Regulation and Role of EZH2 in Cancer
Hirohito Yamaguchi, Mien-Chie Hung
Cancer Res Treat. 2014;46(3):209-222. Published online 2014 Jul 15 DOI: https://doi.org/10.4143/crt.2014.46.3.209
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Melanoma Research.2020; 30(2): 159. CrossRef Genetic or pharmacologic blockade of enhancer of zeste homolog 2 inhibits the progression of peritoneal fibrosis
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Wei Xiang, Lei Lyu, Tao Huang, Fuxin Zheng, Jingdong Yuan, Chuanhua Zhang, Guosong Jiang
Journal of Cellular and Molecular Medicine.2020; 24(20): 11858. CrossRef Elevated expression of RUNX3 co-expressing with EZH2 in esophageal cancer patients from India
Asad Ur Rehman, Mohammad Askandar Iqbal, Real Sumayya Abdul Sattar, Snigdha Saikia, Mohammad Kashif, Wasif Mohammad Ali, Subhash Medhi, Sundeep Singh Saluja, Syed Akhtar Husain
Cancer Cell International.2020;[Epub] CrossRef MicroRNA-33b Suppresses Epithelial–Mesenchymal Transition Repressing the MYC–EZH2 Pathway in HER2+ Breast Carcinoma
Birlipta Pattanayak, Iris Garrido-Cano, Anna Adam-Artigues, Eduardo Tormo, Begoña Pineda, Paula Cabello, Elisa Alonso, Begoña Bermejo, Cristina Hernando, María Teresa Martínez, Ana Rovira, Joan Albanell, Federico Rojo, Octavio Burgués, Juan Miguel Cejalvo
Frontiers in Oncology.2020;[Epub] CrossRef Inhibition of EZH2 via the STAT3/HOTAIR signalling axis contributes to cell cycle arrest and apoptosis induced by polyphyllin I in human non-small cell lung cancer cells
Hok Shing Li, Yao Xu
Steroids.2020; 164: 108729. CrossRef EZH2 overexpression dampens tumor-suppressive signals via an EGR1 silencer to drive breast tumorigenesis
Xiaowen Guan, Houliang Deng, Un Lam Choi, Zhengfeng Li, Yiqi Yang, Jianming Zeng, Yunze Liu, Xuanjun Zhang, Gang Li
Oncogene.2020; 39(48): 7127. CrossRef RETRACTED: Exosome-Delivered LncHEIH Promotes Gastric Cancer Progression by Upregulating EZH2 and Stimulating Methylation of the GSDME Promoter
Yan Lu, Kaiqing Hou, Mengsen Li, Xiaobin Wu, Shaochun Yuan
Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef Impact of the Tumor Microenvironment on Tumor Heterogeneity and Consequences for Cancer Cell Plasticity and Stemness
Ralf Hass, Juliane von der Ohe, Hendrik Ungefroren
Cancers.2020; 12(12): 3716. CrossRef The EZH2–PHACTR2–AS1–Ribosome Axis induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer
Wenhui Chu, Xi Zhang, Lihua Qi, Yenan Fu, Peng Wang, Wei Zhao, Juan Du, Jing Zhang, Jun Zhan, Yunling Wang, Wei-Guo Zhu, Yu Yu, Hongquan Zhang
Cancer Research.2020; 80(13): 2737. CrossRef Inhibition of EZH2 Enhances the Antitumor Efficacy of Metformin in Prostate Cancer
Yifan Kong, Yanquan Zhang, Fengyi Mao, Zhuangzhuang Zhang, Zhiguo Li, Ruixin Wang, Jinghui Liu, Xiaoqi Liu
Molecular Cancer Therapeutics.2020; 19(12): 2490. CrossRef Aberrant differential expression of EZH2 and H3K27me3 in extranodal NK/T-cell lymphoma, nasal type, is associated with disease progression and prognosis
Jumei Liu, Li Liang, Sixia Huang, Lin Nong, Dong Li, Bo Zhang, Ting Li
Human Pathology.2019; 83: 166. CrossRef Retracted: Long noncoding RNA TALNEC2 plays an oncogenic role in breast cancer by binding to EZH2 to target p57KIP2 and involving in p‐p38 MAPK and NF‐κB pathways
Enqi Qiao, Daobao Chen, Qinglin Li, Weiliang Feng, Xingfei Yu, Xiping Zhang, Liang Xia, Ju Jin, Hongjian Yang
Journal of Cellular Biochemistry.2019; 120(3): 3978. CrossRef Interaction of EZH2 and P65 is involved in the arsenic trioxide-induced anti-angiogenesis in human triple-negative breast cancer cells
Fei Jiang, Yuan Li, Lu Si, Zengli Zhang, Zhong Li
Cell Biology and Toxicology.2019; 35(4): 361. CrossRef lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and miR-214 in colorectal cancer
Mu Xu, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Xueni Xu, Bei Pan, Tao Xu, Li Sun, Bangshun He, Yuqin Pan, Huiling Sun, Shukui Wang
Journal of Hematology & Oncology.2019;[Epub] CrossRef Genome-wide expression analysis reveals six contravened targets of EZH2 associated with breast cancer patient survival
Kanchan Kumari, Biswajit Das, Amit K. Adhya, Arabinda K. Rath, Sandip K. Mishra
Scientific Reports.2019;[Epub] CrossRef LncRNA ADAMTS9-AS2 promotes tongue squamous cell carcinoma proliferation, migration and EMT via the miR-600/EZH2 axis
Yingru Li, Quan Wan, Weiwei Wang, Lianxi Mai, Liujuan Sha, Mubarak Mashrah, Zhaoyu Lin, Chaobin Pan
Biomedicine & Pharmacotherapy.2019; 112: 108719. CrossRef New directions in treating peripheral T-cell lymphomas (PTCL): leveraging epigenetic modifiers alone and in combination
Helen Ma, Owen A. O’Connor, Enrica Marchi
Expert Review of Hematology.2019; 12(3): 137. CrossRef iPS-Cell Technology and the Problem of Genetic Instability—Can It Ever Be Safe for Clinical Use?
Stephen W. Attwood, Michael J. Edel
Journal of Clinical Medicine.2019; 8(3): 288. CrossRef Protein dynamics analysis reveals that missense mutations in cancer‐related genes appear frequently on hinge‐neighboring residues
Jan Fehmi Sayılgan, Türkan Haliloğlu, Mehmet Gönen
Proteins: Structure, Function, and Bioinformatics.2019; 87(6): 512. CrossRef Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity
Xin Fang, Nan Ni, John P. Lydon, Ivan Ivanov, Kayla J. Bayless, Monique Rijnkels, Qinglei Li
The American Journal of Pathology.2019; 189(6): 1212. CrossRef Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets
Mark E Pepin, Hayden H Bickerton, Maigen Bethea, Chad S Hunter, Adam R Wende, Ronadip R Banerjee
Endocrinology.2019; 160(5): 1150. CrossRef Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
Jie Zhou, Shuo Huang, Zhongyu Wang, Jiani Huang, Liang Xu, Xuefeng Tang, Yisong Y. Wan, Qi-jing Li, Alistair L. J. Symonds, Haixia Long, Bo Zhu
Nature Communications.2019;[Epub] CrossRef Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/β-catenin pathway in glioma
Yan Chen, Xubin Deng, Weiquan Chen, Pengwei Shi, Mei Lian, Hongxiao Wang, Kewan Wang, Dadi Qian, Dong Xiao, Hao Long
Cell Death & Disease.2019;[Epub] CrossRef EZH2 upregulates the PI3K/AKT pathway through IGF1R and MYC in clinically aggressive chronic lymphocytic leukaemia
Subazini Thankaswamy Kosalai, Mohammad Hamdy Abdelrazak Morsy, Nikos Papakonstantinou, Larry Mansouri, Niki Stavroyianni, Chandrasekhar Kanduri, Kostas Stamatopoulos, Richard Rosenquist, Meena Kanduri
Epigenetics.2019; 14(11): 1125. CrossRef Current state of melanoma diagnosis and treatment
Lauren E. Davis, Sara C. Shalin, Alan J. Tackett
Cancer Biology & Therapy.2019; 20(11): 1366. CrossRef DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations
Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Hummel, Francesco Bertolini
PLOS ONE.2019; 14(8): e0220681. CrossRef HO-1 promotes resistance to an EZH2 inhibitor through the pRB-E2F pathway: correlation with the progression of myelodysplastic syndrome into acute myeloid leukemia
Zhengchang He, Siyu Zhang, Dan Ma, Qin Fang, Liping Yang, Shaoxian Shen, Ying Chen, Lingli Ren, Jishi Wang
Journal of Translational Medicine.2019;[Epub] CrossRef Hematopoietic Differentiation of Human Pluripotent Stem Cells: HOX and GATA Transcription Factors as Master Regulators
Khaled Alsayegh, Lorena V. Cortés-Medina, Gerardo Ramos-Mandujano, Heba Badraiq, Mo Li
Current Genomics.2019; 20(6): 438. CrossRef Long non‐coding small nucleolar RNA host genes in digestive cancers
Huan Yang, Zheng Jiang, Shuang Wang, Yongbing Zhao, Xiaomei Song, Yufeng Xiao, Shiming Yang
Cancer Medicine.2019; 8(18): 7693. CrossRef Aberrant Expression of EZH2 in Pediatric Patients with Myelodysplastic Syndrome: A Potential Biomarker of Leukemic Evolution
Teresa de Souza Fernandez, Tatiana Fonseca Alvarenga, Elaiza Almeida Antônio de Kós, Viviane Lamim Lovatel, Rita de Cássia Tavares, Elaine Sobral da Costa, Cecília de Souza Fernandez, Eliana Abdelhay
BioMed Research International.2019; 2019: 1. CrossRef Epigenetics of Bladder Cancer: Where Biomarkers and Therapeutic Targets Meet
Victor G. Martinez, Ester Munera-Maravilla, Alejandra Bernardini, Carolina Rubio, Cristian Suarez-Cabrera, Cristina Segovia, Iris Lodewijk, Marta Dueñas, Mónica Martínez-Fernández, Jesus Maria Paramio
Frontiers in Genetics.2019;[Epub] CrossRef Cigarette smoke affects the onco-suppressor DAB2IP expression in bronchial epithelial cells of COPD patients
Giulia Anzalone, Giuseppe Arcoleo, Fabio Bucchieri, Angela M. Montalbano, Roberto Marchese, Giusy D. Albano, Caterina Di Sano, Monica Moscato, Rosalia Gagliardo, Fabio L. M. Ricciardolo, Mirella Profita
Scientific Reports.2019;[Epub] CrossRef Stratifying nonfunctional pituitary adenomas into two groups distinguished by macrophage subtypes
Garima Yagnik, Martin J. Rutowski, Sumedh S. Shah, Manish K. Aghi
Oncotarget.2019; 10(22): 2212. CrossRef Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review)
Xiaoxia Ren
Oncology Letters.2019;[Epub] CrossRef EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer
H Yamaguchi, Y Du, K Nakai, M Ding, S-S Chang, J L Hsu, J Yao, Y Wei, L Nie, S Jiao, W-C Chang, C-H Chen, Y Yu, G N Hortobagyi, M-C Hung
Oncogene.2018; 37(2): 208. CrossRef Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-d
Pei-Pei Kung, Patrick Bingham, Alexei Brooun, Michael Collins, Ya-Li Deng, Dac Dinh, Connie Fan, Ketan S. Gajiwala, Rita Grantner, Hovhannes J. Gukasyan, Wenyue Hu, Buwen Huang, Robert Kania, Susan E. Kephart, Cody Krivacic, Robert A. Kumpf, Penney Khamph
Journal of Medicinal Chemistry.2018; 61(3): 650. CrossRef Nicotine associated breast cancer in smokers is mediated through high level of EZH2 expression which can be reversed by methyltransferase inhibitor DZNepA
Kanchan Kumari, Biswajit Das, Amit Adhya, Sanjib Chaudhary, Shantibhusan Senapati, Sandip K. Mishra
Cell Death & Disease.2018;[Epub] CrossRef Long noncoding RNA GAS5 promotes bladder cancer cells apoptosis through inhibiting EZH2 transcription
Miao Wang, Chen Guo, Liang Wang, Gang Luo, Chao Huang, Yawei Li, Dong Liu, Fuqing Zeng, Guosong Jiang, Xingyuan Xiao
Cell Death & Disease.2018;[Epub] CrossRef Valproic Acid Promotes Apoptosis and Cisplatin Sensitivity Through Downregulation of H19 Noncoding RNA in Ovarian A2780 Cells
Zahre Sajadpoor, Zeinab Amini-Farsani, Hossein Teimori, Mehdi Shamsara, Mohammad Hossein Sangtarash, Payam Ghasemi-Dehkordi, Farrokh Yadollahi
Applied Biochemistry and Biotechnology.2018; 185(4): 1132. CrossRef Epigenetic dysregulation of key developmental genes in radiation‐induced rat mammary carcinomas
Kazuhiro Daino, Mayumi Nishimura, Tatsuhiko Imaoka, Masaru Takabatake, Takamitsu Morioka, Yukiko Nishimura, Yoshiya Shimada, Shizuko Kakinuma
International Journal of Cancer.2018; 143(2): 343. CrossRef The role of enhancer of zeste homolog 2: From viral epigenetics to the carcinogenesis of hepatocellular carcinoma
Luca Sanna, Irene Marchesi, Mariarosa A. B. Melone, Luigi Bagella
Journal of Cellular Physiology.2018; 233(9): 6508. CrossRef Decreased expression of microRNA-26b in locally advanced and inflammatory breast cancer
Qingqing Ding, Yan Wang, Zhuang Zuo, Yun Gong, Savitri Krishnamurthy, Chia-Wei Li, Yun-Ju Lai, Wei Wei, Jing Wang, Ganiraju C. Manyam, Lixia Diao, Xinna Zhang, Feng Lin, William F. Symmans, Li Sun, Chang-Gong Liu, Xiuping Liu, Bisrat G. Debeb, Naoto T. Ue
Human Pathology.2018; 77: 121. CrossRef EZH2 induces the expression of miR-1301 as a negative feedback control mechanism in triple negative breast cancer
Qiuju Wu, Zekun Chen, Guihua Zhang, Wenhui Zhou, You Peng, Rong Liu, Ceshi Chen, Jing Feng
Acta Biochimica et Biophysica Sinica.2018; 50(7): 693. CrossRef Impact of OGT deregulation on EZH2 target genes FOXA1 and FOXC1 expression in breast cancer cells
Ewa Forma, Paweł Jóźwiak, Piotr Ciesielski, Agnieszka Zaczek, Katarzyna Starska, Magdalena Bryś, Anna Krześlak, Gokul M. Das
PLOS ONE.2018; 13(6): e0198351. CrossRef Anti-tumor and anti-metastasis activities of honey bee larvae powder by suppressing the expression of EZH2
Masakatsu Kageyama, Kejuan Li, Shuang Sun, Guoqing Xing, Ran Gao, Zhongfang Lei, Zhenya Zhang
Biomedicine & Pharmacotherapy.2018; 105: 690. CrossRef Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma
Yang Yu, Mingjiong Zhang, Ni Wang, Quanpeng Li, Jian Yang, Shuai Yan, Xuezhi He, Guozhong Ji, Lin Miao
Cell Death & Disease.2018;[Epub] CrossRef Emerging roles of Myc in stem cell biology and novel tumor therapies
Go J. Yoshida
Journal of Experimental & Clinical Cancer Research.2018;[Epub] CrossRef The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p
Mu Xu, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Bei Pan, Xueni Xu, Tao Xu, Xiuxiu Hu, Li Sun, Bangshun He, Yuqin Pan, Huiling Sun, Shukui Wang
Molecular Cancer.2018;[Epub] CrossRef Long noncoding RNA PCAT6 functions as an oncogene by binding to EZH2 and suppressing LATS2 in non-small-cell lung cancer
Xuefei Shi, Zhili Liu, Zhicong Liu, Xueren Feng, Feng Hua, Xixian Hu, Bin Wang, Kaihua Lu, Fengqi Nie
EBioMedicine.2018; 37: 177. CrossRef DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2
Yifan Lian, Jiebin Yang, Yikai Lian, Chuangxing Xiao, Xuezhen Hu, Hongzhi Xu
Cancer Communications.2018; 38(1): 1. CrossRef EZH2, HIF-1, and Their Inhibitors: An Overview on Pediatric Cancers
Marco Papale, Elisabetta Ferretti, Giuseppe Battaglia, Diana Bellavia, Antonello Mai, Marco Tafani
Frontiers in Pediatrics.2018;[Epub] CrossRef Long Noncoding RNA ANRIL Supports Proliferation of Adult T-Cell Leukemia Cells through Cooperation with EZH2
Zaowen Song, Wencai Wu, Mengyun Chen, Wenzhao Cheng, Juntao Yu, Jinyong Fang, Lingling Xu, Jun-ichirou Yasunaga, Masao Matsuoka, Tiejun Zhao, Viviana Simon
Journal of Virology.2018;[Epub] CrossRef MET/ERK and MET/JNK Pathway Activation Is Involved in BCR-ABL Inhibitor-resistance in Chronic Myeloid Leukemia
Masanobu Tsubaki
YAKUGAKU ZASSHI.2018; 138(12): 1461. CrossRef EZH2 inhibitors sensitize myeloma cell lines to panobinostat resulting in unique combinatorial transcriptomic changes
Taylor Harding, Jessica Swanson, Brian Van Ness
Oncotarget.2018; 9(31): 21930. CrossRef The untold stories of the speech gene, the FOXP2 cancer gene
Maria Jesus Herrero, Yorick Gitton
Genes & Cancer.2018; 9(1-2): 11. CrossRef SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer
W Lu, S Liu, B Li, Y Xie, M G Izban, B R Ballard, S A Sathyanarayana, S E Adunyah, R J Matusik, Z Chen
Oncogene.2017; 36(10): 1364. CrossRef Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis
Junchao Xue, Yang Liu, Fei Luo, Xiaolin Lu, Hui Xu, Xinlu Liu, Lu Lu, Qianlei Yang, Chao Chen, Weimin Fan, Qizhan Liu
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2017; 1863(3): 753. CrossRef Regulation of cancer epigenomes with a histone-binding synthetic transcription factor
David B. Nyer, Rene M. Daer, Daniel Vargas, Caroline Hom, Karmella A. Haynes
npj Genomic Medicine.2017;[Epub] CrossRef Metastatic biomarkers in synovial sarcoma
Rosalia de Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen, Saied Mirshahidi
Biomarker Research.2017;[Epub] CrossRef Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to β-elemene-inhibited growth of nasopharyngeal carcinoma cells
JingJing Wu, Qing Tang, LiJuan Yang, YuQing Chen, Fang Zheng, Swei Sunny Hann
Scientific Reports.2017;[Epub] CrossRef Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3
Maureen M. Sherry-Lynes, Sejuti Sengupta, Shreya Kulkarni, Brent H. Cochran, Anita B. Hjelmeland
PLOS ONE.2017; 12(4): e0174775. CrossRef Modulation of HAT activity by the BRCA2 N372H variation is a novel mechanism of paclitaxel resistance in breast cancer cell lines
Woo Sun Kwon, Sun Young Rha, Hei-Cheul Jeung, Tae Soo Kim, Hyun Cheol Chung
Biochemical Pharmacology.2017; 138: 163. CrossRef Expression and inhibition of BRD4, EZH2 and TOP2A in neurofibromas and malignant peripheral nerve sheath tumors
Azadeh Amirnasr, Rob M. Verdijk, Patricia F. van Kuijk, Walter Taal, Stefan Sleijfer, Erik A. C. Wiemer, Marta M. Alonso
PLOS ONE.2017; 12(8): e0183155. CrossRef Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options
Robert E. Brown, Syed Naqvi, Mary F. McGuire, Jamie Buryanek, Ron J. Karni
Journal of Otolaryngology - Head & Neck Surgery.2017;[Epub] CrossRef Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation
Hyunjoo Kwon, Kyoungsub Song, Chang Han, Jinqiang Zhang, Lu Lu, Weina Chen, Tong Wu
The American Journal of Pathology.2017; 187(10): 2288. CrossRef The role of EZH2 in overall survival of colorectal cancer: a meta-analysis
Laura Vilorio-Marqués, Vicente Martín, Cristina Diez-Tascón, María Francisca González-Sevilla, Tania Fernández-Villa, Emiliano Honrado, Veronica Davila-Batista, Antonio J. Molina
Scientific Reports.2017;[Epub] CrossRef Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy
Huan Yu, Meng Ma, Junya Yan, Longwen Xu, Jiayi Yu, Jie Dai, Tianxiao Xu, Huan Tang, Xiaowen Wu, Siming Li, Bin Lian, Lili Mao, Zhihong Chi, Chuanliang Cui, Jun Guo, Yan Kong
Journal of Translational Medicine.2017;[Epub] CrossRef Decreased expression of JMJD3 predicts poor prognosis of patients with clear cell renal cell carcinoma
Jiajun Wang, Li Liu, Qilai Long, Qi Bai, Yu Xia, Wei Xi, Jiejie Xu, Jianming Guo
Oncology Letters.2017; 14(2): 1550. CrossRef Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells
Masanobu Tsubaki, Tomoya Takeda, Toshiki Kino, Kazuko Sakai, Tatsuki Itoh, Motohiro Imano, Takashi Nakayama, Kazuto Nishio, Takao Satou, Shozo Nishida
Oncotarget.2017; 8(24): 38717. CrossRef Methylation-mediated silencing of microRNA-211 promotes cell growth and epithelial to mesenchymal transition through activation of the AKT/β-catenin pathway in GBM
Weidong Li, Xiaobo Miao, Lingling Liu, Yue Zhang, Xuejun Jin, Xiaojun Luo, Hai Gao, Xubin Deng
Oncotarget.2017; 8(15): 25167. CrossRef EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis
Kei Ihira, Peixin Dong, Ying Xiong, Hidemichi Watari, Yosuke Konno, Sharon JB Hanley, Masayuki Noguchi, Noriyuki Hirata, Futoshi Suizu, Takahiro Yamada, Masataka Kudo, Noriaki Sakuragi
Oncotarget.2017; 8(8): 13509. CrossRef Inhibition of enhancer of zeste homolog 2 increases the expression of p16 and suppresses the proliferation and migration of ovarian carcinoma cells in�vitro and in�vivo
Fangfang Lu, Hong Xu, Qi Wang, Meiyi Li, Jiahua Meng, Yan Kuang
Oncology Letters.2017;[Epub] CrossRef miR-202 Diminishes TGFβ Receptors and Attenuates TGFβ1-Induced EMT in Pancreatic Cancer
Hardik R. Mody, Sau Wai Hung, Rakesh K. Pathak, Jazmine Griffin, Zobeida Cruz-Monserrate, Rajgopal Govindarajan
Molecular Cancer Research.2017; 15(8): 1029. CrossRef TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis
Min Deng, Ruixin Zhang, Zhengxi He, Qinwei Qiu, Xihong Lu, Jiang Yin, Hao Liu, Xiaoting Jia, Zhimin He
Cancer Research.2017; 77(22): 6069. CrossRef The role of the polycomb repressive complex pathway in T and NK cell lymphoma: biological and prognostic implications
Soo Hee Kim, Woo Ick Yang, Yoo Hong Min, Young Hyeh Ko, Sun Och Yoon
Tumor Biology.2016; 37(2): 2037. CrossRef Interference with endogenous EZH2 reverses the chemotherapy drug resistance in cervical cancer cells partly by up-regulating Dicer expression
Liqiong Cai, Zehua Wang, Denghua Liu
Tumor Biology.2016; 37(5): 6359. CrossRef The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane
Matthew L. Fisher, Gautam Adhikary, Dan Grun, David M. Kaetzel, Richard L. Eckert
Molecular Carcinogenesis.2016; 55(12): 2024. CrossRef Problems of glioblastoma multiforme drug resistance
A. A. Stavrovskaya, S. S. Shushanov, E. Yu. Rybalkina
Biochemistry (Moscow).2016; 81(2): 91. CrossRef High EZH2 Protein Expression Is Associated with Poor Overall Survival in Patients with Luminal A Breast Cancer
Si-Hyong Jang, Jong Eun Lee, Mee-Hye Oh, Ji-Hye Lee, Hyun Deuk Cho, Kyung-Ju Kim, Sung Yong Kim, Sun Wook Han, Han Jo Kim, Sang Byung Bae, Hyun Ju Lee
Journal of Breast Cancer.2016; 19(1): 53. CrossRef Expression of Mirna-26B in the Diagnosis and Prognosis of Patients with Non-Small-Cell Lung Cancer
Li-Peng Jiang, Zhi-Tu Zhu, Chun-Yan He
Future Oncology.2016; 12(9): 1105. CrossRef Targeting NK Cells for Anticancer Immunotherapy: Clinical and Preclinical Approaches
Sebastian Carotta
Frontiers in Immunology.2016;[Epub] CrossRef Role of EZH2 histone methyltrasferase in melanoma progression and metastasis
Fade Mahmoud, Bradley Shields, Issam Makhoul, Laura F. Hutchins, Sara C. Shalin, Alan J. Tackett
Cancer Biology & Therapy.2016; 17(6): 579. CrossRef Prognostic value of UTX expression in patients with clear cell renal cell carcinoma
Jiajun Wang, Li Liu, Wei Xi, Qilai Long, Yiwei Wang, Qi Bai, Yu Xia, Jiejie Xu, Jianming Guo
Urologic Oncology: Seminars and Original Investigations.2016; 34(8): 338.e19. CrossRef Squamous Cell Cancers: A Unified Perspective on Biology and Genetics
G. Paolo Dotto, Anil K. Rustgi
Cancer Cell.2016; 29(5): 622. CrossRef Genomic and Epigenomic Alterations in Cancer
Balabhadrapatruni V.S.K. Chakravarthi, Saroj Nepal, Sooryanarayana Varambally
The American Journal of Pathology.2016; 186(7): 1724. CrossRef Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma
Yusuke Furukawa, Jiro Kikuchi
International Journal of Hematology.2016; 104(3): 281. CrossRef Down-Regulation of TSLP After EZH2 Silencing in ESCC Cell Line
Gholamreza Karami Madani, Abolfazl Rad, Mohammad Mahdi Forghanifard
Journal of Biomedicine.2016;[Epub] CrossRef High EZH2 expression is correlated to metastatic disease in pediatric soft tissue sarcomas
Maria Ramaglia, Velia D’Angelo, Adriana Iannotta, Daniela Di Pinto, Elvira Pota, Maria Carmen Affinita, Vittoria Donofrio, Maria Elena Errico, Angela Lombardi, Cristiana Indolfi, Fiorina Casale, Michele Caraglia
Cancer Cell International.2016;[Epub] CrossRef DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity
Y Wang, H Sun, J Wang, H Wang, L Meng, C Xu, M Jin, B Wang, Y Zhang, Y Zhang, T Zhu
Cell Death & Disease.2016; 7(7): e2316. CrossRef Significance of EZH2 expression in canine mammary tumors
Hyun-Ji Choi, Sungwoong Jang, Jae-Eun Ryu, Hyo-Ju Lee, Han-Byul Lee, Woo-Sung Ahn, Hye-Jin Kim, Hyo-Jin Lee, Hee Jin Lee, Gyung-Yub Gong, Woo-Chan Son
BMC Veterinary Research.2016;[Epub] CrossRef Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitabl
Rishi G. Vaswani, Victor S. Gehling, Les A. Dakin, Andrew S. Cook, Christopher G. Nasveschuk, Martin Duplessis, Priyadarshini Iyer, Srividya Balasubramanian, Feng Zhao, Andrew C. Good, Robert Campbell, Christina Lee, Nico Cantone, Richard T. Cummings, Emm
Journal of Medicinal Chemistry.2016; 59(21): 9928. CrossRef MiR-101 Targets the EZH2/Wnt/β-Catenin the Pathway to Promote the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells
Hongrui Wang, Yake Meng, Quanjun Cui, Fujun Qin, Haisong Yang, Yu Chen, Yajun Cheng, Jiangang Shi, Yongfei Guo
Scientific Reports.2016;[Epub] CrossRef EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells
Ming-Quan Sha, Xiao-Li Zhao, Liang Li, Li-Hui Li, Yi Li, Tian-Geng Dong, Wei-Xin Niu, Li-Jun Jia, Rong-Guang Shao, Yong-Su Zhen, Zhen Wang
Cell Death & Disease.2016; 7(11): e2486. CrossRef Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report
Joseph Hatem, April M. Schrank-Hacker, Christopher D. Watt, Jennifer J. D. Morrissette, Adam I. Rubin, Ellen J. Kim, Sunita D. Nasta, Mariusz A. Wasik, Agata M. Bogusz
Diagnostic Pathology.2016;[Epub] CrossRef Expression Profile and Function Analysis of LncRNAs during Priming Phase of Rat Liver Regeneration
Jun Li, Wei Jin, Yanli Qin, Weiming Zhao, Cuifang Chang, Cunshuan Xu, Klaus Roemer
PLOS ONE.2016; 11(6): e0156128. CrossRef Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer
Cortney L. Lawrence, Albert S. Baldwin, Aamir Ahmad
PLOS ONE.2016; 11(10): e0165005. CrossRef Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids
Qiwei Yang, Archana Laknaur, Lelyand Elam, Nahed Ismail, Larisa Gavrilova-Jordan, John Lue, Michael P. Diamond, Ayman Al-Hendy
Reproductive Sciences.2016; 23(10): 1314. CrossRef The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway
Hiroyoshi Kurihara, Reo Maruyama, Kazuya Ishiguro, Shinichi Kanno, Itaru Yamamoto, Keisuke Ishigami, Kei Mitsuhashi, Hisayoshi Igarashi, Miki Ito, Tokuma Tanuma, Yasutaka Sukawa, Kenji Okita, Tadashi Hasegawa, Kohzoh Imai, Hiroyuki Yamamoto, Yasuhisa Shin
Oncotarget.2016; 7(11): 12704. CrossRef The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia
Nikos Papakonstantinou, Stavroula Ntoufa, Elisavet Chartomatsidou, Konstantia Kotta, Andreas Agathangelidis, Lefki Giassafaki, Tzeni Karamanli, Panagiota Bele, Theodoros Moysiadis, Panagiotis Baliakas, Lesley Ann Sutton, Niki Stavroyianni, Achilles Anagno
Oncotarget.2016; 7(24): 35946. CrossRef Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor α in breast cancer cells
Lydia Edjekouane, Samira Benhadjeba, Maïka Jangal, Hubert Fleury, Nicolas Gévry, Euridice Carmona, André Tremblay
Oncotarget.2016; 7(47): 77276. CrossRef Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential
Ranran Sun, Jacson Shen, Yan Gao, Yubing Zhou, Zujiang Yu, Francis Hornicek, Quancheng Kan, Zhenfeng Duan
Oncotarget.2016; 7(25): 38333. CrossRef GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers
How-Wen Ko, Heng-Huan Lee, Longfei Huo, Weiya Xia, Cheng-Chieh Yang, Jennifer L. Hsu, Long-Yuan Li, Chien-Chen Lai, Li-Chuan Chan, Chien-Chia Cheng, Adam M. Labaff, Hsin-Wei Liao, Seung-Oe Lim, Chia-Wei Li, Yongkun Wei, Lei Nie, Hirohito Yamaguchi, Mien-C
Oncotarget.2016; 7(35): 57131. CrossRef Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma
Youtao Xu, Jie Wang, Mantang Qiu, Lei Xu, Ming Li, Feng Jiang, Rong Yin, Lin Xu
Tumor Biology.2015; 36(3): 1643. CrossRef Role of the ubiquitin proteasome system in hematologic malignancies
Anagh A. Sahasrabuddhe, Kojo S. J. Elenitoba‐Johnson
Immunological Reviews.2015; 263(1): 224. CrossRef The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer
Lili Liao, Joseph R. Testa, Haifeng Yang
Cancer Genetics.2015; 208(5): 206. CrossRef The role of aberrant proteolysis in lymphomagenesis
Anagh A. Sahasrabuddhe, Kojo S.J. Elenitoba-Johnson
Current Opinion in Hematology.2015; 22(4): 369. CrossRef Small Molecule Inhibitors of EZH2: the Emerging Translational Landscape
Heike Keilhack, Jesse J Smith
Epigenomics.2015; 7(3): 337. CrossRef Enhancer of zeste homolog 2 silencing inhibits tumor growth and lung metastasis in osteosarcoma
Yang-Fan Lv, Guang-Ning Yan, Gang Meng, Xi Zhang, Qiao-Nan Guo
Scientific Reports.2015;[Epub] CrossRef Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma
Mehnaz Khan, Laura L Walters, Qiang Li, Dafydd G Thomas, Jason M L Miller, Qitao Zhang, Andrew P Sciallis, Yu Liu, Brian J Dlouhy, Patrice E Fort, Steven M Archer, Hakan Demirci, Yali Dou, Rajesh C Rao
Laboratory Investigation.2015; 95(11): 1278. CrossRef Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer
Emmi I. Joensuu, Taina T. Nieminen, Johanna E. Lotsari, Walter Pavicic, Wael M. Abdel‐Rahman, Päivi Peltomäki
Genes, Chromosomes and Cancer.2015; 54(12): 776. CrossRef Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma
Jiro Kikuchi, Daisuke Koyama, Taeko Wada, Tohru Izumi, Peter O. Hofgaard, Bjarne Bogen, Yusuke Furukawa
Journal of Clinical Investigation.2015; 125(12): 4375. CrossRef Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre- and postoperatively assessed clinicopathological parameters
Nathaniel Melling, Erik Thomsen, Maria Christina Tsourlakis, Martina Kluth, Claudia Hube-Magg, Sarah Minner, Christina Koop, Markus Graefen, Hans Heinzer, Corinna Wittmer, Guido Sauter, Waldemar Wilczak, Hartwig Huland, Ronald Simon, Thorsten Schlomm, Ste
Carcinogenesis.2015; 36(11): 1333. CrossRef EZH2 in Bladder Cancer, a Promising Therapeutic Target
Mónica Martínez-Fernández, Carolina Rubio, Cristina Segovia, Fernando López-Calderón, Marta Dueñas, Jesús Paramio
International Journal of Molecular Sciences.2015; 16(11): 27107. CrossRef siRNA Silencing EZH2 Reverses Cisplatin-resistance of Human Non-small Cell Lung and Gastric Cancer Cells
Wen Zhou, Jian Wang, Wang-Ying Man, Qing-Wei Zhang, Wen-Gui Xu
Asian Pacific Journal of Cancer Prevention.2015; 16(6): 2425. CrossRef H3K27me3 is an Epigenetic Mark of Relevance in Endometriosis
Mariano Colón-Caraballo, Janice B. Monteiro, Idhaliz Flores
Reproductive Sciences.2015; 22(9): 1134. CrossRef A Gene Regulatory Program in Human Breast Cancer
Renhua Li, John Campos, Joji Iida
Genetics.2015; 201(4): 1341. CrossRef MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells
Xiaoping Liu, Qianqian Lei, Zhibin Yu, Gang Xu, Hailin Tang, Wei Wang, Zeyou Wang, Guiyuan Li, Minghua Wu
Oncotarget.2015; 6(10): 7930. CrossRef Enhancer of zeste acts as a major developmental regulator ofCiona intestinalisembryogenesis
Emilie Le Goff, Camille Martinand-Mari, Marianne Martin, Jérôme Feuillard, Yvan Boublik, Nelly Godefroy, Paul Mangeat, Stephen Baghdiguian, Giacomo Cavalli
Biology Open.2015; 4(9): 1109. CrossRef
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