Cancer Research and Treatment

Circular RNAs: Epigenetic regulators of PTEN expression and function in cancer

Mohammad-Mojtaba Farazi, Saeideh Jafarinejad-Farsangi, Zahra Miri Karam, Maryam Gholizadeh, Maryam Hadadi, Abolfazl Yari

Circular RNAs: New layer of complexity evading breast cancer heterogeneity

Alyaa Dawoud, Zeina Ihab Zakaria, Hannah Hisham Rashwan, Maria Braoudaki, Rana A. Youness

Non-coding RNA Research.2023; 8(1): 60. CrossRef

Identification of an unrecognized circRNA associated with development of renal fibrosis

Yun Zhu, Weimin Yan, Shuangyan Xu, Xiaochao Yu, Shuo Sun, Shaoxiong Zhang, Ran Zhao, Jiayue Tao, Yunwei Li, Cuie Li

Modulating epigenetic modifications for cancer therapy (Review)

Leonardo Castro‑Muñoz, Elenaé Ulloa, Cecilia Sahlgren, Marcela Lizano, Erick De La Cruz-Hernández, Adriana Contreras‑Paredes

The potential role and mechanism of circRNAs in foam cell formation

Wujun Chen, Yihui Liu, Ling Li, Bing Liang, Shuai Wang, Xiaodan Xu, Dongming Xing, Xiaolin Wu

Non-coding RNA Research.2023; 8(3): 315. CrossRef

CircZFR promotes pancreatic cancer progression through a novel circRNA-miRNA-mRNA pathway and stabilizing epithelial-mesenchymal transition protein

Jing Wang, Liping Zheng, Chundong Hu, Demiao Kong, Zhongcheng Zhou, Bin Wu, Shaohan Wu, Famin Fei, Yiyu Shen

Cellular Signalling.2023; 107: 110661. CrossRef

The RNA interactome in the Hallmarks of Cancer

Natural products targeting signaling pathways associated with regulated cell death in gastric cancer: Recent advances and perspectives

Qichao Hu, Zhibei Li, Yubing Li, Xinyu Deng, Yuan Chen, Xiao Ma, Jinhao Zeng, Yanling Zhao

Phytotherapy Research.2023; 37(6): 2661. CrossRef

Comprehensive Analysis of Circular RNAs in Endothelial Cells

Sabina Lichołai, Dorota Studzińska, Hanna Plutecka, Tomasz Gubała, Marek Sanak

International Journal of Molecular Sciences.2023; 24(12): 10025. CrossRef

Functions of Circular RNA in Human Diseases and Illnesses

Alison Gu, Dabbu Kumar Jaijyan, Shaomin Yang, Mulan Zeng, Shaokai Pei, Hua Zhu

PTEN, PTENP1, microRNAs, and ceRNA Networks: Precision Targeting in Cancer Therapeutics

Glena Travis, Eileen M. McGowan, Ann M. Simpson, Deborah J. Marsh, Najah T. Nassif

Circular RNAs as biomarkers and therapeutic targets in cancer

Aferin Beilerli, Ilgiz Gareev, Ozal Beylerli, Guang Yang, Valentin Pavlov, Gjumrakch Aliev, Aamir Ahmad

Seminars in Cancer Biology.2022; 83: 242. CrossRef

CircSLC7A6 promotes the progression of Wilms’ tumor via microRNA-107/ ABL proto-oncogene 2 axis

Jiaju Xu, Ying Hao, Xingjuan Gao, Yanqiu Wu, Yanjie Ding, Baohong Wang

An Update on the Roles of circRNA-ZFR in Human Malignant Tumors

Lang Liu, Haicun Wang, Shaobo Yu, Xin Gao, Guanglin Liu, Dongsheng Sun, Xingming Jiang

Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef

WITHDRAWN: Exhausting hsa_circ_0072088 restrains proliferation, motility and angiogenesis of breast carcinoma cells through regulating miR-1236-3p and RRM2 in a ceRNA pathway

Clinical Breast Cancer.2022;[Epub] CrossRef

Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/ nuclear factor -kappa B (NF-κB) pathway

Yun Zhou, Weiwei Tang, Han Zhuo, Deming Zhu, Dawei Rong, Jin Sun, Jinhua Song

Expression of circulating RNA (hsa_circ_0074854) in human gastric cancer and its clinical significance

Fang YUAN, Li CHENG, Zhentao ZHAO, Yunpeng WANG, Bin JIA, Wei LEI

Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR‐223‐3p

Xiuling Tian, Hong Yang, Qian Fang, Hongmei Quan, Hongyu Lu, Xin Wang

Thoracic Cancer.2022; 13(9): 1369. CrossRef

Tumor Cells-derived exosomal CircRNAs: Novel cancer drivers, molecular mechanisms, and clinical opportunities

Ali Vahabi, Jafar Rezaie, Mehdi Hassanpour, Yunes Panahi, Mohadeseh Nemati, Yousef Rasmi, Mahdieh Nemati

Biochemical Pharmacology.2022; 200: 115038. CrossRef

Effect of MiR‐100‐5p on proliferation and apoptosis of goat endometrial stromal cell in vitro and embryo implantation in vivo

Li Ma, Meng Zhang, Fangjun Cao, Jincheng Han, Peng Han, Yeting Wu, Renyi Deng, Guanghui Zhang, Xiaopeng An, Lei Zhang, Yuxuan Song, Binyun Cao

Journal of Cellular and Molecular Medicine.2022; 26(9): 2543. CrossRef

Activation of circ_0072088/miR‐1261/PIK3CA pathway accelerates lung adenocarcinoma progression

Feng Cao, Sihua Liu, Ziyi Li, Lingjiao Meng, Meixiang Sang, Baoen Shan

Thoracic Cancer.2022; 13(11): 1548. CrossRef

Role of circular RNAs in disease progression and diagnosis of cancers: An overview of recent advanced insights

Safir Ullah Khan, Munir Ullah Khan, Muhammad Imran Khan, Adeola Abraham Fadahunsi, Asad Khan, Shuang Gao, Muhammad Bilal, Fenfen Li

International Journal of Biological Macromolecules.2022; 220: 973. CrossRef

Prognostic and clinicopathologic significance of circZFR in multiple human cancers

Zhongyue Liu, Wenchao Zhang, Chao Tu, Wenyi Li, Lin Qi, Zhiming Zhang, Lu Wan, Zhimin Yang, Xiaolei Ren, Zhihong Li

World Journal of Surgical Oncology.2022;[Epub] CrossRef

Circular RNAs as important players in human gastric cancer

Clinical and Translational Oncology.2021; 23(1): 10. CrossRef

Regulatory role of microRNAs on PTEN signaling

Soudeh Ghafouri-Fard, Atefe Abak, Hamed Shoorei, Mahdi Mohaqiq, Jamal Majidpoor, Arezou Sayad, Mohammad Taheri

Biomedicine & Pharmacotherapy.2021; 133: 110986. CrossRef

Circular RNAs emerge as important regulators with great potential for clinical application in gastric cancer

Mei Wang, Zheng Gong, Xinxin Zhao, Wanjun Yu, Feng Huang, Haibo Dong

Biomarkers in Medicine.2021; 15(1): 69. CrossRef

Expression and function of Ndel1 during the differentiation of neural stem cells induced by hippocampal exosomesticle

Wen Li, Shanshan Wang, Hui He, Jianbing Qin, Xiang Cheng, Heyan Zhao, Meiling Tian, Xinhua Zhang, Guohua Jin

Stem Cell Research & Therapy.2021;[Epub] CrossRef

Xiong Wang, Huijun Li, Yanjun Lu, Liming Cheng

Circular RNA circZFR Promotes Hepatocellular Carcinoma Progression by Regulating miR-375/HMGA2 Axis

Rui Xu, Shiwu Yin, Meng Zheng, Xiaohong Pei, Xuebing Ji

Digestive Diseases and Sciences.2021; 66(12): 4361. CrossRef

MiRNA‐107 contributes to inflammatory pain by down‐regulating GLT‐1 expression in rat spinal dorsal horn

Ling Zhang, Rui Wu, Mei‐Jie Xu, Jie Sha, Guang‐Yin Xu, Jian Wu, Ping‐An Zhang

European Journal of Pain.2021; 25(6): 1254. CrossRef

LncRNA PROX1-AS1 Facilitates Gastric Cancer Progression via miR-877-5p/PD-L1 Axis

TianWei Guo, Wei Wang, YueXia Ji, Min Zhang, GuoYing Xu, Sen Lin

Cancer Management and Research.2021; Volume 13: 2669. CrossRef

Circ-ZFR Promotes Progression of Bladder Cancer by Upregulating WNT5A Via Sponging miR-545 and miR-1270

Liping Luo, Pingping Miao, Yao Ming, Jie Tao, Hongchun Shen

Circular RNA hsa_circ_0005397 promotes hepatocellular carcinoma progression by regulating the miR‐326/PDK2 axis

Jianzhuang Gong, Chenxu Du, Nai Sun, Xingguo Xiao, Huili Wu

The Journal of Gene Medicine.2021;[Epub] CrossRef

Animesh Hatibaruah, Mizanur Rahman, Satyakam Agarwala, Seram Anil Singh, Suruchi Gupta, Prosenjit Paul

Circulating Exosomal MiR-107 Restrains Tumorigenesis in Diffuse Large B-Cell Lymphoma by Targeting 14-3-3η

Jiarui Liu, Yang Han, Shunfeng Hu, Yiqing Cai, Juan Yang, Shuai Ren, Yi Zhao, Tiange Lu, Xiangxiang Zhou, Xin Wang

Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef

Long non-coding RNA AFAP1-AS1 facilitates ovarian cancer progression by regulating the miR-107/PDK4 axis

Bao Liu, Li Yan, Yugang Chi, Yuhan Sun, Xiaoyu Yang

Journal of Ovarian Research.2021;[Epub] CrossRef

Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma

Chenyu Ding, Xuehan Yi, Xiangrong Chen, Zanyi Wu, Honghai You, Xiaoyong Chen, Gaoqi Zhang, Yong Sun, Xingyao Bu, Xiyue Wu, Zhangya Lin, Jianjun Gu, Yuanxiang Lin, Dezhi Kang

Journal of Experimental & Clinical Cancer Research.2021;[Epub] CrossRef

The Effect of LncRNA Zinc Finger E-Box-Binding Homeobox 1 Antisense 1 on the Biological Characteristics of Gastric Cancer Cells by Regulating the MiR-200b/Wnt1 Axis

Journal of Biomaterials and Tissue Engineering.2021; 11(3): 541. CrossRef

Circ_0027599 elevates RUNX1 expression via sponging miR‐21‐5p on gastric cancer progression

Jinzhu Han, Zixin Yang, Shan Zhao, Likang Zheng, Yanhua Tian, Yingqian Lv

European Journal of Clinical Investigation.2021;[Epub] CrossRef

Downregulation of MicroRNA-130a Inhibits Oral Squamous Cell Carcinoma Proliferation and Metastasis via the Hippo-YAP Pathway

Yiran Peng, Shoushan Hu, Kun Zhang, Yuru Wang, Maierdanjiang Rouzi, Dan Zhou, Ran Yang

Cancer Management and Research.2021; Volume 13: 4829. CrossRef

Comprehensive analysis of the competing endogenous circRNA-lncRNA-miRNA-mRNA network and identification of a novel potential biomarker for hepatocellular carcinoma

Lu Zhang, Haisu Tao, Jiang Li, Erlei Zhang, Huifang Liang, Bixiang Zhang

circZFR regulates thyroid cancer progression by the miR‐16/MAPK1 axis

Hui Xiong, Huimei Yu, Guangwei Jia, Jinsong Yu, Yang Su, Jianliang Zhang, Jin Zhou

Environmental Toxicology.2021; 36(11): 2236. CrossRef

Circular RNAs and their role in renal cell carcinoma: a current perspective

Cancer Cell International.2021;[Epub] CrossRef

Contribution of circRNAs in gastric cancer

Soudeh Ghafouri-Fard, Kasra Honarmand Tamizkar, Elena Jamali, Mohammad Taheri, Seyed Abdulmajid Ayatollahi

Pathology - Research and Practice.2021; 227: 153640. CrossRef

Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical Applications

Di Chen, Shuai Ping, Yushuang Xu, Mengmeng Wang, Xin Jiang, Lina Xiong, Li Zhang, Honglu Yu, Zhifan Xiong

Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef

circDENND4C Promotes Proliferation and Metastasis of Lung Cancer by Upregulating BRD4 Signaling Pathway

Dongjie Ma, Yingzhi Qin, Shanqing Li, Li Li, Jia He, Yeye Chen, Xiaoyun Zhou, Hongsheng Liu, Qin Yuan

Journal of Oncology.2021; 2021: 1. CrossRef

LncRNA4930473A02Rik promotes cardiac hypertrophy by regulating TCF7 via sponging miR-135a in mice

Jing Ren, Hanping Qi, Chao Song, Lina Ba, Renling Liu, Xiang Feng, Lixin Wang, Meitian Zhang, Yawen Xie, Hongli Sun

Rong Li, Jiajia Jiang, Hui Shi, Hui Qian, Xu Zhang, Wenrong Xu

Cellular and Molecular Life Sciences.2020; 77(9): 1661. CrossRef

Circular RNAs and gastrointestinal cancers: Epigenetic regulators with a prognostic and therapeutic role

Parisa Naeli, Mohammad Hossein Pourhanifeh, Mohammad Reza Karimzadeh, Zahra Shabaninejad, Ahmad Movahedpour, Hossein Tarrahimofrad, Hamid Reza Mirzaei, Hassan Hassani Bafrani, Amir Savardashtaki, Hamed Mirzaei, Michael R. Hamblin

Critical Reviews in Oncology/Hematology.2020; 145: 102854. CrossRef

Functions of circular RNAs and their potential applications in gastric cancer

Yao Ruan, Zhe Li, Yijing Shen, Tianwen Li, Haiyan Zhang, Junming Guo

Expert Review of Gastroenterology & Hepatology.2020; 14(2): 85. CrossRef

circ-NOTCH1 acts as a sponge of miR-637 and affects the expression of its target gene Apelin to regulate gastric cancer cell growth

Biochemistry and Cell Biology.2020; 98(2): 164. CrossRef

Circ_0072083 interference enhances growth-inhibiting effects of cisplatin in non-small-cell lung cancer cells via miR-545-3p/CBLL1 axis

Cancer Cell International.2020;[Epub] CrossRef

The Regulatory Functions of Circular RNAs in Digestive System Cancers

Xiao Yuan, Ya Yuan, Zhi He, Diyan Li, Bo Zeng, Qingyong Ni, Mingyao Yang, Deying Yang

Hsa_circ_0023642 promotes proliferation, invasion, and migration of gastric cancer by sponging microRNA‐223

Yi Zhang, Lei Xia, Jing Wu, Xinyu Xu, Gang Li

Journal of Clinical Laboratory Analysis.2020;[Epub] CrossRef

Non-coding RNAs underlying chemoresistance in gastric cancer

Arash Poursheikhani, Zahra Bahmanpour, Ehsan Razmara, Ladan Mashouri, Mohammad Taheri, Dorsa Morshedi Rad, Hassan Yousefi, Amirreza Bitaraf, Sadegh Babashah

Cellular Oncology.2020; 43(6): 961. CrossRef

The function and mechanism of circular RNAs in gastrointestinal tumours

Hui Nie, Yutong Wang, Zhiming Liao, Jianhua Zhou, Chunlin Ou

A Novel Serum Exosomes-Based Biomarker hsa_circ_0002130 Facilitates Osimertinib-Resistance in Non-Small Cell Lung Cancer by Sponging miR-498

OncoTargets and Therapy.2020; Volume 13: 5293. CrossRef

Circular RNAs in Gastric Cancer: Potential Biomarkers and Therapeutic Targets

BioMed Research International.2020; 2020: 1. CrossRef

CircRNA_101951 promotes migration and invasion of colorectal cancer cells by regulating the KIF3A‑mediated EMT pathway

Yue‑Feng Li, Fu‑Lai Pei, Ming‑Zheng Cao

Experimental and Therapeutic Medicine.2020;[Epub] CrossRef

Association between non-coding circular RNAs and papillary thyroid carcinoma (Review)

World Academy of Sciences Journal.2020;[Epub] CrossRef

Shanshan Xie, Yongxia Chang, Hao Jin, Feng Yang, Yanjun Xu, Xiaoyi Yan, Aifu Lin, Qiang Shu, Tianhua Zhou

The Biological Role of Sponge Circular RNAs in Gastric Cancer: Main Players or Coadjuvants?

Adenilson Leão Pereira, Leandro Magalhães, Rafael Pompeu Pantoja, Gilderlanio Araújo, Ândrea Ribeiro-dos-Santos, Amanda Ferreira Vidal

Chinese Medical Journal.2020; 133(15): 1868. CrossRef

Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma

YunXia Liu, YeFeng Xu, Feng Xiao, JianFeng Zhang, YiQing Wang, YongWei Yao, JieWen Yang

Mediators of Inflammation.2020; 2020: 1. CrossRef

PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation

Milad Ashrafizadeh, Masoud Najafi, Hui Li Ang, Ebrahim Rahmani Moghadam, Mahmood Khaksary Mahabady, Amirhossein Zabolian, Leila Jafaripour, Atefe Kazemzade Bejandi, Kiavash Hushmandi, Hossein Saleki, Ali Zarrabi, Alan Prem Kumar

Circ_0000144 functions as a miR-623 sponge to enhance gastric cancer progression via up-regulating GPRC5A

Lili Mi, Lianhui Lei, Xiaolei Yin, Ning Li, Jianfei Shi, Xin Han, Xiaoling Duan, Man Zhao, Guangjie Han, Jinfeng Wang, Fei Yin

CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression

Zhuo Chen, Fang Wang, Youyi Xiong, Nan Wang, Yuanting Gu, Xinguang Qiu

Cancer Cell International.2020;[Epub] CrossRef

Analysis of circular RNA expression profiles of lung cancer in Xuanwei, China

Yan Wang, Ling‐Jiao Lu, Yong Duan, Xiao Liu, Yue Mao, Yu Chen, Yan‐Liang Zhang

Journal of Clinical Laboratory Analysis.2020;[Epub] CrossRef

CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR‐541‐3p/GPX4 axis

Qinhong Xu, Lijing Zhou, Ganghua Yang, Fandi Meng, Yong Wan, Lin Wang, Lei Zhang

Cell Biology International.2020; 44(11): 2344. CrossRef

The prognostic value of circRNAs for gastric cancer: A systematic review and meta‐analysis

Hui Chen, Chengtong Liang, Xuechun Wang, Yu Liu, Zhanjun Yang, Ming Shen, Chongxu Han, Chuanli Ren

Cancer Medicine.2020; 9(23): 9096. CrossRef

CircRNAs and cancer: Biomarkers and master regulators

Esther Arnaiz, Carla Sole, Lorea Manterola, Leire Iparraguirre, David Otaegui, Charles H. Lawrie

Seminars in Cancer Biology.2019; 58: 90. CrossRef

RETRACTED ARTICLE: CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p

Dawei Rong, Chen Lu, Betty Zhang, Kai Fu, Shuli Zhao, Weiwei Tang, Hongyong Cao

Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers

Min Su, Yuhang Xiao, Junliang Ma, Yanyan Tang, Bo Tian, Yuqin Zhang, Xu Li, Zhining Wu, Desong Yang, Yong Zhou, Hui Wang, Qianjin Liao, Wenxiang Wang

Expression of circular RNAs in gynecological tumors

Kangsheng Liu, Qin Zhang, Feng Pan, Xiang Dong Wang, Hu Wenjing, Hua Tong

circZFR promotes cell proliferation and migration by regulating miR-511/AKT1 axis in hepatocellular carcinoma

Xin Yang, Ling Liu, Heng Zou, Yan-Wen Zheng, Kun- Peng Wang

Digestive and Liver Disease.2019; 51(10): 1446. CrossRef

Role of circular RNAs in gastric cancer: Recent advances and prospects

World Journal of Gastrointestinal Oncology.2019; 11(6): 459. CrossRef

MicroRNA-107 induces cell cycle arrests by directly targeting cyclin E1 in ovarian cancer

Biochemical and Biophysical Research Communications.2019; 512(2): 331. CrossRef

O- glycosylation can regulate the proliferation and migration of human retinal microvascular endothelial cells through ZFR in high glucose condition

Xindan Xing, Hanying Wang, Yuan Zhang, Tian Niu, Yan Jiang, Xin Shi, Chingyi Wang, Kun Liu

Biochemical and Biophysical Research Communications.2019; 512(3): 552. CrossRef

The emerging roles and functions of circular RNAs and their generation

Journal of Biomedical Science.2019;[Epub] CrossRef

Identification of circRNA–miRNA–mRNA regulatory network in gastric cancer by analysis of microarray data

Cancer Cell International.2019;[Epub] CrossRef

Circ_SPECC1 enhances the inhibition of miR-526b on downstream KDM4A/YAP1 pathway to regulate the growth and invasion of gastric cancer cells

Biochemical and Biophysical Research Communications.2019; 517(2): 253. CrossRef

Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression

Haifeng Zhang, Xiaolong Wang, Baoli Hu, Feng Zhang, Haitao Wei, Li Li

Artificial Cells, Nanomedicine, and Biotechnology.2019; 47(1): 3410. CrossRef

CircZFR serves as a prognostic marker to promote bladder cancer progression by regulating miR-377/ZEB2 signaling

Wen-Yuan Zhang, Qing-Hong Liu, Tie-Jun Wang, Jun Zhao, Xiao-Hua Cheng, Jin-Shan Wang

Biogenesis, functions and clinical significance of circRNAs in gastric cancer

Chan Shan, Yinfeng Zhang, Xiaodan Hao, Jinning Gao, Xinzhe Chen, Kun Wang

Circular RNA hsa_circ_0008344 regulates glioblastoma cell proliferation, migration, invasion, and apoptosis

Jinxu Zhou, Hongxiang Wang, Junsheng Chu, Qilin Huang, Guangxu Li, Yong Yan, Tao Xu, Juxiang Chen, Yuhai Wang

Journal of Clinical Laboratory Analysis.2018;[Epub] CrossRef

Micro RNA as a potential blood-based epigenetic biomarker for Alzheimer's disease

Clinical Biochemistry.2018; 58: 5. CrossRef

The emerging role of circRNAs and their clinical significance in human cancers

Ling Qian, Shulin Yu, Zhen Chen, Zhiqiang Meng, Shenglin Huang, Peng Wang

Biochimica et Biophysica Acta (BBA) - Reviews on C.2018;[Epub] CrossRef