Cancer Research and Treatment

Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders

Shahenda Salah Abdelsam, Sarah Khalaf Ghanem, Muhammad Ammar Zahid, Hanan H. Abunada, Loulia Bader, Hicham Raïq, Abbas Khan, Aijaz Parray, Laiche Djouhri, Abdelali Agouni

Journal of Cellular Physiology.2024;[Epub] CrossRef

Targeting the RNA-Binding Protein HuR in Cancer

Jennifer M. Finan, Thomas L. Sutton, Dan A. Dixon, Jonathan R. Brody

CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection

Lulu Liu, Jinjin Zhong, Bilin Chen, Weiping Wang, Haiyan Xi, Xin Su

Journal of Leukocyte Biology.2022; 111(6): 1225. CrossRef

CRC-derived exosomes containing the RNA binding protein HuR promote lung cell proliferation by stabilizing c-Myc mRNA

Hui Xiao, Xiong Ye, Vikalp Vishwakarma, Ranjan Preet, Dan A. Dixon

Cancer Biology & Therapy.2022; 23(1): 139. CrossRef

The RNA-binding protein HuR in human cancer: A friend or foe?

Advanced Drug Delivery Reviews.2022; 184: 114179. CrossRef

The Role of RNA-Binding Protein HuR in Lung Cancer by RNA Sequencing Analysis

miR-29b-3p suppresses the malignant biological behaviors of AML cells via inhibiting NF-κB and JAK/STAT signaling pathways by targeting HuR

Yong-Jing Tang, Wei Wu, Qiao-Qian Chen, Shu-Han Liu, Zhi-Yuan Zheng, Zhao-Lei Cui, Jian-Ping Xu, Yan Xue, Dong-Hong Lin

Mechanistic insights into HuR inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and STORM

Yongqiang Nie, Wei Xu, Geng G. Tian, Xiaowei Li, Yan Guo, Xuefeng Liu, Lin He, Zhifeng Shao, Xiaoyong Li, Ji Wu

Cell Biology and Toxicology.2022; 38(6): 1175. CrossRef

Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein

Meiyin Zhang, Ye Xu, Yongjian Zhang, Bing Li, Ge Lou

Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)

Christopher W. Schultz, Ranjan Preet, Teena Dhir, Dan A. Dixon, Jonathan R. Brody

The Role of VEGFA, COX2, HUR and CUGBP2 in Predicting the Response to Neoadjuvant Therapy in Rectal Cancer Patients

Henrikas Pauzas, Ugne Gyvyte, Tadas Latkauskas, Laura Kairevice, Paulius Lizdenis, Saulius Svagzdys, Erika Birgiolaite, Irma Kuliaviene, Juozas Kupcinskas, Algimantas Tamelis

AU-rich element-binding proteins in colorectal cancer

World Journal of Gastrointestinal Oncology.2019; 11(2): 71. CrossRef

Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?

Lessons from studying the AU-rich elements in chronic inflammation and autoimmunity

Niki Lourou, Maxim Gavriilidis, Dimitris L. Kontoyiannis

Journal of Autoimmunity.2019; 104: 102334. CrossRef

High cytoplasmic HuR expression is associated with advanced pT stage, high grade and increased microvessel density in urothelial bladder carcinoma

Łukasz Piotr Fus, Paweł Pihowicz, Łukasz Koperski, Janina Maja Marczewska, Barbara Górnicka

Annals of Diagnostic Pathology.2018; 33: 40. CrossRef

Divergent Innate and Epithelial Functions of the RNA-Binding Protein HuR in Intestinal Inflammation

Eleni Christodoulou-Vafeiadou, Fotis Ioakeimidis, Margarita Andreadou, Giorgos Giagkas, George Stamatakis, Martin Reczko, Martina Samiotaki, Anastasios D. Papanastasiou, Ioannis Karakasiliotis, Dimitris L. Kontoyiannis

Green Tea Polyphenol Induces Changes in Cancer-Related Factors in an Animal Model of Bladder Cancer

Tomohiro Matsuo, Yasuyoshi Miyata, Akihiro Asai, Yuji Sagara, Bungo Furusato, Junya Fukuoka, Hideki Sakai, Chih-Pin Chuu

Human antigen R as a predictive marker for response to gemcitabine-based chemotherapy in advanced cisplatin-resistant urothelial cancer

Yasuyoshi Miyata, Kensuke Mitsunari, Asai Akihiro, Shin-Ichi Watanabe, Tomohiro Matsuo, Kojiro Ohba, Hideki Sakai

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis

Fernando F. Blanco, Ranjan Preet, Andrea Aguado, Vikalp Vishwakarma, Laura E. Stevens, Alok Vyas, Subhash Padhye, Liang Xu, Scott J. Weir, Shrikant Anant, Nicole Meisner-Kober, Jonathan R. Brody, Dan A. Dixon

Geoffrey Kozak, Fernando F. Blanco, Jonathan R. Brody

HuR represses Wnt/β-catenin-mediated transcriptional activity by promoting cytoplasmic localization of β-catenin

Biochemical and Biophysical Research Communications.2015; 457(1): 65. CrossRef

Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways

Suleiman H. Suleiman, Mahmoud E. Koko, Wafaa H. Nasir, Ommnyiah Elfateh, Ubai K. Elgizouli, Mohammed O. E. Abdallah, Khalid O. Alfarouk, Ayman Hussain, Shima Faisal, Fathelrahamn M. A. Ibrahim, Maurizio Romano, Ali Sultan, Lawrence Banks, Melanie Newport,

Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs

Association ofCELF2polymorphism and the prognosis of nasopharyngeal carcinoma in southern Chinese population

Yun-Miao Guo, Ming-Xia Sun, Jing Li, Tong-Tong Liu, Hang-Zhen Huang, Jie-Rong Chen, Wen-Sheng Liu, Qi-Sheng Feng, Li-Zhen Chen, Jin-Xin Bei, Yi-Xin Zeng

Clinical significance of HuR expression in human malignancy

Ioly Kotta-Loizou, Constantinos Giaginis, Stamatios Theocharis

Expression of the ELAV-like protein HuR in the cytoplasm is associated with endometrial carcinoma progression

Dandan Wang, Min Wang, Chang’e Hu, Ting Shuang, Yingying Zhou, Xiaoyu Yan

HuR Regulates Alternative Splicing of the TRA2β Gene in Human Colon Cancer Cells under Oxidative Stress

Yoko Akaike, Kiyoshi Masuda, Yuki Kuwano, Kensei Nishida, Keisuke Kajita, Ken Kurokawa, Yuzuru Satake, Katsutoshi Shoda, Issei Imoto, Kazuhito Rokutan

Molecular and Cellular Biology.2014; 34(15): 2857. CrossRef

Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis

Jun Wang, Yan Guo, Huili Chu, Yaping Guan, Jingwang Bi, Baocheng Wang

International Journal of Molecular Sciences.2013; 14(5): 10015. CrossRef

Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer

Zhongpeng Zhu, Baocheng Wang, Jingwang Bi, Cong Zhang, Yan Guo, Huili Chu, Xiuju Liang, Chen Zhong, Jun Wang

The flip-flop HuR: part of the problem or the solution in fighting cancer?

Journal of Clinical Investigation.2012; 122(1): 16. CrossRef

Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis

Anthie Yiakouvaki, Marios Dimitriou, Ioannis Karakasiliotis, Christina Eftychi, Stamatis Theocharis, Dimitris L. Kontoyiannis

Journal of Clinical Investigation.2012; 122(1): 48. CrossRef

RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage

Nucleic Acids Research.2012; 40(2): 787. CrossRef

HuR's role in gemcitabine efficacy: an exception or opportunity?

High-constitutive HuR phosphorylation at Ser 318 by PKCδ propagates tumor relevant functions in colon carcinoma cells

Anke Doller, Christine Winkler, Irina Azrilian, Sebastian Schulz, Sylvia Hartmann, Josef Pfeilschifter, Wolfgang Eberhardt

Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer

Association between expression of embryonic lethal abnormal vision‐like protein HuR and cyclooxygenase‐2 in oral squamous cell carcinoma

Posttranscriptional regulation of cancer traits by HuR

BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells