Cancer Research and Treatment

REVIEW ARTICLE 1970 January 1 Clinical Circulating Tumor DNA Testing for Precision Oncology
Circulating tumor DNA (ctDNA) is the portion of the cell-free DNA in the blood of cancer patients released from tumor cells via apoptosis, necrosis, or active release. From 10 mL of blood, the 4-5 mL of plasma obtained from a cancer patient contains 5-10 ng/mL of ctDNA. The plas...

REVIEW ARTICLE 1970 January 1 Utilizing Plasma Circulating Tumor DNA Sequencing for Precision Medicine in the Management of Solid Cancers
Plasma circulating tumor DNA (ctDNA) sequencing has demonstrated clinical utility for tumor molecular profiling at initial diagnosis or tumor progression in advanced solid cancers and is being rapidly incorporated into the clinical practice guidelines, including non–small cell ...

SPECIAL ARTICLE 1970 January 1 Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2020
Purpose The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2020. Materials and Methods Incidence, survival, and prevalence rates of cancer were calculated using the Korea National ...

SPECIAL ARTICLE 1970 January 1 Prediction of Cancer Incidence and Mortality in Korea, 2023
Purpose This study aimed to report the projected cancer incidence and mortality for the year 2023 to estimate Korea’s current cancer burden. Materials and Methods Cancer incidence data from 1999 to 2020 were obtained from the Korea National Cancer Incidence Database, and cance...

Current Issue

Volume 55(2); Apr 2023

Volume 55(1); January 2023

Volume 54(4); October 2022

Accepted and E-pub version articles are published online before they appear in a regular issue of the journal. Accepted articles are PDF versions of manuscripts that have been peer reviewed and accepted for publication, but not yet copyedited or typeset, allowing readers the most rapid access to accepted papers. The accepted article remains on this page until the final proof version of the paper is posted in Epub Ahead-of Print page.
Accepted article is given its own Doi, so it can be citable as it has been linked to PubMed.

It may be cited as shown in the following example:
Park IH, Im SA, Jung KH, Sohn JH, Park YH, Lee KS, et al. Randomized Open Label Phase III Trial of Irinotecan Plus Capecitabine versus Capecitabine Monotherapy in Patients with Metastatic Breast Cancer Previously Treated with Anthracycline and Taxane: PROCEED Trial (KCSG BR 11-01). Cancer Res Treat. 2018 Feb 14 [Epub]. https://doi.org/10.4143/crt.2017.562.

Original Articles

A Phase 3 Randomized Clinical Trial to Compare Efficacy and Safety between Combination Therapy and Monotherapy in Elderly Patients with Advanced Gastric Cancer (KCSG ST13-10)

Keun-Wook Lee, Dae Young Zang, Min-Hee Ryu, Hye Sook Han, Ki Hyang Kim, Mi-Jung Kim, Sung Ae Koh, Sung Sook Lee, Dong- Hoe Koo, Yoon Ho Ko, Byeong Seok Sohn, Jin Won Kim, Jin Hyun Park, Byung-Ho Nam, In Sil Choi

Received January 27, 2023 Accepted May 24, 2023 Published online May 25, 2023
DOI: https://doi.org/10.4143/crt.2023.333
[Accepted]

Targeting CD73 to Overcomes Resistance to First-Generation EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

Miso Kim, Soyeon Kim, Jeemin Yim, Bhumsuk Keam, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Dae Seog Heo

Received January 17, 2023 Accepted May 22, 2023 Published online May 23, 2023
DOI: https://doi.org/10.4143/crt.2023.311
[Accepted]

Expanded Access Program Pralsetinib in Advanced Non-Small Cell Lung Cancer with Rearranged during Transfection (RET) Gene Rearrangement

Youngkyung Jeon, Hyun Ae Jung, Sehhoon Park, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Se-Hoon Lee

Received February 20, 2023 Accepted May 18, 2023 Published online May 22, 2023
DOI: https://doi.org/10.4143/crt.2023.403
[Accepted]

Final Report on Real-World Effectiveness of Sequential Afatinib and Osimertinib in EGFR Positive Advanced Non-Small Cell Lung Cancer: Updated Analysis of the RESET Study

Taeyun Kim, Tae Won Jang, Chang Min Choi, Mi-Hyun Kim, Sung Yong Lee, Yoon Soo Chang, Kye Young Lee, Seung Joon Kim, Sei Hoon Yang, Jeong Seon Ryu, Jeong Eun Lee, Shin Yup Lee, Chan Kwon Park, Sang Hoon Lee, Seung Hun Jang, Seong Hoon Yoon, Hyung-Joo Oh

Received March 22, 2023 Accepted May 18, 2023 Published online May 19, 2023
DOI: https://doi.org/10.4143/crt.2023.493
[Accepted]

Phase II Trial of Combined Durvalumab Plus Tremelimumab with Proton Therapy for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Hana Kim, Sehhoon Park, Hyun Ae Jung, Se-Hoon Lee, Keunchil Park, Yong Chan Ahn, Dongryul Oh, Myung-Ju Ahn

Received March 24, 2023 Accepted May 15, 2023 Published online May 17, 2023
DOI: https://doi.org/10.4143/crt.2023.502
[Accepted]

Safety and Tolerability of Weekly Genexol-PM, a Cremophor-Free Polymeric Micelle Formulation of Paclitaxel, with Carboplatin in Gynecologic Cancer: A Phase I Study

So Hyun Nam, Yong Man Kim, Shin-Wha Lee, Young-Jae Lee

Received November 1, 2022 Accepted May 12, 2023 Published online May 15, 2023
DOI: https://doi.org/10.4143/crt.2022.1436
[Accepted]

Individualized Concurrent Chemotherapy for Patients with Stage III–IVa Nasopharyngeal Carcinoma Receiving Neoadjuvant Chemotherapy Combined with Definitive Intensity-Modulated Radiotherapy

Pengjie Ji, Qiongjiao Lu, Xiaoqiang Chen, Yuebing Chen, Xiane Peng, Zhiwei Chen, Cheng Lin, Shaojun Lin, Jingfeng Zong

Received December 23, 2022 Accepted May 10, 2023 Published online May 11, 2023
DOI: https://doi.org/10.4143/crt.2022.1651
[Accepted]

Outcomes of Salvage Therapy for Oropharyngeal Cancer Recurrence Following Upfront Radiation Therapy and Prognostic Factors

Nayeon Choi, Hack Jung Kim, Heejun Yi, Heejung Kim, Tae Hwan Kim, Han-Sin Jeong, Young-Ik Son, Chung-Hwan Baek, Dongryul Oh, Yong Chan Ahn, Man Ki Chung

Received September 8, 2022 Accepted May 6, 2023 Published online May 8, 2023
DOI: https://doi.org/10.4143/crt.2022.1046
[Accepted]

Analysis of Plasma Circulating Tumor DNA in Borderline Resectable Pancreatic Cancer Treated with Neoadjuvant Modified FOLFIRINOX: Clinical Relevance of DNA Damage Repair Gene Alteration Detection

Dong-Hoon Lim, Hyunseok Yoon, Kyu-pyo Kim, Baek-Yeol Ryoo, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Dae Wook Hwang, Jae Hoon Lee, Ki Byung Song, Song Cheol Kim, Seung-Mo Hong, Jaewon Hyung, Changhoon Yoo

Received March 8, 2023 Accepted May 4, 2023 Published online May 4, 2023
DOI: https://doi.org/10.4143/crt.2023.452
[Accepted]

ARID1A Mutation from Targeted NGS Predicts Primary Resistance to Gemcitabine and Cisplatin Chemotherapy in Advanced Biliary Tract Cancer

Sung Hwan Lee, Jaekyung Cheon, Seoyoung Lee, Beodeul Kang, Chan Kim, Hyo Sup Shim, Young Nyun Park, Sanghoon Jung, Sung Hoon Choi, Hye Jin Choi, Choong-kun Lee, Hong Jae Chon

Received November 3, 2022 Accepted April 25, 2023 Published online May 3, 2023
DOI: https://doi.org/10.4143/crt.2022.1450
[Accepted]