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East Asian Subgroup Analysis of a Randomized, Double-Blind, Phase 3 Study of Docetaxel and Ramucirumab Versus Docetaxel and Placebo in the Treatment of Stage IV Non-small Cell Lung Cancer Following Disease Progression after One Prior Platinum-Based Therapy (REVEL)

Keunchil Park, Joo-Hang Kim, Eun Kyung Cho, Jin-Hyoung Kang, Jin-Yuan Shih, Annamaria Hayden Zimmermann, Pablo Lee, Ekaterine Alexandris, Tarun Puri, Mauro Orlando

Cancer Research and Treatment. 2016;48(4):1177-1186. Published online 2016 February 22 DOI: https://doi.org/10.4143/crt.2015.401

Keunchil Park, Joo-Hang Kim, Eun Kyung Cho, Jin-Hyoung Kang, Jin-Yuan Shih, Annamaria Hayden Zimmermann, Pablo Lee, Ekaterine Alexandris, Tarun Puri, Mauro Orlando

Cancer Research and Treatment. 2016;48(4):1177-1186

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A Randomized, Double-Blind, Phase III Study of Docetaxel and Ramucirumab Versus Docetaxel and Placebo in the Treatment of Stage IV Non–Small-Cell Lung Cancer After Disease Progression After 1 Previous Platinum-Based Therapy (REVEL): Treatment Rationale and Study Design

Edward B. Garon, Dachuang Cao, Ekaterine Alexandris, William J. John, Sergey Yurasov, Maurice Perol

Clinical Lung Cancer. 2012;13(6):505-509

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A randomized, double-blind, phase II study of ramucirumab plus docetaxel vs placebo plus docetaxel in Japanese patients with stage IV non-small cell lung cancer after disease progression on platinum-based therapy

Kiyotaka Yoh, Yukio Hosomi, Kazuo Kasahara, Kazuhiko Yamada, Toshiaki Takahashi, Nobuyuki Yamamoto, Makoto Nishio, Yuichiro Ohe, Toshiko Koue, Takashi Nakamura, Sotaro Enatsu, Pablo Lee, David Ferry, Tomohide Tamura, Kazuhiko Nakagawa

Lung Cancer. 2016;99:186-193

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3073 Exploratory analysis of frontline therapies in REVEL: A randomized phase III study of ramucirumab (RAM) plus docetaxel (DOC) versus DOC for the treatment of stage IV non-small-cell lung cancer (NSCLC) after disease progression on platinum-based therapy

E.B. Garon, G.V. Scagliotti, O. Gautschi, M. Reck, M. Thomas, L.I. Docampo, H. Kalofonos, J.H. Kim, S. Gans, O.T. Brustugun, S.V. Orlov, D. Ferry, A. Melemed, G.C. Carter, A.H. Zimmermann, J.A. Treat, E. Alexandris, P. Lee, M.A. Socinski, M. Perol

European Journal of Cancer. 2015;51:S621

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Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial

Edward B Garon, Tudor-Eliade Ciuleanu, Oscar Arrieta, Kumar Prabhash, Konstantinos N Syrigos, Tuncay Goksel, Keunchil Park, Vera Gorbunova, Ruben Dario Kowalyszyn, Joanna Pikiel, Grzegorz Czyzewicz, Sergey V Orlov, Conrad R Lewanski, Michael Thomas, Paolo Bidoli, Shaker Dakhil, Steven Gans, Joo-Hang Kim, Alexandru Grigorescu, Nina Karaseva, Martin Reck, Federico Cappuzzo, Ekaterine Alexandris, Andreas Sashegyi, Sergey Yurasov, Maurice Pérol

The Lancet. 2014;384(9944):665-673

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Subgroup analysis of adenocarcinoma patients refractory to first-line chemotherapy from REVEL: A randomized phase III study of docetaxel with ramucirumab or placebo for second-line treatment of stage IV non–small cell lung cancer (NSCLC)

M. Reck, L. Paz-Ares, D. Moro-Sibilot, F.A. Shepherd, F. Cappuzzo, K.B. Winfree, E. Alexandris, A. Sashegyi, R. Varea, M. Pérol

Annals of Oncology. 2017;28:ii43

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Update of REVEL: A randomized, double-blind, phase III study of docetaxel (DOC) and ramucirumab (RAM; IMC-1121B) versus DOC and placebo (PL) in the second-line (2L) treatment of stage IV non-small cell lung cancer (NSCLC) including subgroup analysis of histology

P. Bidoli, F. Cappuzzo, A. Favaretto, O. Alabiso, M. Tiseo, A. Chella, V. Gebbia, L. Pizzuti, L. Paz-Ares, M. Perol, E. Garon, P. Lee, A. Zimmermann, G. Cuyun Carter, M.R. Migliorino

Annals of Oncology. 2015;26:vi74

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Ramucirumab in East Asian patients with stage IV non-small cell lung cancer after disease progression on platinum-based therapy: A pooled analysis of two randomized double-blind studies

J-Y Shih, K. Yoh, Y. Hosomi, G-C Chang, T-C Hsia, T. Tamura, R. Varea, T. Nakamura, J. Gallo, R. Cheng, S. Enatsu, K. Nakagawa

Annals of Oncology. 2017;28:x122

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Exploratory analysis of front-line therapies in REVEL: a randomised phase 3 study of ramucirumab plus docetaxel versus docetaxel for the treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy

Edward B. Garon, Giorgio Vittorio Scagliotti, Oliver Gautschi, Martin Reck, Michael Thomas, Lara Iglesias Docampo, Haralabos Kalofonos, Joo-Hang Kim, Steven Gans, Oddrje Te Brustugun, Sergey V. Orlov, Gebra Cuyun Carter, Annamaria H. Zimmermann, Ana B. Oton, Ekaterine Alexandris, Pablo Lee, Katharina Wolff, Victoria Jennifer Stefaniak, Mark A. Socinski, Maurice Pérol

ESMO Open. 2020;5(1):e000567

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Quality of life results from the phase 3 REVEL randomized clinical trial of ramucirumab-plus-docetaxel versus placebo-plus-docetaxel in advanced/metastatic non-small cell lung cancer patients with progression after platinum-based chemotherapy

Maurice Pérol, Tudor-Eliade Ciuleanu, Oscar Arrieta, Kumar Prabhash, Konstantinos N. Syrigos, Tuncay Goksel, Keunchil Park, Ruben Dario Kowalyszyn, Joanna Pikiel, Conrad R. Lewanski, Michael Thomas, Shaker Dakhil, Joo-Hang Kim, Nina Karaseva, Sergey Yurasov, Annamaria Zimmermann, Pablo Lee, Gebra Cuyun Carter, Martin Reck, Federico Cappuzzo, Edward B. Garon

Lung Cancer. 2016;93:95-103

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