Cancer Research and Treatment

The reversibility of cancer radioresistance: a novel potential way to identify factors contributing to tumor radioresistance

Yoshikazu Kuwahara, Kazuo Tomita, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Tomoaki Sato, Akihiro Kurimasa

The role of autophagy in hypoxia-induced radioresistance

Rhianna Mae Hill, Matthew Fok, Gabrielle Grundy, Jason Luke Parsons, Sonia Rocha

Radiotherapy and Oncology.2023; 189: 109951. CrossRef

Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats

Nutrition and Cancer.2022; 74(3): 1090. CrossRef

ABT-737, a BH3 Mimetic, Enhances the Therapeutic Effects of Ionizing Radiation in K-ras Mutant Non-Small Cell Lung Cancer Preclinical Model

Jung Mo Lee, Hey Soo Kim, Arum Kim, Yoon Soo Chang, Jin Gu Lee, Jaeho Cho, Eun Young Kim

Yonsei Medical Journal.2022; 63(1): 16. CrossRef

Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin

Biological and Pharmaceutical Bulletin.2022; 45(1): 63. CrossRef

Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?

Annabella F. Thomas, Gemma L. Kelly, Andreas Strasser

Cell Death & Differentiation.2022; 29(5): 961. CrossRef

Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?

Juliana B. Vilar, Markus Christmann, Maja T. Tomicic

Repurposing autophagy regulators in brain tumors

Edgar Petrosyan, Jawad Fares, Alex Cordero, Aida Rashidi, Víctor A. Arrieta, Deepak Kanojia, Maciej S. Lesniak

International Journal of Cancer.2022; 151(2): 167. CrossRef

Crosstalk between HSPA5 arginylation and sequential ubiquitination leads to AKT degradation through autophagy flux

Hyo Jeong Kim, Sun-Yong Kim, Dae-Ho Kim, Joon Seong Park, Seong Hyun Jeong, Young Won Choi, Chul-Ho Kim

Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in Glioblastoma

Imran Khan, Mohammad Hassan Baig, Sadaf Mahfooz, Moniba Rahim, Busra Karacam, Elif Burce Elbasan, Ilya Ulasov, Jae-June Dong, Mustafa Aziz Hatiboglu

International Journal of Molecular Sciences.2021; 22(3): 1318. CrossRef

Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy?

Thijs A. van Schaik, Kok-Siong Chen, Khalid Shah

Friend or Foe: Paradoxical Roles of Autophagy in Gliomagenesis

Don Carlo Ramos Batara, Moon-Chang Choi, Hyeon-Uk Shin, Hyunggee Kim, Sung-Hak Kim

Breaking Bad: Autophagy Tweaks the Interplay Between Glioma and the Tumor Immune Microenvironment

Yuxiang Fan, Yubo Wang, Jian Zhang, Xuechao Dong, Pu Gao, Kai Liu, Chengyuan Ma, Gang Zhao

Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition

Giuseppina Raspaglio, Marianna Buttarelli, Flavia Filippetti, Alessandra Battaglia, Alexia Buzzonetti, Giovanni Scambia, Daniela Gallo

HMGB1 mediated autophagy protects glioblastoma cells from carbon-ion beam irradiation injury

Runhong Lei, Liben Yan, Yulin Deng, Jin Xu, Tuo Zhao, M. Umer Farooq Awan, Qiang Li, Guangming Zhou, Xiao Wang, Hong Ma

Autophagy as a Potential Therapy for Malignant Glioma

Angel Escamilla-Ramírez, Rosa A. Castillo-Rodríguez, Sergio Zavala-Vega, Dolores Jimenez-Farfan, Isabel Anaya-Rubio, Eduardo Briseño, Guadalupe Palencia, Patricia Guevara, Arturo Cruz-Salgado, Julio Sotelo, Cristina Trejo-Solís

Nano delivery of natural substances as prospective autophagy modulators in glioblastoma

Nanomedicine: Nanotechnology, Biology and Medicine.2020; 29: 102270. CrossRef

Elucidation of gastrointestinal dysfunction in response to irradiation using metabolomics

Mohammed Salah, Saki Osuga, Makiko Nakahana, Yasuhiro Irino, Masakazu Shinohara, Yasuyuki Shimizu, Naritoshi Mukumoto, Hiroaki Akasaka, Ai Nakaoka, Daisuke Miyawaki, Takeaki Ishihara, Kenji Yoshida, Yoshiaki Okamoto, Ryohei Sasaki

Biochemistry and Biophysics Reports.2020; 23: 100789. CrossRef

The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation

Nipa H. Patel, Sahib S. Sohal, Masoud H Manjili, J. Chuck Harrell, David A. Gewirtz

Radiation Research.2020; 194(2): 103. CrossRef

Dexamethasone Interferes with Autophagy and Affects Cell Survival in Irradiated Malignant Glioma Cells

Alfred Komakech, Ji-Hye Im, Ho-Shin Gwak, Kyue-Yim Lee, Jong Heon Kim, Byong Chul Yoo, Heesun Cheong, Jong Bae Park, Ji Woong Kwon, Sang Hoon Shin, Heon Yoo

Journal of Korean Neurosurgical Society.2020; 63(5): 566. CrossRef

Inhibition of Endoplasmic Reticulum Stress-Mediated Autophagy Enhances the Anticancer Effect of Iodine-125 Seed Radiation on Esophageal Squamous Cell Carcinoma

Chao Wang, Tian-Kuan Li, Chu-Hui Zeng, Jian Yang, Yong Wang, Jian Lu, Guang-Yu Zhu, Jin-He Guo

Radiation Research.2020; 194(3): 236. CrossRef

Therapeutic Potential of Autophagy in Glioblastoma Treatment With Phosphoinositide 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway Inhibitors

Qin Xia, Mengchuan Xu, Pei Zhang, Liqun Liu, Xinyi Meng, Lei Dong

Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention

Md. Ataur Rahman, MD. Hasanur Rahman, Md. Shahadat Hossain, Partha Biswas, Rokibul Islam, Md Jamal Uddin, Md. Habibur Rahman, Hyewhon Rhim

High LC3/Beclin Expression Correlates with Poor Survival in Glioma: a Definitive Role for Autophagy as Evidenced by In Vitro Autophagic Flux

Padmakrishnan CJ, Easwer HV, Vinod Vijayakurup, Girish R Menon, Suresh Nair, Srinivas Gopala

Pathology & Oncology Research.2019; 25(1): 137. CrossRef

Epsilon-Globin HBE1 Enhances Radiotherapy Resistance by Down-Regulating BCL11A in Colorectal Cancer Cells

Sang Yoon Park, Seon-Jin Lee, Hee Jun Cho, Jong-Tae Kim, Hyang Ran Yoon, Kyung Ho Lee, Bo Yeon Kim, Younghee Lee, Hee Gu Lee

NOS2 inhibitor 1400W Induces Autophagic Flux and Influences Extracellular Vesicle Profile in Human Glioblastoma U87MG Cell Line

Paola Palumbo, Francesca Lombardi, Francesca Rosaria Augello, Ilaria Giusti, Sabino Luzzi, Vincenza Dolo, Maria Grazia Cifone, Benedetta Cinque

International Journal of Molecular Sciences.2019; 20(12): 3010. CrossRef

Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma

Sushant Lakkadwala, Bruna dos Santos Rodrigues, Chengwen Sun, Jagdish Singh

Journal of Controlled Release.2019; 307: 247. CrossRef

Glioblastoma: Targeting the autophagy in tumorigenesis

Brain Research Bulletin.2019; 153: 334. CrossRef

Radiotherapy of meningioma: a treatment in need of radiobiological research

Valentina Pinzi, Ilaria Bisogno, Francesco Prada, Emilio Ciusani, Laura Fariselli

International Journal of Radiation Biology.2018; 94(7): 621. CrossRef

Radiation, inflammation and the immune response in cancer

Kelly J. McKelvey, Amanda L. Hudson, Michael Back, Tom Eade, Connie I. Diakos

Association between radiation-induced cell death and clinically relevant radioresistance

Yoshikazu Kuwahara, Kazuo Tomita, Yusuke Urushihara, Tomoaki Sato, Akihiro Kurimasa, Manabu Fukumoto

Histochemistry and Cell Biology.2018; 150(6): 649. CrossRef

Autophagic and Apoptotic Pathways as Targets for Chemotherapy in Glioblastoma

Cristina Trejo-Solís, Norma Serrano-Garcia, Ángel Escamilla-Ramírez, Rosa Castillo-Rodríguez, Dolores Jimenez-Farfan, Guadalupe Palencia, Minerva Calvillo, Mayra Alvarez-Lemus, Athenea Flores-Nájera, Arturo Cruz-Salgado, Julio Sotelo

International Journal of Molecular Sciences.2018; 19(12): 3773. CrossRef

Effects of ionizing radiation on the viability and proliferative behavior of the human glioblastoma T98G cell line

Hossam Murad, Yaman Alghamian, Abdulmunim Aljapawe, Ammar Madania

Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells

Xiaoxing Liu, Haiyan Chen, Xin Xu, Ming Ye, Hongbin Cao, Lei Xu, Yanli Hou, Jianmin Tang, Di Zhou, Yongrui Bai, Xiumei Ma

Radiotherapy and immune response: the systemic effects of a local treatment

Heloisa de Andrade Carvalho, Rosangela Correa Villar

Modulating Both Tumor Cell Death and Innate Immunity Is Essential for Improving Radiation Therapy Effectiveness

Qiuji Wu, Awatef Allouch, Isabelle Martins, Catherine Brenner, Nazanine Modjtahedi, Eric Deutsch, Jean-Luc Perfettini

Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy

Ying-Ying Li, Lynn Feun, Angkana Thongkum, Chiao-Hui Tu, Shu-Mei Chen, Medhi Wangpaichitr, Chunjing Wu, Macus Kuo, Niramol Savaraj

International Journal of Molecular Sciences.2017; 18(6): 1297. CrossRef

Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams

Luwei Zhang, Jiawei Yan, Yang Liu, Qiuyue Zhao, Cuixia Di, Sun Chao, Li Jie, Yuanyuan Liu, Hong Zhang

BAMBI overexpression together with β-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-β/Smad2/3 pathway

Xingchun Wang, Minjie Li, Mengyao Hu, Ping Wei, Wei Zhu

The Impact of Non-Lethal Single-Dose Radiation on Tumor Invasion and Cytoskeletal Properties

Tim Hohmann, Urszula Grabiec, Carolin Vogel, Chalid Ghadban, Stephan Ensminger, Matthias Bache, Dirk Vordermark, Faramarz Dehghani

International Journal of Molecular Sciences.2017; 18(9): 2001. CrossRef

Influence of gap junction intercellular communication composed of connexin 43 on the antineoplastic effect of adriamycin in breast cancer cells

Guojun Jiang, Shuying Dong, Meiling Yu, Xi Han, Chao Zheng, Xiaoguang Zhu, Xuhui Tong

To live or let die: Unclear task of autophagy in the radiosensitization battle

Martin Ondrej, Lucie Cechakova, Kamila Durisova, Jaroslav Pejchal, Ales Tichy

Radiotherapy and Oncology.2016; 119(2): 265. CrossRef

Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress

ZHONGLIANG WANG, TINGTING DU, XIAORONG DONG, ZHENYU LI, GANG WU, RUIGUANG ZHANG

International Journal of Oncology.2016; 48(6): 2558. CrossRef

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy

Feven Tameire, Ioannis I. Verginadis, Constantinos Koumenis

Seminars in Cancer Biology.2015; 33: 3. CrossRef

Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy

Byeong Kim, Yunkyung Hong, Seunghoon Lee, Pengda Liu, Ji Lim, Yong Lee, Tae Lee, Kyu Chang, Yonggeun Hong

International Journal of Molecular Sciences.2015; 16(11): 26880. CrossRef