeptide nanoparticles for effective curcumin delivery. Int J Nanomedicine. 2012;7:4207–4222. PMID: 22915849ArticlePubMedPMC
  • 88. Aditya NP, Chimote G, Gunalan K, Banerjee R, Patankar S, Madhusudhan B. Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice. Exp Parasitol. 2012;131:292–299. PMID: 22561991ArticlePubMed
  • 89. Liu CW, Xiong F, Jia HZ, Wang XL, Cheng H, Sun YH, et al. Graphene-based anticancer nanosystem and its biosafety evaluation using a zebrafish model. Biomacromolecules. 2013;14:358–366. PMID: 23286342ArticlePubMed
  • 90. Kumar SS, Surianarayanan M, Vijayaraghavan R, Mandal AB, MacFarlane DR. Curcumin loaded poly(2-hydroxyethyl methacrylate) nanoparticles from gelled ionic liquid: in vitro cytotoxicity and anti-cancer activity in SKOV-3 cells. Eur J Pharm Sci. 2014;51:34–44. PMID: 24012589ArticlePubMed
  • 91. Gangwar RK, Tomar GB, Dhumale VA, Zinjarde S, Sharma RB, Datar S. Curcumin conjugated silica nanoparticles for improving bioavailability and its anticancer applications. J Agric Food Chem. 2013;61:9632–9637. PMID: 24028689ArticlePubMed
  • 92. Singh R, Tonnesen HH, Kristensen S, Berg K. The influence of Pluronics(R) on dark cytotoxicity, photocytotoxicity, localization and uptake of curcumin in cancer cells: studies of curcumin and curcuminoids XLIX. Photochem Photobiol Sci. 2013;12:559–575. PMID: 23108412ArticlePubMed
  • 93. Suwannateep N, Wanichwecharungruang S, Fluhr J, Patzelt A, Lademann J, Meinke MC. Comparison of two encapsulated curcumin particular systems contained in different formulations with regard to in vitro skin penetration. Skin Res Technol. 2013;19:1–9. PMID: 22233515ArticlePubMed
  • 94. Wahlström B, Blennow G. A study on the fate of curcumin in the rat. Acta Pharmacol Toxicol (Copenh). 1978;43:86–92. PMID: 696348ArticlePubMed
  • 95. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64:353–356. PMID: 9619120ArticlePubMed
  • 96. Yang KY, Lin LC, Tseng TY, Wang SC, Tsai TH. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;853:183–189. ArticlePubMed
  • 97. Chang MT, Tsai TR, Lee CY, Wei YS, Chen YJ, Chen CR, et al. Elevating bioavailability of curcumin via encapsulation with a novel formulation of artificial oil bodies. J Agric Food Chem. 2013;61:9666–9671. PMID: 24020431ArticlePubMed
  • 98. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001;21:2895–2900. PMID: 11712783PubMed
  • 99. Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, et al. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. 2004;10:6847–6854. PMID: 15501961ArticlePubMed
  • 100. Guzman-Villanueva D, El-Sherbiny IM, Herrera-Ruiz D, Smyth HD. Design and in vitro evaluation of a new nano-microparticulate system for enhanced aqueous-phase solubility of curcumin. Biomed Res Int. 2013;2013:724763PMID: 23984402ArticlePubMedPMCPDF
  • 101. Gandapu U, Chaitanya RK, Kishore G, Reddy RC, Kondapi AK. Curcumin-loaded apotransferrin nanoparticles provide efficient cellular uptake and effectively inhibit HIV-1 replication in vitro. PLoS One. 2011;6:e23388PMID: 21887247ArticlePubMedPMC
  • 102. Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011;34:660–665. PMID: 21532153ArticlePubMed
  • 103. Cheng KK, Yeung CF, Ho SW, Chow SF, Chow AH, Baum L. Highly stabilized curcumin nanoparticles tested in an in vitro blood-brain barrier model and in Alzheimer's disease Tg2576 mice. AAPS J. 2013;15:324–336. PMID: 23229335ArticlePubMedPMC
  • 104. Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, et al. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol. 2010;79:330–338. PMID: 19735646ArticlePubMedPMC
  • 105. Khalil NM, do Nascimento TC, Casa DM, Dalmolin LF, de Mattos AC, Hoss I, et al. Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in rats. Colloids Surf B Biointerfaces. 2013;101:353–360. PMID: 23010041ArticlePubMed
  • 106. Tsai YM, Chang-Liao WL, Chien CF, Lin LC, Tsai TH. Effects of polymer molecular weight on relative oral bioavailability of curcumin. Int J Nanomedicine. 2012;7:2957–2966. PMID: 22745556ArticlePubMedPMC
  • 107. Xie X, Tao Q, Zou Y, Zhang F, Guo M, Wang Y, et al. PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms. J Agric Food Chem. 2011;59:9280–9289. PMID: 21797282ArticlePubMed
  • 108. Yallapu MM, Gupta BK, Jaggi M, Chauhan SC. Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. J Colloid Interface Sci. 2010;351:19–29. PMID: 20627257ArticlePubMed
  • 109. Takahashi M, Uechi S, Takara K, Asikin Y, Wada K. Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. J Agric Food Chem. 2009;57:9141–9146. PMID: 19757811ArticlePubMed
  • 110. Rachmawati H, Edityaningrum CA, Mauludin R. Molecular inclusion complex of curcumin-beta-cyclodextrin nanoparticle to enhance curcumin skin permeability from hydrophilic matrix gel. AAPS PharmSciTech. 2013;14:1303–1312. PMID: 23990077ArticlePubMedPMC
  • 111. Sharma V, Nehru B, Munshi A, Jyothy A. Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats. Methods Find Exp Clin Pharmacol. 2010;32:227–232. PMID: 20508869ArticlePubMed
  • 112. Suresh D, Srinivasan K. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med Res. 2010;131:682–691. PMID: 20516541PubMed
  • 113. Moorthi C, Krishnan K, Manavalan R, Kathiresan K. Preparation and characterization of curcumin-piperine dual drug loaded nanoparticles. Asian Pac J Trop Biomed. 2012;2:841–848. PMID: 23569859ArticlePubMedPMC
  • 114. Misra R, Sahoo SK. Coformulation of doxorubicin and curcumin in poly(D,L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells. Mol Pharm. 2011;8:852–866. PMID: 21480667ArticlePubMed
  • 115. Agashe H, Sahoo K, Lagisetty P, Awasthi V. Cyclodextrin-mediated entrapment of curcuminoid 4-[3,5-bis (2-chlorobenzylidene-4-oxo-piperidine-1-yl)-4-oxo-2-butenoic acid] or CLEFMA in liposomes for treatment of xenograft lung tumor in rats. Colloids Surf B Biointerfaces. 2011;84:329–337. PMID: 21315563ArticlePubMedPMC
  • 116. Basnet P, Hussain H, Tho I, Skalko-Basnet N. Liposomal delivery system enhances anti-inflammatory properties of curcumin. J Pharm Sci. 2012;101:598–609. PMID: 21989712ArticlePubMed
  • 117. Ryu EK, Choe YS, Lee KH, Choi Y, Kim BT. Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for β-amyloid plaque imaging. J Med Chem. 2006;49:6111–6119. PMID: 17004725ArticlePubMed
  • 118. Ravindranath V, Chandrasekhara N. Absorption and tissue distribution of curcumin in rats. Toxicology. 1980;16:259–265. PMID: 7423534ArticlePubMed
  • 119. Pan MH, Huang TM, Lin JK. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab Dispos. 1999;27:486–494. PMID: 10101144PubMed
  • 120. Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res. 2001;7:1894–1900. PMID: 11448902PubMed
  • 121. Garcea G, Jones DJ, Singh R, Dennison AR, Farmer PB, Sharma RA, et al. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br J Cancer. 2004;90:1011–1015. PMID: 14997198ArticlePubMedPMC
  • 122. Marczylo TH, Steward WP, Gescher AJ. Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method. J Agric Food Chem. 2009;57:797–803. PMID: 19152267ArticlePubMed
  • 123. Ravindranath V, Chandrasekhara N. Metabolism of curcumin--studies with [3H]curcumin. Toxicology. 1981;22:337–344. PMID: 7342372ArticlePubMed
  • 124. Ireson C, Orr S, Jones DJ, Verschoyle R, Lim CK, Luo JL, et al. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res. 2001;61:1058–1064. PMID: 11221833PubMed
  • 125. Asai A, Miyazawa T. Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma. Life Sci. 2000;67:2785–2793. PMID: 11105995ArticlePubMed
  • 126. Holder GM, Plummer JL, Ryan AJ. The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat. Xenobiotica. 1978;8:761–768. PMID: 726520ArticlePubMed
  • 127. Khopde SM, Priyadarsini KI, Guha SN, Satav JG, Venkatesan P, Rao MN. Inhibition of radiation-induced lipid peroxidation by tetrahydrocurcumin: possible mechanisms by pulse radiolysis. Biosci Biotechnol Biochem. 2000;64:503–509. PMID: 10803946ArticlePubMed
  • 128. Okada K, Wangpoengtrakul C, Tanaka T, Toyokuni S, Uchida K, Osawa T. Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. J Nutr. 2001;131:2090–2095. PMID: 11481399ArticlePubMed
  • 129. Lai CS, Wu JC, Yu SF, Badmaev V, Nagabhushanam K, Ho CT, et al. Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis. Mol Nutr Food Res. 2011;55:1819–1828. PMID: 21887819ArticlePubMed
  • 130. Chen CY, Yang WL, Kuo SY. Cytotoxic activity and cell cycle analysis of hexahydrocurcumin on SW 480 human colorectal cancer cells. Nat Prod Commun. 2011;6:1671–1672. PMID: 22224285ArticlePubMed
  • 131. Pan MH, Lin-Shiau SY, Lin JK. Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages. Biochem Pharmacol. 2000;60:1665–1676. PMID: 11077049ArticlePubMed
  • 132. Somparn P, Phisalaphong C, Nakornchai S, Unchern S, Morales NP. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol Pharm Bull. 2007;30:74–78. PMID: 17202663ArticlePubMed
  • 133. Pal A, Sung B, Bhanu Prasad BA, Schuber PT Jr, Prasad S, Aggarwal BB, et al. Curcumin glucuronides: assessing the proliferative activity against human cell lines. Bioorg Med Chem. 2014;22:435–439. PMID: 24280069ArticlePubMedPMC
Fig. 1
Various curcumin-based products include capsules, tablets, ointments, energy drinks, soaps, and cosmetics.
crt-46-2-g001.jpg
Fig. 2
Redesign of curcumin through various strategies to enhance bioavailability. GMO, glyceryl monoleate; PLGA, polylactic-co-glycolic acid; PHEMA, poly(2-hydroxyethyl methacrylate); PEG-PEI, polyethylene glycol-poly(ethylene imine).
crt-46-2-g002.jpg
Fig. 3
Biodistribution of [18F]-curcumin (A) and of [18F]-curcumin co-injected with piperine (B) in mice. Adopted from Ryu et al. [117], J Med Chem. 2006;49:6111-9.
crt-46-2-g003.jpg
Fig. 4
Metabolism of curcumin.
crt-46-2-g004.jpg
Table 1
Reformulation of curcumin for enhanced bioavailability
Formulation Reference Formulation Reference
Nanosuspension [52] PEGylated curcumin analogs [74]
Aqueous formulation [53] Curcumin-loaded MPEG-PCL [52]
Nanoemulsion [54] Aqueous PLGA nanoparticulate [75]
pH-sensitive nanoparticles [55] Curcumin loaded cellulose nanoparticles [76]
Microemulsion-based ion-sensitive [49] PLGA microparticle of curcumin [32]
Curcumin-loaded nanoparticles [56] Curcumin-loaded PLGA nanospheres [77]
Curcumin-loaded carbon nanotubes [57] Curcumin MPEG-PCL micelles [78]
Curcumin co-solvent formulation [58] Curcumin PLGA-b-PEG-TPP [79]
Silica-coated flexible liposomes [59] Curcumin PCL-PEG-PCL [80]
Artemisinin liposomal formulations [60] Curcumin methoxy PEG-zein micelles [81]
Liposomal curcumin [61] Curcumin-loaded alginate foams [82]
TMC-coated liposomes [62] Thermosensitive poloxamer hydrogel [50]
Liposomes-propylene glycol liposomes [63] Curcumin-loaded polymeric micelles [83]
γ-Cyclodextrin liposomal nanoparticles [64] CSO-SA [84]
Cationic liposome-PEG-PEI complex [65] Curcumin-loaded amphiphilic peptide [85]
Curcumin-decorated nanoliposomes [66] Cyclodextrin-curcumin [86]
Liposomes of DMPC and cholesterol [67] Dipeptide nanoparticles [87]
Lipid-based oral formulations [68] Phosphatidylcholine encapsulation [88]
Curcumin-loaded solid lipid nanoparticles [69] Graphene-based curcumin nanosystems [89]
Curcumin nanoglobules/nanoemulsion [70] Curcumin PHEMA-NPs [90]
Curcumin-loaded cationic liposome [71] Silica nanoparticles [91]
PGL nanocapsulated curcumin [72] Pluronic-curcumin formulation [92]
Curcumin TRC-NPs [73] EMC-curcumin [93]

TMC, N-trimethyl chitosan chloride; PEG-PEI, polyethylene glycol-poly(ethylene imine); DMPC, dimyristoyl phosphatidyl choline; PGL, propylene glycol liposomes; TRC-NPs, thermoresponsive chitosan-g-poly(N-isopropylacrylamide) co-polymeric nanoparticles; MPEG-PCL, methoxy poly(ethylene glycol)-poly(ε-caprolactone); PLGA-b-PEG-TPP, poly(d, l-lactic-co-glycolic acid)-block (PLGA-b)-poly(ethylene glycol) (PEG)-triphenylphosphonium (TPP) polymer; PCL-PEG-PCL, poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone); CSO-SA, curcumin encapsulated in stearic acid-g-chitosan oligosaccharide; PHEMA-NPs, poly(2-hydroxyethyl methacrylate) nanoparticles; EMC, ethyl and methyl cellulose.

Figure & Data

REFERENCES

    Citations

    Citations to this article as recorded by  
    • Enhancing the physicochemical stability and bioaccessibility of curcumin-loaded soybean oil bodies emulsions in the in vitro elderly model
      Wenwen Lv, Kaiyi Zou, Fengru Zhang, Yiran Jia, Ikram Alouk, Xiaoyu Li, Wei Chen, Baoguo Sun, Yanbo Wang, Duoxia Xu
      Food Hydrocolloids.2025; 158: 110563.     CrossRef
    • Review: bioavailability and efficacy of ‘free’ curcuminoids from curcumagalactomannoside (CGM) curcumin formulation
      Cristina Matthewman, I.M. Krishnakumar, Andrew G. Swick
      Nutrition Research Reviews.2024; 37(1): 14.     CrossRef
    • Properties and Biological Effects of Curcumin in Food Product Development
      Wing-Fu Lai, Dahong Zhang, Obireddy Sreekanth Reddy, Wing-Tak Wong
      Food Reviews International.2024; 40(5): 1480.     CrossRef
    • Technological Interventions Enhancing Curcumin Bioavailability in Wound-Healing Therapeutics
      Hemant Singh, Mukesh Dhanka, Indu Yadav, Sneh Gautam, Showkeen Muzamil Bashir, Narayan Chandra Mishra, Taruna Arora, Shabir Hassan
      Tissue Engineering Part B: Reviews.2024; 30(2): 230.     CrossRef
    • Effectiveness of curcumin nanoparticles in rat liver fibrosis caused by thioacetamide
      Aliaa M. Radwan, Shahenda A. Fatoh, Ahmed Massoud, Ehab Tousson
      Environmental Toxicology.2024; 39(1): 388.     CrossRef
    • Exploring the potential of spice‐derived phytochemicals as alternative antimicrobial agents
      Young Y. Wong, Yit‐Lai Chow
      eFood.2024;[Epub]     CrossRef
    • Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future perspectives
      Md. Rezaul Islam, Abdur Rauf, Shopnil Akash, Sadiya Islam Trisha, Akram Hossain Nasim, Muniya Akter, Puja Sutro Dhar, Hanan A. Ogaly, Hassan A. Hemeg, Polrat Wilairatana, Muthu Thiruvengadam
      Biomedicine & Pharmacotherapy.2024; 170: 116034.     CrossRef
    • Curcumin and Ferroptosis: a Promising Target for Disease Prevention and Treatment
      Zahra Foroutan, Alexandra E. Butler, Gokhan Zengin, Amirhossein Sahebkar
      Cell Biochemistry and Biophysics.2024; 82(2): 343.     CrossRef
    • Erythrocyte membrane-coated nanocarriers modified by TGN for Alzheimer's disease
      Jinlian Gu, Chang Yan, Shun Yin, Hao Wu, Chi Liu, Ao Xue, Xia Lei, Ning Zhang, Fang Geng
      Journal of Controlled Release.2024; 366: 448.     CrossRef
    • Effects of Curcuma longa (turmeric) and curcumin on the premenstrual syndrome and dysmenorrhea: A systematic review
      Zahra Shabanian Boroujeni, Saeid Heidari-Soureshjani, Catherine MT Sherwin
      Journal of Endometriosis and Pelvic Pain Disorders.2024; 16(1): 33.     CrossRef
    • Microencapsulation of curcumin by complex coacervation of lactoferrin and carboxymethyl tara gum for incorporation into edible films
      Barbara da Silva Soares, Augusto Bene Tomé Constantino, Edwin Elard Garcia-Rojas
      Food Hydrocolloids for Health.2024; 5: 100178.     CrossRef
    • Herbal therapies for pain management: a scoping review of the current evidence
      Md. Kamrul Hasan, Khwaja Zohura Zanzabil, Iffat Ara, Tania Rahman, Alexander Kieu, Linda Östlundh, Sameeha Junaidi, Moien AB Khan
      Phytochemistry Reviews.2024; 23(4): 1065.     CrossRef
    • MMP-7 Levels Decrease in Gingival Epithelium Exposed to Porphyromonas Gingivalis after Curcumin administration
      Agung Krismariono, Carolyn Purnama S
      Research Journal of Pharmacy and Technology.2024; : 309.     CrossRef
    • Longevity and anti-aging effects of curcumin supplementation
      Mehran Izadi, Nariman Sadri, Amirhossein Abdi, Mohammad Mahdi Raeis Zadeh, Dorsa jalaei, Mohammad Mahdi Ghazimoradi, Sara Shouri, Safa Tahmasebi
      GeroScience.2024; 46(3): 2933.     CrossRef
    • Oxidative Stress: The Role of Antioxidant Phytochemicals in the Prevention and Treatment of Diseases
      Adele Muscolo, Oliva Mariateresa, Torello Giulio, Russo Mariateresa
      International Journal of Molecular Sciences.2024; 25(6): 3264.     CrossRef
    • Anti-Inflammatory Potential of Curcumin: From Chemistry and Mechanistic Insight to Nanoformulations
      Diwakar Aggarwal, Mayank Chaudhary, Nandini Bajaj, Deepika Sharma, Sushil Kumar Upadhyay, Vivek Kumar Garg, Hadi Sajid Abdulabbas, Hardeep Singh Tuli, Isha Rani
      Current Bioactive Compounds.2024;[Epub]     CrossRef
    • Advances in Nanocarrier Systems for Overcoming Formulation Challenges of Curcumin: Current Insights
      Shery Jacob, Fathima Kather, Mohamed Morsy, Sai Boddu, Mahesh Attimarad, Jigar Shah, Pottathil Shinu, Anroop Nair
      Nanomaterials.2024; 14(8): 672.     CrossRef
    • Curcumin – Bioavailability Enhancement by Prodrug Approach and Novel Formulations
      Narsaiah Chelimela, Rajasekhar Reddy Alavala, Shobha Rani Satla
      Chemistry & Biodiversity.2024;[Epub]     CrossRef
    • Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites
      Noemi Pagliaricci, Riccardo Pettinari, Fabio Marchetti, Alessia Tombesi, Sara Pagliaricci, Massimiliano Cuccioloni, Agustín Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
      Inorganic Chemistry.2024; 63(17): 7955.     CrossRef
    • Anti-Parkinson potential of hesperetin nanoparticles: in vivo and in silico investigations
      Praveen Kumar Pasala, Prasanth DSNBK, Mithun Rudrapal, Ranadheer Reddy Challa, Sheikh F. Ahmad, Bhaskar Vallamkonda, Ram Babu R.
      Natural Product Research.2024; : 1.     CrossRef
    • Layered silicate nanoparticles as a non-injectable drug delivery system for biomacromolecules
      Jae Geun Song, Sang Hoon Lee, Rajiv Bajracharya, Nonye Linda Ifekpolugo, Gyu-Lin Kim, Seong Jin Park, Seong Hoon Jeong, Chang Hoon Lee, Hyo-Kyung Han
      Journal of Pharmaceutical Investigation.2024; 54(5): 593.     CrossRef
    • Enhanced stability and dissolution of curcumin nanocrystals stabilized by octenyl succinic anhydride modified starch
      Changying Chen, Guoqi Yu, Yanyan Zhou, Hongliang Fu, Wenna Huang, Zhixing Wang, Xiang Luo, Xuguang Yin, Su Mao, Kewu Zhu
      Journal of Drug Delivery Science and Technology.2024; 96: 105701.     CrossRef
    • Curcumin as a Promising Therapy for COVID-19: A Review
      Arunava Kali, M. V. Pravin Charles
      Global Journal of Medical, Pharmaceutical, and Biomedical Update.2024; 19: 2.     CrossRef
    • NF‐κB pathway as a molecular target for curcumin in diabetes mellitus treatment: Focusing on oxidative stress and inflammation
      Mohammad Yasin Zamanian, Hashem O. Alsaab, Maryam Golmohammadi, Alexey Yumashev, Abeer Mhussan Jabba, Mohammed Kadhem Abid, Abhishek Joshi, Ahmed Hussien Alawadi, Noor S. Jafer, Farzaneh Kianifar, Samuel Baker Obakiro
      Cell Biochemistry and Function.2024;[Epub]     CrossRef
    • The effects of dietary Spirulina platensis or curcumin nanoparticles on performance, body chemical composition, blood biochemical, digestive enzyme, antioxidant and immune activities of Oreochromis niloticus fingerlings
      El-Sayed Hemdan Eissa, Marwa S. Khattab, Samia Elbahnaswy, Gehad E. Elshopakey, Muna Omer Alamoudi, Rabab Mohamed Aljàrari, Mohammad B. Munir, Zulhisyam A. Kari, Mohammed A.E. Naiel
      BMC Veterinary Research.2024;[Epub]     CrossRef
    • Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients
      Tantry Maulina, Yohanes Purnomo, Nadya Khamila, Devy Garna, Endang Sjamsudin, Arief Cahyanto
      Journal of Pain Research.2024; Volume 17: 1903.     CrossRef
    • Chondroitin sulfate–functionalized selenium nanoparticle–induced S‐phase cell cycle arrest and apoptosis in HeLa Cells
      Jianping Chen, Xuehua Chen, Anqi Tang, Zhuo Wang, Kit‐Leong Cheong, Xiaofei Liu, Saiyi Zhong
      Journal of Food Science.2024; 89(7): 4469.     CrossRef
    • Analysis of Clinical Trials Using Anti-Tumor Traditional Chinese Medicine Monomers
      Dan Lv, Yuling Liu, Ruying Tang, Sai Fu, Shasha Kong, Qian Liao, Hui Li, Longfei Lin
      Drug Design, Development and Therapy.2024; Volume 18: 1997.     CrossRef
    • Effects of polymer microstructure introduced by radical ring-opening polymerization on nanoencapsulation and controlled release
      Algin Oh Biying, Srinivasa Reddy Mothe, Alexander W. Jackson, Parijat Kanaujia, Praveen Thoniyot
      Polymer.2024; 307: 127284.     CrossRef
    • Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer’s Disease
      Nikita Navolokin, Viktoria Adushkina, Daria Zlatogorskaya, Valeria Telnova, Arina Evsiukova, Elena Vodovozova, Anna Eroshova, Elina Dosadina, Sergey Diduk, Oxana Semyachkina-Glushkovskaya
      Pharmaceuticals.2024; 17(6): 788.     CrossRef
    • Nanoencapsulation-mediated curcumin and its incorporation in nutraceutical cookies: Cell viability, bioavailability, and anti-inflammatory activity studies
      Pooja J. Rao, M.L. Sudha, Manoj P., Seema Mudhol, Kaila Nova Henna Jemimah, Gopika G., Ashwini S., Muthukumar Serva Peddha
      Industrial Crops and Products.2024; 218: 119009.     CrossRef
    • Effects of Cyclodextrin Curcumin Formulation on Ischemia-Reperfusion Injury in Porcine DCD Liver Transplantation
      Nicolas Meurisse, Tine Wylin, Veerle Heedfeld, Steffen Fieuws, Laurens Ceulemans, Ina Jochmans, Jacques Pirenne, Diethard Monbaliu
      Transplantation.2024; 108(12): 2366.     CrossRef
    • Phyto-additive fueling fertility: Nanocurcumin enhances red tilapia foundation stock breeding in saline waters
      Ghada R. Sallam, Walied M. Fayed, Mazen A. Elsawaf, Hafez A.H. Mabrouk, Mohamed A. Al-Absawey, Shimaa Henish, Mohammed F. El Basuini, Akram Ismael Shehata
      Aquaculture.2024; 592: 741268.     CrossRef
    • Antibacterial rice protein nanoparticles with a high curcumin loading for fruit preservation
      Pengcheng Xu, Tao Wang, Jian He, Wenfei Xiong, Jingnan Ren, Wei Feng, Zhengxing Chen, Ren Wang
      Food Bioscience.2024; 61: 104935.     CrossRef
    • Ternary nanoparticles of sodium caseinate-zein-hexaglycerol monooleate: Fabrication, characterization, and curcumin encapsulation
      Xinyu Zhang, Yingxue Cheng, Hong Lin, Hailong Zhang, Weinong Zhang, Junbo He
      LWT.2024; 203: 116376.     CrossRef
    • Cyclodextrin Nanosponges: A Revolutionary Drug Delivery Strategy
      Sonia Singh, Khushi Sharma, Himanshu Sharma
      Pharmaceutical Nanotechnology.2024; 12(4): 300.     CrossRef
    • The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases
      Geir Bjørklund, Petro Oliinyk, Oksana Khavrona, Iryna Lozynska, Roman Lysiuk, Roman Darmohray, Halyna Antonyak, Natalia Dub, Vasyl Zayachuk, Olha Antoniv, Oksana Rybak, Massimiliano Peana
      Molecular Neurobiology.2024;[Epub]     CrossRef
    • Oral recombinant Pichia pastoris P-I20H combined with immunopotentiator curcumin remarkably inhibits and clears LMBV in largemouth bass (Micropterus salmoides)
      Pengxu Wang, Fengxia Zhao, Xingchen Huo, Chunrong Yang, Jianguo Su
      Aquaculture.2024; 593: 741361.     CrossRef
    • Curcumin alone not combined with piperine exerts cardioprotective effects in pressure-overload rats by increasing glucagon-like peptide-1 receptor signaling and additional properties
      Xiao-jie Bai, Jun-tao Hao, Qi-long Feng, Chen-meng Guo, Min Pang, Jia Li, Jin Wang, Jian-feng Xing
      Journal of Traditional and Complementary Medicine.2024;[Epub]     CrossRef
    • Evaluation of the Antibacterial Potency of Phytochemicals and Their Effects on Host Xenobiotic Response Using Caenorhabditis elegans
      Young Yau Wong, Tsun-Thai Chai, Yit-Lai Chow
      Revista Brasileira de Farmacognosia.2024; 34(6): 1276.     CrossRef
    • Combining luteolin and curcumin synergistically suppresses triple-negative breast cancer by regulating IFN and TGF-β signaling pathways
      Xiaoyong Wang, Lijuan Zhang, Hongwei Si
      Biomedicine & Pharmacotherapy.2024; 178: 117221.     CrossRef
    • An efficient approach for the extraction of polyphenols from pomegranate peel using the green solvent and profiling by UPLC-Q-TOF-MS/MS analysis
      Ju-Zhao Liu, Xiao-Xian Lu, Xin-Tong Yang, Li-Jie Jiang, Qi Cui
      Microchemical Journal.2024; 205: 111421.     CrossRef
    • Targeted pathophysiological treatment of ischemic stroke using nanoparticle-based drug delivery system
      Wei Liu, Lubin Liu, Hong Li, Yutong Xie, Ju Bai, Jialiang Guan, Hongzhao Qi, Jinping Sun
      Journal of Nanobiotechnology.2024;[Epub]     CrossRef
    • Potential Application of Plant-Derived Compounds in Multiple Sclerosis Management
      Seth Woodfin, Sierra Hall, Alexis Ramerth, Brooke Chapple, Dane Fausnacht, William Moore, Hana Alkhalidy, Dongmin Liu
      Nutrients.2024; 16(17): 2996.     CrossRef
    • Development of egg yolk lipoprotein hydrolysate for nano-delivery of curcumin: Structure-function relationship
      Lili Jiang, Yanjun Yang, Yujie Su, Cuihua Chang, Luping Gu, Chunfang Liu, Junhua Li
      Innovative Food Science & Emerging Technologies.2024; 97: 103804.     CrossRef
    • Enhancing wheat tolerance to salinity using nanomaterials, proline, and biochar-inoculated with Bacillus subtilis
      Muhammad Ayman, Mohamed A. Fahmy, Ahmed S.M. Elnahal, Haifa E. Alfassam, Hassan A. Rudayni, Ahmed A. Allam, Eman M. Farahat
      Heliyon.2024; 10(17): e37160.     CrossRef
    • Ferroptosis-targeting drugs in breast cancer
      Shuxian Zhang, Lijuan Guo, Ran Tao, Shuangping Liu
      Journal of Drug Targeting.2024; : 1.     CrossRef
    • Efficacy and safety of an oral complementary medicine combination in people with symptomatic knee osteoarthritis: Protocol for the double-blind, randomized, placebo-controlled ATLAS trial
      Arashi Shahid, Xiaoqian Liu, Karen Bracken, Robin Christensen, Leticia Alle Deveza, Simone Collins, Joanna Harnett, David J. Hunter, Andrew J. McLachlan, Sarah Robbins, Jocelyn L. Bowden
      Osteoarthritis and Cartilage Open.2024; 6(4): 100522.     CrossRef
    • On the health effects of curcumin and its derivatives
      Hudda Ayub, Mahad Islam, Munnaza Saeed, Husnat Ahmad, Fahad Al‐Asmari, Mohamed Fawzy Ramadan, Mohammed Alissa, Muhammad Adnan Arif, Muhammad Umair Jamil Rana, Muhammad Subtain, Muhammad Abdul Rahim, Eliasse Zongo, Nazir Ahmad
      Food Science & Nutrition.2024; 12(11): 8623.     CrossRef
    • Improving curcumin bioavailability: Targeted delivery of curcumin and loading systems in intestinal inflammation
      Junyi Zhao, Wei Jia, Rong Zhang, Xin Wang, Li Zhang
      Food Research International.2024; 196: 115079.     CrossRef
    • Design, synthesis and biological evaluation of novel curcumin-fluorouracil hybrids as potential anti-cancer agents
      Xiaotong Wang, Xin Li, Xu Zhang, Xuekun Wang, Jie Yang, Guoyun Liu
      Biochemical Pharmacology.2024; 230: 116559.     CrossRef
    • The Protective Effects of Curcumin against Renal Toxicity
      Jianan Zhai, Zhengguo Chen, Qi Zhu, Zhifang Guo, Ningning Wang, Cong Zhang, Haoyuan Deng, Shaopeng Wang, Guang Yang
      Current Medicinal Chemistry.2024; 31(35): 5661.     CrossRef
    • In Vitro Effect of Photodynamic Therapy With Curcumin in Combination With Photobiomodulation Therapy by 660 nm on the Viability of Human Gingival Fibroblasts
      Ardavan Etemadi, Seyed Khashayar Koochak Hosseini, Morteza Neshandar, Nasim Chiniforush
      Journal of Lasers in Medical Sciences.2024; 15: e42.     CrossRef
    • In Silico Comparison of Quantum and Bioactivity Parameters of a Series of Natural Diphenyl Acetone Analogues, and In Vitro Caco-2 Studies on Three Main Chalcone Derivatives
      Amalia Stefaniu, Georgeta Neagu, Adrian Albulescu, Nicoleta Radu, Lucia Camelia Pirvu
      Symmetry.2024; 16(10): 1383.     CrossRef
    • Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration
      Anchal Trisal, Abhishek Kumar Singh
      Cellular and Molecular Neurobiology.2024;[Epub]     CrossRef
    • Healing effect of curcumin on tooth extraction sockets in diabetic rats
      Tipthanan Chotipinit, Weera Supronsinchai, Soranun Chantarangsu, Supaporn Suttamanatwong
      Journal of Applied Oral Science.2024;[Epub]     CrossRef
    • Spongosome-based co-delivery of curcumin and Piperine: A novel strategy for mitigating pollution-induced skin damage
      Agnese Bondi, Francesca Ferrara, Walter Pula, Paolo Mariani, Alessia Pepe, Markus Drechsler, Leda Montesi, Stefano Manfredini, Giuseppe Valacchi, Elisabetta Esposito
      Colloid and Interface Science Communications.2024; 63: 100811.     CrossRef
    • Identifying xenobiotic metabolites with in silico prediction tools and LCMS suspect screening analysis
      Matthew Boyce, Kristin A. Favela, Jessica A. Bonzo, Alex Chao, Lucina E. Lizarraga, Laura R. Moody, Elizabeth O. Owens, Grace Patlewicz, Imran Shah, Jon R. Sobus, Russell S. Thomas, Antony J. Williams, Alice Yau, John F. Wambaugh
      Frontiers in Toxicology.2023;[Epub]     CrossRef
    • Current insights into epigenetics, noncoding RNA interactome and clinical pharmacokinetics of dietary polyphenols in cancer chemoprevention
      Deepa Shah, Manav Gandhi, Arun Kumar, Natália Cruz-Martins, Rohit Sharma, Sujit Nair
      Critical Reviews in Food Science and Nutrition.2023; 63(12): 1755.     CrossRef
    • Polyvinylpyrrolidone-Curcumin Nanoconjugate as a Biocompatible, Non-toxic Material for Biological Applications
      Sumit Mukherjee, Pranita Rananaware, Varsha Brahmkhatri, Monalisa Mishra
      Journal of Cluster Science.2023; 34(1): 395.     CrossRef
    • Assessment of the Anti-inflammatory Effects of NORFLO® ORO in Acute Relapses of HLA-B27-associated Autoimmune Uveitis: A Multicenter, Randomized, Placebo-controlled, Double-blind Clinical Study
      Pia Allegri, Luca Cimino, Janet L. Davis, Ilknur Tugal-Tutkun
      Ocular Immunology and Inflammation.2023; 31(3): 526.     CrossRef
    • Phytotherapy in Diabetic Foot Ulcers: A Promising Strategy for Effective Wound Healing
      Sonal Sekhar Miraj, Shilia Jacob Kurian, Gabriel Sunil Rodrigues, Kavitha Saravu, Mahadev Rao, Siba Prasad Raychaudhuri, Bernard W. Downs, Debasis Bagchi
      Journal of the American Nutrition Association.2023; 42(3): 295.     CrossRef
    • The effects of curcumin on anthropometric and cardiometabolic parameters of patients with metabolic related diseases: a systematic review and dose-effect meta-analysis of randomized controlled trials
      Zhuo Sun, Xiaohui Wei, Jianan Bai, Wenyun Li, Jiaqi Yang, Zequn Deng, Min Wu, Tao Ying, Gengsheng He
      Critical Reviews in Food Science and Nutrition.2023; 63(28): 9282.     CrossRef
    • Complexity of Tumor Microenvironment: Therapeutic Role of Curcumin and Its Metabolites
      Sahdeo Prasad, Priyanka Saha, Bilash Chatterjee, Anis Ahmad Chaudhary, Rajiv Lall, Amit K Srivastava
      Nutrition and Cancer.2023; 75(1): 1.     CrossRef
    • Liquid crystal precursor system as a vehicle for curcumin‐mediated photodynamic inactivation of oral biofilms
      Bárbara Donadon Reina, Carolina Santezi, Samuel Santana Malheiros, Giovana Calixto, Camila Rodero, Francesca Damiani Victorelli, Marlus Chorilli, Lívia Nordi Dovigo
      Journal of Biophotonics.2023;[Epub]     CrossRef
    • Liver Injury Associated with Turmeric—A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN]
      Dina Halegoua-DeMarzio, Victor Navarro, Jawad Ahmad, Bharathi Avula, Huiman Barnhart, A. Sidney Barritt, Herbert L. Bonkovsky, Robert J. Fontana, Marwan S. Ghabril, Jay H. Hoofnagle, Ikhlas A. Khan, David E. Kleiner, Elizabeth Phillips, Andrew Stolz, Raj
      The American Journal of Medicine.2023; 136(2): 200.     CrossRef
    • Curcumin in human osteosarcoma: From analogs to carriers
      Ko-Hsiu Lu, Peace Wun-Ang Lu, Chiao-Wen Lin, Shun-Fa Yang
      Drug Discovery Today.2023; 28(2): 103437.     CrossRef
    • Biophysical interactions of mixed lipid-polymer nanoparticles incorporating curcumin: Potential as antibacterial agent
      Nikolaos Naziris, Szymon Sekowski, Ewa Olchowik-Grabarek, Adam Buczkowski, Łucja Balcerzak, Varvara Chrysostomou, Stergios Pispas, Magdalena Małecka, Maria Bryszewska, Maksim Ionov
      Biomaterials Advances.2023; 144: 213200.     CrossRef
    • Formulation and Development of Curcumin–Piperine-Loaded S-SNEDDS for the Treatment of Alzheimer’s Disease
      Shmmon Ahmad, Abdul Hafeez
      Molecular Neurobiology.2023; 60(2): 1067.     CrossRef
    • Chitosan and carboxymethyl cellulose-based 3D multifunctional bioactive hydrogels loaded with nano-curcumin for synergistic diabetic wound repair
      Syed Ahmed Shah, Muhammad Sohail, Marcel Karperien, Castro Johnbosco, Arshad Mahmood, Mubeen Kousar
      International Journal of Biological Macromolecules.2023; 227: 1203.     CrossRef
    • A novel solvent-free co-grinding preparation improves curcumin bioavailability in healthy volunteers: A single-center crossover study
      Chenjing Wang, Xin Jiang, Xiaolei Zhang, Yi Xu, Li Li, Xin Li, Shanglong Wang, Ping Shi, Xiaomeng Gao, Zimin Liu, W. Dennis Clark, Yu Cao
      Heliyon.2023; 9(1): e12829.     CrossRef
    • Curcumin-loaded alginate hydrogels for cancer therapy and wound healing applications: A review
      Ankur Sood, Atul Dev, Sabya Sachi Das, Hyeon Jin Kim, Anuj Kumar, Vijay Kumar Thakur, Sung Soo Han
      International Journal of Biological Macromolecules.2023; 232: 123283.     CrossRef
    • Efficacy of alginate and chickpea protein polymeric matrices in encapsulating curcumin for improved stability, sustained release and bioaccessibility
      I. Farrah Shakoor, Geethi K. Pamunuwa, D. Nedra Karunaratne
      Food Hydrocolloids for Health.2023; 3: 100119.     CrossRef
    • Langmuir and Langmuir–Blodgett technologies as nanoarchitectonic tools for the incorporation of curcumin in membrane systems
      Laura Dotor, José Miguel García-Pinilla, Santiago Martín, Pilar Cea
      Nanoscale.2023; 15(6): 2891.     CrossRef
    • Brain Targeted Curcumin Loaded Turmeric Oil Microemulsion Protects Against Trimethyltin Induced Neurodegeneration in Adult Zebrafish: A Pharmacokinetic and Pharmacodynamic Insight
      Suraj More, Atmaram Pawar
      Pharmaceutical Research.2023; 40(3): 675.     CrossRef
    • Partial depolymerization of tamarind seed xyloglucan and its functionality toward enhancing the solubility of curcumin
      Weeranuch Lang, Takayoshi Tagami, Hye-Jin Kang, Masayuki Okuyama, Nobuo Sakairi, Atsuo Kimura
      Carbohydrate Polymers.2023; 307: 120629.     CrossRef
    • Nutraceuticals as Supportive Therapeutic Agents in Diabetes and Pancreatic Ductal Adenocarcinoma: A Systematic Review
      Iveta Mikolaskova, Tatjana Crnogorac-Jurcevic, Bozena Smolkova, Luba Hunakova
      Biology.2023; 12(2): 158.     CrossRef
    • Curcumin-Functionalized Graphene Oxide Strongly Prevents Candida parapsilosis Adhesion and Biofilm Formation
      Margherita Cacaci, Damiano Squitieri, Valentina Palmieri, Riccardo Torelli, Giordano Perini, Michela Campolo, Maura Di Vito, Massimiliano Papi, Brunella Posteraro, Maurizio Sanguinetti, Francesca Bugli
      Pharmaceuticals.2023; 16(2): 275.     CrossRef
    • Polysaccharides-based nanocarriers enhance the anti-inflammatory effect of curcumin
      Wei Luo, Liangyu Bai, Jing Zhang, Zhangwang Li, Yinuo Liu, Xiaoyi Tang, Panpan Xia, Minxuan Xu, Ao Shi, Xiao Liu, Deju Zhang, Peng Yu
      Carbohydrate Polymers.2023; 311: 120718.     CrossRef
    • The Differential Antagonistic Ability of Curcumin against Cytotoxicity and Genotoxicity Induced by Distinct Heavy Metals
      Qiao Liu, Mengzi Sun, Tong Wang, Yemian Zhou, Meng Sun, Han Li, Yun Liu, An Xu
      Toxics.2023; 11(3): 233.     CrossRef
    • The Chelating Ability of Plant Polyphenols Can Affect Iron Homeostasis and Gut Microbiota
      Aurelia Scarano, Barbara Laddomada, Federica Blando, Stefania De Santis, Giulio Verna, Marcello Chieppa, Angelo Santino
      Antioxidants.2023; 12(3): 630.     CrossRef
    • The effect of curcumin supplementation on weight loss and anthropometric indices: an umbrella review and updated meta-analyses of randomized controlled trials
      Chanita Unhapipatpong, Nint Polruang, Prapimporn Chattranukulchai Shantavasinkul, Narachai Julanon, Pawin Numthavaj, Ammarin Thakkinstian
      The American Journal of Clinical Nutrition.2023; 117(5): 1005.     CrossRef
    • Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?
      Mangala Hegde, Sosmitha Girisa, Bandari BharathwajChetty, Ravichandran Vishwa, Ajaikumar B. Kunnumakkara
      ACS Omega.2023; 8(12): 10713.     CrossRef
    • LIPID AND SURFACTANT-BASED PHYTOFORMULATION FOR AMELIORATION OF INFLAMMATION
      ROOPAM RAUT, JESSY SHAJI
      International Journal of Applied Pharmaceutics.2023; : 201.     CrossRef
    • Hesperetin-loaded polymeric nanofibers: assessment of bioavailability and neuroprotective effect
      Yogesh Chand Yadav, Satyanarayan Pattnaik
      Drug Development and Industrial Pharmacy.2023; 49(2): 240.     CrossRef
    • Curcumin Confers Anti-Inflammatory Effects in Adults Who Recovered from COVID-19 and Were Subsequently Vaccinated: A Randomized Controlled Trial
      Samantha N. Fessler, Yung Chang, Li Liu, Carol S. Johnston
      Nutrients.2023; 15(7): 1548.     CrossRef
    • Basic research on curcumin in cervical cancer: Progress and perspectives
      Xiaoyu Zhang, Lin Zhu, Xuezhen Wang, Hairong Zhang, Lianzhong Wang, Lei Xia
      Biomedicine & Pharmacotherapy.2023; 162: 114590.     CrossRef
    • Improved Bioavailablity of Curcumin by Derivatisation with Isoleucine in Plasma and Reproductive Tissues of Female Rats is Mainly Due to Altered Affinity for P-gp Transporter
      Sheshadri Divyashree, Prakash Janhavi, Nanjundaswamy Vijendra Kumar, Bheemanakere Kempaiah Bettadaiah, Serva Peddha Muthukumar
      Current Bioactive Compounds.2023;[Epub]     CrossRef
    • Impact of active sites on encapsulation of curcumin in Metal Organic Frameworks
      Vihanga K Munasinghe, Dilhan Manawadu, Rohini M de Silva, K M Nalin de Silva
      Materials Research Express.2023; 10(3): 035102.     CrossRef
    • Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose
      Mejo C Korah, V.S. Harikrishnan, S. Deepa, Anil Arya, A. Sabareeswaran, P.V. Mohanan, Lissy K Krishnan
      Canadian Journal of Physiology and Pharmacology.2023; 101(6): 304.     CrossRef
    • Curcumin Alleviates Thioacetamide-Induced Kidney Toxicity in Rats: Enhancing Antioxidant System, and Attenuating Oxidative Stress, DNA Damage, and Inflammation
      Aliaa M. Radwan, Mustafa Karhib, Shahenda A. Fatoh, Ehab Tousson
      Biomedical and Pharmacology Journal.2023; 16(1): 441.     CrossRef
    • Overview of Curcumin and Piperine Effects on Glucose Metabolism: The Case of an Insulinoma Patient’s Loss of Consciousness
      Simona Servida, Elena Panzeri, Laura Tomaino, Giovanni Marfia, Emanuele Garzia, Giuseppe Ciniglio Appiani, Gianluca Moroncini, Vito De Gennaro Colonna, Carlo La Vecchia, Luisella Vigna
      International Journal of Molecular Sciences.2023; 24(7): 6621.     CrossRef
    • Enriching and Smart Releasing Curcumin via Phenylboronic Acid‐Anchored Bioinspired Hydrogel for Diabetic Wound Healing
      Bangjiao Zhao, Shuangli Zhu, YuWei Liu, Jiayi Zhu, Huitong Luo, Maocai Li, Hao Wang, Qi Feng, Xiaodong Cao
      Advanced NanoBiomed Research.2023;[Epub]     CrossRef
    • Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action
      Siti Nur Hidayah Jamil, Amatul Hamizah Ali, Shevin Rizal Feroz, Su Datt Lam, Hani Kartini Agustar, Mohd Ridzuan Mohd Abd Razak, Jalifah Latip
      Pharmaceuticals.2023; 16(4): 609.     CrossRef
    • Anti-Neuroinflammatory and Neuroprotective Effect of Intermedin B Isolated from the Curcuma longa L. via NF-κB and ROS Inhibition in BV2 Microglia and HT22 Hippocampal Cells
      Hwan Lee, Zhiming Liu, Linsha Dong, Dae Young Lee, Dahye Yoon, Hyuncheol Oh, Youn-Chul Kim, Ren-Bo An, Dong-Sung Lee
      International Journal of Molecular Sciences.2023; 24(8): 7390.     CrossRef
    • Optical signatures of cisplatin assembled with curcuminoids: Theoretical simulations to develop novel anticancer prodrugs
      José P. Cerón-Carrasco, Natalia Sánchez, Denis Jacquemin
      Dyes and Pigments.2023; 216: 111312.     CrossRef
    • Role of the Dietary Phytochemical Curcumin in Targeting Cancer Cell Signalling Pathways
      Abhay Prakash Mishra, Swetanshu, Pratichi Singh, Shikha Yadav, Manisha Nigam, Veronique Seidel, Celia Fortuna Rodrigues
      Plants.2023; 12(9): 1782.     CrossRef
    • Influence of Nanocurcumin and Photodynamic Therapy Using Nanocurcumin in Treatment of Rat Tongue Oral Squamous Cell Carcinoma Through Histological Examination and Gene Expression of BCL2 and Caspase-3
      Latifa Mohamed Abdelgawad, Ahmed Abdullatif Abdelaziz, Mahmoud Bawdy El-Begawey, Ali Mohamed Saafan
      Reports of Biochemistry and Molecular Biology.2023; 11(4): 730.     CrossRef
    • Applications of Turmeric Starch and Curcumin
      Kevser Kübra KIRBOĞA, Burcu TEKİN, Münevver DEMİR
      Bayburt Üniversitesi Fen Bilimleri Dergisi.2023; 6(1): 99.     CrossRef
    • Combining nano-curcumin with catechin improves COVID-19-infected patient's inflammatory conditions
      Talar Ahmad Merza Mohammad
      Human Immunology.2023; 84(9): 471.     CrossRef
    • pH-controlled release feature of chitosan assembled silica nanoparticles containing nano-formulated curcumin over in vitro gastric and physiological condition
      Ozi Adi Saputra, Wahyu Nur Safitriono, Dyah Ellyawati Kusumaningtyas Maharani, Amalia Febiana, Fajar Rakhman Wibowo
      Food Bioscience.2023; 53: 102793.     CrossRef
    • Effects of extraction time on total phenolic and flavonoid contents and antioxidant activities of a polyherbal drink
      A Hamad, D Hartanti
      IOP Conference Series: Earth and Environmental Science.2023; 1200(1): 012047.     CrossRef
    • The Reply
      Dina Halegoua-DeMarzio, Victor Navarro, Ikhlas Khan
      The American Journal of Medicine.2023; 136(8): e168.     CrossRef
    • Physicochemical and Functional Properties and Storage Stability of Chitosan–Starch Films Containing Micellar Nano/Microstructures with Turmeric and Hibiscus Extracts
      Liliana Woszczak, Karen Khachatryan, Magdalena Krystyjan, Teresa Witczak, Mariusz Witczak, Dorota Gałkowska, Małgorzata Makarewicz, Gohar Khachatryan
      International Journal of Molecular Sciences.2023; 24(15): 12218.     CrossRef
    • Advanced effect of curcumin and resveratrol on mitigating hepatic steatosis in metabolic associated fatty liver disease via the PI3K/AKT/mTOR and HIF-1/VEGF cascade
      Yuhui He, Huan Wang, Shiling Lin, Tao Chen, Dennis Chang, Yibin Sun, Chenxiang Wang, Yang Liu, Yusheng Lu, Jianyuan Song, Shaohua Li, Wen Xu, Yanxiang Lin, Yanfang Zheng, Xian Zhou, Qiumei Huang, Mingqing Huang
      Biomedicine & Pharmacotherapy.2023; 165: 115279.     CrossRef
    • Sustained Release of Neuroprotective Drugs Curcumin and Edaravone from Supramolecular Hydrogel for Ischemic Stroke Treatment
      Yanpeng Jia, Yi Zhang, Wenjun Zhan, Yu Wang, Xianbao Sun, Yuan Zhang, Xiaoyang Liu, Bing Han, Ying Bai, Ling Shen, Gaolin Liang, Honghong Yao
      Advanced Functional Materials.2023;[Epub]     CrossRef
    • An eco-friendly one-pot extraction process for curcumin and its bioenhancer, piperine, from edible plants in exosome-like nanovesicles
      Meghana N. Kumar, Sreeram Peringattu Kalarikkal, Cathrine M. S. Bethi, Sukriti Narendra Singh, Janakiraman Narayanan, Gopinath M. Sundaram
      Green Chemistry.2023; 25(16): 6472.     CrossRef
    • The Homoleptic Curcumin–Copper Single Crystal (ML2): A Long Awaited Breakthrough in the Field of Curcumin Metal Complexes
      Antonino Arenaza-Corona, Marco A. Obregón-Mendoza, William Meza-Morales, María Teresa Ramírez-Apan, Antonio Nieto-Camacho, Rubén A. Toscano, Leidys L. Pérez-González, Rubén Sánchez-Obregón, Raúl G. Enríquez
      Molecules.2023; 28(16): 6033.     CrossRef
    • Development and Characterization of a Hydrogel Containing Curcumin-Loaded Nanoemulsion for Enhanced In Vitro Antibacteria and In Vivo Wound Healing
      Thi Thanh Ngoc Le, Thi Kieu Nhi Nguyen, Van Minh Nguyen, Thi Cam Minh Dao, Hoai Bao Chau Nguyen, Cong Thuan Dang, Thi Bao Chi Le, Thi Khanh Linh Nguyen, Phuong Thao Tien Nguyen, Le Hoang Nam Dang, Van Minh Doan, Hoang Nhan Ho
      Molecules.2023; 28(17): 6433.     CrossRef
    • Dual Functional Diblock Amino Acid Copolymer Displaying Synergistic Effect with Curcumin against MRSA and Encapsulation of Curcumin†
      Yueming Wu, Yuan Chen, Haowen Yu, Alideertu Dong, Runhui Liu
      Chinese Journal of Chemistry.2023; 41(23): 3333.     CrossRef
    • EFFECT OF CURCUMIN ON LIPID PEROXIDATION IN THE RAT BRAIN UNDER CONDITIONS OF ROUND-THE-CLOCK ILLUMINATION AND HIGH-CALORIE CARBOHYDRATE-LIPID DIET
      Y.D. Frankel, V.O. Zyuzin, V.S. Cherno
      Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії.2023; 23(2.2): 55.     CrossRef
    • Curcumin Mitigates Malathion-Induced Renal Injury: Suppression of Apoptosis and Modulation of NF-κβ/TNF-α and Nrf2, and HO-1 Signaling
      Mamdouh Eldesoqui, Magda E. Ahmed, Mona A. Abdel-Kareem, Mohamed Moharram Badawy, Amal Fahmy Dawood, Abdelaty Shawky Mohamed, Ateya Megahed Ibrahim, Ahmed A. El-Mansi, Mohamad El-Sherbiny, Mahmoud Hendawy
      Metabolites.2023; 13(11): 1117.     CrossRef
    • Enhanced in vivo absorption and biodistribution of curcumin loaded into emulsions with high medium-chain triglyceride content
      Júlia Teixé-Roig, Gemma Oms-Oliu, María Artiga-Artigas, Isabel Odriozola-Serrano, Olga Martín-Belloso
      Food Research International.2023; 174: 113595.     CrossRef
    • The effects of a highly bioavailable curcumin PhytosomeTM preparation on the retinal architecture and glial reactivity in the GFAP-IL6 mice
      Víctor Pérez-Fernández, Akshaya Lakshmi Thananjeyan, Faheem Ullah, Gerald Münch, Morven Cameron, Erika Gyengesi
      Frontiers in Ophthalmology.2023;[Epub]     CrossRef
    • In Vivo Efficacy of Curcumin and Curcumin Nanoparticle in Trypanosoma congolense, Broden 1904 (Kinetoplastea: Trypanosomatidae)-Infected Mice
      Nthatisi Innocentia Molefe-Nyembe, Oluyomi Stephen Adeyemi, Daisuke Kondoh, Kentaro Kato, Noboru Inoue, Keisuke Suganuma
      Pathogens.2023; 12(10): 1227.     CrossRef
    • Nanoformulations of curcumin: An alliance for effective cancer therapeutics
      Mangala Hegde, Aviral Kumar, Sosmitha Girisa, Babu Santha Aswani, Ravichandran Vishwa, Gautam Sethi, Ajaikumar B. Kunnumakkara
      Food Bioscience.2023; 56: 103095.     CrossRef
    • Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
      Vicenç Ruiz de Porras, Mariona Figols, Albert Font, Eva Pardina
      Life Sciences.2023; 332: 122119.     CrossRef
    • Chitosan-Based Self-Healing Hydrogel: From Fabrication to Biomedical Application
      Siyu Pan, Chongyu Zhu, Yuwei Wu, Lei Tao
      Polymers.2023; 15(18): 3768.     CrossRef
    • Curcumin Transferosome-Loaded Thermosensitive Intranasal in situ Gel as Prospective Antiviral Therapy for SARS-Cov-2
      Nermin E Eleraky, Mahmoud El-Badry, Mahmoud Omar, Wesam El-Koussi, Noha Mohamed, Mohamed Abdel-Lateef, Abeer Hassan
      International Journal of Nanomedicine.2023; Volume 18: 5831.     CrossRef
    • Effect of Lactobacillus rhamnosus and Diclofenac with Curcumin for Neuronal Restoration and Repair Against Scopolamine Induced Dementia in Zebrafish (Danio rerio)
      Sonal Pande, Chirag Patel
      Current Enzyme Inhibition.2023; 19(2): 147.     CrossRef
    • Influence of 8 Weeks of Tabata High-Intensity Interval Training and Nanocurcumin Supplementation on Inflammation and Cardiorespiratory Health among Overweight Elderly Women
      Sepideh Noorbakhsh, Valiollah Dabidi Roshan
      Preventive Nutrition and Food Science.2023; 28(3): 224.     CrossRef
    • Advances in the pharmaceutical research of curcumin for oral administration
      Cheng Li, Abid Naeem, Jiangwen Shen, Weiwei Zha, Qingyun Zeng, Peng Zhang, Lin Li, Zhenggen Liao, Xulong Chen
      Open Chemistry.2023;[Epub]     CrossRef
    • Amorphous systems for delivery of nutraceuticals: challenges opportunities
      Devendrasingh Tomar, Pankaj K. Singh, Sajidul Hoque, Sheela Modani, Anitha Sriram, Rahul Kumar, Jitender Madan, Dharmendra Khatri, Kamal Dua
      Critical Reviews in Food Science and Nutrition.2022; 62(5): 1204.     CrossRef
    • Phase solubility and thermoanalytical studies of the inclusion complex formation between curcumin and hydroxypropyl-β-cyclodextrin in hydroalcoholic solutions
      Dzhovidon Kabirov, Teresa Silvestri, Marcella Niccoli, Tatiana Usacheva, Laura Mayol, Marco Biondi, Concetta Giancola
      Journal of Thermal Analysis and Calorimetry.2022; 147(1): 347.     CrossRef
    • The effects of oral administration of curcumin–galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study
      Aman Khanna, Syam Das S, R. Kannan, Andrew G. Swick, Cristina Matthewman, Balu Maliakel, Sibi P. Ittiyavirah, I. M. Krishnakumar
      Nutritional Neuroscience.2022; 25(6): 1240.     CrossRef
    • Ten Days of Curcumin Supplementation Attenuates Subjective Soreness and Maintains Muscular Power Following Plyometric Exercise
      Angela R. Hillman, Alexa Gerchman, Erin O’Hora
      Journal of Dietary Supplements.2022; 19(3): 303.     CrossRef
    • Curcumin, a potent therapeutic nutraceutical and its enhanced delivery and bioaccessibility by pickering emulsions
      Shima Saffarionpour, Levente L. Diosady
      Drug Delivery and Translational Research.2022; 12(1): 124.     CrossRef
    • Identification of curcumin as a potential α‐glucosidase and dipeptidyl‐peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation
      Wanxiu Cao, Xin Chen, Yaoxian Chin, Jinkai Zheng, Phaik Eem Lim, Changhu Xue, Qingjuan Tang
      Journal of Food Biochemistry.2022;[Epub]     CrossRef
    • Brain regional pharmacokinetics following the oral administration of curcumagalactomannosides and its relation to cognitive function
      Ramalingam G. Kannan, Maliakal B. Abhilash, Kumar Dinesh, Das S. Syam, Maliakel Balu, Ittiyavirah Sibi, I. M. Krishnakumar
      Nutritional Neuroscience.2022; 25(9): 1928.     CrossRef
    • Structured edible lipid-based particle systems for oral drug-delivery
      Areen Ashkar, Alejandro Sosnik, Maya Davidovich-Pinhas
      Biotechnology Advances.2022; 54: 107789.     CrossRef
    • Shoot meristem culture eliminates bacterial and fungal infections from elite varieties of turmeric (Curcuma longa L.)
      Cattarin Theerawitaya, Myo Myat Myat Kyaw, Thapanee Samphumphuang, Umpawa Pinruan, Natthawut Wiriyathanawudhiwong, Suriyan Cha-um
      In Vitro Cellular & Developmental Biology - Plant.2022; 58(1): 146.     CrossRef
    • Hydrophilic silicon nanoparticles as a turn-off and colorimetric fluorescent probe for curcuminoids detection in food samples and cell imaging
      Qin-Ying Li, Ya-Qian Wang, Ming Jiang, Yuanyuan Cui, Xu Yu, Li Xu
      Food Chemistry.2022; 366: 130629.     CrossRef
    • In-depth multidisciplinary review of the usage, manufacturing, regulations & market of dietary supplements
      Matthew Lam, Parsa Khoshkhat, Mehdi Chamani, Shadab Shahsavari, Farid A. Dorkoosh, Anthony Rajabi, Mohammed Maniruzzaman, Ali Nokhodchi
      Journal of Drug Delivery Science and Technology.2022; 67: 102985.     CrossRef
    • Recent advances in nanocarriers for nutrient delivery
      Srividya Gorantla, Geetika Wadhwa, Shailja Jain, Shridula Sankar, Kshitij Nuwal, Arisha Mahmood, Sunil Kumar Dubey, Rajeev Taliyan, Prashant Kesharwani, Gautam Singhvi
      Drug Delivery and Translational Research.2022; 12(10): 2359.     CrossRef
    • Delivery of curcumin through colloidal systems and its applications in functional foods
      Shima Saffarionpour, Levente L Diosady
      Current Opinion in Food Science.2022; 43: 155.     CrossRef
    • The inhibition of interaction with serum albumin enhances the physiological activity of curcumin by increasing its cellular uptake
      Mayuko Itaya, Taiki Miyazawa, Saoussane Khalifa, Naoki Shimizu, Kiyotaka Nakagawa
      Food & Function.2022; 13(2): 639.     CrossRef
    • A Comorbid Rat Model of Neuroendocrine-Immune System Alterations Under the Impact of Risk Factors for Stroke
      Bailiu Ya, Xuezhi Li, Jingyi Wang, Mingsheng Zhao, Ting Yu, Haiying Wang, Qing Xin, Qinqin Wang, Xin Mu, Xuanyu Dong, Yang Gao, Huabao Xiong, Hui Zhang
      Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
    • Curcumin: Biological Activities and Modern Pharmaceutical Forms
      Maja Urošević, Ljubiša Nikolić, Ivana Gajić, Vesna Nikolić, Ana Dinić, Vojkan Miljković
      Antibiotics.2022; 11(2): 135.     CrossRef
    • Rice bran wax structured oleogels and in vitro bioaccessibility of curcumin
      Terrence Dent, Robert Hallinan, Chureeporn Chitchumroonchokchai, Farnaz Maleky
      Journal of the American Oil Chemists' Society.2022; 99(4): 299.     CrossRef
    • An Update on the Exploratory Use of Curcumin in Neuropsychiatric Disorders
      Nicolás Lamanna-Rama, Diego Romero-Miguel, Manuel Desco, Maria Luisa Soto-Montenegro
      Antioxidants.2022; 11(2): 353.     CrossRef
    • Hyaluronic Acid–Zein Core-Shell Nanoparticles Improve the Anticancer Effect of Curcumin Alone or in Combination with Oxaliplatin against Colorectal Cancer via CD44-Mediated Cellular Uptake
      Lu Liu, Shufang Yang, Feng Chen, Ka-Wing Cheng
      Molecules.2022; 27(5): 1498.     CrossRef
    • Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in C. elegans
      Arvie Camille V. de Guzman, Md. Abdur Razzak, Joong Hee Cho, Ji Yi Kim, Shin Sik Choi
      Nanomaterials.2022; 12(5): 758.     CrossRef
    • Curcumin-Loaded mPEG-PLGA Nanoparticles Attenuates the Apoptosis and Corticosteroid Resistance Induced by Cigarette Smoke Extract
      Xi Chen, Di Wang, Xuejun Guo, Xiaoming Li, Wenjing Ye, Yang Qi, Wen Gu
      Frontiers in Pharmacology.2022;[Epub]     CrossRef
    • The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment
      Tarek Zieneldien, Janice Kim, Chuanhai Cao
      Geriatrics.2022; 7(2): 24.     CrossRef
    • Novel 3D porous aerogels engineered at nano scale from cellulose nano fibers and curcumin: An effective treatment for chronic wounds
      Jiya Jose, Avinash R. Pai, Deepu A. Gopakumar, Yogesh Dalvi, V. Ruby, Sarita G. Bhat, Daniel Pasquini, Nandakumar Kalarikkal, Sabu Thomas
      Carbohydrate Polymers.2022; 287: 119338.     CrossRef
    • Self-assembled nano-micelles of lactoferrin peptides: Structure, physicochemical properties, and application for encapsulating and delivering curcumin
      Yiyang Wang, Wen Jiang, Yuchu Jiang, David Julian McClements, Fuguo Liu, Xuebo Liu
      Food Chemistry.2022; 387: 132790.     CrossRef
    • Encapsulation of Alpha-Lipoic Acid in Functional Hybrid Liposomes: Promising Tool for the Reduction of Cisplatin-Induced Ototoxicity
      Manuela Curcio, Giuseppe Cirillo, Rosario Amato, Lorenzo Guidotti, Diana Amantea, Michele De Luca, Fiore Pasquale Nicoletta, Francesca Iemma, Mercedes Garcia-Gil
      Pharmaceuticals.2022; 15(4): 394.     CrossRef
    • Modulation of Notch Signaling Pathway by Bioactive Dietary Agents
      Violet A. Kiesel, Silvia D. Stan
      International Journal of Molecular Sciences.2022; 23(7): 3532.     CrossRef
    • Polyphenolic HRMS Characterization, Contents and Antioxidant Activity of Curcuma longa Rhizomes from Costa Rica
      María Isabel Quirós-Fallas, Felipe Vargas-Huertas, Silvia Quesada-Mora, Gabriela Azofeifa-Cordero, Krissia Wilhelm-Romero, Felipe Vásquez-Castro, Diego Alvarado-Corella, Andrés Sánchez-Kopper, Mirtha Navarro-Hoyos
      Antioxidants.2022; 11(4): 620.     CrossRef
    • Dietary curcumin nanoparticles promoted the performance, antioxidant activity, and humoral immunity, and modulated the hepatic and intestinal histology of Nile tilapia fingerlings
      Mohsen Abdel-Tawwab, El-Sayed Hemdan Eissa, Wesam A. Tawfik, Heba E. Abd Elnabi, Saadea Saadony, Walaa K. Bazina, Ragaa A. Ahmed
      Fish Physiology and Biochemistry.2022; 48(3): 585.     CrossRef
    • The Impact of Curcumin on Growth Performance, Growth-Related Gene Expression, Oxidative Stress, and Immunological Biomarkers in Broiler Chickens at Different Stocking Densities
      Mona H. Hafez, Sara E. El-Kazaz, Badr Alharthi, Heba I. Ghamry, Mohammed A. Alshehri, Samy Sayed, Mustafa Shukry, Yasser S. El-Sayed
      Animals.2022; 12(8): 958.     CrossRef
    • Pharmacokinetic profiles, cytotoxicity, and redox metabolism of free and nanoencapsulated curcumin
      Priscila Marquezan Copetti, Bianca Fagan Bissacotti, Samanta da Silva Gündel, Nathieli Bianchin Bottari, Michele Rorato Sagrillo, Alencar Kolinski Machado, Aline Ferreira Ourique, Maria Rosa Chitolina Schetinger, Aleksandro Schafer da Silva
      Journal of Drug Delivery Science and Technology.2022; 72: 103352.     CrossRef
    • The Cooperative Anti-Neoplastic Activity of Polyphenolic Phytochemicals on Human T-Cell Acute Lymphoblastic Leukemia Cell Line MOLT-4 In Vitro
      Patrycja Koszałka, Grzegorz Stasiłojć, Natalia Miękus-Purwin, Maciej Niedźwiecki, Maciej Purwin, Szymon Grabowski, Tomasz Bączek
      International Journal of Molecular Sciences.2022; 23(9): 4753.     CrossRef
    • Foliar Spraying of Salicylic Acid Enhances Growth, Yield, and Curcuminoid Biosynthesis Gene Expression as Well as Curcuminoid Accumulation in Curcuma longa
      Fadia El Sherif, Mayyadah Abdullah Alkuwayti, Salah Khattab
      Horticulturae.2022; 8(5): 417.     CrossRef
    • Antibiotics-Free Compounds for Chronic Wound Healing
      David O. Oluwole, Lucy Coleman, William Buchanan, Tao Chen, Roberto M. La Ragione, Lian X. Liu
      Pharmaceutics.2022; 14(5): 1021.     CrossRef
    • Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways
      Zi-Wei Zhou, Hui-Zhi Long, Shuo-Guo Xu, Feng-Jiao Li, Yan Cheng, Hong-Yu Luo, Li-Chen Gao
      Frontiers in Pharmacology.2022;[Epub]     CrossRef
    • Curcumin alleviated lipopolysaccharide-evoked H9c2 cells damage via suppression of intercellular adhesion molecule 1/CD40/NF-κB signaling
      Yi Liu, Xiaoli Li, Yan Zhao
      Human & Experimental Toxicology.2022;[Epub]     CrossRef
    • Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing
      Yue Shan, Bowen Tan, Min Zhang, Xi Xie, Jinfeng Liao
      Journal of Nanobiotechnology.2022;[Epub]     CrossRef
    • Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status
      Arash Karimi, Fatemeh Naeini, Hamid Reza Niazkar, Helda Tutunchi, Vali Musazadeh, Ata Mahmoodpoor, Vahid Asghariazar, Majid Mobasseri, Ali Tarighat-Esfanjani
      Food & Function.2022; 13(12): 6596.     CrossRef
    • Insights into Aptamer–Drug Delivery Systems against Prostate Cancer
      Xueni Wang, Qian Zhou, Xiaoning Li, Xia Gan, Peng Liu, Xiaotao Feng, Gang Fang, Yonghong Liu
      Molecules.2022; 27(11): 3446.     CrossRef
    • Curcuminoids for Metabolic Syndrome: Meta-Analysis Evidences Toward Personalized Prevention and Treatment Management
      Agustina Dwi Retno Nurcahyanti, Fonny Cokro, Martha P. Wulanjati, Mona F. Mahmoud, Michael Wink, Mansour Sobeh
      Frontiers in Nutrition.2022;[Epub]     CrossRef
    • Long-term Survival, Tolerability, and Safety of First-Line Bevacizumab and FOLFIRI in Combination With Ginsenoside-Modified Nanostructured Lipid Carrier Containing Curcumin in Patients With Unresectable Metastatic Colorectal Cancer
      Youngbae Jeon, Sun Jin Sym, Bong Kyu Yoo, Jeong-Heum Baek
      Integrative Cancer Therapies.2022;[Epub]     CrossRef
    • Supramolecular Hydrogels Consisting of Nanofibers Increase the Bioavailability of Curcuminoids in Inflammatory Skin Diseases
      David Limón, Pablo Gil-Lianes, Laura Rodríguez-Cid, Helen L. Alvarado, Natalia Díaz-Garrido, Mireia Mallandrich, Laura Baldomà, Ana C. Calpena, Concepción Domingo, Núria Aliaga-Alcalde, Arántzazu González-Campo, Lluïsa Pérez-García
      ACS Applied Nano Materials.2022; 5(10): 13829.     CrossRef
    • Zinc-curcumin based complexes in health and diseases: An approach in chemopreventive and therapeutic improvement
      Sahdeo Prasad, Rajiv Lall
      Journal of Trace Elements in Medicine and Biology.2022; 73: 127023.     CrossRef
    • Investigating Polyphenol Nanoformulations for Therapeutic Targets against Diabetes Mellitus
      Fahadul Islam, Jannatul Fardous Khadija, Md. Rezaul Islam, Sheikh Shohag, Saikat Mitra, Saad Alghamdi, Ahmad O. Babalghith, Abdulrahman Theyab, Mohammad Tauhidur Rahman, Aklima Akter, Abdullah Al Mamun, Fahad A. Alhumaydhi, Talha Bin Emran, Xuanqin Chen
      Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
    • Formulation of the novel structure curcumin derivative–loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening in vitro
      Ke Li, Chao Pi, Jie Wen, Yingmeng He, Jiyuan Yuan, Hongping Shen, Wenmei Zhao, Mingtang Zeng, Xinjie Song, Robert J. Lee, Yumeng Wei, Ling Zhao
      Drug Delivery.2022; 29(1): 2044.     CrossRef
    • Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells
      Tahereh Jalali Varnamkhasti, Meisam Jafarzadeh, Majid Sadeghizadeh, Mahdi Aghili
      Pharmacological Reports.2022; 74(4): 718.     CrossRef
    • Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review
      K. Nanavati, K. Rutherfurd-Markwick, S. J. Lee, N. C. Bishop, A. Ali
      European Journal of Nutrition.2022; 61(8): 3835.     CrossRef
    • A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health
      Siyu Liu, Jie Liu, Lan He, Liu Liu, Bo Cheng, Fangliang Zhou, Deliang Cao, Yingchun He
      Molecules.2022; 27(14): 4400.     CrossRef
    • Antiviral activity of medicinal plant-derived products against SARS-CoV-2
      Jonatas Rafael de Oliveira, Beatriz Sales Antunes, Gabriela Oliveira do Nascimento, Jaqueline Cadorini de Souza Kawall, João Victor Bianco Oliveira, Kevin Gustavo dos Santos Silva, Mariana Aparecida de Toledo Costa, Carlos Rocha Oliveira
      Experimental Biology and Medicine.2022; 247(20): 1797.     CrossRef
    • An examination of the protective effects and molecular mechanisms of curcumin, a polyphenol curcuminoid in diabetic nephropathy
      Xiaoyu Zhu, Xingli Xu, Chigang Du, Yanping Su, Lixue Yin, Xiaoqiu Tan, Hui Liu, Yiru Wang, Lei Xu, Xinghua Xu
      Biomedicine & Pharmacotherapy.2022; 153: 113438.     CrossRef
    • Tackling Atherosclerosis via Selected Nutrition
      Anna Vesnina, Alexander Prosekov, Victor Atuchin, Varvara Minina, Anastasia Ponasenko
      International Journal of Molecular Sciences.2022; 23(15): 8233.     CrossRef
    • Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials: A Meta-Research Study
      Bruna Mimica, Viljemka Bučević Popović, Ines Banjari, Antonia Jeličić Kadić, Livia Puljak
      Pharmaceuticals.2022; 15(8): 939.     CrossRef
    • Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy
      Chenxiang Wang, Yibin Sun, Wenjing Liu, Yang Liu, Sualiha Afzal, Jahnavi Grover, Dennis Chang, Gerald Münch, Chun Guang Li, Shiling Lin, Jianyu Chen, Yiping Zhang, Zaixing Cheng, Yanxiang Lin, Yanfang Zheng, Mingqing Huang, Xian Zhou
      Frontiers in Endocrinology.2022;[Epub]     CrossRef
    • The aphrodisiac potential of β-cyclodextrin–curcumin via stimulating cAMP-PKA pathway in testicular Leydig cells
      Liu Yang, Shan Xue, Lin Yuan, Zihan Li, Haitao Hu, Yichang Zhang, Yimei Liu, Juan Li
      Scientific Reports.2022;[Epub]     CrossRef
    • Ethnomedicinal, Phytochemistry and Antiviral Potential of Turmeric (Curcuma longa)
      Bajarang Bal Lal Srivastava, Asha Shabani Ripanda, Hossein Miraji Mwanga
      Compounds.2022; 2(3): 200.     CrossRef
    • Curcumin against gastrointestinal cancer: A review of the pharmacological mechanisms underlying its antitumor activity
      Yuanyuan Fan, Xiqin Zhang, Yuxin Tong, Suning Chen, Jingjing Liang
      Frontiers in Pharmacology.2022;[Epub]     CrossRef
    • Therapeutic potency of curcumin for allergic diseases: A focus on immunomodulatory actions
      Saeed Mohammadian Haftcheshmeh, Seyed Reza Mirhafez, Maliheh Abedi, Hanieh Heydarlou, Abolfazl Shakeri, Asadollah Mohammadi, Amirhossein Sahebkar
      Biomedicine & Pharmacotherapy.2022; 154: 113646.     CrossRef
    • An Ode to Curcumin: One Hundred Mechanisms of Curcumin’s Effectiveness Against Human Pathological Conditions
      S. V. Orlova, E. A. Nikitina, E. V. Prokopenko, N. V. Balashova, A. N. Vodolazkaya
      Medical alphabet.2022; (16): 127.     CrossRef
    • Bioavailability enhancement of curcumin via esterification processes: A review
      Nidhi Agrawal, Meenakshi Jaiswal
      European Journal of Medicinal Chemistry Reports.2022; 6: 100081.     CrossRef
    • A Composition of Phytonutrients for Glycemic and Weight Management
      Yasuyo Urasaki, Thuc T. Le
      Nutrients.2022; 14(18): 3784.     CrossRef
    • The Regulatory Effects of Traditional Chinese Medicine on Ferroptosis
      Qian Gao, Xue-dong Yin, Fan Zhang, Yi-Zhun Zhu, Zhi-ling Li, Lianxiang Luo
      Oxidative Medicine and Cellular Longevity.2022; 2022: 1.     CrossRef
    • Enhancement of curcumin level and hepatoprotective effect in rats through antioxidant activity following modification into nanosized particles
      Ni Made Dwi Sandhiutami, Rika Sari Dewi, Sondang Khairani, Raka Nitya Agasti Putri
      Veterinary World.2022; : 2323.     CrossRef
    • Pegylated Curcumin Derivative: Water-Soluble Conjugates with Antitumor and Antibacterial Activity
      Guldjan Yakub, Nevena E. Manolova, Iliya B. Rashkov, Nadya Markova, Reneta Toshkova, Ani Georgieva, Rosica Mincheva, Antoniya Toncheva, Jean-Marie Raquez, Philippe Dubois
      ACS Omega.2022; 7(41): 36403.     CrossRef
    • Chemical Features and Therapeutic Applications of Curcumin (A Review)
      Aditi Arora, Sumit Kumar, Sandeep Kumar, Rajesh Kumar, Ashok K. Prasad
      Russian Journal of General Chemistry.2022; 92(9): 1785.     CrossRef
    • Curcumin: A Review of its’ Efficacy in the Management of Psoriasis
      K.M. Reena, Lalit Singh, Shipra Sharma
      Drug Delivery Letters.2022; 12(3): 163.     CrossRef
    • Is it possible for Curcumin to conjugate with a carbon nanotube in photodynamic therapy?
      Siu Kan Law, Albert Wing Nang Leung, Chuanshan Xu, Dawn Ching Tung Au
      Photodiagnosis and Photodynamic Therapy.2022; 40: 103189.     CrossRef
    • Investigation of Curcumin-Loaded OA400 Nanoparticle’s Effect on the Expression of E6 and E7 Human Papilloma-Virus Oncogenes and P53 and Rb Factors in HeLa Cell Line
      Rezvaneh Vahedian Sadeghi, Masoud Parsania, Majid Sadeghizadeh, Setareh Haghighat
      Iranian Journal of Pharmaceutical Research.2022;[Epub]     CrossRef
    • The Impact of Curcumin on Immune Response: An Immunomodulatory Strategy to Treat Sepsis
      Alessandro Allegra, Giuseppe Mirabile, Roberta Ettari, Giovanni Pioggia, Sebastiano Gangemi
      International Journal of Molecular Sciences.2022; 23(23): 14710.     CrossRef
    • Hyaluronic acid microneedles loaded with curcumin nanodrugs and new indocyanine green inhibits human tongue squamous carcinoma cells <italic>in vitro</italic>
      Xi XIE, Yue SHAN, Xu ZHANG, Yongzhi WU, Jinfeng LIAO
      Journal of Zhejiang University (Medical Sciences).2022; 51(5): 585.     CrossRef
    • Exploring the protective effect exhibited by curcumin-loaded coconut oil microemulsion in the experimental models of neurodegeneration: an insight of formulation development, in vitro and in vivo study
      Vijay Patil, Shruti Mhamane, Suraj More, Atmaram Pawar, S. Arulmozhi
      Future Journal of Pharmaceutical Sciences.2022;[Epub]     CrossRef
    • Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease
      FERNANDA O. ARAUJO, MATHEUS B. FELÍCIO, CÁSSIO F. LIMA, MAYRA S. PICCOLO, VIRGÍNIA R. PIZZIOLO, GASPAR DIAZ-MUÑOZ, DANIEL S.S. BASTOS, LEANDRO L. OLIVEIRA, MARIA DO C.G. PELUZIO, MARISA A.N. DIAZ
      Anais da Academia Brasileira de Ciências.2022;[Epub]     CrossRef
    • A Review of Cyclodextrin Encapsulation and Intelligent Response for the Release of Curcumin
      Jing Li, Fang Xu, Yujie Dai, Jiawen Zhang, Yuan Shi, Danning Lai, Natthida Sriboonvorakul, Jiamiao Hu
      Polymers.2022; 14(24): 5421.     CrossRef
    • A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look
      Pitchai Balakumar, Taha Alqahtani, Ali Alqahtani, R. Sulochana Lakshmiraj, Gurfateh Singh, Mani Rupeshkumar, A. Thangathirupathi, Karupiah Sundram
      Current Drug Metabolism.2022; 23(11): 897.     CrossRef
    • Optimization and Fabrication of Curcumin Loaded Solid Lipid Nanoparticles Using Box-Behnken Design for Nasal Delivery
      Sherry Sharma, Jai Bharti Sharma, Shailendra Bhatt, Manish Kumar
      Nanoscience & Nanotechnology-Asia.2022;[Epub]     CrossRef
    • A Novel Solvent-Free Co-Grinding Preparation Improves Curcumin Bioavailability in Healthy Volunteers: A Single-Center Crossover Study
      Chenjing Wang, Xin Jiang, Xiaolei Zhang, Yi Xu, Li Li, Xin Li, Shanglong Wang, Ping Shi, Xiaomeng Gao, Zimin Liu, W. Dennis Clark, Yu Cao
      SSRN Electronic Journal .2022;[Epub]     CrossRef
    • Curcumin: The Golden Nutraceutical on the Road to Cancer Prevention and Therapeutics. A Clinical Perspective
      Aviral Kumar, Mangala Hegde, Dey Parama, Ajaikumar B. Kunnumakkara
      Critical Reviews™ in Oncogenesis.2022; 27(3): 33.     CrossRef
    • Immunomodulatory; Anti-inflammatory/antioxidant Effects of Polyphenols: A Comparative Review on the Parental Compounds and Their Metabolites
      Mahsa Sobhani, Mohammad Hosein Farzaei, Sarah Kiani, Reza Khodarahmi
      Food Reviews International.2021; 37(8): 759.     CrossRef
    • Curcumin Administered as Micellar Solution Suppresses Intestinal Inflammation and Colorectal Carcinogenesis
      Nina Seiwert, Jörg Fahrer, Georg Nagel, Jan Frank, Dariush Behnam, Bernd Kaina
      Nutrition and Cancer.2021; 73(4): 686.     CrossRef
    • A review on toxicity of turmeric derived Nano-Formulates against bacterial and fungal cells with special emphasis on electrospun nanofibers
      Arghya Chakravorty, Bhabatush Biswas, Siva Sankar Sana, Rehab A. Rayan, Neeta L. Lala, Seeram Ramakrishna
      Materials Today: Proceedings.2021; 46: 6358.     CrossRef
    • Curcumin: A therapeutic strategy for colorectal cancer?
      Vicenç Ruiz de Porras, Laura Layos, Eva Martínez-Balibrea
      Seminars in Cancer Biology.2021; 73: 321.     CrossRef
    • Curcumin and its different forms: A review on fish nutrition
      Mahmoud Alagawany, Mayada R. Farag, Sameh A. Abdelnour, Mahmoud A.O. Dawood, Shaaban S. Elnesr, Kuldeep Dhama
      Aquaculture.2021; 532: 736030.     CrossRef
    • pH-sensitive molecularly imprinted polymer based on graphene oxide for stimuli actuated controlled release of curcumin
      Roya Sedghi, Somayeh Ashrafzadeh, Bahareh Heidari
      Journal of Alloys and Compounds.2021; 857: 157603.     CrossRef
    • Sustained release of curcumin from fibrin matrix induces cancer cell death and immunomodulation
      S.R. Aravind, S. Lakshmi, Ranjith S, Lissy K. Krishnan
      Biomedicine & Pharmacotherapy.2021; 133: 110967.     CrossRef
    • Armamentarium of anticancer analogues of curcumin: Portray of structural insight, bioavailability, drug-target interaction and therapeutic efficacy
      Sheshank Sethi, Shalki Choudhary, Deepika Sharma, Vaskuri G S Sainaga Jyothi, Ashish Baldi, Neelesh Kumar Mehrac Jitender Madan
      Journal of Molecular Structure.2021; 1231: 129691.     CrossRef
    • Biodegradable polymers in drug delivery and oral vaccination
      Pradip Jana, Mousumi Shyam, Sneha Singh, Venkatesan Jayaprakash, Abhimanyu Dev
      European Polymer Journal.2021; 142: 110155.     CrossRef
    • Nitrogen, sulfur, phosphorus, and chlorine co-doped carbon nanodots as an “off-on” fluorescent probe for sequential detection of curcumin and europium ion and luxuriant applications
      Yumin Hao, Huiping Wang, Zihan Wang, Wenjuan Dong, Qin Hu, Shaomin Shuang, Chuan Dong, Xiaojuan Gong
      Microchimica Acta.2021;[Epub]     CrossRef
    • Enhanced Solubility and Antitumor Activity of Curcumin via Breaking and Rebuilding of the Hydrogen Bond
      Qiu-Hong Zhu, Guo-Hao Zhang, Ling He, Song Qin, Jia-He Tian, Lijian Ma, Guo-Hong Tao
      ACS Applied Bio Materials.2021; 4(1): 918.     CrossRef
    • Effect of nanocurcumin and fish oil as natural anti-inflammatory compounds vs. glucocorticoids in a lipopolysaccharide inflammation model on Holstein calves’ health status
      S. Kamel Oroumieh, L. Vanhaecke, R. Valizadeh, L. Van Meulebroek, A.A. Naserian
      Heliyon.2021; 7(1): e05894.     CrossRef
    • Curcumin ameliorates IL‐1β‐induced apoptosis by activating autophagy and inhibiting the NF‐κB signaling pathway in rat primary articular chondrocytes
      Tianyi Chen, Renpeng Zhou, Yong Chen, Wanjin Fu, Xin Wei, Ganggang Ma, Wei Hu, Chao Lu
      Cell Biology International.2021; 45(5): 976.     CrossRef
    • A Contribution to the Solid State Forms of Bis(demethoxy)curcumin: Co-Crystal Screening and Characterization
      Steffi Wünsche, Lina Yuan, Andreas Seidel-Morgenstern, Heike Lorenz
      Molecules.2021; 26(3): 720.     CrossRef
    • Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol
      Shubha Singhal, Nazer Hasan, Kirti Nirmal, Rohit Chawla, Shalini Chawla, Bhupinder Singh Kalra, Anil Dhal
      Trials.2021;[Epub]     CrossRef
    • Anti-diabesity potential of various multifunctional natural molecules
      Priyanka Rathod, Raman P. Yadav
      Journal of Herbal Medicine.2021; 27: 100430.     CrossRef
    • Antioxidative Stress: Inhibiting Reactive Oxygen Species Production as a Cause of Radioresistance and Chemoresistance
      Yanchi Chen, Yiling Li, Linyang Huang, Yu Du, Feihong Gan, Yanxi Li, Yang Yao, Qiang Tong
      Oxidative Medicine and Cellular Longevity.2021;[Epub]     CrossRef
    • Curcumin-Polyallyhydrocarbon Nanocapsules Potently Suppress 1,2-Dimethylhydrazine-Induced Colorectal Cancer in Mice by Inhibiting Wnt/β-Catenin Pathway
      Alaa Al Moubarak, Manal El Joumaa, Layal Slika, Digambara Patra, Jamilah Borjac
      BioNanoScience.2021; 11(2): 518.     CrossRef
    • Curcumin as Scaffold for Drug Discovery against Neurodegenerative Diseases
      Filippa Lo Cascio, Paola Marzullo, Rakez Kayed, Antonio Palumbo Piccionello
      Biomedicines.2021; 9(2): 173.     CrossRef
    • Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review
      Arghavan Memarzia, Mohammad R. Khazdair, Sepideh Behrouz, Zahra Gholamnezhad, Maryam Jafarnezhad, Saeideh Saadat, Mohammad H. Boskabady
      BioFactors.2021; 47(3): 311.     CrossRef
    • Enhanced absorption of curcuminoids and 3-Acetyl-11-keto-β-boswellic acid from fenugreek galactomannan hydrogel beadlets: A natural approach to the co-delivery of lipophilic phytonutrients
      Maliakkal Balakrishnan Abhilash, Dinesh Kumar, Ayswaria Deepti, Aswathi Nair, Vanheule Greet, Vynckier An-Katrien, Van Den Driessche Mieke, Syam Das Sivadasan, Balu Maliakel, Baby Chakrapani PS, Krishnakumar Illathu Madhavamenon
      Journal of Functional Foods.2021; 79: 104405.     CrossRef
    • Curcumin restores the engraftment capacity of aged hematopoietic stem cells and also reduces PD‐1 expression on cytotoxic T cells
      Prajakta Shinde, Rutuja Kuhikar, Rohan Kulkarni, Nikhat Khan, Lalita Limaye, Vaijayanti Kale
      Journal of Tissue Engineering and Regenerative Medicine.2021; 15(4): 388.     CrossRef
    • Assessing encapsulation of curcumin in cocoliposome: In vitro study
      Dwi Hudiyanti, Muhammad Fuad Al Khafiz, Khairul Anam, Parsaoran Siahaan, Linda Suyati
      Open Chemistry.2021; 19(1): 358.     CrossRef
    • Comparative bioavailability of curcuminoids from a water-dispersible high curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over, comparative, pharmacokinetic study
      Shefali Thanawala, Rajat Shah, KrishnaRaju Venkata Alluri, Venkateswarlu Somepalli, Sanjay Vaze, Vivek Upadhyay
      Journal of Pharmacy and Pharmacology.2021; 73(6): 816.     CrossRef
    • Adjuvant effects of curcumin as a photoantimicrobial or irrigant in the non-surgical treatment of periodontitis: Systematic review and meta-analysis
      Eduardo Quintão Manhanini Souza, Tiago Esgalha da Rocha, Luan Felipe Toro, Isabella Zacarin Guiati, Jéssica de Oliveira Alvarenga Freire, Edilson Ervolino, Daniela Atili Brandini, Valdir Gouveia Garcia, Letícia Helena Theodoro
      Photodiagnosis and Photodynamic Therapy.2021; 34: 102265.     CrossRef
    • Therapeutic effect of modulating the NLRP3-regulated transforming growth factor-β signaling pathway on interstitial cystitis/bladder pain syndrome
      Hung-Jen Shih, Chao-Yuan Chang, Chung-Howe Lai, Chun-Jen Huang
      Biomedicine & Pharmacotherapy.2021; 138: 111522.     CrossRef
    • In vitro evaluation of curcumin-loaded chitosan-coated hydroxyapatite nanocarriers as a potential system for effective treatment of cancer
      Katayon Hemmati, Navid Ahmadi Nasab, Saeed Hesaraki, Nader Nezafati
      Journal of Biomaterials Science, Polymer Edition.2021; 32(10): 1267.     CrossRef
    • Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery
      Trong-Ming Don, Wan-Ju Chang, Pei-Ru Jheng, Yi-Cheng Huang, Er-Yuan Chuang
      International Journal of Biological Macromolecules.2021; 181: 835.     CrossRef
    • Pharmacokinetics of a Single Dose of Turmeric Curcuminoids Depends on Formulation: Results of a Human Crossover Study
      Pascale Fança-Berthon, Mathieu Tenon, Sabrina Le Bouter-Banon, Alexis Manfré, Corinne Maudet, Angelina Dion, Hélène Chevallier, Julie Laval, Richard B van Breemen
      The Journal of Nutrition.2021; 151(7): 1802.     CrossRef
    • Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy
      Devesh Tewari, Sweta Bawari, Shikha Sharma, Lindsay K. DeLiberto, Anupam Bishayee
      Pharmacology & Therapeutics.2021; 227: 107876.     CrossRef
    • Promising role of curcumin against viral diseases emphasizing COVID-19 management: A review on the mechanistic insights with reference to host-pathogen interaction and immunomodulation
      Shrinjana Dhar, Pritha Bhattacharjee
      Journal of Functional Foods.2021; 82: 104503.     CrossRef
    • Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review
      Paramita Basu, Camelia Maier, Arpita Basu
      International Journal of Molecular Sciences.2021; 22(9): 4666.     CrossRef
    • Improved drug delivery and accelerated diabetic wound healing by chondroitin sulfate grafted alginate-based thermoreversible hydrogels
      Syed Ahmed Shah, Muhammad Sohail, Shujaat Ali Khan, Mubeen Kousar
      Materials Science and Engineering: C.2021; 126: 112169.     CrossRef
    • Design and characterization of highly porous curcumin loaded freeze-dried wafers for wound healing
      Islam M. Adel, Mohamed F. ElMeligy, AbdelFattah A. Abdelkhalek, Nermeen A. Elkasabgy
      European Journal of Pharmaceutical Sciences.2021; 164: 105888.     CrossRef
    • Multiple strategies with the synergistic approach for addressing colorectal cancer
      Chenmala Karthika, Balaji Hari, Md. Habibur Rahman, Rokeya Akter, Agnieszka Najda, Ghadeer M. Albadrani, Amany A. Sayed, Muhammad Furqan Akhtar, Mohamed M. Abdel-Daim
      Biomedicine & Pharmacotherapy.2021; 140: 111704.     CrossRef
    • A New Metabolite
      Yen-Chun Koh, Sheng-Yang Liu, Jia-Ching Wu, Ya-Chun Chou, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
      Journal of Cancer Research and Practice.2021; 8(2): 41.     CrossRef
    • Dietary Curcumin Promotes Gilthead Seabream Larvae Digestive Capacity and Modulates Oxidative Status
      Maria J. Xavier, Gian Marco Dardengo, Carmen Navarro-Guillén, André Lopes, Rita Colen, Luisa M. P. Valente, Luís E. C. Conceição, Sofia Engrola
      Animals.2021; 11(6): 1667.     CrossRef
    • Molecular docking and dynamics studies of curcumin with COVID-19 proteins
      Renuka Suravajhala, Abhinav Parashar, Gourav Choudhir, Anuj Kumar, Babita Malik, Viswanathan Arun Nagaraj, Govindarajan Padmanaban, Rathnagiri Polavarapu, Prashanth Suravajhala, P. B. Kavi Kishor
      Network Modeling Analysis in Health Informatics and Bioinformatics.2021;[Epub]     CrossRef
    • The Effect of Adjunctive Mangosteen Pericarp on Cognition in People With Schizophrenia: Secondary Analysis of a Randomized Controlled Trial
      Wolfgang Marx, David R. Skvarc, Mohammadreza Mohebbi, Adam J. Walker, Alcy Meehan, Alyna Turner, Andrea Baker, Seetal Dodd, Sue M. Cotton, James Graham Scott, Bianca E. Kavanagh, Melanie M. Ashton, Ellie Brown, John J. McGrath, Michael Berk, Olivia May De
      Frontiers in Psychiatry.2021;[Epub]     CrossRef
    • Coaxial electrospun membranes of poly(ε‐caprolactone)/poly(lactic acid) with reverse core‐shell structures loaded with curcumin as tunable drug delivery systems
      Gianluca Viscusi, Elena Lamberti, Vittoria Vittoria, Giuliana Gorrasi
      Polymers for Advanced Technologies.2021; 32(10): 4005.     CrossRef
    • Curcumin-laden hyaluronic acid-co-Pullulan-based biomaterials as a potential platform to synergistically enhance the diabetic wound repair
      Syed Ahmed Shah, Muhammad Sohail, Muhammad Usman Minhas, Shahzeb Khan, Zahid Hussain, Arshad Mahmood, Mubeen Kousar, Hnin Ei Thu, Mudassir Abbasi, Mehboob ur Rehman Kashif
      International Journal of Biological Macromolecules.2021; 185: 350.     CrossRef
    • Krill Lecithin as Surfactant for Preparation of Oil/Water Nanoemulsions as Curcumin Carriers
      Luz del C. Velasco‐Rodríguez, Martha P. Rascón, Maria V. Calvo, Rita M. Montalvo, Javier Fontecha, Hugo S. García
      European Journal of Lipid Science and Technology.2021;[Epub]     CrossRef
    • Understanding the Gastrointestinal Protective Effects of Polyphenols using Foodomics-Based Approaches
      Wenwen Zhang, Suzhen Qi, Xiaofeng Xue, Yahya Al Naggar, Liming Wu, Kai Wang
      Frontiers in Immunology.2021;[Epub]     CrossRef
    • Targeting TLR4 Signaling to Blunt Viral-Mediated Acute Lung Injury
      Kari Ann Shirey, Jorge C. G. Blanco, Stefanie N. Vogel
      Frontiers in Immunology.2021;[Epub]     CrossRef
    • Effectiveness of Curcuma longa extract versus placebo for the treatment of knee osteoarthritis: A systematic review and meta‐analysis of randomized controlled trials
      Wenli Dai, Wenqiang Yan, Xi Leng, Jing Chen, Xiaoqing Hu, Yingfang Ao
      Phytotherapy Research.2021; 35(11): 5921.     CrossRef
    • Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin
      Sahdeo Prasad, Dan DuBourdieu, Ajay Srivastava, Prafulla Kumar, Rajiv Lall
      International Journal of Molecular Sciences.2021; 22(13): 7094.     CrossRef
    • Cytotoxic, Genotoxic and Senolytic Potential of Native and Micellar Curcumin
      Lea Beltzig, Anna Frumkina, Christian Schwarzenbach, Bernd Kaina
      Nutrients.2021; 13(7): 2385.     CrossRef
    • Self Nano-Emulsifying Curcumin (SNEC30) attenuates arsenic-induced cell death in mice
      Zarqua Jamal, Joydeep Das, Payal Gupta, Pubali Dhar, Sreya Chattopadhyay, Urmi Chatterji
      Toxicology Reports.2021; 8: 1428.     CrossRef
    • A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents
      Bibi Marjan Razavi, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
      Phytotherapy Research.2021; 35(12): 6489.     CrossRef
    • Methomyl-induced nephrotoxicity and protective effect of curcumin in male rats
      Ayse Aslanturk, Yusuf Kalender
      Toxicology Research.2021; 10(5): 1003.     CrossRef
    • Phenolic-protein interactions in foods and post ingestion: Switches empowering health outcomes
      Hui Guan, Wenyuan Zhang, Dongxiao Sun-Waterhouse, Yang Jiang, Feng Li, Geoffrey I.N. Waterhouse, Dapeng Li
      Trends in Food Science & Technology.2021; 118: 71.     CrossRef
    • Chemical modification of different compounds with nitrogen-containing heterocycles
      E. A. Akishina, Е. А. Dikusar
      Proceedings of the National Academy of Sciences of Belarus, Chemical Series.2021; 57(3): 356.     CrossRef
    • Current clinical developments in curcumin‐based therapeutics for cancer and chronic diseases
      Aviral Kumar, Choudhary Harsha, Dey Parama, Sosmitha Girisa, Uzini Devi Daimary, Xinliang Mao, Ajaikumar B. Kunnumakkara
      Phytotherapy Research.2021; 35(12): 6768.     CrossRef
    • Potential Health Benefits of Curcumin on Female Reproductive Disorders: A Review
      Datu Agasi Mohd Kamal, Norizam Salamt, Allia Najmie Muhammad Yusuf, Mohd Izhar Ariff Mohd Kashim, Mohd Helmy Mokhtar
      Nutrients.2021; 13(9): 3126.     CrossRef
    • Immunological responses and anti-tumor effects of HPV16/18 L1-L2-E7 multiepitope fusion construct along with curcumin and nanocurcumin in C57BL/6 mouse model
      Matin Kayyal, Azam Bolhassani, Zahra Noormohammadi, Majid Sadeghizadeh
      Life Sciences.2021; 285: 119945.     CrossRef
    • The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis
      An-Fang Hsiao, Yi-Chieh Lien, I-Shiang Tzeng, Chien-Ting Liu, Sheng-Hsun Chou, Yi-Shiung Horng
      Complementary Therapies in Medicine.2021; 63: 102775.     CrossRef
    • Possible potentials of curcumin for pregnancies complicated by intra-uterine growth restriction: role of inflammation, angiogenesis, and oxidative stress
      Mahsa Naemi, Zahra Farahani, Amir Hossein Norooznezhad, Reza Khodarahmi‬, Sedigheh Hantoushzadeh, Roghaye Ahangari, Mamak Shariat
      Heliyon.2021; 7(9): e08034.     CrossRef
    • Curcumin inhibited hepatitis B viral entry through NTCP binding
      Piyanoot Thongsri, Yongyut Pewkliang, Suparerk Borwornpinyo, Adisak Wongkajornsilp, Suradej Hongeng, Khanit Sa-ngiamsuntorn
      Scientific Reports.2021;[Epub]     CrossRef
    • Effect of oxidized dextran on the stability of gallic acid-modified chitosan–sodium caseinate nanoparticles
      Dongyan Shen, Qiaobin Hu, Jing Sun, Xinyi Pang, Xiangfei Li, Yingjian Lu
      International Journal of Biological Macromolecules.2021; 192: 360.     CrossRef
    • Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature
      Eslam El Nebrisi
      International Journal of Molecular Sciences.2021; 22(20): 11248.     CrossRef
    • Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model
      Mohammad Moniruzzaman, Hunhwan Kim, Haewon Shin, Hyunsoo Kim, Nayoung Kim, Sungyeon Chin, Adhimoolam Karthikeyan, Hyojick Choi, Gonsup Kim, Taesun Min
      Antibiotics.2021; 10(11): 1280.     CrossRef
    • Curcumin and Radiotherapy Exert Synergistic Anti-Glioma Effect In Vitro
      Vasiliki Zoi, Vasiliki Galani, Evrysthenis Vartholomatos, Natalia Zacharopoulou, Eftichia Tsoumeleka, Georgios Gkizas, Georgios Bozios, Pericles Tsekeris, Ieremias Chousidis, Ioannis Leonardos, Andreas G. Tzakos, Athanasios P. Kyritsis, George A. Alexiou
      Biomedicines.2021; 9(11): 1562.     CrossRef
    • Antitumoral Effects of Curcumin (Curcuma longa L.) and Thymoquinone (Nigella sativa L.) on Neuroblastoma Cell Lines
      Johanna Maria Korff, Katrin Menke, Melanie Schwermer, Katharina Falke, Alexander Schramm, Alfred Längler, Tycho Jan Zuzak
      Complementary Medicine Research.2021; 28(2): 164.     CrossRef
    • Curcumin supplementation improves biomarkers of oxidative stress and inflammation in conditions of obesity, type 2 diabetes and NAFLD: updating the status of clinical evidence
      Kabelo Mokgalaboni, Yonela Ntamo, Khanyisani Ziqubu, Tawanda M. Nyambuya, Bongani B. Nkambule, Sithandiwe E. Mazibuko-Mbeje, Kwazikwakhe B. Gabuza, Nireshni Chellan, Luca Tiano, Phiwayinkosi V. Dludla
      Food & Function.2021; 12(24): 12235.     CrossRef
    • CPD article: Guiding the owner: the use of supplements in canine osteoarthritis management
      Robyn Lowe
      Companion Animal.2021; 26(11): 248.     CrossRef
    • Biomedical Applications and Bioavailability of Curcumin—An Updated Overview
      Soo-In Sohn, Arumugam Priya, Boopathi Balasubramaniam, Pandiyan Muthuramalingam, Chandran Sivasankar, Anthonymuthu Selvaraj, Alaguvel Valliammai, Ravi Jothi, Subramani Pandian
      Pharmaceutics.2021; 13(12): 2102.     CrossRef
    • Antiproliferative and ROS Regulation Activity of Photoluminescent Curcumin-Derived Nanodots
      Durga M. Arvapalli, Alex T. Sheardy, John J. Bang, Jianjun Wei
      ACS Applied Bio Materials.2021; 4(12): 8477.     CrossRef
    • Phytochemicals Mediate Autophagy Against Osteoarthritis by Maintaining Cartilage Homeostasis
      Zheng Tian, Xinan Zhang, Mingli Sun
      Frontiers in Pharmacology.2021;[Epub]     CrossRef
    • Curcumin May Prevent Basement Membrane Disassembly by Matrix Metalloproteinases and Progression of the Bladder Cancer
      Paweł Wroński, Stanisław Wroński, Marcin Kurant, Bartosz Malinowski, Michał Wiciński
      Nutrients.2021; 14(1): 32.     CrossRef
    • Curcumin Oxidation Is Required for Inhibition of Helicobacter pylori Growth, Translocation and Phosphorylation of Cag A
      Ashwini Kumar Ray, Paula B. Luis, Surabhi Kirti Mishra, Daniel P. Barry, Mohammad Asim, Achyut Pandey, Maya Chaturvedi, Jyoti Gupta, Shilpi Gupta, Shweta Mahant, Rajashree Das, Pramod Kumar, Shalimar, Keith T. Wilson, Claus Schneider, Rupesh Chaturvedi
      Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
    • Lactobacillus Rhamnosus UBLR-58 and Diclofenac Potentiate the Anti- Alzheimer Activity of Curcumin in Mice
      Sonal Pande, Chirag Patel, Dipta Sarkar, Sanjeev Acharya
      Current Enzyme Inhibition.2021; 17(1): 49.     CrossRef
    • The effect of nanomicellar curcuminoids on renal ischemia/reperfusion injury and the expressions of COX-2 and Na +/K +-ATPase in rat’s kidney
      Zeinab Karimi, Roksana Soukhak Lari, Leila Malekmakan, Zahra Esmaili, Maryam Moosavi
      Physiology and Pharmacology.2021;[Epub]     CrossRef
    • 43 Natural Anticancer Products: Classified under the Cancer Hallmarks and the Available Evidence of their Anticancer Activities
      Dwight L. McKee, Mamoona S. Lodhi
      Journal of Cancer Research Updates.2021; 10: 56.     CrossRef
    • Anti-Candida Activity of Curcumin: A Systematic Review
      Kourosh Cheraghipour, Behrouz Ezatpour, Leila Masoori, Abdolrazagh Marzban, Asghar Sepahvand, Arian Karimi Rouzbahani, Abbas Moridnia, Sayyad Khanizadeh, Hossein Mahmoudvand
      Current Drug Discovery Technologies.2021; 18(3): 379.     CrossRef
    • Comparative neuroprotective effects of native curcumin and its galactomannoside formulation in carbofuran-induced neurotoxicity model
      Sindhu E. R., Binitha P. P., Saritha S. Nair, Balu Maliakel, Ramadasan Kuttan, Krishnakumar I. M.
      Natural Product Research.2020; 34(10): 1456.     CrossRef
    • Bioactivity of dietary polyphenols: The role of metabolites
      Simon Vlad Luca, Irina Macovei, Alexandra Bujor, Anca Miron, Krystyna Skalicka-Woźniak, Ana Clara Aprotosoaie, Adriana Trifan
      Critical Reviews in Food Science and Nutrition.2020; 60(4): 626.     CrossRef
    • Plant-derived natural agents as dietary supplements for the regulation of glycosylated hemoglobin: A review of clinical trials
      Elnaz Rezaeiamiri, Roodabeh Bahramsoltani, Roja Rahimi
      Clinical Nutrition.2020; 39(2): 331.     CrossRef
    • Hydro-ethanolic extract of Curcuma longa affects tracheal responsiveness and lung pathology in ovalbumin-sensitized rats
      Farzaneh Shakeri, Nama Mohamadian Roshan, Mohammad Hossein Boskabady
      International Journal for Vitamin and Nutrition Research.2020; 90(1-2): 141.     CrossRef
    • The nanotech potential of turmeric (Curcuma longa L.) in food technology: A review
      Angélica M. Serpa Guerra, Catalina Gómez Hoyos, Jorge Andrés Velásquez-Cock, Lina Vélez Acosta, Piedad Gañán Rojo, Ana María Velásquez Giraldo, Robin Zuluaga Gallego
      Critical Reviews in Food Science and Nutrition.2020; 60(11): 1842.     CrossRef
    • Sonochemical Functionalization of Cotton and Non‐Woven Fabrics with Bio‐Inspired Self‐Assembled Nanostructures
      Lialy Khadeja, Irena Grigoriants, Michal Halperin‐Sternfeld, Aviv Yona, Lihi Adler‐Abramovich
      Israel Journal of Chemistry.2020; 60(12): 1190.     CrossRef
    • Development of PCL/PEO electrospun fibrous membranes blended with silane-modified halloysite nanotube as a curcumin release system
      Y. Emre Bulbul, Mujgan Okur, Funda Demirtas-Korkmaz, Nursel Dilsiz
      Applied Clay Science.2020; 186: 105430.     CrossRef
    • Curcumin Can Decrease Tissue Inflammation and the Severity of HSV-2 Infection in the Female Reproductive Mucosa
      Danielle Vitali, Puja Bagri, Jocelyn M. Wessels, Meenakshi Arora, Raghu Ganugula, Ankit Parikh, Talveer Mandur, Allison Felker, Sanjay Garg, M.N.V. Ravi Kumar, Charu Kaushic
      International Journal of Molecular Sciences.2020; 21(1): 337.     CrossRef
    • Preparation and Characterization of Chitosan-Coated Pectin Aerogels: Curcumin Case Study
      Milica Pantić, Gabrijela Horvat, Željko Knez, Zoran Novak
      Molecules.2020; 25(5): 1187.     CrossRef
    • Curcumin-C3 Complexed with α-, β-cyclodextrin Exhibits Antibacterial and Antioxidant Properties Suitable for Cancer Treatments
      Desu N. K. Reddy, Ramya Kumar, Shao-Pin Wang, Fu-Yung Huang
      Current Drug Metabolism.2020; 20(12): 988.     CrossRef
    • Curcumin
      De-Biao Xiang, Kai-Qiang Zhang, Ya-Ling Zeng, Qing-Zi Yan, Zhe Shi, Qin-Hui Tuo, Li-Mei Lin, Bo-Hou Xia, Ping Wu, Duan-Fang Liao
      Medicine.2020; 99(2): e18467.     CrossRef
    • Curcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model
      Zeynep Busra Bolat, Zeynep Islek, Bilun Nas Demir, Elif Nur Yilmaz, Fikrettin Sahin, Mehmet Hikmet Ucisik
      Frontiers in Bioengineering and Biotechnology.2020;[Epub]     CrossRef
    • Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases
      Lalita Subedi, Si Eun Lee, Syeda Madiha, Bhakta Prasad Gaire, Mirim Jin, Silvia Yumnam, Sun Yeou Kim
      International Journal of Molecular Sciences.2020; 21(3): 764.     CrossRef
    • One‐step formation of polyurea gel as a multifunctional approach for biological and environmental applications
      Vinicius H Bonattini, Lucas AL Paula, Natana AM de Jesus, Denise C Tavares, Heloiza D Nicolella, Lizandra G Magalhães, Eduardo F Molina
      Polymer International.2020; 69(5): 476.     CrossRef
    • Some cetyltrimethylammonium bromide modified polysaccharide supports as sustained release systems for curcumin
      Neera Raghav, Nitika Mor, Renu D. Gupta, Ravinder Kaur, Manishita R. Sharma, Priyanka Arya
      International Journal of Biological Macromolecules.2020; 154: 361.     CrossRef
    • Neuroprotective effects of curcumin through autophagy modulation
      Fatemeh Forouzanfar, Morgayn I. Read, George E. Barreto, Amirhossein Sahebkar
      IUBMB Life.2020; 72(4): 652.     CrossRef
    • Polyphenol conjugated poly(beta‐amino ester) polymers with hydrogen peroxide triggered degradation and active antioxidant release
      Carolyn T. Jordan, J. Zach Hilt, Thomas D. Dziubla
      Journal of Applied Polymer Science.2020;[Epub]     CrossRef
    • Significant decrease in the viability and tumor stem cell marker expression in tumor cell lines treated with curcumin
      Constanze Buhrmann, Mina Yazdi, Ali Bashiri Dezfouli, Fazel Samani Sahraneshin, Seyed Morteza Ebrahimi, Seyed Hamidollah Ghaffari, Marjan Yaghmaie, Abbas Barin, Mehdi Shakibaei, Parviz Shayan
      Journal of Herbal Medicine.2020; 22: 100339.     CrossRef
    • Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives
      Der-Yen Lee, Yu-Chi Hou, Jai-Sing Yang, Hui-Yi Lin, Tsu-Yuan Chang, Kuo-Hsiung Lee, Sheng-Chu Kuo, Min-Tsang Hsieh
      Molecules.2020; 25(3): 479.     CrossRef
    • The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance
      Anna Winiarska-Mieczan, Ewa Baranowska-Wójcik, Małgorzata Kwiecień, Eugeniusz R. Grela, Dominik Szwajgier, Katarzyna Kwiatkowska, Bożena Kiczorowska
      Nutrients.2020; 12(2): 435.     CrossRef
    • Biophysical interactions between silver nanoparticle-albumin interface and curcumin
      Vinod D. Jaiswal, P.M. Dongre
      Journal of Pharmaceutical Analysis.2020; 10(2): 164.     CrossRef
    • Modulatory effects of curcumin on the atherogenic activities of inflammatory monocytes: Evidence from in vitro and animal models of human atherosclerosis
      Saeed Mohammadian Haftcheshmeh, Mohammad R. Karimzadeh, Sara Azhdari, Parviz Vahedi, Elham Abdollahi, Amir A. Momtazi‐Borojeni
      BioFactors.2020; 46(3): 341.     CrossRef
    • Turmeric
      Keith Singletary
      Nutrition Today.2020; 55(1): 45.     CrossRef
    • Curcumin-Based Treatment for Macular Edema from Uncommon Etiologies: Efficacy and Safety Assessment
      Mariantonia Ferrara, Davide Allegrini, Tania Sorrentino, Giancarlo Sborgia, Francesco Parmeggiani, Alfredo Borgia, Mario R. Romano
      Journal of Medicinal Food.2020; 23(8): 834.     CrossRef
    • Potential of nano-phytochemicals in cervical cancer therapy
      Neera Yadav, Shama Parveen, Monisha Banerjee
      Clinica Chimica Acta.2020; 505: 60.     CrossRef
    • Click chemistry-based imaging to study the tissue distribution of the curcumin–protein complex in mice
      Jingyi Zhou, Weicang Wang, Jianan Zhang, Zheyuan Du, Haixia Yang, Guodong Zhang
      Food & Function.2020; 11(2): 1684.     CrossRef
    • An ethyl-acetate fraction of Holothuria scabra modulates inflammation in vitro through inhibiting the production of nitric oxide and pro-inflammatory cytokines via NF-κB and JNK pathways
      Kanta Pranweerapaiboon, Somjai Apisawetakan, Saksit Nobsathian, Arunporn Itharat, Prasert Sobhon, Kulathida Chaithirayanon
      Inflammopharmacology.2020; 28(4): 1027.     CrossRef
    • Curcumin-loaded polysaccharides-based complex particles obtained by polyelectrolyte complexation and ionic gelation. I-Particles obtaining and characterization
      Camelia-Elena Iurciuc-Tincu, Leonard Ionuţ Atanase, Lăcrămioara Ochiuz, Christine Jérôme, Vincent Sol, Patrick Martin, Marcel Popa
      International Journal of Biological Macromolecules.2020; 147: 629.     CrossRef
    • RETRACTED: Development of curcumin-loaded silk fibroin nanoparticles as drug delivery vehicle for the treatment of ischemic stroke for patients in nursing care in hospitals
      Liang Zhang, Yue Zhang, Yan Du, Jing Wang, Lijun Chi
      Journal of Drug Delivery Science and Technology.2020; 55: 101360.     CrossRef
    • Imaging and therapeutic applications of Zn(ii)-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy
      Qi-Pin Qin, Zu-Zhuang Wei, Zhen-Feng Wang, Xiao-Ling Huang, Ming-Xiong Tan, Hua-Hong Zou, Hong Liang
      Chemical Communications.2020; 56(28): 3999.     CrossRef
    • Anti‐microbial activity of curcumin nanoformulations: New trends and future perspectives
      Simin Sharifi, Nazanin Fathi, Mohammad Yousef Memar, Seyed Mahdi Hosseiniyan Khatibi, Rovshan Khalilov, Ramin Negahdari, Sepideh Zununi Vahed, Solmaz Maleki Dizaj
      Phytotherapy Research.2020; 34(8): 1926.     CrossRef
    • Efficient synergistic combination effect of Quercetin with Curcumin on breast cancer cell apoptosis through their loading into Apo ferritin cavity
      Fariba Mansourizadeh, Diego Alberti, Valeria Bitonto, Martina Tripepi, Houri Sepehri, Sepideh Khoee, Simonetta Geninatti Crich
      Colloids and Surfaces B: Biointerfaces.2020; 191: 110982.     CrossRef
    • Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review
      Sidney J. Stohs, Oliver Chen, Sidhartha D. Ray, Jin Ji, Luke R. Bucci, Harry G. Preuss
      Molecules.2020; 25(6): 1397.     CrossRef
    • Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer
      Nurul Azwa Abd. Wahab, Nordin H. Lajis, Faridah Abas, Iekhsan Othman, Rakesh Naidu
      Nutrients.2020; 12(3): 679.     CrossRef
    • Curcumin and Endometriosis
      Alexandre Vallée, Yves Lecarpentier
      International Journal of Molecular Sciences.2020; 21(7): 2440.     CrossRef
    • Topical medicines for wound healing: A systematic review of Unani literature with recent advances
      Mohammad Fazil, Sadia Nikhat
      Journal of Ethnopharmacology.2020; 257: 112878.     CrossRef
    • Curcumin-human serum albumin nanoparticles decorated with PDL1 binding peptide for targeting PDL1-expressing breast cancer cells
      Zahra Hasanpoor, Ali Mostafaie, Iraj Nikokar, Zuhair Mohammad Hassan
      International Journal of Biological Macromolecules.2020; 159: 137.     CrossRef
    • Deciphering the Role of Polyphenols in Sports Performance: From Nutritional Genomics to the Gut Microbiota toward Phytonutritional Epigenomics
      Vincenzo Sorrenti, Stefano Fortinguerra, Giada Caudullo, Alessandro Buriani
      Nutrients.2020; 12(5): 1265.     CrossRef
    • Combating Iron Overload: A Case for Deferoxamine-Based Nanochelators
      Gregory Jones, Sumanta Kumar Goswami, Homan Kang, Hak Soo Choi, Jonghan Kim
      Nanomedicine.2020; 15(13): 1341.     CrossRef
    • In Silico Exploration of the Molecular Mechanism of Clinically Oriented Drugs for Possibly Inhibiting SARS-CoV-2’s Main Protease
      Tien Huynh, Haoran Wang, Binquan Luan
      The Journal of Physical Chemistry Letters.2020; 11(11): 4413.     CrossRef
    • Potentiation of anti-Alzheimer activity of curcumin by probiotic Lactobacillus rhamnosus UBLR-58 against scopolamine-induced memory impairment in mice
      Chirag Patel, Sonal Pande, Sanjeev Acharya
      Naunyn-Schmiedeberg's Archives of Pharmacology.2020; 393(10): 1955.     CrossRef
    • The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction
      Cristina Carresi, Micaela Gliozzi, Vincenzo Musolino, Miriam Scicchitano, Federica Scarano, Francesca Bosco, Saverio Nucera, Jessica Maiuolo, Roberta Macrì, Stefano Ruga, Francesca Oppedisano, Maria Caterina Zito, Lorenza Guarnieri, Rocco Mollace, Annamar
      Nutrients.2020; 12(5): 1504.     CrossRef
    • Curcumin, Curcumin Nanoparticles and Curcumin Nanospheres: A Review on Their Pharmacodynamics Based on Monogastric Farm Animal, Poultry and Fish Nutrition
      Mohammad Moniruzzaman, Taesun Min
      Pharmaceutics.2020; 12(5): 447.     CrossRef
    • In VitroEvaluation of Curcumin-Encapsulated Chitosan Nanoparticles against Feline Infectious Peritonitis Virus and Pharmacokinetics Study in Cats
      Shing Wei Ng, Gayathri Thevi Selvarajah, Mohd Zobir Hussein, Swee Keong Yeap, Abdul Rahman Omar
      BioMed Research International.2020; 2020: 1.     CrossRef
    • Formamidine-based thiuram disulfides: Synthesis, structural characterization, biological studies, and preliminary cheminformatics evaluation
      Segun D. Oladipo, Fisayo A. Olotu, Mahmoud Soliman, Chunderika Mocktar, Bernard Omondi
      Journal of Molecular Structure.2020; 1219: 128553.     CrossRef
    • Effect of Morning vs. Evening Turmeric Consumption on Urine Oxidative Stress Biomarkers in Obese, Middle-Aged Adults: A Feasibility Study
      Cynthia Blanton, Barbara Gordon
      International Journal of Environmental Research and Public Health.2020; 17(11): 4088.     CrossRef
    • A novel predict-verify strategy for targeted metabolomics: Comparison of the curcuminoids between crude and fermented turmeric
      Xingliang Xiang, Chengwu Song, Qingxin Shi, Ji Tian, Cheng Chen, Jiaxin Huang, Bo She, Xueyan Zhao, Rongzeng Huang, Shuna Jin
      Food Chemistry.2020; 331: 127281.     CrossRef
    • Curcumin derivatives for Type 2 Diabetes management and prevention of complications
      Sara Oliveira, Tamaeh Monteiro-Alfredo, Sónia Silva, Paulo Matafome
      Archives of Pharmacal Research.2020; 43(6): 567.     CrossRef
    • Formulation of More Efficacious Curcumin Delivery Systems Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability
      Bingjing Zheng, David Julian McClements
      Molecules.2020; 25(12): 2791.     CrossRef
    • Mechanism of action of the curcumin cis-diammineplatinum(ii) complex as a photocytotoxic agent
      Eslam Dabbish, Gloria Mazzone, Nino Russo, Emilia Sicilia
      Inorganic Chemistry Frontiers.2020; 7(15): 2759.     CrossRef
    • Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo
      Sariya Mapoung, Shugo Suzuki, Satoshi Fuji, Aya Naiki-Ito, Hiroyuki Kato, Supachai Yodkeeree, Natee Sakorn, Chitchamai Ovatlarnporn, Satoru Takahashi, Pornngarm Limtrakul (Dejkriengkraikul)
      Molecules.2020; 25(12): 2737.     CrossRef
    • Nutritional traditional and complementary medicine strategies in pediatric cancer: A narrative review
      Caroline Diorio, Kara M. Kelly, Glenn M. Afungchwi, Elena J. Ladas, Stacey Marjerrison
      Pediatric Blood & Cancer.2020;[Epub]     CrossRef
    • Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study
      Aman Khanna, Sivadasan Syam Das, Thozhuthum Parambil Smina, Jestin V. Thomas, Ajaikumar B. Kunnumakkara, Balu Maliakel, Illathu Madhavamenon Krishnakumar, Ratheesh Mohanan
      The Journal of Alternative and Complementary Medicine.2020; 26(10): 945.     CrossRef
    • Curcumin Ameliorates Heat-Induced Injury through NADPH Oxidase–Dependent Redox Signaling and Mitochondrial Preservation in C2C12 Myoblasts and Mouse Skeletal Muscle
      Tianzheng Yu, Jacob Dohl, Li Wang, Yifan Chen, Heath G Gasier, Patricia A Deuster
      The Journal of Nutrition.2020; 150(9): 2257.     CrossRef
    • Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults
      Helena Tiekou Lorinczova, Owen Fitzsimons, Leah Mursaleen, Derek Renshaw, Gulshanara Begum, Mohammed Gulrez Zariwala
      Antioxidants.2020; 9(8): 645.     CrossRef
    • The in vivo preventive and therapeutic properties of curcumin in bile reflux‐related oncogenesis of the hypopharynx
      Sotirios G. Doukas, Panagiotis G. Doukas, Clarence T. Sasaki, Dimitra Vageli
      Journal of Cellular and Molecular Medicine.2020; 24(18): 10311.     CrossRef
    • Micro and nanoscale technologies in oral drug delivery
      Samad Ahadian, Joel A. Finbloom, Mohammad Mofidfar, Sibel Emir Diltemiz, Fatemeh Nasrollahi, Elham Davoodi, Vahid Hosseini, Ioanna Mylonaki, Sivakoti Sangabathuni, Hossein Montazerian, Kirsten Fetah, Rohollah Nasiri, Mehmet Remzi Dokmeci, Molly M. Stevens
      Advanced Drug Delivery Reviews.2020; 157: 37.     CrossRef
    • Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis
      Nathan Earl Rainey, Aoula Moustapha, Patrice Xavier Petit
      Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
    • Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases
      Samanta C. Funes, Mariana Rios, Ayleen Fernández-Fierro, Camila Covián, Susan M. Bueno, Claudia A. Riedel, Juan Pablo Mackern-Oberti, Alexis M. Kalergis
      Frontiers in Immunology.2020;[Epub]     CrossRef
    • Photo-physical, theoretical and photo-cytotoxic evaluation of a new class of lanthanide(iii)–curcumin/diketone complexes for PDT application
      Dulal Musib, Mrityunjoy Pal, Md Kausar Raza, Mithun Roy
      Dalton Transactions.2020; 49(31): 10786.     CrossRef
    • A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer’s Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model
      Ih-Jen Su, Hong-Yi Chang, Hui-Chen Wang, Kuen-Jer Tsai
      International Journal of Molecular Sciences.2020; 21(15): 5459.     CrossRef
    • Curcumin-Loaded Bacterial Cellulose/Alginate/Gelatin as A Multifunctional Biopolymer Composite Film
      Nadda Chiaoprakobkij, Thapanar Suwanmajo, Neeracha Sanchavanakit, Muenduen Phisalaphong
      Molecules.2020; 25(17): 3800.     CrossRef
    • The effects of different doses of curcumin compound on growth performance, antioxidant status, and gut health of broiler chickens challenged with Eimeria species
      Sudhir Yadav, Po-Yun Teng, Tatiane Souza dos Santos, Rebecca Lizabeth Gould, Steven Wesley Craig, Alberta Lorraine Fuller, Robert Pazdro, Woo Kyun Kim
      Poultry Science.2020; 99(11): 5936.     CrossRef
    • Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies
      Monica Benvenuto, Loredana Albonici, Chiara Focaccetti, Sara Ciuffa, Sara Fazi, Loredana Cifaldi, Martino Tony Miele, Fernando De Maio, Ilaria Tresoldi, Vittorio Manzari, Andrea Modesti, Laura Masuelli, Roberto Bei
      International Journal of Molecular Sciences.2020; 21(18): 6635.     CrossRef
    • Obstacles against the Marketing of Curcumin as a Drug
      Kambiz Hassanzadeh, Lucia Buccarello, Jessica Dragotto, Asadollah Mohammadi, Massimo Corbo, Marco Feligioni
      International Journal of Molecular Sciences.2020; 21(18): 6619.     CrossRef
    • Transthyretin Amyloidogenesis Inhibitors: From Discovery to Current Developments
      Takeshi Yokoyama, Mineyuki Mizuguchi
      Journal of Medicinal Chemistry.2020; 63(23): 14228.     CrossRef
    • Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee Osteoarthritis
      Zhiqiang Wang, Graeme Jones, Tania Winzenberg, Guoqi Cai, Laura L. Laslett, Dawn Aitken, Ingrid Hopper, Ambrish Singh, Robert Jones, Jurgen Fripp, Changhai Ding, Benny Antony
      Annals of Internal Medicine.2020; 173(11): 861.     CrossRef
    • Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications
      Javad Sharifi-Rad, Youssef El Rayess, Alain Abi Rizk, Carmen Sadaka, Raviella Zgheib, Wissam Zam, Simona Sestito, Simona Rapposelli, Katarzyna Neffe-Skocińska, Dorota Zielińska, Bahare Salehi, William N. Setzer, Noura S. Dosoky, Yasaman Taheri, Marc El Be
      Frontiers in Pharmacology.2020;[Epub]     CrossRef
    • Navigating the Maze of Dietary Supplements
      Darla Daniel O'Dwyer
      Topics in Clinical Nutrition.2020; 35(4): 309.     CrossRef
    • Recent developments in formulation design for improving oral bioavailability of curcumin: A review
      Zhenqi Liu, John D. Smart, Ananth S. Pannala
      Journal of Drug Delivery Science and Technology.2020; 60: 102082.     CrossRef
    • Curcumin: A therapeutic potential in ageing-related disorders
      Alexander Vaiserman, Alexander Koliada, Alina Zayachkivska, Oleh Lushchak
      PharmaNutrition.2020; 14: 100226.     CrossRef
    • The effect of curcumin ointment on knee pain in older adults with osteoarthritis: a randomized placebo trial
      Neda Jamali, Mohsen Adib-Hajbaghery, Alireza Soleimani
      BMC Complementary Medicine and Therapies.2020;[Epub]     CrossRef
    • An Update on the Pharmacological Usage of Curcumin: Has it Failed in the Drug Discovery Pipeline?
      Fisayo Olotu, Clement Agoni, Opeyemi Soremekun, Mahmoud E. S. Soliman
      Cell Biochemistry and Biophysics.2020; 78(3): 267.     CrossRef
    • Emerging Trends in Topical Delivery of Curcumin Through Lipid Nanocarriers: Effectiveness in Skin Disorders
      Tejashree Waghule, Srividya Gorantla, Vamshi Krishna Rapalli, Pranav Shah, Sunil Kumar Dubey, Ranendra Narayan Saha, Gautam Singhvi
      AAPS PharmSciTech.2020;[Epub]     CrossRef
    • Enhancing Bioavailability and Stability of Curcumin Using Solid Lipid Nanoparticles (CLEN): A Covenant for Its Effectiveness
      Tanvi Gupta, Joga Singh, Sandeep Kaur, Simarjot Sandhu, Gurpal Singh, Indu Pal Kaur
      Frontiers in Bioengineering and Biotechnology.2020;[Epub]     CrossRef
    • Does systemic oral administration of curcumin effectively reduce alveolar bone loss associated with periodontal disease? A systematic review and meta-analysis of preclinical in vivo studies
      Juliana Simeão Borges, Luiz Renato Paranhos, Gabriela Leite de Souza, Felipe de Souza Matos, Ítalo de Macedo Bernardino, Camilla Christian Gomes Moura, Priscilla Barbosa Ferreira Soares
      Journal of Functional Foods.2020; 75: 104226.     CrossRef
    • Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols
      Bingyan Yang, Yixin Dong, Fei Wang, Yu Zhang
      Molecules.2020; 25(20): 4613.     CrossRef
    • Ethnopharmacological study of natural products used for traditional cancer therapy in Algeria
      Khaled Taïbi, Leila Ait Abderrahim, Karima Ferhat, Soria Betta, Fadhila Taïbi, Fatiha Bouraada, Mohamed Boussaid
      Saudi Pharmaceutical Journal.2020; 28(11): 1451.     CrossRef
    • Modulating disease-relevant tau oligomeric strains by small molecules
      Filippa Lo Cascio, Stephanie Garcia, Mauro Montalbano, Nicha Puangmalai, Salome McAllen, Andrea Pace, Antonio Palumbo Piccionello, Rakez Kayed
      Journal of Biological Chemistry.2020; 295(44): 14807.     CrossRef
    • Enhanced oral bioavailability of self-assembling curcumin–vitamin E prodrug-nanoparticles by co-nanoprecipitation with vitamin E TPGS
      Huiyun Zhang, Baoding Chen, Yuan Zhu, Congyong Sun, Michael Adu-Frimpong, Wenwen Deng, Jiangnan Yu, Ximing Xu
      Drug Development and Industrial Pharmacy.2020; 46(11): 1800.     CrossRef
    • Therapeutic role of curcumin and its novel formulations in gynecological cancers
      Mohammad Hossein Pourhanifeh, Maryam Darvish, Javad Tabatabaeian, Mahboobeh Rabbani Fard, Reza Mottaghi, Mohammad Javad Azadchehr, Moghaddaseh Jahanshahi, Amirhossein Sahebkar, Hamed Mirzaei
      Journal of Ovarian Research.2020;[Epub]     CrossRef
    • Nanocurcumin Inhibits Angiogenesis via Down-regulating hif1a/VEGF-A Signaling in Zebrafish
      Zigang Cao, Shicong He, Yuyang Peng, Xinjun Liao, Huiqiang Lu
      Current Neurovascular Research.2020; 17(2): 147.     CrossRef
    • The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19
      Panagiotis Kritis, Irene Karampela, Styliani Kokoris, Maria Dalamaga
      Metabolism Open.2020; 8: 100066.     CrossRef
    • Electrochemotherapy Modulates Mammary Tumor Growth in Rats on a Western Diet Supplemented with Curcumin
      Raji Sundararajan, Lakshya Mittal, Ignacio G. Camarillo
      Biomedicines.2020; 8(11): 498.     CrossRef
    • Reductive metabolites of curcumin and their therapeutic effects
      Achyut Pandey, Maya Chaturvedi, Shruti Mishra, Pramod Kumar, Pallavi Somvanshi, Rupesh Chaturvedi
      Heliyon.2020; 6(11): e05469.     CrossRef
    • EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2
      Wael H. Roshdy, Helmy A. Rashed, Ahmed Kandeil, Ahmed Mostafa, Yassmin Moatasim, Omnia Kutkat, Noura M. Abo Shama, Mokhtar R. Gomaa, Ibrahim H. El-Sayed, Nancy M. El Guindy, Amal Naguib, Ghazi Kayali, Mohamed A. Ali, Dong-Yan Jin
      PLOS ONE.2020; 15(11): e0241739.     CrossRef
    • Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells
      Ruihua Li, Jing Zhang, Yongfeng Zhou, Qi Gao, Rui Wang, Yurong Fu, Lianwen Zheng, Hao Yu, Luciano Saso
      Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
    • Pancreatic Cancer (PDAC): Introduction of Evidence-Based Complementary Measures into Integrative Clinical Management
      Valerie Jentzsch, James Davis, Mustafa Djamgoz
      Cancers.2020; 12(11): 3096.     CrossRef
    • Curcumin in Depression: Potential Mechanisms of Action and Current Evidence—A Narrative Review
      Tahiana Ramaholimihaso, Fayçal Bouazzaoui, Arthur Kaladjian
      Frontiers in Psychiatry.2020;[Epub]     CrossRef
    • Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review
      Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Vahideh Zarrin, Ebrahim Rahmani Moghadam, Farid Hashemi, Pooyan Makvandi, Saeed Samarghandian, Haroon Khan, Fardin Hashemi, Masoud Najafi, Hamed Mirzaei
      Frontiers in Pharmacology.2020;[Epub]     CrossRef
    • The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent Effects
      Larisa Ryskalin, Francesca Biagioni, Carla L. Busceti, Gloria Lazzeri, Alessandro Frati, Francesco Fornai
      Molecules.2020; 25(20): 4839.     CrossRef

    • Review of Curcumin Physicochemical Targeting Delivery System


      Lanmei Li, Xiaomei Zhang, Chao Pi, Hongru Yang, Xiaoli Zheng, Ling Zhao, Yumeng Wei
      International Journal of Nanomedicine.2020; Volume 15: 9799.     CrossRef
    • Current Status of Drug Targets and Emerging Therapeutic Strategies in the Management of Alzheimer's Disease
      Shampa Ghosh, Shantanu Durgvanshi, Shreya Agarwal, Manchala Raghunath, Jitendra Kumar Sinha
      Current Neuropharmacology.2020; 18(9): 883.     CrossRef
    • Comment on: Efficacy of Curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis
      Ali Mobasheri, Yves Henrotin
      Seminars in Arthritis and Rheumatism.2019; 48(4): e25.     CrossRef
    • Polymeric Encapsulation of Turmeric Extract for Bioimaging and Antimicrobial Applications
      Minghuan Liu, Choon Peng Teng, Khin Yin Win, Yisong Chen, Xiaoyan Zhang, Da‐Peng Yang, Zibiao Li, Enyi Ye
      Macromolecular Rapid Communications.2019;[Epub]     CrossRef
    • Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review
      Yunes Panahi, Omid Fazlolahzadeh, Stephen L. Atkin, Muhammed Majeed, Alexandra E. Butler, Thomas P. Johnston, Amirhossein Sahebkar
      Journal of Cellular Physiology.2019; 234(2): 1165.     CrossRef
    • Nanoencapsulation of quercetin and curcumin in casein-based delivery systems
      Nazanin Ghayour, Seyed Mohammad Hashem Hosseini, Mohammad Hadi Eskandari, Sara Esteghlal, Abdo-Reza Nekoei, Hadi Hashemi Gahruie, Mohsen Tatar, Fakhraddin Naghibalhossaini
      Food Hydrocolloids.2019; 87: 394.     CrossRef
    • Evaluating the effect of chitosan layer on bioaccessibility and cellular uptake of curcumin nanoemulsions
      Hélder D. Silva, Eliška Beldíková, Joana Poejo, Luís Abrunhosa, Ana Teresa Serra, Catarina M.M. Duarte, Tomáš Brányik, Miguel A. Cerqueira, Ana C. Pinheiro, António A. Vicente
      Journal of Food Engineering.2019; 243: 89.     CrossRef
    • Curcumin induces concentration‐dependent alterations in mitochondrial function through ROS in C2C12 mouse myoblasts
      Tianzheng Yu, Jacob Dohl, Falicia Elenberg, Yifan Chen, Patricia Deuster
      Journal of Cellular Physiology.2019; 234(5): 6371.     CrossRef
    • Neuro-protective role of nanocapsulated curcumin against cerebral ischemia-reperfusion induced oxidative injury
      Abhishek Mukherjee, Sibani Sarkar, Sayantan Jana, Snehasikta Swarnakar, Nirmalendu Das
      Brain Research.2019; 1704: 164.     CrossRef
    • Dietary cosupplementation with curcumin and different selenium sources (nanoparticulate, organic, and inorganic selenium): influence on growth performance, body composition, immune responses, and glutathione peroxidase activity of rainbow trout (Oncorhync
      Ayyoub Jamali Kohshahi, Iman Sourinejad, Mehrdad Sarkheil, Seyed Ali Johari
      Fish Physiology and Biochemistry.2019; 45(2): 793.     CrossRef
    • Pharmacokinetics of liposomal curcumin (Lipocurc™) infusion: effect of co-medication in cancer patients and comparison with healthy individuals
      Gordon T. Bolger, Albert Licollari, Amin Tan, Richard Greil, Brigitta Vcelar, Sigrun Greil-Ressler, Lukas Weiss, Charlotte Schönlieb, Teresa Magnes, Bianca Radl, Muhammed Majeed, Peter P. Sordillo
      Cancer Chemotherapy and Pharmacology.2019; 83(2): 265.     CrossRef
    • Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects
      Haroon Khan, Hammad Ullah, Seyed M. Nabavi
      Food and Chemical Toxicology.2019; 124: 182.     CrossRef
    • The therapeutic potential of curcumin: A review of clinical trials
      Bahare Salehi, Zorica Stojanović-Radić, Jelena Matejić, Mehdi Sharifi-Rad, Nanjangud V. Anil Kumar, Natália Martins, Javad Sharifi-Rad
      European Journal of Medicinal Chemistry.2019; 163: 527.     CrossRef
    • Curcumin analogs: Their roles in pancreatic cancer growth and metastasis
      Ganji Purnachandra Nagaraju, Leah Benton, Shipra Reddy Bethi, Mamoru Shoji, Bassel F. El‐Rayes
      International Journal of Cancer.2019; 145(1): 10.     CrossRef
    • A diet enriched with curcumin promotes resilience to chronic social defeat stress
      Antonio V. Aubry, Hameda Khandaker, Rebecca Ravenelle, Itamar S. Grunfeld, Valentina Bonnefil, Kenny L. Chan, Flurin Cathomas, Jia Liu, Glenn E. Schafe, Nesha S. Burghardt
      Neuropsychopharmacology.2019; 44(4): 733.     CrossRef
    • Protective effects of curcumin against ischemia-reperfusion injury in the liver
      Kowsar Bavarsad, Maryam Matbou Riahi, Saeideh Saadat, George Barreto, Stephen L. Atkin, Amirhossein Sahebkar
      Pharmacological Research.2019; 141: 53.     CrossRef
    • Hypoxia-targeted drug delivery
      Amit Sharma, Jonathan F. Arambula, Seyoung Koo, Rajesh Kumar, Hardev Singh, Jonathan L. Sessler, Jong Seung Kim
      Chemical Society Reviews.2019; 48(3): 771.     CrossRef
    • In vitro and in vivo evaluation of enzymatic and antioxidant activity, cytotoxicity and genotoxicity of curcumin-loaded solid dispersions
      Igor Silva de Sá, Ana Paula Peron, Fernanda Vitória Leimann, Getúlio Nicola Bressan, Bárbara Nunes Krum, Roselei Fachinetto, José Pinela, Ricardo Costa Calhelha, Maria Filomena Barreiro, Isabel C.F.R. Ferreira, Odinei Hess Gonçalves, Rafael Porto Ineu
      Food and Chemical Toxicology.2019; 125: 29.     CrossRef
    • Impact of curcumin on toll‐like receptors
      Motahare Boozari, Alexandra E. Butler, Amirhossein Sahebkar
      Journal of Cellular Physiology.2019; 234(8): 12471.     CrossRef
    • Photocatalytic and antibacterial activities study of prepared self-cleaning nanostructure surfaces using synthesized and coated ZnO nanoparticles with Curcumin nanodispersion
      Zahra Sayyar, Hoda Jafarizadeh Malmiri
      Zeitschrift für Kristallographie - Crystalline Materials .2019; 234(5): 307.     CrossRef
    • Efficacy of curcumin for management of oral submucous fibrosis: a systematic review of randomized clinical trials
      Sadeq Ali Al-Maweri
      Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2019; 127(4): 300.     CrossRef
    • Experimental and theoretical solubility advantage screening of bi-component solid curcumin formulations
      Maciej Przybyłek, Łukasz Recki, Karina Mroczyńska, Tomasz Jeliński, Piotr Cysewski
      Journal of Drug Delivery Science and Technology.2019; 50: 125.     CrossRef
    • In Vitro Cytotoxicity and Bioavailability of Ginsenoside-Modified Nanostructured Lipid Carrier Containing Curcumin
      Ajay Vijayakumar, Rengarajan Baskaran, Jeong-Heum Baek, Pasupathi Sundaramoorthy, Bong Kyu Yoo
      AAPS PharmSciTech.2019;[Epub]     CrossRef
    • Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation
      Valentina Oliveri
      European Journal of Medicinal Chemistry.2019; 167: 10.     CrossRef
    • Advances of nanosystems containing cyclodextrins and their applications in pharmaceuticals
      Paula dos Passos Menezes, Tatianny de Araújo Andrade, Luiza Abrahão Frank, Eloísa Portugal Barros Silva Soares de Souza, Gabriela das Graças Gomes Trindade, Igor Araújo Santos Trindade, Mairim Russo Serafini, Sílvia Stanisçuaski Guterres, Adriano Antunes
      International Journal of Pharmaceutics.2019; 559: 312.     CrossRef
    • Porous Silicon Carrier Delivery System for Curcumin: Preparation, Characterization, and Cytotoxicity in Vitro
      Qingxia Lin, Wei Li, Di Liu, Mengyuan Zhao, Xuerui Zhu, Weiwei Li, Longfeng Wang, Tiesong Zheng, Jianlin Li
      ACS Applied Bio Materials.2019; 2(3): 1041.     CrossRef
    • EF24 Suppresses Cholangiocellular Carcinoma Progression, Inhibits STAT3 Phosphorylation, and Induces Apoptosis via ROS-Mediated Oxidative Stress
      Savita Bisht, Jens Nolting, Jörg Wenzel, Peter Brossart, Georg Feldmann
      Journal of Oncology.2019; 2019: 1.     CrossRef
    • Polyphenols as Potential Attenuators of Heat Stress in Poultry Production
      Ruizhi Hu, Yujia He, Muhammed Adebayo Arowolo, Shusong Wu, Jianhua He
      Antioxidants.2019; 8(3): 67.     CrossRef
    • Effect of curcumin-nanoemulsion associated with photodynamic therapy in breast adenocarcinoma cell line
      Francielly Cristina Machado, Renata Prandini Adum de Matos, Fernando Lucas Primo, Antonio Claudio Tedesco, Paula Rahal, Marília Freitas Calmon
      Bioorganic & Medicinal Chemistry.2019; 27(9): 1882.     CrossRef
    • Curcumin: Recent Advances in the Development of Strategies to Improve Oral Bioavailability
      Katherine Z. Sanidad, Elvira Sukamtoh, Hang Xiao, David Julian McClements, Guodong Zhang
      Annual Review of Food Science and Technology.2019; 10(1): 597.     CrossRef
    • Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials
      Maryam Azhdari, Majid Karandish, Anahita Mansoori
      Phytotherapy Research.2019; 33(5): 1289.     CrossRef
    • Polymorphs of Curcumin and Its Cocrystals With Cinnamic Acid
      Noopur Rathi, Anant Paradkar, Vilas G. Gaikar
      Journal of Pharmaceutical Sciences.2019; 108(8): 2505.     CrossRef
    • Sustainable production of natural phenolics for functional food applications
      Rita Mark, Xiaomei Lyu, Jaslyn J.L. Lee, Roberto Parra-Saldívar, Wei Ning Chen
      Journal of Functional Foods.2019; 57: 233.     CrossRef
    • Bread enriched with phytosterols with or without curcumin modulates lipoprotein profiles in hypercholesterolaemic individuals. A randomised controlled trial
      Jessica J. A. Ferguson, Anna Wolska, Alan T. Remaley, Elizabeth Stojanovski, Lesley MacDonald-Wicks, Manohar L. Garg
      Food & Function.2019; 10(5): 2515.     CrossRef
    • Green synthesis of carrier-free curcumin nanodrugs for light-activated breast cancer photodynamic therapy
      Madi Sun, Yue Zhang, Yan He, Menghua Xiong, Hanyao Huang, Shucheng Pei, Jinfeng Liao, Yingshuai Wang, Dan Shao
      Colloids and Surfaces B: Biointerfaces.2019; 180: 313.     CrossRef
    • Curcumin in Autoimmune and Rheumatic Diseases
      Melissa Yang, Umair Akbar, Chandra Mohan
      Nutrients.2019; 11(5): 1004.     CrossRef
    • Wound Healing Property of Curcuminoids as a Microcapsule-Incorporated Cream
      Lee Ang, Yusrida Darwis, Rhun Koh, Kenny Gah Leong, Mei Yew, Lip Por, Mun Yam
      Pharmaceutics.2019; 11(5): 205.     CrossRef
    • Effectiveness and therapeutic value of phytochemicals in acute pancreatitis: A review
      Aleksandra Tarasiuk, Jakub Fichna
      Pancreatology.2019; 19(4): 481.     CrossRef
    • Turmeric (Curcuma longa L.) products: What quality differences exist?
      Loukiani Chatzinasiou, Anthony Booker, Euan MacLennan, Marion Mackonochie, Michael Heinrich
      Journal of Herbal Medicine.2019; 17-18: 100281.     CrossRef
    • An evaluation of the wound healing potential of tetrahydrocurcumin-loaded MPEG-PLA nanoparticles
      Peng He, Hong Yan, Junning Zhao, Maling Gou, Xiaolu Li
      Journal of Biomaterials Applications.2019; 34(3): 315.     CrossRef
    • DNA-binding and in vitro cytotoxic activity of platinum(II) complexes of curcumin and caffeine
      Valentina Censi, Ana B. Caballero, Marta Pérez-Hernández, Vanessa Soto-Cerrato, Luís Korrodi-Gregório, Ricardo Pérez-Tomás, Maria Michela Dell'Anna, Piero Mastrorilli, Patrick Gamez
      Journal of Inorganic Biochemistry.2019; 198: 110749.     CrossRef
    • Chitosan/iota-carrageenan/curcumin-based materials performed by precipitating miscible solutions prepared in ionic liquid
      Beatriz B.S. Ramin, Késsily B. Rufato, Roberta M. Sabino, Ketul C. Popat, Matt J. Kipper, Alessandro F. Martins, Edvani C. Muniz
      Journal of Molecular Liquids.2019; 290: 111199.     CrossRef
    • Investigation of Curcumin Water Solubility Through Emulsifying with Biocompatible Polyethylene Glycol–Based Polymers
      Gulcemal Yildiz, Zeynep Aydoğmuş, Filiz Senkal, Gulcin Turan
      Food Analytical Methods.2019; 12(10): 2129.     CrossRef
    • Efficacy of curcumin on prevention of drug‐induced nephrotoxicity: A review of animal studies
      Javad Motaharinia, Yunes Panahi, George E. Barreto, Fatemeh Beiraghdar, Amirhossein Sahebkar
      BioFactors.2019; 45(5): 690.     CrossRef
    • Anti-glycation, anti-hemolysis, and ORAC activities of demethylcurcumin and tetrahydroxycurcumin in vitro and reductions of oxidative stress in d-galactose-induced BALB/c mice in vivo
      Yuh-Hwa Liu, Tai-Lin Lee, Chuan-Hsiao Han, Yi-Shan Lee, Wen-Chi Hou
      Botanical Studies.2019;[Epub]     CrossRef
    • Assessment of anti-diabetic activity of a novel hydrazine-thiazole derivative: in vitro and in vivo method
      Marina Ferrara de Resende, Cleudiomar Inácio Lino, Elaine Maria de Souza-Fagundes, João Vitor Paes Rettore, Renata Barbosa de Oliveira, Renata Adriana Labanca
      Brazilian Journal of Pharmaceutical Sciences.2019;[Epub]     CrossRef
    • Low-Dose Curcumin Nanoparticles Normalise Blood Pressure in Male Wistar Rats with Diet-Induced Metabolic Syndrome
      Ryan du Preez, Jessica Pahl, Meenakshi Arora, M. N. V. Ravi Kumar, Lindsay Brown, Sunil K. Panchal
      Nutrients.2019; 11(7): 1542.     CrossRef
    • Curcumin as tyrosine kinase inhibitor in cancer treatment
      A. Golonko, H. Lewandowska, R. Świsłocka, U.T. Jasińska, W. Priebe, W. Lewandowski
      European Journal of Medicinal Chemistry.2019; 181: 111512.     CrossRef
    • Dextran-immobilized curcumin: An efficient agent against food pathogens and cancer cells
      Mahboobeh Zare, Malihe Norouzi Sarkati, Hamed Tashakkorian, Razieh Partovi, Somayeh Rahaiee
      Journal of Bioactive and Compatible Polymers.2019; 34(4-5): 309.     CrossRef
    • A critical review of analytical methods for determination of curcuminoids in turmeric
      Venkata Subba Rao Kotra, Laishram Satyabanta, Tridib Kumar Goswami
      Journal of Food Science and Technology.2019; 56(12): 5153.     CrossRef
    • Antibacterial activity of new structural class of semisynthetic molecule, triphenyl-phosphonium conjugated diarylheptanoid
      Shweta Kumari, Sundarraj Jayakumar, Gagan D. Gupta, Subhash C. Bihani, Deepak Sharma, Vijay K. Kutala, Santosh K. Sandur, Vinay Kumar
      Free Radical Biology and Medicine.2019; 143: 140.     CrossRef
    • Novel osmium(ii)–cymene complexes containing curcumin and bisdemethoxycurcumin ligands
      Riccardo Pettinari, Fabio Marchetti, Corrado Di Nicola, Claudio Pettinari, Massimiliano Cuccioloni, Laura Bonfili, Anna Maria Eleuteri, Bruno Therrien, Lucinda K. Batchelor, Paul J. Dyson
      Inorganic Chemistry Frontiers.2019; 6(9): 2448.     CrossRef
    • Loading natural emulsions with nutraceuticals using the pH-driven method: formation & stability of curcumin-loaded soybean oil bodies
      Bingjing Zheng, Xiaoyun Zhang, Helen Lin, David Julian McClements
      Food & Function.2019; 10(9): 5473.     CrossRef
    • Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects
      Raghavendhar R. Kotha, Devanand L. Luthria
      Molecules.2019; 24(16): 2930.     CrossRef
    • Improved Bioavailability of Curcumin in Gliadin-Protected Gold Quantum Cluster for Targeted Delivery
      Meegle S. Mathew, Kavya Vinod, Prasad S. Jayaram, Ramapurath S. Jayasree, Kuruvilla Joseph
      ACS Omega.2019; 4(10): 14169.     CrossRef
    • Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives
      Filippa Lo Cascio, Nicha Puangmalai, Anna Ellsworth, Fabio Bucchieri, Andrea Pace, Antonio Palumbo Piccionello, Rakez Kayed
      Scientific Reports.2019;[Epub]     CrossRef
    • Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats
      Hardik Ghelani, Valentina Razmovski-Naumovski, Dennis Chang, Srinivas Nammi
      BMC Nephrology.2019;[Epub]     CrossRef
    • Curcumin inhibits poly(dA:dT)-induced IL-18 secretion by inhibiting the ASC oligomerization in human keratinocytes
      Yujin Lee, Junghoon Kang, Mihee Yun, Seong-Beom Lee
      Molecular & Cellular Toxicology.2019; 15(4): 399.     CrossRef
    • The Effect of Curcumin in Patients with Chronic Fatigue Syndrome (or) Myalgic Encephalomyelitis Disparate Responses in Different Disease Severities
      MC van Campen C(Linda)
      Pharmacovigilance and Pharmacoepidemiology.2019; : 22.     CrossRef
    • Curcuma longa aqueous extract possesses tocolytic potentials

      Savannah Veterinary Journal.2019; : 1.     CrossRef
    • Antioxidant and Anti-Inflammatory Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Diabetic Rats
      Paul-Mihai Boarescu, Ioana Boarescu, Ioana Corina Bocșan, Dan Gheban, Adriana Elena Bulboacă, Cristina Nicula, Raluca Maria Pop, Ruxandra-Mioara Râjnoveanu, Sorana D. Bolboacă
      Antioxidants.2019; 8(10): 504.     CrossRef
    • Mechanistic Understanding of Curcumin’s Therapeutic Effects in Lung Cancer
      Wan Nur Baitty Wan Mohd Tajuddin, Nordin H. Lajis, Faridah Abas, Iekhsan Othman, Rakesh Naidu
      Nutrients.2019; 11(12): 2989.     CrossRef
    • The fallacy of enzymatic hydrolysis for the determination of bioactive curcumin in plasma samples as an indication of bioavailability: a comparative study
      Sidney J. Stohs, C. Y. O. Chen, Harry G. Preuss, Sidhartha D. Ray, Luke R. Bucci, Jin Ji, Kevin J. Ruff
      BMC Complementary and Alternative Medicine.2019;[Epub]     CrossRef
    • Potential of Curcumin in Skin Disorders
      Laura Vollono, Mattia Falconi, Roberta Gaziano, Federico Iacovelli, Emi Dika, Chiara Terracciano, Luca Bianchi, Elena Campione
      Nutrients.2019; 11(9): 2169.     CrossRef
    • Understanding Interactions of Curcumin with Lipid Bilayers: A Coarse-Grained Molecular Dynamics Study
      Nazar Ileri Ercan
      Journal of Chemical Information and Modeling.2019; 59(10): 4413.     CrossRef
    • Dietary Curcumin: Correlation between Bioavailability and Health Potential
      Michele Dei Cas, Riccardo Ghidoni
      Nutrients.2019; 11(9): 2147.     CrossRef
    • Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model
      Sabri Sudirman, Ching-Shu Lai, Yi-Ling Yan, Hung-I Yeh, Zwe-Ling Kong
      Scientific Reports.2019;[Epub]     CrossRef
    • Plant Bioactives and the Prevention of Prostate Cancer: Evidence from Human Studies
      Tracey L. Livingstone, Gemma Beasy, Robert D. Mills, Jenny Plumb, Paul W. Needs, Richard Mithen, Maria H. Traka
      Nutrients.2019; 11(9): 2245.     CrossRef
    • Is curcumin bioavailability a problem in humans: lessons from clinical trials
      Ajaikumar B. Kunnumakkara, Choudhary Harsha, Kishore Banik, Rajesh Vikkurthi, Bethsebie L. Sailo, Devivasha Bordoloi, Subash C. Gupta, Bharat B. Aggarwal
      Expert Opinion on Drug Metabolism & Toxicology.2019; 15(9): 705.     CrossRef
    • Turmeric, Pepper, Cinnamon, and Saffron Consumption and Mortality
      Maryam Hashemian, Hossein Poustchi, Gwen Murphy, Arash Etemadi, Farin Kamangar, Akram Pourshams, Masoud Khoshnia, Abdolsamad Gharavi, Paul J. Brennan, Paolo Boffetta, Sanford M. Dawsey, Christian C. Abnet, Reza Malekzadeh
      Journal of the American Heart Association.2019;[Epub]     CrossRef
    • Screening of curcumin analogues targeting Sortase A enzyme of Enterococcus faecalis: a molecular dynamics approach
      Muthusaravanan Sivaramakrishnan, Vivek Jagadeesan Sharavanan, D. Ruban Durairaj, Kumaravel Kandaswamy, Shanmughavel Piramanayagam, Ram Kothandan
      Journal of Proteins and Proteomics.2019; 10(3): 245.     CrossRef
    • A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-κB inactivation in colorectal cancer cells
      Seyung S. Chung, Pranabananda Dutta, Nathaniel Chard, Yong Wu, Qiao-Hong Chen, Guanglin Chen, Jaydutt Vadgama
      Oncotarget.2019; 10(44): 4516.     CrossRef
    • Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer
      Siqi Chen, Wei Gao, Min‑Juan Zhang, Jimmy Chan, Thian‑Sze Wong
      Oncology Letters.2019;[Epub]     CrossRef
    • Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives
      Takanori Tsuda
      Food & Function.2018; 9(2): 705.     CrossRef
    • Determination of oral bioavailability of curcuminoid dispersions and nanoemulsions prepared from Curcuma longa Linnaeus
      Pei Shan Lu, Baskaran Stephen Inbaraj, Bing Huei Chen
      Journal of the Science of Food and Agriculture.2018; 98(1): 51.     CrossRef
    • A Comparative Pharmacokinetic Assessment of a Novel Highly Bioavailable Curcumin Formulation with 95% Curcumin: A Randomized, Double-Blind, Crossover Study
      Sidney J. Stohs, Jin Ji, Luke R. Bucci, Harry G. Preuss
      Journal of the American College of Nutrition.2018; 37(1): 51.     CrossRef
    • Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial
      Gary W. Small, Prabha Siddarth, Zhaoping Li, Karen J. Miller, Linda Ercoli, Natacha D. Emerson, Jacqueline Martinez, Koon-Pong Wong, Jie Liu, David A. Merrill, Stephen T. Chen, Susanne M. Henning, Nagichettiar Satyamurthy, Sung-Cheng Huang, David Heber, J
      The American Journal of Geriatric Psychiatry.2018; 26(3): 266.     CrossRef
    • Curcumin and endometriosis: Review on potential roles and molecular mechanisms
      Tahereh Arablou, Roya Kolahdouz-Mohammadi
      Biomedicine & Pharmacotherapy.2018; 97: 91.     CrossRef
    • Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer’s disease
      Elham kheradmand, Akbar Hajizadeh Moghaddam, Mahboobeh Zare
      Biomedicine & Pharmacotherapy.2018; 97: 1096.     CrossRef
    • Antimicrobial wound dressing film utilizing cellulose nanocrystal as drug delivery system for curcumin
      Woei Yenn Tong, Ahmad Yassin Kamari bin Abdullah, Nur Amiera Syuhada binti Rozman, Muhamad Izul Aimin bin Wahid, Md. Sohrab Hossain, Leong Chean Ring, Yusriah Lazim, Wen-Nee Tan
      Cellulose.2018; 25(1): 631.     CrossRef
    • Hepatocellular uptake of cyclodextrin‐complexed curcumin during liver preservation: A feasibility study
      Saber Abdelkader Saidi, Nicolas Meurisse, Ina Jochmans, Veerle Heedfeld, Tine Wylin, Jaakko Parkkinen, Jacques Pirenne, Diethard Monbaliu, Abdelfattah El Feki, Jos van Pelt
      Biopharmaceutics & Drug Disposition.2018; 39(1): 18.     CrossRef
    • Facile and large-scale synthesis of curcumin/PVA hydrogel: effectively kill bacteria and accelerate cutaneous wound healing in the rat
      Fei He, Hongjing Jiao, Yu Tian, Libo Zhao, Xiaozhu Liao, Zengjie Fan, Bin Liu
      Journal of Biomaterials Science, Polymer Edition.2018; 29(4): 325.     CrossRef
    • Curcumin Cocrystal Micelles—Multifunctional Nanocomposites for Management of Neurodegenerative Ailments
      Preshita P. Desai, Vandana B. Patravale
      Journal of Pharmaceutical Sciences.2018; 107(4): 1143.     CrossRef
    • Targeting renal fibrosis: Mechanisms and drug delivery systems
      Madalina V. Nastase, Jinyang Zeng-Brouwers, Malgorzata Wygrecka, Liliana Schaefer
      Advanced Drug Delivery Reviews.2018; 129: 295.     CrossRef
    • Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
      Armine Haroyan, Vahan Mukuchyan, Nana Mkrtchyan, Naira Minasyan, Srbuhi Gasparyan, Aida Sargsyan, Mikael Narimanyan, Areg Hovhannisyan
      BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
    • Effect of Curcumin-Nanoemulsion Associated with Photodynamic Therapy in Cervical Carcinoma Cell Lines
      Renata Prandini Adum de Matos, Marilia Freitas Calmon, Camila Fernanda Amantino, Luisa Lina Villa, Fernando Lucas Primo, Antonio Claudio Tedesco, Paula Rahal
      BioMed Research International.2018; 2018: 1.     CrossRef
    • Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum
      Marco Cocorocchio, Amy J. Baldwin, Balint Stewart, Lou Kim, Adrian J. Harwood, Christopher R. L. Thompson, Paul L. R. Andrews, Robin S. B. Williams
      Disease Models & Mechanisms.2018;[Epub]     CrossRef
    • Enzymatic formation of curcumin in vitro and in vivo
      Jiaqing Wang, Taotao Xiong, Jie Zhou, Hongjian He, Dongdong Wu, Xuewen Du, Xingyi Li, Bing Xu
      Nano Research.2018; 11(6): 3453.     CrossRef
    • Pharmacokinetic-pharmacodynamic correlations in the development of ginger extract as an anticancer agent
      Rao Mukkavilli, Chunhua Yang, Reenu Singh Tanwar, Roopali Saxena, Sushma R. Gundala, Yingyi Zhang, Ahmed Ghareeb, Stephan D. Floyd, Subrahmanyam Vangala, Wei-Wen Kuo, Padmashree C. G. Rida, Ritu Aneja
      Scientific Reports.2018;[Epub]     CrossRef
    • New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity
      Yali Zhang, Zhiguo Liu, Jianzhang Wu, Bin Bai, Hongjin Chen, Zhongxiang Xiao, Lingfeng Chen, Yunjie Zhao, Hazel Lum, Yi Wang, Hong Zhang, Guang Liang
      European Journal of Medicinal Chemistry.2018; 148: 291.     CrossRef
    • Curcumin-mediated Photodynamic Therapy for the treatment of oral infections—A review
      Carolina Santezi, Bárbara Donadon Reina, Lívia Nordi Dovigo
      Photodiagnosis and Photodynamic Therapy.2018; 21: 409.     CrossRef
    • Nutraceuticals and osteoarthritis pain
      Angela Wang, Daniel J. Leong, Luis Cardoso, Hui B. Sun
      Pharmacology & Therapeutics.2018; 187: 167.     CrossRef
    • Which supplements can I recommend to my osteoarthritis patients?
      Xiaoqian Liu, Jillian Eyles, Andrew J McLachlan, Ali Mobasheri
      Rheumatology.2018; 57(suppl_4): iv75.     CrossRef
    • Curcumin on the “flying carpets” to modulate different signal transduction cascades in cancers: Next‐generation approach to bridge translational gaps
      Hulya Celik, Tuba Aydin, Kubra Solak, Sumbul Khalid, Ammad A. Farooqi
      Journal of Cellular Biochemistry.2018; 119(6): 4293.     CrossRef
    • Water Soluble Octenyl Succinylated Cassava Starch‐Curcumin Nanoformulation With Enhanced Bioavailability and Anticancer Potential
      Geetha K. Athira, Alummoottil N. Jyothi, Vijayakumar R. Vishnu
      Starch - Stärke.2018;[Epub]     CrossRef
    • Inhibition of Protein Aggregation by Several Antioxidants
      Samra Hasanbašić, Alma Jahić, Selma Berbić, Magda Tušek Žnidarič, Eva Žerovnik, Swaran J. S. Flora
      Oxidative Medicine and Cellular Longevity.2018;[Epub]     CrossRef
    • Dose-reduction antiangiogenic curcumin-low molecular weight heparin nanodrugs for enhanced combinational antitumor therapy
      Yan Xiao, Cheng Xu, Hui Xiong, Shi Du, Jianping Zhou, Lifang Yin, Jing Yao
      European Journal of Pharmaceutical Sciences.2018; 119: 121.     CrossRef
    • Investigational agents to enhance the efficacy of chemotherapy or radiation in pancreatic cancer
      Myrna Hurtado, Umesh T. Sankpal, Amalendu Ranjan, Rajasekhar Maram, Jamboor K. Vishwanatha, Ganji Purnachandra Nagaraju, Bassel F. El-Rayes, Riyaz Basha
      Critical Reviews in Oncology/Hematology.2018; 126: 201.     CrossRef
    • Effects of PCL, PEG and PLGA polymers on curcumin release from calcium phosphate matrix for in vitro and in vivo bone regeneration
      Susmita Bose, Naboneeta Sarkar, Dishary Banerjee
      Materials Today Chemistry.2018; 8: 110.     CrossRef
    • An LC–MS/MS method for simultaneous determination of curcumin, curcumin glucuronide and curcumin sulfate in a phase II clinical trial
      Sandeep R. Kunati, Shuming Yang, Basem M. William, Yan Xu
      Journal of Pharmaceutical and Biomedical Analysis.2018; 156: 189.     CrossRef
    • Dietary addition of a standardized extract of turmeric (TurmaFEEDTM) improves growth performance and carcass quality of broilers
      Johannah NM, Ashil Joseph, Balu Maliakel, Krishnakumar IM
      Journal of Animal Science and Technology.2018;[Epub]     CrossRef
    • NGF and PI3K/Akt signaling participate in the ventral motor neuronal protection of curcumin in sciatic nerve injury rat models
      Qiuling Sang, Daju Sun, Zonghan Chen, Weijia Zhao
      Biomedicine & Pharmacotherapy.2018; 103: 1146.     CrossRef
    • The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease
      Maja Jazvinšćak Jembrek, Neda Slade, Patrick R. Hof, Goran Šimić
      Progress in Neurobiology.2018; 168: 104.     CrossRef
    • Curcumin, A Polyphenolic Curcuminoid With Its Protective Effects and Molecular Mechanisms in Diabetes and Diabetic Cardiomyopathy
      Jia Zheng, Jing Cheng, Sheng Zheng, Qianyun Feng, Xinhua Xiao
      Frontiers in Pharmacology.2018;[Epub]     CrossRef
    • Endometriosis and food habits: Can diet make the difference?
      Ilaria Soave, Tommaso Occhiali, Jean-Marie Wenger, Nicola Pluchino, Donatella Caserta, Roberto Marci
      Journal of Endometriosis and Pelvic Pain Disorders.2018; 10(2): 59.     CrossRef
    • Dendrosomal nanocurcumin and exogenous p53 can act synergistically to elicit anticancer effects on breast cancer cells
      Narges Baghi, Babak Bakhshinejad, Reihaneh Keshavarz, Sadegh Babashah, Majid Sadeghizadeh
      Gene.2018; 670: 55.     CrossRef
    • Evaluation of the Enhanced Antioxidant Activity of Curcumin within Exosomes by Fluorescence Monitoring
      Eun Seo Choi, Yoon Young Kang, Hyejung Mok
      Biotechnology and Bioprocess Engineering.2018; 23(2): 150.     CrossRef
    • Nanocarbon Effect of Smoking Biofilms for Effective Control
      Vimala Anthonydhason, Judy Gopal, Sechul Chun, Manikandan Muthu
      Journal of Cluster Science.2018; 29(4): 541.     CrossRef
    • Curcumin-loaded redox-responsive mesoporous silica nanoparticles for targeted breast cancer therapy
      Nana Li, Zhi Wang, Yongtai Zhang, Kai Zhang, Jianxu Xie, Ying Liu, Wansi Li, Nianping Feng
      Artificial Cells, Nanomedicine, and Biotechnology.2018; 46(sup2): 921.     CrossRef
    • Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bioavailability
      Ankit Parikh, Krishna Kathawala, Yunmei Song, Xin-Fu Zhou, Sanjay Garg
      Drug Delivery and Translational Research.2018; 8(5): 1389.     CrossRef
    • Curcumin: pharmaceutical solids as a platform to improve solubility and bioavailability
      Kuthuru Suresh, Ashwini Nangia
      CrystEngComm.2018; 20(24): 3277.     CrossRef
    • A comparative study to evaluate the efficacy of lycopene and curcumin in oral submucous fibrosis patients: A randomized clinical trial
      Gargi Saran, Deepak Umapathy, Neeta Misra, ShivakumarGaniga Channaiah, Priya Singh, Saurabh Srivastava, Sahana Shivakumar
      Indian Journal of Dental Research.2018; 29(3): 303.     CrossRef
    • The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1
      Felipe Teixeira Lima, Viviane Seba, Gabriel Silva, Guilherme Silva Torrezan, Carlos Roberto Polaquini, Vitor Caressato Pinhanelli, Seung J. Baek, Ana Lúcia Fachin, Luis Octavio Regasini, Mozart Marins
      International Journal of Molecular Sciences.2018; 19(7): 1909.     CrossRef
    • Bent Keto Form of Curcumin, Preferential Stabilization of Enol by Piperine, and Isomers of Curcumin∩Cyclodextrin Complexes: Insights from Ion Mobility Mass Spectrometry
      Abhijit Nag, Papri Chakraborty, Ganapati Natarajan, Ananya Baksi, Sathish Kumar Mudedla, Venkatesan Subramanian, Thalappil Pradeep
      Analytical Chemistry.2018; 90(15): 8776.     CrossRef
    • Potential synergistic effects of quercetin with other phytoconstituents of Costus pictus (insulin plant) extract in the control of hyperglycemia and prevention of NSAID-induced gastroenteropathy in diabetic rats
      Swapnil P. Borse, Devendra Pratap Singh, Dilawar Upadhyay, Manish Nivsarkar
      Food and Chemical Toxicology.2018; 120: 448.     CrossRef
    • Curcumin as a therapeutic agent for blocking NF-κB activation in ulcerative colitis
      Yiqing Wang, Qichun Tang, Peibei Duan, Lihua Yang
      Immunopharmacology and Immunotoxicology.2018; 40(6): 476.     CrossRef
    • Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure
      Levi W. Evans, Bradley S. Ferguson
      Nutrients.2018; 10(8): 1120.     CrossRef
    • Site-directed non-covalent polymer-drug complexes for inflammatory bowel disease (IBD): Formulation development, characterization and pharmacological evaluation
      Siddharth S. Kesharwani, Rizwan Ahmad, Mohammed Ali Bakkari, Mrigendra K.S. Rajput, Rakesh Dachineni, Chaitanya K. Valiveti, Saurabh Kapur, G. Jayarama Bhat, Amar B. Singh, Hemachand Tummala
      Journal of Controlled Release.2018; 290: 165.     CrossRef
    • The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients’ self‐reported well‐being: A randomized double‐blind controlled trial
      Mohsen Masoodi, Mohammad Ali Mahdiabadi, Marjan Mokhtare, Sharam Agah, Amir Hossein Faghihi Kashani, Amir Mansoor Rezadoost, Mohammad Sabzikarian, Atefeh Talebi, Amirhossein Sahebkar
      Journal of Cellular Biochemistry.2018; 119(11): 9552.     CrossRef
    • Mechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectives
      Muhammad Younas, Christophe Hano, Nathalie Giglioli-Guivarc'h, Bilal Haider Abbasi
      RSC Advances.2018; 8(52): 29714.     CrossRef
    • Janus nanocarriers for magnetically targeted and hyperthermia-enhanced curcumin therapy of liver cancer
      Hao Xing, Zheng Wang, Dan Shao, Zhimin Chang, Mingfeng Ge, Li Li, Mingdi Wu, Zhuangzhi Yan, Wenfei Dong
      RSC Advances.2018; 8(53): 30448.     CrossRef
    • Complementary and Alternative Medicine Therapies for Psoriasis
      A. Caresse Gamret, Alexandra Price, Raymond M. Fertig, Hadar Lev-Tov, Anna J. Nichols
      JAMA Dermatology.2018; 154(11): 1330.     CrossRef
    • A sustainable production method of mycelium biomass using an isolated fungal strain Phanerochaete chrysosporium (accession no: KY593186): Its exploitation in wound healing patch formation
      Moumita Khamrai, Sovan Lal Banerjee, Patit Paban Kundu
      Biocatalysis and Agricultural Biotechnology.2018;[Epub]     CrossRef
    • Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery
      Chutima Jantarat, Pornpak Sirathanarun, Somruedee Boonmee, Wanida Meechoosin, Husna Wangpittaya
      Scientia Pharmaceutica.2018; 86(3): 39.     CrossRef
    • A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study
      Naveen T. Krishnareddy, Jestin V. Thomas, Saritha S. Nair, Johannah N. Mulakal, Balu P. Maliakel, I. M. Krishnakumar
      BioMed Research International.2018; 2018: 1.     CrossRef
    • Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer
      Namrata Khurana, Suresh Sikka
      Cancers.2018; 10(10): 352.     CrossRef
    • Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the model drug curcumin
      Beatriz D. Cardoso, Irina S. R. Rio, Ana Rita O. Rodrigues, Francisca C. T. Fernandes, B. G. Almeida, A. Pires, A. M. Pereira, J. P. Araújo, Elisabete M. S. Castanheira, Paulo J. G. Coutinho
      Royal Society Open Science.2018; 5(10): 181017.     CrossRef
    • Effect of quercetin on myocardial potency of curcumin against ischemia reperfusion induced myocardial toxicity
      Manodeep Chakraborty, Mohammed Gulzar Ahmed, Ananya Bhattacharjee
      Synergy.2018; 7: 25.     CrossRef
    • Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives
      Xiao-Yu Xu, Xiao Meng, Sha Li, Ren-You Gan, Ya Li, Hua-Bin Li
      Nutrients.2018; 10(10): 1553.     CrossRef
    • Brazilian Curcuma longa L. attenuates comorbidities by modulating adipose tissue dysfunction in obese rats
      Angelo Thompson Colombo Lo, Fabiane Valentini Francisqueti, Fabiana Kurokawa Hasimoto, Ana Paula Costa Rodrigues Ferraz, Igor Otávio Minatel, Jéssica Leite Garcia, Klinsmann Carolo dos Santos, Pedro Henrique Rizzi Alves, Giuseppina Pace Pereira Lima, Fern
      Nutrire.2018;[Epub]     CrossRef
    • Development of UPLC–MS/MS method for quantitative analysis of curcumin in human plasma
      Hayun Hayun, Rina Rahmawati, Yahdiana Harahap, Santi Purna Sari
      Acta Chromatographica.2018; 30(4): 207.     CrossRef
    • Chemoprevention of Colorectal Cancer by Dietary Compounds
      Teodora Costea, Ariana Hudiță, Oana-Alina Ciolac, Bianca Gălățeanu, Octav Ginghină, Marieta Costache, Constanța Ganea, Maria-Magdalena Mocanu
      International Journal of Molecular Sciences.2018; 19(12): 3787.     CrossRef
    • Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin
      Rehab Ibrahim Ali, Mahrous Abdelbasset Ibrahim
      Egyptian Journal of Forensic Sciences.2018;[Epub]     CrossRef
    • Acquired Resilience: An Evolved System of Tissue Protection in Mammals
      Jonathan Stone, John Mitrofanis, Daniel M. Johnstone, Benedetto Falsini, Silvia Bisti, Paul Adam, Arturo Bravo Nuevo, Mindy George-Weinstein, Rebecca Mason, Janis Eells
      Dose-Response.2018;[Epub]     CrossRef
    • Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer’s disease mouse model
      Yi-Heng Tai, Yu-Yi Lin, Kai-Chen Wang, Chao-Lin Chang, Ru-Yin Chen, Chia-Chu Wu, Irene H. Cheng
      Oncotarget.2018; 9(12): 10681.     CrossRef
    • Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging
      Carolina Simioni, Giorgio Zauli, Alberto M. Martelli, Marco Vitale, Gianni Sacchetti, Arianna Gonelli, Luca M. Neri
      Oncotarget.2018; 9(24): 17181.     CrossRef
    • Effects of turmeric curcuminoids and metformin against central sensitivity to pain in mice
      Suruchi Verma, Deepak Mundkinajeddu, Amit Agarwal, Shyam Sunder Chatterjee, Vikas Kumar
      Journal of Traditional and Complementary Medicine.2017; 7(2): 145.     CrossRef
    • In vivo and in vitro effects of curcumin on head and neck carcinoma: a systematic review
      Gabriel Álvares Borges, Daniela Fortunato Rêgo, Daniele Xavier Assad, Ricardo D. Coletta, Graziela De Luca Canto, Eliete Neves Silva Guerra
      Journal of Oral Pathology & Medicine.2017; 46(1): 3.     CrossRef
    • Understanding curcumin-induced modulation of protein aggregation
      Basir Ahmad, Mohanish S. Borana, Ankur P. Chaudhary
      International Journal of Biological Macromolecules.2017; 100: 89.     CrossRef
    • Development of resveratrol-curcumin hybrids as potential therapeutic agents for inflammatory lung diseases
      Jialing Pan, Tingting Xu, Fengli Xu, Yali Zhang, Zhiguo Liu, Wenbo Chen, Weitao Fu, Yuanrong Dai, Yunjie Zhao, Jianpeng Feng, Guang Liang
      European Journal of Medicinal Chemistry.2017; 125: 478.     CrossRef
    • Enhancement of Curcumin Bioavailability Via the Prodrug Approach: Challenges and Prospects
      Pahweenvaj Ratnatilaka Na Bhuket, Asma El-Magboub, Ian S. Haworth, Pornchai Rojsitthisak
      European Journal of Drug Metabolism and Pharmacokinetics.2017; 42(3): 341.     CrossRef
    • Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy
      Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Vijayasree V. Giridharan, Remya Sreedhar, Rajendran J.C. Bose, Jyothi Vanama, Suresh S. Palaniyandi, Tetsuya Konishi, Kenichi Watanabe, Rajarajan A. Thandavarayan
      Nutrition.2017; 34: 47.     CrossRef
    • Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases
      Ajaikumar B Kunnumakkara, Devivasha Bordoloi, Ganesan Padmavathi, Javadi Monisha, Nand Kishor Roy, Sahdeo Prasad, Bharat B Aggarwal
      British Journal of Pharmacology.2017; 174(11): 1325.     CrossRef
    • HPV16 induces a wasting syndrome in transgenic mice: Amelioration by dietary polyphenols via NF-κB inhibition
      Rui M. Gil da Costa, Sofia Aragão, Magda Moutinho, Antonieta Alvarado, Diogo Carmo, Fátima Casaca, Sandra Silva, Joana Ribeiro, Hugo Sousa, Rita Ferreira, Rita Nogueira-Ferreira, Maria João Pires, Bruno Colaço, Rui Medeiros, Carlos Venâncio, Maria Manuel
      Life Sciences.2017; 169: 11.     CrossRef
    • Platinum(II) Complexes of Curcumin Showing Photocytotoxicity in Visible Light
      Koushambi Mitra, Srishti Gautam, Paturu Kondaiah, Akhil R. Chakravarty
      European Journal of Inorganic Chemistry.2017; 2017(12): 1753.     CrossRef
    • Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies
      Hamed Mirzaei, Abolfazl Shakeri, Bahman Rashidi, Amin Jalili, Zarrin Banikazemi, Amirhossein Sahebkar
      Biomedicine & Pharmacotherapy.2017; 85: 102.     CrossRef
    • Curcumin, a Compound from Natural Sources, a True Scientific Challenge – A Review
      Zorka Stanić
      Plant Foods for Human Nutrition.2017; 72(1): 1.     CrossRef
    • Efficacy of Curcuma for Treatment of Osteoarthritis
      Kimberly Perkins, William Sahy, Robert D. Beckett
      Journal of Evidence-Based Complementary & Alternative Medicine.2017; 22(1): 156.     CrossRef
    • Injectable dopamine‐modified poly(α,β‐aspartic acid) nanocomposite hydrogel as bioadhesive drug delivery system
      Chu Gong, Caicai Lu, Bingqiang Li, Meng Shan, Guolin Wu
      Journal of Biomedical Materials Research Part A.2017; 105(4): 1000.     CrossRef
    • High drug payload curcumin nanosuspensions stabilized by mPEG-DSPE and SPC: in vitro and in vivo evaluation
      Jingyi Hong, Yingying Liu, Yao Xiao, Xiaofeng Yang, Wenjing Su, Mingzhu Zhang, Yonghong Liao, Haixue Kuang, Xiangtao Wang
      Drug Delivery.2017; 24(1): 109.     CrossRef
    • Curcumin complexation with cyclodextrins by the autoclave process: Method development and characterization of complex formation
      Turki Al Hagbani, Sami Nazzal
      International Journal of Pharmaceutics.2017; 520(1-2): 173.     CrossRef
    • ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases
      Alexandru Filippi, Oana-Alina Ciolac, Constanța Ganea, Maria-Magdalena Mocanu
      Journal of Oncology.2017; 2017: 1.     CrossRef
    • Preparation of a novel bioavailable curcuminoid formulation (Cureit™) using Polar-Nonpolar-Sandwich (PNS) technology and its characterization and applications
      Augustine Amalraj, Shintu Jude, Karthik Varma, Joby Jacob, Sreeraj Gopi, Oluwatobi S. Oluwafemi, Sabu Thomas
      Materials Science and Engineering: C.2017; 75: 359.     CrossRef
    • Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis
      Rabah Rashad Falah, Wamidh H. Talib, Seba Jamal Shbailat
      Therapeutic Advances in Medical Oncology.2017; 9(4): 235.     CrossRef
    • Curcumin Nanotechnologies and Its Anticancer Activity
      Parasuraman Aiya Subramani, Kalpana Panati, Venkata Ramireddy Narala
      Nutrition and Cancer.2017; 69(3): 381.     CrossRef
    • New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds
      Saúl Redondo-Blanco, Javier Fernández, Ignacio Gutiérrez-del-Río, Claudio J. Villar, Felipe Lombó
      Frontiers in Pharmacology.2017;[Epub]     CrossRef
    • Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers
      Chih-Hung Lin, Chun-Han Chen, Zih-Chan Lin, Jia-You Fang
      Journal of Food and Drug Analysis.2017; 25(2): 219.     CrossRef
    • Curcumin and linseed oil co-delivered in phospholipid nanoemulsions enhances the levels of docosahexaenoic acid in serum and tissue lipids of rats
      D. Sugasini, B.R. Lokesh
      Prostaglandins, Leukotrienes and Essential Fatty Acids.2017; 119: 45.     CrossRef
    • Bio-synthesis of peppermint leaf extract polyphenols capped nano-platinum and their in-vitro cytotoxicity towards colon cancer cell lines (HCT 116)
      Chuang Yang, Minghua Wang, Junde Zhou, Qiang Chi
      Materials Science and Engineering: C.2017; 77: 1012.     CrossRef
    • Natural product-based amyloid inhibitors
      Paul Velander, Ling Wu, Frances Henderson, Shijun Zhang, David R. Bevan, Bin Xu
      Biochemical Pharmacology.2017; 139: 40.     CrossRef
    • Overcoming the exacerbating effects of ranitidine on NSAID-induced small intestinal toxicity with quercetin: Providing a complete GI solution
      Devendra Pratap Singh, Swapnil P. Borse, Manish Nivsarkar
      Chemico-Biological Interactions.2017; 272: 53.     CrossRef
    • Improving antioxidant and antimicrobial properties of curcumin by means of encapsulation in gelatin through electrohydrodynamic atomization
      J. Gómez-Estaca, M.P. Balaguer, G. López-Carballo, R. Gavara, P. Hernández-Muñoz
      Food Hydrocolloids.2017; 70: 313.     CrossRef
    • Selective Targeting of Cancer Cells by Oxidative Vulnerabilities with Novel Curcumin Analogs
      Christopher Pignanelli, Dennis Ma, Megan Noel, Jesse Ropat, Fadi Mansour, Colin Curran, Simon Pupulin, Kristen Larocque, Jianzhang Wu, Guang Liang, Yi Wang, Siyaram Pandey
      Scientific Reports.2017;[Epub]     CrossRef
    • Arctigenin inhibits prostate tumor cell growth in vitro and in vivo
      Piwen Wang, Walter Solorzano, Tanya Diaz, Clara E. Magyar, Susanne M. Henning, Jaydutt V. Vadgama
      Clinical Nutrition Experimental.2017; 13: 1.     CrossRef
    • Towards the antioxidant therapy in Osteoarthritis: Contribution of nanotechnology
      M.L. González-Rodríguez, A.M. Fernández-Romero, A.M. Rabasco
      Journal of Drug Delivery Science and Technology.2017; 42: 94.     CrossRef
    • Enhancement of Curcumin Bioavailability Using Nanocellulose Reinforced Chitosan Hydrogel
      Thennakoon Udeni Gunathilake, Yern Ching, Cheng Chuah
      Polymers.2017; 9(2): 64.     CrossRef
    • Hepatoprotective effect of Phytosome Curcumin against paracetamol-induced liver toxicity in mice
      Bui Thanh Tung, Nguyen Thanh Hai, Phan Ke Son
      Brazilian Journal of Pharmaceutical Sciences.2017;[Epub]     CrossRef
    • Thermal, Structural and Mechanical Properties of Melt Drawn Cur-loaded Poly(lactic acid) Fibers
      I.S.S. Sharifah, A.A.B. Qairol, H.N. Azlina, M.K. Nor Khairusshima
      Procedia Engineering.2017; 184: 544.     CrossRef
    • The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer
      Jingna Su, Xiuxia Zhou, Xuyuan Yin, Lixia Wang, Zhe Zhao, Yingying Hou, Nana Zheng, Jun Xia, Zhiwei Wang
      Biochemical Pharmacology.2017; 140: 28.     CrossRef
    • Curcumin Anti-Apoptotic Action in a Model of Intestinal Epithelial Inflammatory Damage
      Claudia Loganes, Sara Lega, Matteo Bramuzzo, Liza Vecchi Brumatti, Elisa Piscianz, Erica Valencic, Alberto Tommasini, Annalisa Marcuzzi
      Nutrients.2017; 9(6): 578.     CrossRef
    • Effects of starch composition and type of non-solvent on the formation of starch nanoparticles and improvement of curcumin stability in aqueous media
      Rohollah Sadeghi, Zsazsa Daniella, Suzan Uzun, Jozef Kokini
      Journal of Cereal Science.2017;[Epub]     CrossRef
    • Improved antioxidant activity and physicochemical properties of curcumin by adding ovalbumin and its structural characterization
      Yujia Liu, Danyang Ying, Yanxue Cai, Xueyi Le
      Food Hydrocolloids.2017; 72: 304.     CrossRef
    • Effects of liposomal-curcumin on five opportunistic bacterial strains found in the equine hindgut - preliminary study
      S. D. Bland, E. B. Venable, J. L. McPherson, R. L. Atkinson
      Journal of Animal Science and Technology.2017;[Epub]     CrossRef
    • A Pilot Study on the Effects of Curcumin on Parasites, Inflammation, and Opportunistic Bacteria in Riding Horses
      Samantha Wuest, Rebecca L. Atkinson, Stephanie D. Bland, Darcie Hastings
      Journal of Equine Veterinary Science.2017; 57: 46.     CrossRef
    • Ginsenoside improves physicochemical properties and bioavailability of curcumin-loaded nanostructured lipid carrier
      Ajay Vijayakumar, Rengarajan Baskaran, Han-Joo Maeng, Bong Kyu Yoo
      Archives of Pharmacal Research.2017; 40(7): 864.     CrossRef
    • Multifunctional Nanotube–Mucoadhesive Poly(methyl vinyl ether‐co‐maleic acid)@Hydroxypropyl Methylcellulose Acetate Succinate Composite for Site‐Specific Oral Drug Delivery
      Nattha Kerdsakundee, Wei Li, João Pedro Martins, Zehua Liu, Feng Zhang, Marianna Kemell, Alexandra Correia, Yaping Ding, Mikko Airavaara, Jouni Hirvonen, Ruedeekorn Wiwattanapatapee, Hélder A. Santos
      Advanced Healthcare Materials.2017;[Epub]     CrossRef
    • Curcumin, a component of turmeric, efficiently prevents diclofenac sodium-induced gastroenteropathic damage in rats: A step towards translational medicine
      Devendra Pratap Singh, Swapnil P. Borse, Rita Rana, Manish Nivsarkar
      Food and Chemical Toxicology.2017; 108: 43.     CrossRef
    • Tetrahydrocurcumin attenuates carbon tetrachloride-induced hepatic fibrogenesis by inhibiting the activation and autophagy of hepatic stellate cells
      Mei-Ling Tsai, Siao-Ping Tsai, Chi-Tang Ho
      Journal of Functional Foods.2017; 36: 418.     CrossRef
    • Nanocurcumin is superior to native curcumin in preventing degenerative changes in Experimental Cerebral Malaria
      Chaitanya Dende, Jairam Meena, Perumal Nagarajan, Viswanathan Arun Nagaraj, Amulya Kumar Panda, Govindarajan Padmanaban
      Scientific Reports.2017;[Epub]     CrossRef
    • The Effects of Curcumin and Curcumin–Phospholipid Complex on the Serum Pro‐oxidant–Antioxidant Balance in Subjects with Metabolic Syndrome
      Maryam Ghazimoradi, Maryam Saberi‐Karimian, Farzane Mohammadi, Amirhossein Sahebkar, Shima Tavallaie, Hamideh Safarian, Gordon A. Ferns, Majid Ghayour‐Mobarhan, Mohsen Moohebati, Habibollah Esmaeili, Malihe Ahmadinejad
      Phytotherapy Research.2017; 31(11): 1715.     CrossRef
    • Curcumin revitalizes Amyloid beta (25–35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2
      Bibekananda Sarkar, Monisha Dhiman, Sunil Mittal, Anil K. Mantha
      Metabolic Brain Disease.2017; 32(6): 2045.     CrossRef
    • Curcumin bioactive nanosizing: Increase of bioavailability
      Lívia C. Massimino, Henrique A.M. Faria, Sergio A. Yoshioka
      Industrial Crops and Products.2017; 109: 493.     CrossRef
    • Visible Light-Cured Glycol Chitosan Hydrogel Containing a Beta-Cyclodextrin-Curcumin Inclusion Complex Improves Wound Healing In Vivo
      Sun-Jung Yoon, Hoon Hyun, Deok-Won Lee, Dae Yang
      Molecules.2017; 22(9): 1513.     CrossRef
    • Comparative Oral Absorption of Curcumin in a Natural Turmeric Matrix with Two Other Curcumin Formulations: An Open‐label Parallel‐arm Study
      Sreeraj Gopi, Joby Jacob, Karthik Varma, Shintu Jude, Augustine Amalraj, C.A. Arundhathy, Robin George, T.R. Sreeraj, C. Divya, Ajaikumar B. Kunnumakkara, Sidney J. Stohs
      Phytotherapy Research.2017; 31(12): 1883.     CrossRef
    • Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin
      Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Ramesh Gupta
      The AAPS Journal.2017; 19(6): 1691.     CrossRef
    • Delivering Natural Products and Biotherapeutics to Improve Drug Efficacy
      Mohammad A. Obeid, Mohammed M. Al Qaraghuli, Manal Alsaadi, Abdullah R. Alzahrani, Kanidta Niwasabutra, Valerie A. Ferro
      Therapeutic Delivery.2017; 8(11): 947.     CrossRef
    • Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity
      Sundarraj Jayakumar, Raghavendra S. Patwardhan, Debojyoti Pal, Babita Singh, Deepak Sharma, Vijay Kumar Kutala, Santosh Kumar Sandur
      Free Radical Biology and Medicine.2017; 113: 530.     CrossRef
    • Drug-loaded nanoemulsion as positive control is an alternative to DMSO solutions for in vitro evaluation of curcumin delivery to MCF-7 cells
      Eduarda Schultze, Karine Coradini, Paula dos Santos Chaves, Liziane Pereira da Silva, Julieti Buss, Silvia S. Guterres, Tiago Collares, Ruy Carlos Ruver Beck, Adriana R. Pohlmann, Fabiana Kömmling Seixas
      Pharmacological Reports.2017; 69(6): 1408.     CrossRef
    • Efficacité thérapeutique comme ligne de fuite
      Julie Laplante, Marcus Sacrini
      Anthropologie et Sociétés.2017; 40(3): 137.     CrossRef
    • Curcumin limits weight gain, adipose tissue growth, and glucose intolerance following the cessation of exercise and caloric restriction in rats
      Trevor Teich, Jacklyn A. Pivovarov, Deanna P. Porras, Emily C. Dunford, Michael C. Riddell
      Journal of Applied Physiology.2017; 123(6): 1625.     CrossRef
    • The Role of Compounds Derived from Natural Supplement as Anticancer Agents in Renal Cell Carcinoma: A Review
      Inamul Haque, Arvind Subramanian, Chao Huang, Andrew Godwin, Peter Van Veldhuizen, Snigdha Banerjee, Sushanta Banerjee
      International Journal of Molecular Sciences.2017; 19(1): 107.     CrossRef
    • Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems
      Arpa Petchsomrit, Namfa Sermkaew, Ruedeekorn Wiwattanapatapee
      Scientia Pharmaceutica.2017; 85(1): 11.     CrossRef
    • Curcumin in Hepatobiliary Disease: Pharmacotherapeutic Properties and Emerging Potential Clinical Applications
      Robert W. Hu, Elizabeth J. Carey, Keith D. Lindor, James H. Tabibian
      Annals of Hepatology.2017; 16(6): 835.     CrossRef
    • Curcumin mediates anticancer effects by modulating multiple cell signaling pathways
      Ajaikumar B. Kunnumakkara, Devivasha Bordoloi, Choudhary Harsha, Kishore Banik, Subash C. Gupta, Bharat B. Aggarwal
      Clinical Science.2017; 131(15): 1781.     CrossRef
    • Nanoformulations of curcumin: an emerging paradigm for improved remedial application
      Meeta Gera, Neelesh Sharma, Mrinmoy Ghosh, Do Luong Huynh, Sung Jin Lee, Taesun Min, Taeho Kwon, Dong Kee Jeong
      Oncotarget.2017; 8(39): 66680.     CrossRef
    • Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line
      Laura Masuelli, Monica Benvenuto, Enrica Di Stefano, Rosanna Mattera, Massimo Fantini, Giuseppina De Feudis, Enrico De Smaele, Ilaria Tresoldi, Maria Gabriella Giganti, Andrea Modesti, Roberto Bei
      Oncotarget.2017; 8(21): 34405.     CrossRef
    • TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma
      Longzhu Piao, Sumit Mukherjee, Qing Chang, Xiujie Xie, Hong Li, Mario R. Castellanos, Probal Banerjee, Hassan Iqbal, Ryan Ivancic, Xueqian Wang, Theodoros N. Teknos, Quintin Pan
      Oncotarget.2017; 8(36): 60025.     CrossRef
    • Polyethylenimine‐modified curcumin‐loaded mesoporus silica nanoparticle (MCM‐41) induces cell death in MCF‐7 cell line
      Lakshminarasimhan Harini, Bose Karthikeyan, Sweta Srivastava, Srinag Bangalore Suresh, Cecil Ross, Georgepeter Gnanakumar, Srinivasan Rajagopal, Krishnan Sundar, Thandavarayan Kathiresan
      IET Nanobiotechnology.2017; 11(1): 57.     CrossRef
    • Curcuminoids from Curcuma longa L. reduced intestinal mucositis induced by 5-fluorouracil in mice: Bioadhesive, proliferative, anti-inflammatory and antioxidant effects
      Edvande Xavier dos Santos Filho, Paulo Henrique Marcelino Ávila, Carla Caroline Cunha Bastos, Aline Carvalho Batista, Letícia Nasser Naves, Ricardo Neves Marreto, Eliana Martins Lima, Elismauro Frascisco Mendonça, Marize Campos Valadares
      Toxicology Reports.2016; 3: 55.     CrossRef
    • Molecular complexation of curcumin with pH sensitive cationic copolymer enhances the aqueous solubility, stability and bioavailability of curcumin
      Sunny Kumar, Siddharth S. Kesharwani, Himanshi Mathur, Mohit Tyagi, G. Jayarama Bhat, Hemachand Tummala
      European Journal of Pharmaceutical Sciences.2016; 82: 86.     CrossRef
    • Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease
      K. G. Goozee, T. M. Shah, H. R. Sohrabi, S. R. Rainey-Smith, B. Brown, G. Verdile, R. N. Martins
      British Journal of Nutrition.2016; 115(3): 449.     CrossRef
    • Cyclodextrin‐based nanosponges: a versatile platform for cancer nanotherapeutics development
      Shankar Swaminathan, Roberta Cavalli, Francesco Trotta
      WIREs Nanomedicine and Nanobiotechnology.2016; 8(4): 579.     CrossRef
    • Neuroprotective effect of curcumin-loaded lactoferrin nano particles against rotenone induced neurotoxicity
      V. Satish Bollimpelli, Prashant Kumar, Sonali Kumari, Anand K. Kondapi
      Neurochemistry International.2016; 95: 37.     CrossRef
    • Molecular mechanisms underlying chemopreventive potential of curcumin: Current challenges and future perspectives
      Gaurav Kumar, Sonam Mittal, Katrin Sak, Hardeep Singh Tuli
      Life Sciences.2016; 148: 313.     CrossRef
    • Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery
      Jayachandran Venkatesan, Sukumaran Anil, Se-Kwon Kim, Min Shim
      Polymers.2016; 8(2): 30.     CrossRef
    • Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin – The importance of turmerones
      Grace Gar-Lee Yue, Lei Jiang, Hin-Fai Kwok, Julia Kin-Ming Lee, Kar-Man Chan, Kwok-Pui Fung, Ping-Chung Leung, Clara Bik-San Lau
      Journal of Functional Foods.2016; 22: 565.     CrossRef
    • Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study
      Dinesh Kumar, Della Jacob, Subash PS, Abhilash Maliakkal, Johannah NM, Ramadassan Kuttan, Balu Maliakel, Veera Konda, Krishnakumar IM
      Journal of Functional Foods.2016; 22: 578.     CrossRef
    • Quantitation of curcuminoid contents, dissolution profile, and volatile oil content of turmeric capsules produced at some secondary government hospitals
      Chaowalit Monton, Laksana Charoenchai, Jirapornchai Suksaeree, Lukman Sueree
      Journal of Food and Drug Analysis.2016; 24(3): 493.     CrossRef
    • Curcumin and Health
      Mario Pulido-Moran, Jorge Moreno-Fernandez, Cesar Ramirez-Tortosa, MCarmen Ramirez-Tortosa
      Molecules.2016; 21(3): 264.     CrossRef
    • Is Curcumin a Chemopreventive Agent for Colorectal Cancer?
      Bernard Uzzan, Robert Benamouzig
      Current Colorectal Cancer Reports.2016; 12(1): 35.     CrossRef
    • Piperine Augments the Protective Effect of Curcumin Against Lipopolysaccharide-Induced Neurobehavioral and Neurochemical Deficits in Mice
      Ashok Jangra, Mohit Kwatra, Tavleen Singh, Rajat Pant, Pawan Kushwah, Yogita Sharma, Babita Saroha, Ashok Kumar Datusalia, Babul Kumar Bezbaruah
      Inflammation.2016;[Epub]     CrossRef
    • Chili Peppers, Curcumins, and Prebiotics in Gastrointestinal Health and Disease
      Tanisa Patcharatrakul, Sutep Gonlachanvit
      Current Gastroenterology Reports.2016;[Epub]     CrossRef
    • Nutrient management systems in turmeric: Effects on soil quality, rhizome yield and quality
      V. Srinivasan, C.K. Thankamani, R. Dinesh, K. Kandiannan, T.J. Zachariah, N.K. Leela, S. Hamza, O. Shajina, O. Ansha
      Industrial Crops and Products.2016; 85: 241.     CrossRef
    • Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection
      Xiyuan Bai, Rebecca E. Oberley‐Deegan, An Bai, Alida R. Ovrutsky, William H. Kinney, Michael Weaver, Gong Zhang, Jennifer R. Honda, Edward D. Chan
      Respirology.2016; 21(5): 951.     CrossRef
    • Preparation, characterization and photostability assessment of curcumin microencapsulated within methacrylic copolymers
      Tiziana M.G. Pecora, Simona Cianciolo, Alfio Catalfo, Guido De Guidi, Barbara Ruozi, Maria Chiara Cristiano, Donatella Paolino, Adriana C.E. Graziano, Massimo Fresta, Rosario Pignatello
      Journal of Drug Delivery Science and Technology.2016; 33: 88.     CrossRef
    • Activation of microbubbles by low-intensity pulsed ultrasound enhances the cytotoxicity of curcumin involving apoptosis induction and cell motility inhibition in human breast cancer MDA-MB-231 cells
      Yixiang Li, Pan Wang, Xiyang Chen, Jianmin Hu, Yichen Liu, Xiaobing Wang, Quanhong Liu
      Ultrasonics Sonochemistry.2016; 33: 26.     CrossRef
    • Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway
      Vicenç Ruiz de Porras, Sara Bystrup, Anna Martínez-Cardús, Raquel Pluvinet, Lauro Sumoy, Lynne Howells, Mark I. James, Chinenye Iwuji, José Luis Manzano, Laura Layos, Cristina Bugés, Albert Abad, Eva Martínez-Balibrea
      Scientific Reports.2016;[Epub]     CrossRef
    • Emu oil based nano-emulgel for topical delivery of curcumin
      Manish Kumar Jeengar, Sri Vishnu Kiran Rompicharla, Shweta Shrivastava, Naveen Chella, Nalini R. Shastri, V.G.M. Naidu, Ramakrishna Sistla
      International Journal of Pharmaceutics.2016; 506(1-2): 222.     CrossRef
    • Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer
      Amol Shindikar, Akshita Singh, Malcolm Nobre, Saurabh Kirolikar
      Journal of Oncology.2016; 2016: 1.     CrossRef
    • The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium
      Monica Benvenuto, Rosanna Mattera, Gloria Taffera, Maria Giganti, Paolo Lido, Laura Masuelli, Andrea Modesti, Roberto Bei
      Nutrients.2016; 8(5): 275.     CrossRef
    • Cardioprotective Potentials of Plant‐Derived Small Molecules against Doxorubicin Associated Cardiotoxicity
      Shreesh Ojha, Hasan Al Taee, Sameer Goyal, Umesh B. Mahajan, Chandrgouda R. Patil, D. S. Arya, Mohanraj Rajesh, Sidhartha D. Ray
      Oxidative Medicine and Cellular Longevity.2016;[Epub]     CrossRef
    • Water soluble nanocurcumin extracted from turmeric challenging the microflora from human oral cavity
      Judy Gopal, Manikandan Muthu, Se-Chul Chun
      Food Chemistry.2016; 211: 903.     CrossRef
    • Combined therapy using bevacizumab and turmeric ethanolic extract (with absorbable curcumin) exhibited beneficial efficacy in colon cancer mice
      Grace Gar-Lee Yue, Hin-Fai Kwok, Julia Kin-Ming Lee, Lei Jiang, Eric Chun-Wai Wong, Si Gao, Hing-Lok Wong, Lin Li, Kar-Man Chan, Ping-Chung Leung, Kwok-Pui Fung, Zhong Zuo, Clara Bik-San Lau
      Pharmacological Research.2016; 111: 43.     CrossRef
    • Potential of curcumin-mediated photodynamic inactivation to reduce oral colonization
      Carolina Santezi, Juliane M.G. Tanomaru, Vanderlei S. Bagnato, Osmir B. Oliveira Júnior, Lívia N. Dovigo
      Photodiagnosis and Photodynamic Therapy.2016; 15: 46.     CrossRef
    • Evaluation of antimicrobial photodynamic therapy with indocyanine green and curcumin on human gingival fibroblast cells: An in vitro photocytotoxicity investigation
      M. Pourhajibagher, N. Chiniforush, S. Parker, S. Shahabi, R. Ghorbanzadeh, M.J. Kharazifard, A Bahador
      Photodiagnosis and Photodynamic Therapy.2016; 15: 13.     CrossRef
    • A novel aminoclay–curcumin hybrid for enhanced chemotherapy
      Suhang Wang, Han Cao, Yiming Zhong, Yuhong Yang, Zhengzhong Shao
      Journal of Materials Chemistry B.2016; 4(24): 4295.     CrossRef
    • The bounty of nature for changing the cancer landscape
      Aamir Ahmad, Yiwei Li, Fazlul H. Sarkar
      Molecular Nutrition & Food Research.2016; 60(6): 1251.     CrossRef
    • The potential role of some phytochemicals in recognition of mitochondrial damage-associated molecular patterns
      Malgorzata Pierzchalska, Maja Grabacka
      Mitochondrion.2016; 30: 24.     CrossRef
    • A mechanistic investigation of the bioavailability enhancing potential of lysergol, a novel bioenhancer, using curcumin
      M. Shukla, M. Y. Malik, S. Jaiswal, A. Sharma, D. K. Tanpula, R. Goyani, J. Lal
      RSC Advances.2016; 6(64): 58933.     CrossRef
    • Polyphenol compounds and PKC signaling
      Joydip Das, Rashmi Ramani, M. Olufemi Suraju
      Biochimica et Biophysica Acta (BBA) - General Subjects.2016; 1860(10): 2107.     CrossRef
    • Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells
      Yao Fei, Yajie Xiong, Yifan Zhao, Wenjuan Wang, Meilin Han, Long Wang, Caihong Tan, Zhongqin Liang
      Brain Research.2016; 1646: 580.     CrossRef
    • Curcumin: A new candidate for melanoma therapy?
      Hamed Mirzaei, Gholamreza Naseri, Ramin Rezaee, Mohsen Mohammadi, Zarrin Banikazemi, Hamid Reza Mirzaei, Hossein Salehi, Mostafa Peyvandi, John M. Pawelek, Amirhossein Sahebkar
      International Journal of Cancer.2016; 139(8): 1683.     CrossRef
    • Redox maintenance and concerted modulation of gene expression and signaling pathways by a nanoformulation of curcumin protects peripheral blood mononuclear cells against gamma radiation
      Behrooz Soltani, Nasser Ghaemi, Majid Sadeghizadeh, Farhood Najafi
      Chemico-Biological Interactions.2016; 257: 81.     CrossRef
    • PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells
      Huda A. Al-Howail, Hana A. Hakami, Basem Al-Otaibi, Amer Al-Mazrou, Maha H. Daghestani, Ibrahim Al-Jammaz, Huda H. Al-Khalaf, Abdelilah Aboussekhra
      BMC Cancer.2016;[Epub]     CrossRef
    • Photoactive platinum(ii) β-diketonates as dual action anticancer agents
      Md Kausar Raza, Koushambi Mitra, Abhijith Shettar, Uttara Basu, Paturu Kondaiah, Akhil R. Chakravarty
      Dalton Transactions.2016; 45(33): 13234.     CrossRef
    • A novel antifungal surface-coating application to limit postharvest decay on coated apples: Molecular, thermal and morphological properties of electrospun zein–nanofiber mats loaded with curcumin
      Azime Yilmaz, Fatih Bozkurt, Perihan Kubra Cicek, Enes Dertli, Muhammed Zeki Durak, Mustafa Tahsin Yilmaz
      Innovative Food Science & Emerging Technologies.2016; 37: 74.     CrossRef
    • Inhibition of Autophagy Enhances Curcumin United light irradiation-induced Oxidative Stress and Tumor Growth Suppression in Human Melanoma Cells
      Tianhui Niu, Yan Tian, Zhusong Mei, Guangjin Guo
      Scientific Reports.2016;[Epub]     CrossRef
    • Curcumin Monoglucoside Shows Improved Bioavailability and Mitigates Rotenone Induced Neurotoxicity in Cell and Drosophila Models of Parkinson’s Disease
      M. D. Pandareesh, M. K. Shrivash, H. N. Naveen Kumar, K. Misra, M. M. Srinivas Bharath
      Neurochemical Research.2016; 41(11): 3113.     CrossRef
    • The Role of Natural Polyphenols in the Prevention and Treatment of Cervical Cancer—An Overview
      Marius Moga, Oana Dimienescu, Cristian Arvatescu, Aurel Mironescu, Laura Dracea, Liana Ples
      Molecules.2016; 21(8): 1055.     CrossRef
    • Spices for Prevention and Treatment of Cancers
      Jie Zheng, Yue Zhou, Ya Li, Dong-Ping Xu, Sha Li, Hua-Bin Li
      Nutrients.2016; 8(8): 495.     CrossRef
    • Affinity of nat/68Ga-Labelled Curcumin and Curcuminoid Complexes for β-Amyloid Plaques: Towards the Development of New Metal-Curcumin Based Radiotracers
      Sara Rubagotti, Stefania Croci, Erika Ferrari, Michele Iori, Pier Capponi, Luca Lorenzini, Laura Calzà, Annibale Versari, Mattia Asti
      International Journal of Molecular Sciences.2016; 17(9): 1480.     CrossRef
    • Soluble curcumin amalgamated chitosan microspheres augmented drug delivery and cytotoxicity in colon cancer cells: In vitro and in vivo study
      Kiran Jyoti, Richa Kaur Bhatia, Elvis A.F. Martis, Evans C. Coutinho, Upendra Kumar Jain, Ramesh Chandra, Jitender Madan
      Colloids and Surfaces B: Biointerfaces.2016; 148: 674.     CrossRef
    • Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence?
      Gabriela Mazzanti, Silvia Di Giacomo
      Molecules.2016; 21(9): 1243.     CrossRef
    • Pluronic stabilized Fe3O4 magnetic nanoparticles for intracellular delivery of curcumin
      K. C. Barick, Ekta Ekta, Santosh L. Gawali, Avipsha Sarkar, A. Kunwar, K. I. Priyadarsini, P. A. Hassan
      RSC Advances.2016; 6(101): 98674.     CrossRef
    • Quinazoline derivative from indigenous isolate,Nocardiopsis albainhibits human telomerase enzyme
      K.G. Kiran, M. Thandeeswaran, K.A. Ayub Nawaz, M. Easwaran, K.K. Jayagopi, L. Ebrahimi, M. Palaniswamy, R. Mahendran, J. Angayarkanni
      Journal of Applied Microbiology.2016; 121(6): 1637.     CrossRef
    • Roles of Curcumin and Monochromatic Light in Optimizing Liver Function to Support Egg Yolk Biosynthesis in Magelang Ducks
      Kasiyati ., Sumiati ., Damiana Rita Ekast, Wasmen Manalu
      International Journal of Poultry Science.2016; 15(10): 414.     CrossRef
    • Bulk Manufacture of Complex Geometry Millirod Implants and their Degradation and Drug Delivery Characteristics
      Melissa Slagle, Iris V. Rivero
      Procedia Manufacturing.2016; 5: 466.     CrossRef
    • Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review
      Sin-Yeang Teow, Kitson Liew, Syed A. Ali, Alan Soo-Beng Khoo, Suat-Cheng Peh
      Journal of Tropical Medicine.2016; 2016: 1.     CrossRef
    • Release of siRNA from Liposomes Induced by Curcumin
      Kazuyo Fujita, Yoshie Hiramatsu, Hideki Minematsu, Masaharu Somiya, Shun’ichi Kuroda, Masaharu Seno, Shuji Hinuma
      Journal of Nanotechnology.2016; 2016: 1.     CrossRef
    • Unraveling the Anticancer Effect of Curcumin and Resveratrol
      Aline Pavan, Gabriel Silva, Daniela Jornada, Diego Chiba, Guilherme Fernandes, Chung Man Chin, Jean Dos Santos
      Nutrients.2016; 8(11): 628.     CrossRef
    • Curcumin and insulin resistance—Molecular targets and clinical evidences
      Angélica Saraí Jiménez‐Osorio, Adriana Monroy, Silvestre Alavez
      BioFactors.2016; 42(6): 561.     CrossRef
    • Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet
      Donald R. Senger, Dan Li, Shou-Ching Jaminet, Shugeng Cao, Yoshiaki Tsuji
      PLOS ONE.2016; 11(2): e0148042.     CrossRef
    • Improvement of Oral Bioavailability of Curcumin upon Microencapsulation with Methacrylic Copolymers
      Donatella Paolino, Ada Vero, Donato Cosco, Tiziana M. G. Pecora, Simona Cianciolo, Massimo Fresta, Rosario Pignatello
      Frontiers in Pharmacology.2016;[Epub]     CrossRef

    • Taiki MIYAZAWA, Takahiro HARIGAE, Kiyotaka NAKAGAWA
      Kagaku To Seibutsu.2016; 54(7): 500.     CrossRef
    • Promising Anti-Hepatitis C Virus Compounds from Natural Resources
      Tutik Sri Wahyuni, Chie Aoki Utsubo, Hak Hotta
      Natural Product Communications.2016;[Epub]     CrossRef
    • Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid
      Stella Pesakhov, Matan Nachliely, Zeev Barvish, Nasma Aqaqe, Bar Schwartzman, Elena Voronov, Yoav Sharoni, George P. Studzinski, Daniel Fishman, Michael Danilenko
      Oncotarget.2016; 7(22): 31847.     CrossRef
    • Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence
      Ritesh Kotecha, Akiyoshi Takami, J. Luis Espinoza
      Oncotarget.2016; 7(32): 52517.     CrossRef
    • Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells
      Xiuxia Zhou, Jingna Su, Shaoyan Feng, Lixia Wang, Xuyuan Yin, Jingzhe Yan, Zhiwei Wang
      Oncotarget.2016; 7(48): 79076.     CrossRef
    • Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas
      Alfeu Zanotto-Filho, Elizandra Braganhol, Karina Klafke, Fabrício Figueiró, Sílvia Resende Terra, Francis Jackson Paludo, Maurílio Morrone, Ivi Juliana Bristot, Ana Maria Battastini, Cassiano Mateus Forcelini, Alexander James Roy Bishop, Daniel Pens Gelai
      Cancer Letters.2015; 358(2): 220.     CrossRef
    • Evaluation of two novel antioxidants with differential effects on curcumin-induced apoptosis in C2 skeletal myoblasts; involvement of JNKs
      Maria Peleli, Ioanna-Katerina Aggeli, Alexios N. Matralis, Angeliki P. Kourounakis, Isidoros Beis, Catherine Gaitanaki
      Bioorganic & Medicinal Chemistry.2015; 23(3): 390.     CrossRef
    • Enhanced bioavailability and safety of curcumagalactomannosides as a dietary ingredient
      Vijayasteltar B. Liju, Kottarapat Jeena, Dinesh Kumar, Balu Maliakel, Ramadasan Kuttan, Krishnakumar IM
      Food & Function.2015; 6(1): 275.     CrossRef
    • A Diet Enriched with Curcumin Impairs Newly Acquired and Reactivated Fear Memories
      Melissa S Monsey, Danielle M Gerhard, Lara M Boyle, Miguel A Briones, Ma'ayan Seligsohn, Glenn E Schafe
      Neuropsychopharmacology.2015; 40(5): 1278.     CrossRef
    • Curcumin improves neural function after spinal cord injury by the joint inhibition of the intracellular and extracellular components of glial scar
      Jichao Yuan, Mingming Zou, Xin Xiang, Haitao Zhu, Weihua Chu, Wei Liu, Fei Chen, Jiangkai Lin
      Journal of Surgical Research.2015; 195(1): 235.     CrossRef
    • Excipient pharmacokinetics and profiling
      Thorsteinn Loftsson
      International Journal of Pharmaceutics.2015; 480(1-2): 48.     CrossRef
    • Improved blood–brain-barrier permeability and tissue distribution following the oral administration of a food-grade formulation of curcumin with fenugreek fibre
      Krishnakumar IM, Abhilash Maliakel, Gopakumar G, Dinesh Kumar, Balu Maliakel, Ramadasan Kuttan
      Journal of Functional Foods.2015; 14: 215.     CrossRef
    • Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury
      Yali Zhang, Dandan Liang, Lili Dong, Xiangting Ge, Fengli Xu, Wenbo Chen, Yuanrong Dai, Huameng Li, Peng Zou, Shulin Yang, Guang Liang
      Respiratory Research.2015;[Epub]     CrossRef
    • Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric
      Liran Horev, Yuval Ramot, Laurent Klapholz
      Drug Safety - Case Reports.2015;[Epub]     CrossRef
    • Novel anti-angiogenic effects of aromatic-turmerone, essential oil isolated from spice turmeric
      Grace Gar-Lee Yue, Hin-Fai Kwok, Julia Kin-Ming Lee, Lei Jiang, Kar-Man Chan, Ling Cheng, Eric Chun-Wai Wong, Ping-Chung Leung, Kwok-Pui Fung, Clara Bik-San Lau
      Journal of Functional Foods.2015; 15: 243.     CrossRef
    • New concepts to fight oxidative stress: nanosized three-dimensional supramolecular antioxidant assemblies
      Pascal U Richard, Jason T Duskey, Svetlana Stolarov, Mariana Spulber, Cornelia G Palivan
      Expert Opinion on Drug Delivery.2015; 12(9): 1527.     CrossRef
    • Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)
      Vânia Ortega Gutierres, Michel Leandro Campos, Carlos Alberto Arcaro, Renata Pires Assis, Helen Mariana Baldan-Cimatti, Rosângela Gonçalves Peccinini, Silvia Paula-Gomes, Isis Carmo Kettelhut, Amanda Martins Baviera, Iguatemy Lourenço Brunetti
      Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
    • Enhanced absorption and pharmacokinetics of fresh turmeric (Curcuma Longa L) derived curcuminoids in comparison with the standard curcumin from dried rhizomes
      IM Krishnakumar, Dinesh Kumar, Eapen Ninan, Ramadassan Kuttan, Balu Maliakel
      Journal of Functional Foods.2015; 17: 55.     CrossRef
    • Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
      SKS Sarada, M Titto, P Himadri, S Saumya, V Vijayalakshmi
      Journal of Neuroinflammation.2015;[Epub]     CrossRef
    • Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes
      Jelena Dinić, Teodora Ranđelović, Tijana Stanković, Miodrag Dragoj, Aleksandra Isaković, Miroslav Novaković, Milica Pešić
      Fitoterapia.2015; 105: 169.     CrossRef
    • Lyophilized sponges loaded with curcumin solid lipid nanoparticles for buccal delivery: Development and characterization
      Heba A. Hazzah, Ragwa M. Farid, Maha M.A. Nasra, Magda A. EL-Massik, Ossama Y. Abdallah
      International Journal of Pharmaceutics.2015; 492(1-2): 248.     CrossRef
    • Gelucire-Based Nanoparticles for Curcumin Targeting to Oral Mucosa: Preparation, Characterization, and Antimicrobial Activity Assessment
      Heba A. Hazzah, Ragwa M. Farid, Maha M.A. Nasra, Walaa A. Hazzah, Magda A. El-Massik, Ossama Y. Abdallah
      Journal of Pharmaceutical Sciences.2015; 104(11): 3913.     CrossRef
    • Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats
      Vikram Patial, Mahesh S, Supriya Sharma, Kunal Pratap, Damanpreet Singh, Yogendra S. Padwad
      Environmental Toxicology and Pharmacology.2015; 40(2): 445.     CrossRef
    • Interaction of metallic clusters with biologically active curcumin molecules
      Sanjeev K. Gupta, Haiying He, Chunhui Liu, Ranu Dutta, Ravindra Pandey
      Chemical Physics Letters.2015; 636: 163.     CrossRef
    • Simultaneously targeting inflammatory response and parasite sequestration in brain to treat Experimental Cerebral Malaria
      Chaitanya Dende, Jairam Meena, Perumal Nagarajan, Amulya K. Panda, Pundi N. Rangarajan, Govindarajan Padmanaban
      Scientific Reports.2015;[Epub]     CrossRef
    • Curcumin as an Anti-Human Papillomavirus and Anti-Cancer Compound
      Alok Mishra, Bhudev C Das
      Future Oncology.2015; 11(18): 2487.     CrossRef
    • Dietary intervention for osteoarthritis: Clinical trials after the ‘Bone and Joint Decade’
      R. K. Davidson, I. M. Clark
      Nutrition Bulletin.2015; 40(3): 203.     CrossRef
    • Protective effects of bioconjugates of curcumin with nicotinic and picolinic acids on markers of oxidative stress in human erythrocytes
      Syed Ibrahim Rizvi, Archana Pandey, Ravindra Kumar Gupta, Kanti Bhooshan Pandey
      Biologia.2015; 70(5): 703.     CrossRef
    • The cis‐Diammineplatinum(II) Complex of Curcumin: A Dual Action DNA Crosslinking and Photochemotherapeutic Agent
      Koushambi Mitra, Srishti Gautam, Paturu Kondaiah, Akhil R. Chakravarty
      Angewandte Chemie International Edition.2015; 54(47): 13989.     CrossRef
    • The cis‐Diammineplatinum(II) Complex of Curcumin: A Dual Action DNA Crosslinking and Photochemotherapeutic Agent
      Koushambi Mitra, Srishti Gautam, Paturu Kondaiah, Akhil R. Chakravarty
      Angewandte Chemie.2015; 127(47): 14195.     CrossRef
    • Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling
      A R Fetoni, F Paciello, D Mezzogori, R Rolesi, S L M Eramo, G Paludetti, D Troiani
      British Journal of Cancer.2015; 113(10): 1434.     CrossRef
    • Self‐assembled penetratin‐deferasirox micelles as potential carriers for hydrophobic drug delivery
      Dibakar Goswami, Hector Aguilar Vitorino, M. Teresa Machini, Breno P. Espósito
      Peptide Science.2015; 104(6): 712.     CrossRef
    • Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitro
      I-TSANG CHIANG, WEI-SHU WANG, HSIN-CHUNG LIU, SU-TSO YANG, NOU-YING TANG, JING-GUNG CHUNG
      Oncology Reports.2015; 34(4): 1853.     CrossRef
    • In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment
      Massimo Fantini, Monica Benvenuto, Laura Masuelli, Giovanni Frajese, Ilaria Tresoldi, Andrea Modesti, Roberto Bei
      International Journal of Molecular Sciences.2015; 16(5): 9236.     CrossRef
    • Nanoparticles Containing Curcumin Useful for Suppressing Macrophages In Vivo in Mice
      Chie Amano, Hideki Minematsu, Kazuyo Fujita, Shinki Iwashita, Masaki Adachi, Koichi Igarashi, Shuji Hinuma, Masaharu Seno
      PLOS ONE.2015; 10(9): e0137207.     CrossRef
    • Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway
      Jong-Rung Tsai, Po-Len Liu, Yung-Hsiang Chen, Shah-Hwa Chou, Yu-Jen Cheng, Jhi-Jhu Hwang, Inn-Wen Chong, Jeremy J.W. Chen
      PLOS ONE.2015; 10(12): e0144462.     CrossRef
    • Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin
      Tianhui Niu, Yan Tian, Qing Cai, Qu Ren, Lizhao Wei, Andrzej T Slominski
      PLOS ONE.2015; 10(9): e0138754.     CrossRef
    • Nutrition Facts in Multiple Sclerosis
      Paolo Riccio, Rocco Rossano
      ASN Neuro.2015; 7(1): 175909141456818.     CrossRef
    • Monoamine oxidase-A inhibitory activity of novel Curcumin analogues
      Vishnu Nayak Badavath, İpek Baysal, Gulberk Ucar, Barij Nayan Sinha, Susanta Kumar Mondal, Venkatesan Jayaprakash
      JOURNAL OF PHARMACEUTICAL CHEMISTRY.2015; 2(3-4): 12.     CrossRef
    • Synergistic Effects of Dietary Natural Products as Anti-Prostate Cancer Agents
      Bao Vue, Sheng Zhang, Qiao-Hong Chen
      Natural Product Communications.2015;[Epub]     CrossRef
    • Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells
      Lixia Wang, Xiantao Ye, Xingming Cai, Jingna Su, Renqiang Ma, Xuyuan Yin, Xiuxia Zhou, Huabin Li, Zhiwei Wang
      Oncotarget.2015; 6(20): 18027.     CrossRef
    • Novel Evidence for Curcumin and Boswellic Acid–Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer
      Shusuke Toden, Yoshinaga Okugawa, Constanze Buhrmann, Durgha Nattamai, Esperanza Anguiano, Nicole Baldwin, Mehdi Shakibaei, C. Richard Boland, Ajay Goel
      Cancer Prevention Research.2015; 8(5): 431.     CrossRef
    • CHITOSAN ENCAPSULATED CURCUMIN NANOPARTICLES AS AN EFFECTIVE DRUG DELIVERY SYSTEM FOR ORAL CANCER TREATMENT
      . Keerthikumar, S. S. Jalalpure , P. V. S. N. Malleshwara Rao
      INDIAN DRUGS.2015; 52(10): 40.     CrossRef
    • Novel antitumor mechanisms of curcumin: implication of altered tumor metabolism, reconstituted tumor microenvironment and augmented myelopoiesis
      Naveen Kumar Vishvakarma
      Phytochemistry Reviews.2014; 13(3): 717.     CrossRef
    • Curcumin From Traditional Iranian Medicine to Molecular Medicine
      Hamid Reza Rahimi, Reza Kazemi Oskuee
      Razavi International Journal of Medicine.2014;[Epub]     CrossRef
    • Synthesis, Characterization andIn VitroAnticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation
      Amit Anthwal, Bandana K. Thakur, M. S. M. Rawat, D. S. Rawat, Amit K. Tyagi, Bharat B. Aggarwal
      BioMed Research International.2014; 2014: 1.     CrossRef
    • Curcumin: A Potential Candidate in Prevention of Cancer via Modulation of Molecular Pathways
      Arshad H. Rahmani, Mohammad A. Al Zohairy, Salah M. Aly, Masood A. Khan
      BioMed Research International.2014; 2014: 1.     CrossRef
    • Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells
      Jia Ma, Binbin Fang, Fanpeng Zeng, Haijie Pang, Jing Zhang, Ying Shi, Xueping Wu, Long Cheng, Cong Ma, Jun Xia, Zhiwei Wang
      Toxicology Letters.2014; 231(1): 82.     CrossRef
    • Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer
      N Hasima, B Ozpolat
      Cell Death & Disease.2014; 5(11): e1509.     CrossRef
    • Curcumin's Neuroprotective Efficacy in Drosophila Model of Idiopathic Parkinson's Disease Is Phase Specific: Implication of its Therapeutic Effectiveness
      Limamanen Phom, Bovito Achumi, Debasmita P. Alone, Muralidhara, Sarat Chandra Yenisetti
      Rejuvenation Research.2014; 17(6): 481.     CrossRef
    • Therapeutic Effects of Curcumin on Alzheimer’s Disease
      Edward C. Yao, Lei Xue
      Advances in Alzheimer's Disease.2014; 03(04): 145.     CrossRef
    • Curcumin and Chronic Kidney Disease (CKD): Major Mode of Action through Stimulating Endogenous Intestinal Alkaline Phosphatase
      Siddhartha Ghosh, Todd Gehr, Shobha Ghosh
      Molecules.2014; 19(12): 20139.     CrossRef
    • The Chemistry of Curcumin: From Extraction to Therapeutic Agent
      Kavirayani Priyadarsini
      Molecules.2014; 19(12): 20091.     CrossRef
    • Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses
      Bharat Aggarwal, Lokesh Deb, Sahdeo Prasad
      Molecules.2014; 20(1): 185.     CrossRef
    • Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFκB Signaling and Macrophage Migration
      Nicholas A. Young, Michael S. Bruss, Mark Gardner, William L. Willis, Xiaokui Mo, Giancarlo R. Valiente, Yu Cao, Zhongfa Liu, Wael N. Jarjour, Lai-Chu Wu, Gernot Zissel
      PLoS ONE.2014; 9(11): e111559.     CrossRef
    • Piperine, a Natural Bioenhancer, Nullifies the Antidiabetic and Antioxidant Activities of Curcumin in Streptozotocin-Diabetic Rats
      Carlos Alberto Arcaro, Vânia Ortega Gutierres, Renata Pires Assis, Thais Fernanda Moreira, Paulo Inácio Costa, Amanda Martins Baviera, Iguatemy Lourenço Brunetti, M. Faadiel Essop
      PLoS ONE.2014; 9(12): e113993.     CrossRef
    • Synergistic Apoptosis-Inducing Effects on A375 Human Melanoma Cells of Natural Borneol and Curcumin
      Jianping Chen, Lin Li, Jianyu Su, Bing Li, Tianfeng Chen, Yum-Shing Wong, Robert Lafrenie
      PLoS ONE.2014; 9(6): e101277.     CrossRef
    • Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies
      Lynne M. Howells, Jagdish Mahale, Stewart Sale, Laura McVeigh, William P. Steward, Anne Thomas, Karen Brown
      Journal of Pharmacology and Experimental Therapeutics.2014; 350(3): 483.     CrossRef
    • Gastrointestinal Dise ases and Curcumin: Developments and Challenges
      Khushwant Bhullar, Indu Parmar, Gurpreet Dhillon
      Current Research in Nutrition and Food Science Journal.2014; 2(3): 111.     CrossRef
    • Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas
      Laura Masuelli, Enrica Di Stefano, Massimo Fantini, Rosanna Mattera, Monica Benvenuto, Laura Marzocchella, Pamela Sacchetti, Chiara Focaccetti, Roberta Bernardini, Ilaria Tresoldi, Valerio Izzi, Maurizio Mattei, Giovanni Vanni Frajese, Florigio Lista, And
      Oncotarget.2014; 5(21): 10745.     CrossRef

    • PubReader PubReader
    • ePub LinkePub Link
    • Cite
      CITE
      export Copy Download
      Close
      Download Citation
      Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
      Format:
      • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
      • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
      Include:
      • Citation for the content below
      Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice
      Cancer Res Treat. 2014;46(1):2-18.   Published online January 15, 2014
      DOI: https://doi.org/10.4143/crt.2014.46.1.2
      Close
    • XML DownloadXML Download
    • 0
    • 1
    • 2
    • 3
    Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice
    Image Image Image Image
    Fig. 1 Various curcumin-based products include capsules, tablets, ointments, energy drinks, soaps, and cosmetics.
    Fig. 2 Redesign of curcumin through various strategies to enhance bioavailability. GMO, glyceryl monoleate; PLGA, polylactic-co-glycolic acid; PHEMA, poly(2-hydroxyethyl methacrylate); PEG-PEI, polyethylene glycol-poly(ethylene imine).
    Fig. 3 Biodistribution of [18F]-curcumin (A) and of [18F]-curcumin co-injected with piperine (B) in mice. Adopted from Ryu et al. [117], J Med Chem. 2006;49:6111-9.
    Fig. 4 Metabolism of curcumin.

    Fig. 1

    Fig. 2

    Fig. 3

    Fig. 4

    Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice
    Formulation Reference Formulation Reference
    Nanosuspension [52] PEGylated curcumin analogs [74]
    Aqueous formulation [53] Curcumin-loaded MPEG-PCL [52]
    Nanoemulsion [54] Aqueous PLGA nanoparticulate [75]
    pH-sensitive nanoparticles [55] Curcumin loaded cellulose nanoparticles [76]
    Microemulsion-based ion-sensitive [49] PLGA microparticle of curcumin [32]
    Curcumin-loaded nanoparticles [56] Curcumin-loaded PLGA nanospheres [77]
    Curcumin-loaded carbon nanotubes [57] Curcumin MPEG-PCL micelles [78]
    Curcumin co-solvent formulation [58] Curcumin PLGA-b-PEG-TPP [79]
    Silica-coated flexible liposomes [59] Curcumin PCL-PEG-PCL [80]
    Artemisinin liposomal formulations [60] Curcumin methoxy PEG-zein micelles [81]
    Liposomal curcumin [61] Curcumin-loaded alginate foams [82]
    TMC-coated liposomes [62] Thermosensitive poloxamer hydrogel [50]
    Liposomes-propylene glycol liposomes [63] Curcumin-loaded polymeric micelles [83]
    γ-Cyclodextrin liposomal nanoparticles [64] CSO-SA [84]
    Cationic liposome-PEG-PEI complex [65] Curcumin-loaded amphiphilic peptide [85]
    Curcumin-decorated nanoliposomes [66] Cyclodextrin-curcumin [86]
    Liposomes of DMPC and cholesterol [67] Dipeptide nanoparticles [87]
    Lipid-based oral formulations [68] Phosphatidylcholine encapsulation [88]
    Curcumin-loaded solid lipid nanoparticles [69] Graphene-based curcumin nanosystems [89]
    Curcumin nanoglobules/nanoemulsion [70] Curcumin PHEMA-NPs [90]
    Curcumin-loaded cationic liposome [71] Silica nanoparticles [91]
    PGL nanocapsulated curcumin [72] Pluronic-curcumin formulation [92]
    Curcumin TRC-NPs [73] EMC-curcumin [93]
    Table 1 Reformulation of curcumin for enhanced bioavailability

    TMC, N-trimethyl chitosan chloride; PEG-PEI, polyethylene glycol-poly(ethylene imine); DMPC, dimyristoyl phosphatidyl choline; PGL, propylene glycol liposomes; TRC-NPs, thermoresponsive chitosan-g-poly(N-isopropylacrylamide) co-polymeric nanoparticles; MPEG-PCL, methoxy poly(ethylene glycol)-poly(ε-caprolactone); PLGA-b-PEG-TPP, poly(d, l-lactic-co-glycolic acid)-block (PLGA-b)-poly(ethylene glycol) (PEG)-triphenylphosphonium (TPP) polymer; PCL-PEG-PCL, poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone); CSO-SA, curcumin encapsulated in stearic acid-g-chitosan oligosaccharide; PHEMA-NPs, poly(2-hydroxyethyl methacrylate) nanoparticles; EMC, ethyl and methyl cellulose.

    Table 1

    Cancer Res Treat : Cancer Research and Treatment
    © Korean Cancer Association.
    Close layer
    TOP