Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis
Seongyeong Kim, Ahrum Min, Kyung-Hun Lee, Yaewon Yang, Tae-Yong Kim, Jee Min Lim, So Jung Park, Hyun-Jin Nam, Jung Eun Kim, Sang-Hyun Song, Sae-Won Han, Do-Youn Oh, Jee Hyun Kim, Tae-You Kim, David Hangauer, Johnson Yiu-Nam Lau, Kyongok Im, Dong Soon Lee, Yung-Jue Bang, Seock-Ah Im
Cancer Res Treat. 2017;49(3):643-655.   Published online 2016 Oct 6     DOI: https://doi.org/10.4143/crt.2016.168
Citations to this article as recorded by Crossref logo
The Potential Strategies for Overcoming Multidrug Resistance and Reducing Side Effects of Monomer Tubulin Inhibitors for Cancer Therapy
Yingjie Cui, Jing Zhang, Guifang Zhang
Current Medicinal Chemistry.2024; 31(14): 1874.     CrossRef
Efficacy and tolerability of tirbanibulin 1% ointment in the treatment of cancerization field: a real‐life Italian multicenter observational study of 250 patients
Gianluca Nazzaro, Andrea Carugno, Paolo Bortoluzzi, Stefano Buffon, Chiara Astrua, Elena Zappia, Emanuele Trovato, Stefano Caccavale, Vincenzo Pellegrino, Giovanni Paolino, Riccardo Balestri, Rossella Lacava, Giulia Ciccarese, Alice Verdelli, Stefania Bar
International Journal of Dermatology.2024;[Epub]     CrossRef
Dickkopf-1 (DKK1) drives growth and metastases in castration-resistant prostate cancer
Letizia Rinella, Gloria Fiorentino, Mara Compagno, Cristina Grange, Massimo Cedrino, Francesca Marano, Ornella Bosco, Elena Vissio, Luisa Delsedime, Patrizia D’Amelio, Benedetta Bussolati, Emanuela Arvat, Maria Graziella Catalano
Cancer Gene Therapy.2024;[Epub]     CrossRef
Anti-tumor effects of tirbanibulin in squamous cell carcinoma cells are mediated via disruption of tubulin-polymerization
Viola K. DeTemple, Antje Walter, Sabine Bredemeier, Ralf Gutzmer, Katrin Schaper-Gerhardt
Archives of Dermatological Research.2024;[Epub]     CrossRef
Real-world experience with histological confirmation of clinical response of squamous cell carcinoma to topical tirbanibulin
Angela Moore, Kara Hurley, Stephen A. Moore, Luke Moore
JAAD Case Reports.2023; 40: 141.     CrossRef
Synthesis and evaluation of tirbanibulin derivatives: a detailed exploration of the structure–activity relationship for anticancer activity
Jaebeom Park, Minji Kang, Ahyoung Lim, Kyung-Jin Cho, Chong Hak Chae, Byumseok Koh, Hongjun Jeon
RSC Advances.2023; 13(50): 35583.     CrossRef
Tirbanibulina: revisión de su mecanismo de acción novedoso y de cómo encaja en el tratamiento de la queratosis actínica
Y. Gilaberte, M.T. Fernández-Figueras
Actas Dermo-Sifiliográficas.2022; 113(1): 58.     CrossRef
Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants
Maan T. Khayat, Abdelsattar M. Omar, Farid Ahmed, Mohammad I. Khan, Sara M. Ibrahim, Yosra A. Muhammad, Azizah M. Malebari, Thikryat Neamatallah, Moustafa E. El-Araby
Frontiers in Pharmacology.2022;[Epub]     CrossRef
Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening
Katya Nardou, Michael Nicolas, Fabien Kuttler, Katarina Cisarova, Elifnaz Celik, Mathieu Quinodoz, Nicolo Riggi, Olivier Michielin, Carlo Rivolta, Gerardo Turcatti, Alexandre Pierre Moulin
Cancers.2022; 14(6): 1575.     CrossRef
Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies
Minru Liao, Rui Qin, Wei Huang, Hong-Ping Zhu, Fu Peng, Bo Han, Bo Liu
Journal of Hematology & Oncology.2022;[Epub]     CrossRef
SAR Probing of KX2-391 Provided Analogues With Juxtaposed Activity Profile Against Major Oncogenic Kinases
Abdelsattar M. Omar, Maan T. Khayat, Farid Ahmed, Yosra A. Muhammad, Azizah M. Malebari, Sara M. Ibrahim, Mohammad I. Khan, Dhaval K. Shah, Wayne E. Childers, Moustafa E. El-Araby
Frontiers in Oncology.2022;[Epub]     CrossRef
Topical Tirbanibulin, a Dual Src Kinase and Tubulin Polymerization Inhibitor, for the Treatment of Plaque-Type Psoriasis: Phase I Results
Jin-Bon Hong, Po-Yuan Wu, Albert Qin, Yi-Wen Huang, Kuan-Chiao Tseng, Ching-Yu Lai, Wing-Kai Chan, Jane Fang, David L. Cutler, Tsen-Fang Tsai
Pharmaceutics.2022; 14(10): 2159.     CrossRef
Tirbanibulin for Actinic Keratosis: Insights into the Mechanism of Action
Todd Schlesinger, Eggert Stockfleth, Ayman Grada, Brian Berman
Clinical, Cosmetic and Investigational Dermatology.2022; Volume 15: 2495.     CrossRef
Dual Kinase Targeting in Leukemia
Luca Mologni, Giovanni Marzaro, Sara Redaelli, Alfonso Zambon
Cancers.2021; 13(1): 119.     CrossRef
Recent Progress on Tubulin Inhibitors with Dual Targeting Capabilities for Cancer Therapy
Wen Shuai, Guan Wang, Yiwen Zhang, Faqian Bu, Sicheng Zhang, Duane D. Miller, Wei Li, Liang Ouyang, Yuxi Wang
Journal of Medicinal Chemistry.2021; 64(12): 7963.     CrossRef
New FDA oncology small molecule drugs approvals in 2020: Mechanism of action and clinical applications
Thais Cristina Mendonça Nogueira, Marcus Vinicius Nora de Souza
Bioorganic & Medicinal Chemistry.2021; 46: 116340.     CrossRef
Tirbanibulin: review of its novel mechanism of action and how it fits into the treatment of actinic keratosis
Y. Gilaberte, M.T. Fernández-Figueras
Actas Dermo-Sifiliográficas (English Edition).2021;[Epub]     CrossRef
Recent progress in small molecule agents for the targeted therapy of triple-negative breast cancer
Rajibul Islam, Kok Wai Lam
European Journal of Medicinal Chemistry.2020; 207: 112812.     CrossRef
Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy
Kinsie E Arnst, Souvik Banerjee, Hao Chen, Shanshan Deng, Dong‐Jin Hwang, Wei Li, Duane D Miller
Medicinal Research Reviews.2019; 39(4): 1398.     CrossRef
Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity
Lu Niu, Jianhong Yang, Wei Yan, Yamei Yu, Yunhua Zheng, Haoyu Ye, Qiang Chen, Lijuan Chen
Journal of Biological Chemistry.2019; 294(48): 18099.     CrossRef
Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)
Michael P. Smolinski, Yahao Bu, James Clements, Irwin H. Gelman, Taher Hegab, David L. Cutler, Jane W. S. Fang, Gerald Fetterly, Rudolf Kwan, Allen Barnett, Johnson Y. N. Lau, David G. Hangauer
Journal of Medicinal Chemistry.2018; 61(11): 4704.     CrossRef
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma
Michael J. Ciesielski, Yahao Bu, Stephan A. Munich, Paola Teegarden, Michael P. Smolinski, James L. Clements, Johnson Y. N. Lau, David G. Hangauer, Robert A. Fenstermaker
Journal of Neuro-Oncology.2018; 140(3): 519.     CrossRef